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Volumn 279, Issue 5350, 1998, Pages 563-566

Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C;

EID: 0032559272     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5350.563     Document Type: Article
Times cited : (1819)

References (35)
  • 8
    • 15444353599 scopus 로고    scopus 로고
    • note
    • Acromegaly and GH deficiency are examples where changes in tissues are correlated with serum IGF-I levels, implying a relation between serum IGF-I levels and tissue IGF-I bioactivity.
  • 12
    • 0024406369 scopus 로고
    • Steering Committee of the Physicians' Health Study Research Group, N. Engl. J. Med. 321, 129 (1989). The Physicians' Health Study began in 1982 as a randomized, double-blinded, placebo-controlled trial of β-carotene and aspirin in 22,017 U.S. male physicians aged 40 to 82 without prior diagnosed cardiovascular disease or cancer. Each participant provided informed consent. Before randomization, the men had their blood drawn into vacutainer tubes containing EDTA (anti-coagulant). The blood was centrifuged and returned in polypropylene cryopreservation vials by overnight prepaid courier with cold packs to keep it cool. Upon receipt, the plasma was stored at -82°C. No specimen thawed or warmed substantially during storage.
    • (1989) N. Engl. J. Med. , vol.321 , pp. 129
  • 13
    • 15444343099 scopus 로고    scopus 로고
    • note
    • The Whitmore-Jewett classification scheme was used to identify stage, and cases without pathological staging were considered indeterminate, unless there was evidence of metastases. Cases presenting as stage C or D were considered "high grade/ stage cancer." Also, we assigned that category to stage A, B, or indeterminate cases with either poor histological differentiation or a Gleason score of 7 or higher.
  • 17
    • 15444347129 scopus 로고    scopus 로고
    • note
    • Selection bias is minimal here as it is unlikely that subjects returned blood samples or provided adequate blood volume differentially on the basis of any relation between their IGF levels in 1982 and later development of prostate cancer. Previous study has shown that cases who did and did not provide blood samples were not appreciably different in their baseline lifestyle characteristics (15).
  • 18
    • 15444357836 scopus 로고    scopus 로고
    • note
    • The IGF-I values obtained by the ELISA were highly correlated (Pearson r = 0.97) with values obtained by radioimmunoassay after acid chromatography. All assays were carried out in a blinded manner, and quality control samples were included within assay runs. Average intra-assay coefficients of variation for IGF-I, IGF-II, and IGFBP-3 were 4.9%, 3.0%, and 9.0%, respectively.
  • 19
    • 15444352170 scopus 로고    scopus 로고
    • note
    • To evaluate the effect of our blood collection methods on IGF-I levels, we compared IGF-I and IGFBP-3 levels in blood samples that were processed and serum frozen immediately after venipuncture (the usual collection and processing methods) to samples that were stored as heparinized whole blood for 24 and 36 hours before processing (mimicking our collection conditions). The mean IGF-I and IGFBP-3 values were almost identical and the interclass correlations between results of the two collection methods were 0.98 for IGF-I and 0.96 for IGFBP-3, indicating that our collection methods did not adversely affect sample integrity.
  • 20
    • 15444344628 scopus 로고    scopus 로고
    • note
    • To examine how well a single measurement of IGF-I represents levels over time, we collected two blood samples each from 16 people, 8 weeks apart (time 1 and time 2). The correlation between blood levels taken at time 1 and time 2 was 0.65.
  • 24
    • 0039531299 scopus 로고
    • Little, Brown, Boston, MA
    • K. J. Rothman, Modern Epidemiology (Little, Brown, Boston, MA, 1986), pp. 82-97 and 286-310.
    • (1986) Modern Epidemiology , pp. 82-97
    • Rothman, K.J.1
  • 35
    • 15444348021 scopus 로고    scopus 로고
    • note
    • Supported by National Research Service Award 5 T32 CA 09001-20, National Cancer Institute grants CA-58684 and CA-42182, and the National Cancer Institute of Canada.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.