메뉴 건너뛰기




Volumn 15, Issue 2, 2016, Pages 196-207

Long live FOXO: Unraveling the role of FOXO proteins in aging and longevity

Author keywords

Aging; Animal models; FOXO transcription factors; Insulin and IGF 1 signaling pathway; Longevity

Indexed keywords

TRANSCRIPTION FACTOR FOXO; UBIQUITIN; FORKHEAD TRANSCRIPTION FACTOR;

EID: 84959862066     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12427     Document Type: Review
Times cited : (518)

References (176)
  • 2
    • 84859051249 scopus 로고    scopus 로고
    • Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span
    • Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT (2012) Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J. Gerontol. A Biol. Sci. Med. Sci. 67, 395-405.
    • (2012) J. Gerontol. A Biol. Sci. Med. Sci. , vol.67 , pp. 395-405
    • Andersen, S.L.1    Sebastiani, P.2    Dworkis, D.A.3    Feldman, L.4    Perls, T.T.5
  • 3
    • 0032518255 scopus 로고    scopus 로고
    • Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily
    • Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC (1998) Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics 47, 187-199.
    • (1998) Genomics , vol.47 , pp. 187-199
    • Anderson, M.J.1    Viars, C.S.2    Czekay, S.3    Cavenee, W.K.4    Arden, K.C.5
  • 5
    • 10644282295 scopus 로고    scopus 로고
    • The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
    • Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R (2004) The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev. 18, 3004-3009.
    • (2004) Genes Dev. , vol.18 , pp. 3004-3009
    • Apfeld, J.1    O'Connor, G.2    McDonagh, T.3    DiStefano, P.S.4    Curtis, R.5
  • 12
    • 33744976074 scopus 로고    scopus 로고
    • C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
    • Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165-1177.
    • (2006) Cell , vol.125 , pp. 1165-1177
    • Berdichevsky, A.1    Viswanathan, M.2    Horvitz, H.R.3    Guarente, L.4
  • 13
    • 33644772542 scopus 로고    scopus 로고
    • Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling
    • Berman JR, Kenyon C (2006) Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell 124, 1055-1068.
    • (2006) Cell , vol.124 , pp. 1055-1068
    • Berman, J.R.1    Kenyon, C.2
  • 14
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • Biggs WH 3rd, Meisenhelder J, Hunter T, Cavenee WK, Arden KC (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl Acad. Sci. USA 96, 7421-7426.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7421-7426
    • Biggs, W.H.1    Meisenhelder, J.2    Hunter, T.3    Cavenee, W.K.4    Arden, K.C.5
  • 15
    • 0035019007 scopus 로고    scopus 로고
    • Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
    • Biggs WH, Cavenee WK, Arden KC (2001) Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm. Genome 12, 416-425.
    • (2001) Mamm. Genome , vol.12 , pp. 416-425
    • Biggs, W.H.1    Cavenee, W.K.2    Arden, K.C.3
  • 16
    • 35348972430 scopus 로고    scopus 로고
    • Genetic links between diet and lifespan: shared mechanisms from yeast to humans
    • Bishop NA, Guarente L (2007) Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat. Rev. Genet. 8, 835-844.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 835-844
    • Bishop, N.A.1    Guarente, L.2
  • 17
    • 84891887779 scopus 로고    scopus 로고
    • Aging is not programmed: genetic pseudo-program is a shadow of developmental growth
    • Blagosklonny MV (2013a) Aging is not programmed: genetic pseudo-program is a shadow of developmental growth. Cell Cycle 12, 3736-3742.
    • (2013) Cell Cycle , vol.12 , pp. 3736-3742
    • Blagosklonny, M.V.1
  • 18
    • 84884941853 scopus 로고    scopus 로고
    • Rapamycin extends life- and health span because it slows aging
    • Blagosklonny MV (2013b) Rapamycin extends life- and health span because it slows aging. Aging (Albany NY) 5, 592-598.
    • (2013) Aging (Albany NY) , vol.5 , pp. 592-598
    • Blagosklonny, M.V.1
  • 21
    • 0038637217 scopus 로고    scopus 로고
    • Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control
    • Bonafe M, Barbieri M, Marchegiani F, Olivieri F, Ragno E, Giampieri C, Mugianesi E, Centurelli M, Franceschi C, Paolisso G (2003) Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J. Clin. Endocrinol. Metab. 88, 3299-3304.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 3299-3304
    • Bonafe, M.1    Barbieri, M.2    Marchegiani, F.3    Olivieri, F.4    Ragno, E.5    Giampieri, C.6    Mugianesi, E.7    Centurelli, M.8    Franceschi, C.9    Paolisso, G.10
  • 22
    • 65449182840 scopus 로고    scopus 로고
    • Hydra and the evolution of stem cells
    • Bosch TCG (2009) Hydra and the evolution of stem cells. BioEssays 31, 478-486.
    • (2009) BioEssays , vol.31 , pp. 478-486
    • Bosch, T.C.G.1
  • 24
    • 84907518698 scopus 로고    scopus 로고
    • Adult stem cells and diseases of aging
    • Boyette LB, Tuan RS (2014) Adult stem cells and diseases of aging. J. Clin. Med. 3, 88-134.
    • (2014) J. Clin. Med. , vol.3 , pp. 88-134
    • Boyette, L.B.1    Tuan, R.S.2
  • 27
    • 84889264077 scopus 로고    scopus 로고
    • Genetics of healthy aging and longevity
    • Brooks-Wilson AR (2013) Genetics of healthy aging and longevity. Hum. Genet. 132, 1323-1338.
    • (2013) Hum. Genet. , vol.132 , pp. 1323-1338
    • Brooks-Wilson, A.R.1
  • 30
  • 31
    • 41849128523 scopus 로고    scopus 로고
    • The FoxO code
    • Calnan DR, Brunet A (2008) The FoxO code. Oncogene 27, 2276-2288.
    • (2008) Oncogene , vol.27 , pp. 2276-2288
    • Calnan, D.R.1    Brunet, A.2
  • 32
    • 0038152845 scopus 로고    scopus 로고
    • Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
    • Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA (2003) Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301, 215-218.
    • (2003) Science , vol.301 , pp. 215-218
    • Castrillon, D.H.1    Miao, L.2    Kollipara, R.3    Horner, J.W.4    DePinho, R.A.5
  • 34
    • 33646863656 scopus 로고    scopus 로고
    • The quest for genetic determinants of human longevity: challenges and insights
    • Christensen K, Johnson TE, Vaupel JW (2006) The quest for genetic determinants of human longevity: challenges and insights. Nat. Rev. Genet. 7, 436-448.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 436-448
    • Christensen, K.1    Johnson, T.E.2    Vaupel, J.W.3
  • 35
    • 0141987860 scopus 로고    scopus 로고
    • The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg
    • Ciechanover A, Brundin P (2003) The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 40, 427-446.
    • (2003) Neuron , vol.40 , pp. 427-446
    • Ciechanover, A.1    Brundin, P.2
  • 38
    • 0030586350 scopus 로고    scopus 로고
    • Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90
    • Conconi M, Szweda LI, Levine RL, Stadtman ER, Friguet B (1996) Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90. Arch. Biochem. Biophys. 331, 232-240.
    • (1996) Arch. Biochem. Biophys. , vol.331 , pp. 232-240
    • Conconi, M.1    Szweda, L.I.2    Levine, R.L.3    Stadtman, E.R.4    Friguet, B.5
  • 39
    • 78650918920 scopus 로고    scopus 로고
    • FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
    • Demontis F, Perrimon N (2010) FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell 143, 813-825.
    • (2010) Cell , vol.143 , pp. 813-825
    • Demontis, F.1    Perrimon, N.2
  • 40
    • 45549090182 scopus 로고    scopus 로고
    • Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
    • Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF (2008) Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 8, 65-76.
    • (2008) Cell Metab. , vol.8 , pp. 65-76
    • Dong, X.C.1    Copps, K.D.2    Guo, S.3    Li, Y.4    Kollipara, R.5    DePinho, R.A.6    White, M.F.7
  • 42
    • 84872899284 scopus 로고    scopus 로고
    • FOXOs: signalling integrators for homeostasis maintenance
    • Eijkelenboom A, Burgering BM (2013) FOXOs: signalling integrators for homeostasis maintenance. Nat. Rev. Mol. Cell Biol. 14, 83-97.
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 83-97
    • Eijkelenboom, A.1    Burgering, B.M.2
  • 44
    • 50049116926 scopus 로고    scopus 로고
    • C. elegans dauer formation and the molecular basis of plasticity
    • Fielenbach N, Antebi A (2008) C. elegans dauer formation and the molecular basis of plasticity. Genes Dev. 22, 2149-2165.
    • (2008) Genes Dev. , vol.22 , pp. 2149-2165
    • Fielenbach, N.1    Antebi, A.2
  • 46
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span - from yeast to humans
    • Fontana L, Partridge L, Longo VD (2010) Extending healthy life span - from yeast to humans. Science 328, 321-326.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 47
    • 0018876664 scopus 로고
    • Aging, natural death, and the compression of morbidity
    • Fries JF (1980) Aging, natural death, and the compression of morbidity. N. Engl. J. Med. 303, 130-135.
    • (1980) N. Engl. J. Med. , vol.303 , pp. 130-135
    • Fries, J.F.1
  • 49
    • 78650820298 scopus 로고    scopus 로고
    • Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor
    • Ganapathy S, Chen Q, Singh KP, Shankar S, Srivastava RK (2010) Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLoS ONE 5, e15627.
    • (2010) PLoS ONE , vol.5 , pp. e15627
    • Ganapathy, S.1    Chen, Q.2    Singh, K.P.3    Shankar, S.4    Srivastava, R.K.5
  • 50
    • 0036021375 scopus 로고    scopus 로고
    • Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation
    • Garigan D, Hsu A-L, Fraser AG, Kamath RS, Ahringer J, Kenyon C (2002) Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-1112.
    • (2002) Genetics , vol.161 , pp. 1101-1112
    • Garigan, D.1    Hsu, A.-L.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Kenyon, C.6
  • 51
    • 84901413107 scopus 로고    scopus 로고
    • Concise review: forkhead pathway in the control of adult neurogenesis
    • Genin EC, Caron N, Vandenbosch R, Nguyen L, Malgrange B (2014) Concise review: forkhead pathway in the control of adult neurogenesis. Stem Cells 32, 1398-1407.
    • (2014) Stem Cells , vol.32 , pp. 1398-1407
    • Genin, E.C.1    Caron, N.2    Vandenbosch, R.3    Nguyen, L.4    Malgrange, B.5
  • 52
    • 40549146580 scopus 로고    scopus 로고
    • Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response
    • Giannakou ME, Goss M, Partridge L (2008) Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell 7, 187-198.
    • (2008) Aging Cell , vol.7 , pp. 187-198
    • Giannakou, M.E.1    Goss, M.2    Partridge, L.3
  • 53
    • 0032981396 scopus 로고    scopus 로고
    • Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene
    • Gil EB, Malone Link E, Liu LX, Johnson CD, Lees JA (1999) Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene. Proc. Natl Acad. Sci. USA 96, 2925-2930.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2925-2930
    • Gil, E.B.1    Malone Link, E.2    Liu, L.X.3    Johnson, C.D.4    Lees, J.A.5
  • 54
    • 0028334880 scopus 로고
    • daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans
    • Gottlieb S, Ruvkun G (1994) daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics 137, 107-120.
    • (1994) Genetics , vol.137 , pp. 107-120
    • Gottlieb, S.1    Ruvkun, G.2
  • 56
    • 34848861463 scopus 로고    scopus 로고
    • The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
    • Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A (2007b) The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J. Biol. Chem. 282, 30107-30119.
    • (2007) J. Biol. Chem. , vol.282 , pp. 30107-30119
    • Greer, E.L.1    Oskoui, P.R.2    Banko, M.R.3    Maniar, J.M.4    Gygi, M.P.5    Gygi, S.P.6    Brunet, A.7
  • 57
    • 0033546192 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
    • Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T (1999) Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J. Biol. Chem. 274, 17184-17192.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17184-17192
    • Guo, S.1    Rena, G.2    Cichy, S.3    He, X.4    Cohen, P.5    Unterman, T.6
  • 58
    • 62549108593 scopus 로고    scopus 로고
    • The evolution of Fox genes and their role in development and disease
    • Hannenhalli S, Kaestner KH (2009) The evolution of Fox genes and their role in development and disease. Nat. Rev. Genet. 10, 233-240.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 233-240
    • Hannenhalli, S.1    Kaestner, K.H.2
  • 59
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • Hansen M, Taubert S, Crawford D, Libina N, Lee S-J, Kenyon C (2007) Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6, 95-110.
    • (2007) Aging Cell , vol.6 , pp. 95-110
    • Hansen, M.1    Taubert, S.2    Crawford, D.3    Libina, N.4    Lee, S.-J.5    Kenyon, C.6
  • 60
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
    • Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C (2008) A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 4, e24.
    • (2008) PLoS Genet. , vol.4 , pp. e24
    • Hansen, M.1    Chandra, A.2    Mitic, L.L.3    Onken, B.4    Driscoll, M.5    Kenyon, C.6
  • 62
    • 77954395996 scopus 로고    scopus 로고
    • Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
    • Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC (2010) Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J. Exp. Med. 207, 1381-1391.
    • (2010) J. Exp. Med. , vol.207 , pp. 1381-1391
    • Harada, Y.1    Elly, C.2    Ying, G.3    Paik, J.H.4    DePinho, R.A.5    Liu, Y.C.6
  • 63
    • 77950865186 scopus 로고    scopus 로고
    • Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1
    • Heidler T, Hartwig K, Daniel H, Wenzel U (2010) Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1. Biogerontology 11, 183-195.
    • (2010) Biogerontology , vol.11 , pp. 183-195
    • Heidler, T.1    Hartwig, K.2    Daniel, H.3    Wenzel, U.4
  • 64
    • 0035846604 scopus 로고    scopus 로고
    • daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • Henderson ST, Johnson TE (2001) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11, 1975-1980.
    • (2001) Curr. Biol. , vol.11 , pp. 1975-1980
    • Henderson, S.T.1    Johnson, T.E.2
  • 65
    • 0030062815 scopus 로고    scopus 로고
    • The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900
    • Herskind AM, McGue M, Holm NV, Sörensen TI, Harvald B, Vaupel JW (1996) The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum. Genet. 97, 319-323.
    • (1996) Hum. Genet. , vol.97 , pp. 319-323
    • Herskind, A.M.1    McGue, M.2    Holm, N.V.3    Sörensen, T.I.4    Harvald, B.5    Vaupel, J.W.6
  • 66
    • 84924280352 scopus 로고    scopus 로고
    • A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes
    • Hill R, Kalathur RK, Callejas S, Colaco L, Brandao R, Serelde B, Cebria A, Blanco-Aparicio C, Pastor J, Futschik M, Dopazo A, Link W (2014) A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. Breast Cancer Res. 16, 482.
    • (2014) Breast Cancer Res. , vol.16 , pp. 482
    • Hill, R.1    Kalathur, R.K.2    Callejas, S.3    Colaco, L.4    Brandao, R.5    Serelde, B.6    Cebria, A.7    Blanco-Aparicio, C.8    Pastor, J.9    Futschik, M.10    Dopazo, A.11    Link, W.12
  • 67
    • 0345540639 scopus 로고    scopus 로고
    • Centenarians: the older you get, the healthier you have been
    • Hitt R, Young-Xu Y, Silver M, Perls T (1999) Centenarians: the older you get, the healthier you have been. Lancet 354, 652.
    • (1999) Lancet , vol.354 , pp. 652
    • Hitt, R.1    Young-Xu, Y.2    Silver, M.3    Perls, T.4
  • 69
    • 59649120539 scopus 로고    scopus 로고
    • Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
    • Honjoh S, Yamamoto T, Uno M, Nishida E (2009) Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature 457, 726-730.
    • (2009) Nature , vol.457 , pp. 726-730
    • Honjoh, S.1    Yamamoto, T.2    Uno, M.3    Nishida, E.4
  • 70
    • 1542267804 scopus 로고    scopus 로고
    • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    • Hosaka T, Biggs WH 3rd, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC (2004) Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl Acad. Sci. USA 101, 2975-2980.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 2975-2980
    • Hosaka, T.1    Biggs, W.H.2    Tieu, D.3    Boyer, A.D.4    Varki, N.M.5    Cavenee, W.K.6    Arden, K.C.7
  • 71
    • 0033609291 scopus 로고    scopus 로고
    • Signals from the reproductive system regulate the lifespan of C. elegans
    • Hsin H, Kenyon C (1999) Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362-366.
    • (1999) Nature , vol.399 , pp. 362-366
    • Hsin, H.1    Kenyon, C.2
  • 72
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • Hsu A-L, Murphy CT, Kenyon C (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science (New York, NY) 300, 1142-1145.
    • (2003) Science (New York, NY) , vol.300 , pp. 1142-1145
    • Hsu, A.-L.1    Murphy, C.T.2    Kenyon, C.3
  • 74
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • Hwangbo DS, Gershman B, Gersham B, Tu M-P, Palmer M, Tatar M (2004) Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429, 562-566.
    • (2004) Nature , vol.429 , pp. 562-566
    • Hwangbo, D.S.1    Gershman, B.2    Gersham, B.3    Tu, M.-P.4    Palmer, M.5    Tatar, M.6
  • 76
    • 70149085849 scopus 로고    scopus 로고
    • Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance
    • Jia K, Thomas C, Akbar M, Sun Q, Adams-Huet B, Gilpin C, Levine B (2009) Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc. Natl Acad. Sci. USA 106, 14564-14569.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 14564-14569
    • Jia, K.1    Thomas, C.2    Akbar, M.3    Sun, Q.4    Adams-Huet, B.5    Gilpin, C.6    Levine, B.7
  • 78
    • 0242539698 scopus 로고    scopus 로고
    • The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    • Junger MA, Rintelen F, Stocker H, Wasserman JD, Vegh M, Radimerski T, Greenberg ME, Hafen E (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2, 20.
    • (2003) J. Biol. , vol.2 , pp. 20
    • Junger, M.A.1    Rintelen, F.2    Stocker, H.3    Wasserman, J.D.4    Vegh, M.5    Radimerski, T.6    Greenberg, M.E.7    Hafen, E.8
  • 80
    • 0342614209 scopus 로고    scopus 로고
    • Unified nomenclature for the winged helix/forkhead transcription factors
    • Kaestner KH, Knochel W, Martinez DE (2000) Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 14, 142-146.
    • (2000) Genes Dev. , vol.14 , pp. 142-146
    • Kaestner, K.H.1    Knochel, W.2    Martinez, D.E.3
  • 81
    • 13944269223 scopus 로고    scopus 로고
    • The plasticity of aging: insights from long-lived mutants
    • Kenyon C (2005) The plasticity of aging: insights from long-lived mutants. Cell 120, 449-460.
    • (2005) Cell , vol.120 , pp. 449-460
    • Kenyon, C.1
  • 82
    • 77956244148 scopus 로고    scopus 로고
    • A pathway that links reproductive status to lifespan in Caenorhabditis elegans
    • Kenyon C (2010a) A pathway that links reproductive status to lifespan in Caenorhabditis elegans. Ann. N. Y. Acad. Sci. 1204, 156-162.
    • (2010) Ann. N. Y. Acad. Sci. , vol.1204 , pp. 156-162
    • Kenyon, C.1
  • 83
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ (2010b) The genetics of ageing. Nature 464, 504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 84
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 86
    • 34548130839 scopus 로고    scopus 로고
    • Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation
    • Khalturin K, Anton-Erxleben F, Milde S, Plötz C, Jr Wittlieb, Hemmrich G, Bosch TCG (2007) Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation. Dev. Biol. 309, 32-44.
    • (2007) Dev. Biol. , vol.309 , pp. 32-44
    • Khalturin, K.1    Anton-Erxleben, F.2    Milde, S.3    Plötz, C.4    Jr, W.5    Hemmrich, G.6    Bosch, T.C.G.7
  • 87
    • 78049383942 scopus 로고    scopus 로고
    • Protein homeostasis in models of aging and age-related conformational disease
    • Kikis EA, Gidalevitz T, Morimoto RI (2010) Protein homeostasis in models of aging and age-related conformational disease. Adv. Exp. Med. Biol. 694, 138-159.
    • (2010) Adv. Exp. Med. Biol. , vol.694 , pp. 138-159
    • Kikis, E.A.1    Gidalevitz, T.2    Morimoto, R.I.3
  • 88
    • 84898854708 scopus 로고    scopus 로고
    • A DAF-16/FoxO3a-dependent longevity signal is initiated by antioxidants
    • Kim J, Ishihara N, Lee TR (2014) A DAF-16/FoxO3a-dependent longevity signal is initiated by antioxidants. BioFactors 40, 247-257.
    • (2014) BioFactors , vol.40 , pp. 247-257
    • Kim, J.1    Ishihara, N.2    Lee, T.R.3
  • 89
    • 0030813398 scopus 로고    scopus 로고
    • daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (New York, NY) 277, 942-946.
    • (1997) Science (New York, NY) , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 90
    • 9644270707 scopus 로고    scopus 로고
    • Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways
    • Kojima T, Kamei H, Aizu T, Arai Y, Takayama M, Nakazawa S, Ebihara Y, Inagaki H, Masui Y, Gondo Y, Sakaki Y, Hirose N (2004) Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. Exp. Gerontol. 39, 1595-1598.
    • (2004) Exp. Gerontol. , vol.39 , pp. 1595-1598
    • Kojima, T.1    Kamei, H.2    Aizu, T.3    Arai, Y.4    Takayama, M.5    Nakazawa, S.6    Ebihara, Y.7    Inagaki, H.8    Masui, Y.9    Gondo, Y.10    Sakaki, Y.11    Hirose, N.12
  • 96
    • 77951665583 scopus 로고    scopus 로고
    • Apoptosis in pre-Bilaterians: Hydra as a model
    • Lasi M, David CN, Bottger A (2010) Apoptosis in pre-Bilaterians: Hydra as a model. Apoptosis 15, 269-278.
    • (2010) Apoptosis , vol.15 , pp. 269-278
    • Lasi, M.1    David, C.N.2    Bottger, A.3
  • 97
    • 0035846601 scopus 로고    scopus 로고
    • Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
    • Lee RY, Hench J, Ruvkun G (2001) Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11, 1950-1957.
    • (2001) Curr. Biol. , vol.11 , pp. 1950-1957
    • Lee, R.Y.1    Hench, J.2    Ruvkun, G.3
  • 98
    • 0037466652 scopus 로고    scopus 로고
    • DAF-16 target genes that control C. elegans life-span and metabolism
    • Lee SS, Kennedy S, Tolonen AC, Ruvkun G (2003) DAF-16 target genes that control C. elegans life-span and metabolism. Science (New York, NY) 300, 644-647.
    • (2003) Science (New York, NY) , vol.300 , pp. 644-647
    • Lee, S.S.1    Kennedy, S.2    Tolonen, A.C.3    Ruvkun, G.4
  • 99
    • 70350365110 scopus 로고    scopus 로고
    • Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression
    • Lee S-J, Murphy CT, Kenyon C (2009) Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10, 379-391.
    • (2009) Cell Metab. , vol.10 , pp. 379-391
    • Lee, S.-J.1    Murphy, C.T.2    Kenyon, C.3
  • 103
    • 0345447590 scopus 로고    scopus 로고
    • Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    • Libina N, Berman JR, Kenyon C (2003) Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115, 489-502.
    • (2003) Cell , vol.115 , pp. 489-502
    • Libina, N.1    Berman, J.R.2    Kenyon, C.3
  • 104
    • 0030657540 scopus 로고    scopus 로고
    • daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • Lin K, Dorman JB, Rodan A, Kenyon C (1997) daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science (New York, NY) 278, 1319-1322.
    • (1997) Science (New York, NY) , vol.278 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 105
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • Lin K, Hsin H, Libina N, Kenyon C (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28, 139-145.
    • (2001) Nat. Genet. , vol.28 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 111
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • McElwee J, Bubb K, Thomas JH (2003) Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2, 111-121.
    • (2003) Aging Cell , vol.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 112
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B (2003) Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301, 1387-1391.
    • (2003) Science , vol.301 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.L.4    Hall, D.H.5    Levine, B.6
  • 114
    • 0033595003 scopus 로고    scopus 로고
    • The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
    • Mihaylova VT, Borland CZ, Manjarrez L, Stern MJ, Sun H (1999) The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc. Natl Acad. Sci. USA 96, 7427-7432.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7427-7432
    • Mihaylova, V.T.1    Borland, C.Z.2    Manjarrez, L.3    Stern, M.J.4    Sun, H.5
  • 115
    • 84905045240 scopus 로고    scopus 로고
    • Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
    • Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N (2014) Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell 13, 769-771.
    • (2014) Aging Cell , vol.13 , pp. 769-771
    • Milman, S.1    Atzmon, G.2    Huffman, D.M.3    Wan, J.4    Crandall, J.P.5    Cohen, P.6    Barzilai, N.7
  • 116
    • 40549127471 scopus 로고    scopus 로고
    • Drosophila lifespan control by dietary restriction independent of insulin-like signaling
    • Min K-JJ, Yamamoto R, Buch S, Pankratz M, Tatar M (2008) Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell 7, 199-206.
    • (2008) Aging Cell , vol.7 , pp. 199-206
    • Min, K.-J.1    Yamamoto, R.2    Buch, S.3    Pankratz, M.4    Tatar, M.5
  • 118
    • 0742323000 scopus 로고    scopus 로고
    • Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
    • Morley JF, Morimoto RI (2004) Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol. Biol. Cell 15, 657-664.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 657-664
    • Morley, J.F.1    Morimoto, R.I.2
  • 119
    • 0036678146 scopus 로고    scopus 로고
    • The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    • Morley JF, Brignull HR, Weyers JJ, Morimoto RI (2002) The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 99, 10417-10422.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 10417-10422
    • Morley, J.F.1    Brignull, H.R.2    Weyers, J.J.3    Morimoto, R.I.4
  • 120
    • 84860125157 scopus 로고    scopus 로고
    • The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
    • Murabito JM, Yuan R, Lunetta KL (2012) The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals. J. Gerontol. A Biol. Sci. Med. Sci. 67, 470-479.
    • (2012) J. Gerontol. A Biol. Sci. Med. Sci. , vol.67 , pp. 470-479
    • Murabito, J.M.1    Yuan, R.2    Lunetta, K.L.3
  • 122
    • 37649022616 scopus 로고    scopus 로고
    • Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
    • Murphy CT, Lee S-J, Kenyon C (2007) Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 104, 19046-19050.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 19046-19050
    • Murphy, C.T.1    Lee, S.-J.2    Kenyon, C.3
  • 123
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto S, Finkel T (2002) Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295, 2450-2452.
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 124
    • 80052964810 scopus 로고    scopus 로고
    • Structural basis for DNA recognition by FOXO proteins
    • Obsil T, Obsilova V (2011) Structural basis for DNA recognition by FOXO proteins. Biochim. Biophys. Acta 1813, 1946-1953.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1946-1953
    • Obsil, T.1    Obsilova, V.2
  • 125
    • 0032238299 scopus 로고    scopus 로고
    • The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
    • Ogg S, Ruvkun G (1998) The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 2, 887-893.
    • (1998) Mol. Cell , vol.2 , pp. 887-893
    • Ogg, S.1    Ruvkun, G.2
  • 126
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999.
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6    Ruvkun, G.7
  • 127
    • 0037418579 scopus 로고    scopus 로고
    • Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans
    • Ookuma S, Fukuda M, Nishida E (2003) Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Curr. Biol. 13, 427-431.
    • (2003) Curr. Biol. , vol.13 , pp. 427-431
    • Ookuma, S.1    Fukuda, M.2    Nishida, E.3
  • 128
    • 84891833906 scopus 로고    scopus 로고
    • The association of FOXO3A gene polymorphisms with serum FOXO3A levels and oxidative stress markers in vitiligo patients
    • Ozel Turkcu U, Solak Tekin N, Gokdogan Edgunlu T, Karakas Celik S, Oner S (2014) The association of FOXO3A gene polymorphisms with serum FOXO3A levels and oxidative stress markers in vitiligo patients. Gene 536, 129-134.
    • (2014) Gene , vol.536 , pp. 129-134
    • Ozel Turkcu, U.1    Solak Tekin, N.2    Gokdogan Edgunlu, T.3    Karakas Celik, S.4    Oner, S.5
  • 136
    • 84894293156 scopus 로고    scopus 로고
    • FOXO3 determines the accumulation of alpha-synuclein and controls the fate of dopaminergic neurons in the substantia nigra
    • Pino E, Amamoto R, Zheng L, Cacquevel M, Sarria JC, Knott GW, Schneider BL (2014) FOXO3 determines the accumulation of alpha-synuclein and controls the fate of dopaminergic neurons in the substantia nigra. Hum. Mol. Genet. 23, 1435-1452.
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 1435-1452
    • Pino, E.1    Amamoto, R.2    Zheng, L.3    Cacquevel, M.4    Sarria, J.C.5    Knott, G.W.6    Schneider, B.L.7
  • 137
    • 79251583486 scopus 로고    scopus 로고
    • Understanding Forkhead box class O function: lessons from Drosophila melanogaster
    • Puig O, Mattila J (2011) Understanding Forkhead box class O function: lessons from Drosophila melanogaster. Antioxid. Redox Signal. 14, 635-647.
    • (2011) Antioxid. Redox Signal. , vol.14 , pp. 635-647
    • Puig, O.1    Mattila, J.2
  • 138
    • 0042161896 scopus 로고    scopus 로고
    • Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway
    • Puig O, Marr MT, Ruhf ML, Tjian R (2003) Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17, 2006-2020.
    • (2003) Genes Dev. , vol.17 , pp. 2006-2020
    • Puig, O.1    Marr, M.T.2    Ruhf, M.L.3    Tjian, R.4
  • 140
    • 0033602383 scopus 로고    scopus 로고
    • Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
    • Rouault JP, Kuwabara PE, Sinilnikova OM, Duret L, Thierry-Mieg D, Billaud M (1999) Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN. Curr. Biol. 9, 329-332.
    • (1999) Curr. Biol. , vol.9 , pp. 329-332
    • Rouault, J.P.1    Kuwabara, P.E.2    Sinilnikova, O.M.3    Duret, L.4    Thierry-Mieg, D.5    Billaud, M.6
  • 144
    • 84887622359 scopus 로고    scopus 로고
    • FOXO in aging: did evolutionary diversification of FOXO function distract it from prolonging life?
    • Schaible R, Sussman M (2013) FOXO in aging: did evolutionary diversification of FOXO function distract it from prolonging life? BioEssays 35, 1101-1110.
    • (2013) BioEssays , vol.35 , pp. 1101-1110
    • Schaible, R.1    Sussman, M.2
  • 145
    • 84876160000 scopus 로고    scopus 로고
    • The genetics of extreme longevity: lessons from the new England centenarian study
    • Sebastiani P, Perls TT (2012) The genetics of extreme longevity: lessons from the new England centenarian study. Front Genet. 3, 277.
    • (2012) Front Genet. , vol.3 , pp. 277
    • Sebastiani, P.1    Perls, T.T.2
  • 146
    • 70350500068 scopus 로고    scopus 로고
    • FoxO transcription factors promote autophagy in cardiomyocytes
    • Sengupta A, Molkentin JD, Yutzey KE (2009) FoxO transcription factors promote autophagy in cardiomyocytes. J. Biol. Chem. 284, 28319-28331.
    • (2009) J. Biol. Chem. , vol.284 , pp. 28319-28331
    • Sengupta, A.1    Molkentin, J.D.2    Yutzey, K.E.3
  • 147
    • 52049093450 scopus 로고    scopus 로고
    • The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging
    • Sheaffer KL, Updike DL, Mango SE (2008) The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Curr. Biol. 18, 1355-1364.
    • (2008) Curr. Biol. , vol.18 , pp. 1355-1364
    • Sheaffer, K.L.1    Updike, D.L.2    Mango, S.E.3
  • 149
    • 78249280592 scopus 로고    scopus 로고
    • Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data
    • Soerensen M, Dato S, Christensen K, McGue M, Stevnsner T, Bohr VA, Christiansen L (2010) Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 9, 1010-1017.
    • (2010) Aging Cell , vol.9 , pp. 1010-1017
    • Soerensen, M.1    Dato, S.2    Christensen, K.3    McGue, M.4    Stevnsner, T.5    Bohr, V.A.6    Christiansen, L.7
  • 152
    • 79251548626 scopus 로고    scopus 로고
    • Forkhead homeobox type O transcription factors in the responses to oxidative stress
    • Storz P (2011) Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid. Redox Signal. 14, 593-605.
    • (2011) Antioxid. Redox Signal. , vol.14 , pp. 593-605
    • Storz, P.1
  • 154
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science (New York, NY) 292, 107-110.
    • (2001) Science (New York, NY) , vol.292 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.P.4    Yin, C.M.5    Garofalo, R.S.6
  • 155
    • 79956016645 scopus 로고    scopus 로고
    • Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles
    • Tazearslan C, Huang J, Barzilai N, Suh Y (2011) Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles. Aging Cell 10, 551-554.
    • (2011) Aging Cell , vol.10 , pp. 551-554
    • Tazearslan, C.1    Huang, J.2    Barzilai, N.3    Suh, Y.4
  • 156
    • 34547660196 scopus 로고    scopus 로고
    • FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system
    • Tothova Z, Gilliland DG (2007) FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system. Cell Stem Cell 1, 140-152.
    • (2007) Cell Stem Cell , vol.1 , pp. 140-152
    • Tothova, Z.1    Gilliland, D.G.2
  • 158
    • 84876415141 scopus 로고    scopus 로고
    • Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice
    • Tsuchiya K, Westerterp M, Murphy AJ, Subramanian V, Ferrante AW Jr, Tall AR, Accili D (2013) Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice. Circ. Res. 112, 992-1003.
    • (2013) Circ. Res. , vol.112 , pp. 992-1003
    • Tsuchiya, K.1    Westerterp, M.2    Murphy, A.J.3    Subramanian, V.4    Ferrante, A.W.5    Tall, A.R.6    Accili, D.7
  • 160
    • 0041507039 scopus 로고    scopus 로고
    • Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals
    • Walker GA, Lithgow GJ (2003) Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell 2, 131-139.
    • (2003) Aging Cell , vol.2 , pp. 131-139
    • Walker, G.A.1    Lithgow, G.J.2
  • 161
    • 17044408768 scopus 로고    scopus 로고
    • JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
    • Wang MC, Bohmann D, Jasper H (2005) JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121, 115-125.
    • (2005) Cell , vol.121 , pp. 115-125
    • Wang, M.C.1    Bohmann, D.2    Jasper, H.3
  • 162
    • 55849101681 scopus 로고    scopus 로고
    • Fat metabolism links germline stem cells and longevity in C. elegans
    • Wang MC, O'Rourke EJ, Ruvkun G (2008) Fat metabolism links germline stem cells and longevity in C. elegans. Science (New York, NY) 322, 957-960.
    • (2008) Science (New York, NY) , vol.322 , pp. 957-960
    • Wang, M.C.1    O'Rourke, E.J.2    Ruvkun, G.3
  • 164
    • 84897414264 scopus 로고    scopus 로고
    • FOXO transcription factors: key regulators of cellular quality control
    • Webb AE, Brunet A (2014) FOXO transcription factors: key regulators of cellular quality control. Trends Biochem. Sci. 39, 159-169.
    • (2014) Trends Biochem. Sci. , vol.39 , pp. 159-169
    • Webb, A.E.1    Brunet, A.2
  • 165
    • 33645017887 scopus 로고    scopus 로고
    • Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm
    • Weinkove D, Halstead JR, Gems D, Divecha N (2006) Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biol. 4, 1.
    • (2006) BMC Biol. , vol.4 , pp. 1
    • Weinkove, D.1    Halstead, J.R.2    Gems, D.3    Divecha, N.4
  • 171
    • 77950680198 scopus 로고    scopus 로고
    • Understanding FOXO, new views on old transcription factors
    • Zanella F, Link W, Carnero A (2010) Understanding FOXO, new views on old transcription factors. Curr. Cancer Drug Targets 10, 135-146.
    • (2010) Curr. Cancer Drug Targets , vol.10 , pp. 135-146
    • Zanella, F.1    Link, W.2    Carnero, A.3
  • 174
    • 81055130277 scopus 로고    scopus 로고
    • microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause
    • Zhang X, Zabinsky R, Teng Y, Cui M, Han M (2011b) microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause. Proc. Natl Acad. Sci. USA 108, 17997-18002.
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 17997-18002
    • Zhang, X.1    Zabinsky, R.2    Teng, Y.3    Cui, M.4    Han, M.5
  • 175
    • 36448968532 scopus 로고    scopus 로고
    • FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
    • Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL (2007) FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 6, 472-483.
    • (2007) Cell Metab. , vol.6 , pp. 472-483
    • Zhao, J.1    Brault, J.J.2    Schild, A.3    Cao, P.4    Sandri, M.5    Schiaffino, S.6    Lecker, S.H.7    Goldberg, A.L.8
  • 176
    • 82955212994 scopus 로고    scopus 로고
    • FoxO4 inhibits atherosclerosis through its function in bone marrow derived cells
    • Zhu M, Zhang QJ, Wang L, Li H, Liu ZP (2011) FoxO4 inhibits atherosclerosis through its function in bone marrow derived cells. Atherosclerosis 219, 492-498.
    • (2011) Atherosclerosis , vol.219 , pp. 492-498
    • Zhu, M.1    Zhang, Q.J.2    Wang, L.3    Li, H.4    Liu, Z.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.