Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway

Experimental Gerontology

Volumn 48, Issue 5, 2013, Pages 499-506

  Wan, Qin Li ^a,b   Zheng, Shan Qing ^a,b   Wu, Gui Sheng ^c   Luo, Huai Rong ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c KUNMING INSTITUTE OF ZOOLOGY   (China)

Author keywords

AMPK; Aspirin; Caenorhabditis elegans; DAF 16 FOXO; Dietary restriction; Lifespan

Indexed keywords

ACETYLSALICYLIC ACID; EXTRACELLULAR SUPEROXIDE DISMUTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE LKB1; PROTEINASE ACTIVATED RECEPTOR 4; SILENT INFORMATION REGULATOR PROTEIN 2; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR FOXO;

AGING; ARTICLE; CAENORHABDITIS ELEGANS; CLK 1 GENE; CONTROLLED STUDY; DIET RESTRICTION; DRUG STRUCTURE; EAT 2 GENE; ENZYME ACTIVATION; GENE; GENE EXPRESSION; HEAT STRESS; INTRACELLULAR SIGNALING; ISP 1 GENE; LETHALITY; LIFE EXTENSION; LONGEVITY; MITOCHONDRIAL RESPIRATION; NEMATODE LIFE CYCLE STAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SOD 3 GENE; STRESS;

ANIMALS; ASPIRIN; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTRON TRANSPORT COMPLEX III; FOOD DEPRIVATION; HOT TEMPERATURE; LONGEVITY; MOVEMENT; MUTATION; PHENOTYPE; PROTEIN KINASES; RECEPTORS, NICOTINIC; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TELOMERE-BINDING PROTEINS; TRANSCRIPTION FACTORS;

CAENORHABDITIS ELEGANS;

EID: 84875673610     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.02.020     Document Type: Article

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