Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 37, 2010, Pages 16268-16273

  Mariño, Guillermo ^a   Ugalde, Alejandro P ^a   Fernández, Álvaro F ^a   Osorio, Fernando G ^a   Fueyo, Antonio ^b   Freije, José M P ^a   López Otín, Carlos ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b UNIVERSIDAD DE OVIEDO   (Spain)

Author keywords

Cancer; Laminopathy; MicroRNA; Progeria; Protease

Indexed keywords

CYTOKINE INDUCIBLE SH2 CONTAINING PROTEIN; ESTROGEN RELATED RECEPTOR ALPHA; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR RECEPTOR 4; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; INSULIN LIKE GROWTH FACTOR BINDING PROTEIN ACID LABILE SUBUNIT; JANUS KINASE 2; METALLOPROTEINASE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE; PROSPEC; PROTEIN; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C; STAT5B PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; SUPPRESSOR OF CYTOKINE SIGNALING 5; THYROXINE DEIODINASE; UNCLASSIFIED DRUG; ZMPSTE24 PROTEIN; MEMBRANE PROTEIN; MICRORNA; ZMPSTE24 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSCRIPTION; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE SECRETING CELL; LIFESPAN; LONGEVITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGERIA; PROTEIN BLOOD LEVEL; AGING, PREMATURE; ANIMAL; BLOOD; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; LIVER; METABOLISM; NUCLEOTIDE SEQUENCE;

ANIMALIA; MUS;

AGING, PREMATURE; ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; LIVER; LONGEVITY; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; MICRORNAS; SOMATOTROPHS;

EID: 77957981121     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002696107     Document Type: Article

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