-
3
-
-
0026049726
-
-
P. Cohen, D. M. Peehl, G. Lamson, R. G. Rosenfeld, J. Clin. Endocrinol. Metab. 73, 401 (1991).
-
(1991)
J. Clin. Endocrinol. Metab.
, vol.73
, pp. 401
-
-
Cohen, P.1
Peehl, D.M.2
Lamson, G.3
Rosenfeld, R.G.4
-
8
-
-
15444353599
-
-
note
-
Acromegaly and GH deficiency are examples where changes in tissues are correlated with serum IGF-I levels, implying a relation between serum IGF-I levels and tissue IGF-I bioactivity.
-
-
-
-
12
-
-
0024406369
-
-
Steering Committee of the Physicians' Health Study Research Group, N. Engl. J. Med. 321, 129 (1989). The Physicians' Health Study began in 1982 as a randomized, double-blinded, placebo-controlled trial of β-carotene and aspirin in 22,017 U.S. male physicians aged 40 to 82 without prior diagnosed cardiovascular disease or cancer. Each participant provided informed consent. Before randomization, the men had their blood drawn into vacutainer tubes containing EDTA (anti-coagulant). The blood was centrifuged and returned in polypropylene cryopreservation vials by overnight prepaid courier with cold packs to keep it cool. Upon receipt, the plasma was stored at -82°C. No specimen thawed or warmed substantially during storage.
-
(1989)
N. Engl. J. Med.
, vol.321
, pp. 129
-
-
-
13
-
-
15444343099
-
-
note
-
The Whitmore-Jewett classification scheme was used to identify stage, and cases without pathological staging were considered indeterminate, unless there was evidence of metastases. Cases presenting as stage C or D were considered "high grade/ stage cancer." Also, we assigned that category to stage A, B, or indeterminate cases with either poor histological differentiation or a Gleason score of 7 or higher.
-
-
-
-
14
-
-
0029813882
-
-
P. H. Gann, C. H. Hennekens, J. Ma, C. Longcope, M. J. Stampfer, J. Natl. Cancer Inst. 88, 1118 (1996).
-
(1996)
J. Natl. Cancer Inst.
, vol.88
, pp. 1118
-
-
Gann, P.H.1
Hennekens, C.H.2
Ma, J.3
Longcope, C.4
Stampfer, M.J.5
-
17
-
-
15444347129
-
-
note
-
Selection bias is minimal here as it is unlikely that subjects returned blood samples or provided adequate blood volume differentially on the basis of any relation between their IGF levels in 1982 and later development of prostate cancer. Previous study has shown that cases who did and did not provide blood samples were not appreciably different in their baseline lifestyle characteristics (15).
-
-
-
-
18
-
-
15444357836
-
-
note
-
The IGF-I values obtained by the ELISA were highly correlated (Pearson r = 0.97) with values obtained by radioimmunoassay after acid chromatography. All assays were carried out in a blinded manner, and quality control samples were included within assay runs. Average intra-assay coefficients of variation for IGF-I, IGF-II, and IGFBP-3 were 4.9%, 3.0%, and 9.0%, respectively.
-
-
-
-
19
-
-
15444352170
-
-
note
-
To evaluate the effect of our blood collection methods on IGF-I levels, we compared IGF-I and IGFBP-3 levels in blood samples that were processed and serum frozen immediately after venipuncture (the usual collection and processing methods) to samples that were stored as heparinized whole blood for 24 and 36 hours before processing (mimicking our collection conditions). The mean IGF-I and IGFBP-3 values were almost identical and the interclass correlations between results of the two collection methods were 0.98 for IGF-I and 0.96 for IGFBP-3, indicating that our collection methods did not adversely affect sample integrity.
-
-
-
-
20
-
-
15444344628
-
-
note
-
To examine how well a single measurement of IGF-I represents levels over time, we collected two blood samples each from 16 people, 8 weeks apart (time 1 and time 2). The correlation between blood levels taken at time 1 and time 2 was 0.65.
-
-
-
-
22
-
-
16944362998
-
-
E. Giovannucci, E. B. Rimm, M. J. Stampfer, G. A. Colditz, W. C. Willett, Cancer Epidemiol. Biomarkers Prev. 6, 557 (1997).
-
(1997)
Cancer Epidemiol. Biomarkers Prev.
, vol.6
, pp. 557
-
-
Giovannucci, E.1
Rimm, E.B.2
Stampfer, M.J.3
Colditz, G.A.4
Willett, W.C.5
-
24
-
-
0039531299
-
-
Little, Brown, Boston, MA
-
K. J. Rothman, Modern Epidemiology (Little, Brown, Boston, MA, 1986), pp. 82-97 and 286-310.
-
(1986)
Modern Epidemiology
, pp. 82-97
-
-
Rothman, K.J.1
-
30
-
-
0029072776
-
-
G. Tibllin, M. Eriksoon, S. Cnattingius, A. Ekbom, Epidemiology 6, 423 (1995).
-
(1995)
Epidemiology
, vol.6
, pp. 423
-
-
Tibllin, G.1
Eriksoon, M.2
Cnattingius, S.3
Ekbom, A.4
-
35
-
-
15444348021
-
-
note
-
Supported by National Research Service Award 5 T32 CA 09001-20, National Cancer Institute grants CA-58684 and CA-42182, and the National Cancer Institute of Canada.
-
-
-
|