-
1
-
-
0347854376
-
Regulation of C. elegans longevity by specific gustatory and olfactory neurons
-
J. Alcedo, and C. Kenyon Regulation of C. elegans longevity by specific gustatory and olfactory neurons Neuron 41 2004 45 55
-
(2004)
Neuron
, vol.41
, pp. 45-55
-
-
Alcedo, J.1
Kenyon, C.2
-
2
-
-
0032538315
-
Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span
-
J. Apfeld, and C. Kenyon Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span Cell 95 1998 199 210
-
(1998)
Cell
, vol.95
, pp. 199-210
-
-
Apfeld, J.1
Kenyon, C.2
-
3
-
-
0033576579
-
Regulation of lifespan by sensory perception in Caenorhabditis elegans
-
J. Apfeld, and C. Kenyon Regulation of lifespan by sensory perception in Caenorhabditis elegans Nature 402 1999 804 809
-
(1999)
Nature
, vol.402
, pp. 804-809
-
-
Apfeld, J.1
Kenyon, C.2
-
4
-
-
10644282295
-
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
-
J. Apfeld, G. O'Connor, T. McDonagh, P.S. DiStefano, and R. Curtis The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans Genes Dev. 18 2004 3004 3009
-
(2004)
Genes Dev.
, vol.18
, pp. 3004-3009
-
-
Apfeld, J.1
O'Connor, G.2
McDonagh, T.3
Distefano, P.S.4
Curtis, R.5
-
5
-
-
4043165678
-
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
-
T. Araki, Y. Sasaki, and J. Milbrandt Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration Science 305 2004 1010 1013
-
(2004)
Science
, vol.305
, pp. 1010-1013
-
-
Araki, T.1
Sasaki, Y.2
Milbrandt, J.3
-
6
-
-
0037127026
-
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
-
N. Arantes-Oliveira, J. Apfeld, A. Dillin, and C. Kenyon Regulation of life-span by germ-line stem cells in Caenorhabditis elegans Science 295 2002 502 505
-
(2002)
Science
, vol.295
, pp. 502-505
-
-
Arantes-Oliveira, N.1
Apfeld, J.2
Dillin, A.3
Kenyon, C.4
-
8
-
-
0037448528
-
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
-
K. Ashrafi, F.Y. Chang, J.L. Watts, A.G. Fraser, R.S. Kamath, J. Ahringer, and G. Ruvkun Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes Nature 421 2003 268 272
-
(2003)
Nature
, vol.421
, pp. 268-272
-
-
Ashrafi, K.1
Chang, F.Y.2
Watts, J.L.3
Fraser, A.G.4
Kamath, R.S.5
Ahringer, J.6
Ruvkun, G.7
-
9
-
-
0035082093
-
Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans
-
D. Barsyte, D.A. Lovejoy, and G.J. Lithgow Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans FASEB J. 15 2001 627 634
-
(2001)
FASEB J.
, vol.15
, pp. 627-634
-
-
Barsyte, D.1
Lovejoy, D.A.2
Lithgow, G.J.3
-
10
-
-
0035936147
-
Extending the lifespan of long-lived mice
-
A. Bartke, J.C. Wright, J.A. Mattison, D.K. Ingram, R.A. Miller, and G.S. Roth Extending the lifespan of long-lived mice Nature 414 2001 412
-
(2001)
Nature
, vol.414
, pp. 412
-
-
Bartke, A.1
Wright, J.C.2
Mattison, J.A.3
Ingram, D.K.4
Miller, R.A.5
Roth, G.S.6
-
11
-
-
0142088521
-
Unique lipoprotein phenotype and genotype associated with exceptional longevity
-
N. Barzilai, G. Atzmon, C. Schechter, E.J. Schaefer, A.L. Cupples, R. Lipton, S. Cheng, and A.R. Shuldiner Unique lipoprotein phenotype and genotype associated with exceptional longevity JAMA 290 2003 2030 2040
-
(2003)
JAMA
, vol.290
, pp. 2030-2040
-
-
Barzilai, N.1
Atzmon, G.2
Schechter, C.3
Schaefer, E.J.4
Cupples, A.L.5
Lipton, R.6
Cheng, S.7
Shuldiner, A.R.8
-
12
-
-
84966143698
-
Carcinogenesis in the pituitary dwarf mouse. The response to dimethylbenzanthracene applied to the skin
-
F.B. Bielschowsky Carcinogenesis in the pituitary dwarf mouse. The response to dimethylbenzanthracene applied to the skin Br. J. Cancer 15 1961 257 262
-
(1961)
Br. J. Cancer
, vol.15
, pp. 257-262
-
-
Bielschowsky, F.B.1
-
13
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
M.A. Blasco, H.W. Lee, M.P. Hande, E. Samper, P.M. Lansdorp, R.A. DePinho, and C.W. Greider Telomere shortening and tumor formation by mouse cells lacking telomerase RNA Cell 91 1997 25 34
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
Depinho, R.A.6
Greider, C.W.7
-
14
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
M. Bluher, B.B. Kahn, and C.R. Kahn Extended longevity in mice lacking the insulin receptor in adipose tissue Science 299 2003 572 574
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Bluher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
15
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
A.G. Bodnar, M. Ouellette, M. Frolkis, S.E. Holt, C.P. Chiu, G.B. Morin, C.B. Harley, J.W. Shay, S. Lichtsteiner, and W.E. Wright Extension of life-span by introduction of telomerase into normal human cells Science 279 1998 349 352
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
16
-
-
20044393471
-
Longer lifespan, altered metabolism and stress resistance in Drosophila from ablation of cells making insulin-like ligands
-
in press. Published online February 11, 2005.
-
Broughton, S., Piper, M., Ikeya, T., Bass, T., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D., Leevers, S., and Partridge, L. (2005). Longer lifespan, altered metabolism and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl. Acad. Sci. USA in press. Published online February 11, 2005.
-
(2005)
Proc. Natl. Acad. Sci. USA
-
-
Broughton, S.1
Piper, M.2
Ikeya, T.3
Bass, T.4
Jacobson, J.5
Driege, Y.6
Martinez, P.7
Hafen, E.8
Withers, D.9
Leevers, S.10
Partridge, L.11
-
18
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
A. Brunet, A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, and M.E. Greenberg Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Cell 96 1999 857 868
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
19
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
A. Brunet, L.B. Sweeney, J.F. Sturgill, K.F. Chua, P.L. Greer, Y. Lin, H. Tran, S.E. Ross, R. Mostoslavsky, and H.Y. Cohen Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase Science 303 2004 2011 2015
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsky, R.9
Cohen, H.Y.10
-
20
-
-
0036629251
-
Cell cycle and death control: Long live Forkheads
-
B.M. Burgering, and G.J. Kops Cell cycle and death control: long live Forkheads Trends Biochem. Sci. 27 2002 352 360
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 352-360
-
-
Burgering, B.M.1
Kops, G.J.2
-
21
-
-
0141447476
-
Age of ovary determines remaining life expectancy in old ovariectomized mice
-
S.L. Cargill, J.R. Carey, H.G. Muller, and G. Anderson Age of ovary determines remaining life expectancy in old ovariectomized mice Aging Cell 2 2003 185 190
-
(2003)
Aging Cell
, vol.2
, pp. 185-190
-
-
Cargill, S.L.1
Carey, J.R.2
Muller, H.G.3
Anderson, G.4
-
22
-
-
0037308404
-
Association between telomere length in blood and mortality in people aged 60 years or older
-
R.M. Cawthon, K.R. Smith, E. O'Brien, A. Sivatchenko, and R.A. Kerber Association between telomere length in blood and mortality in people aged 60 years or older Lancet 361 2003 393 395
-
(2003)
Lancet
, vol.361
, pp. 393-395
-
-
Cawthon, R.M.1
Smith, K.R.2
O'Brien, E.3
Sivatchenko, A.4
Kerber, R.A.5
-
23
-
-
3543043128
-
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
-
S. Chang, A.S. Multani, N.G. Cabrera, M.L. Naylor, P. Laud, D. Lombard, S. Pathak, L. Guarente, and R.A. DePinho Essential role of limiting telomeres in the pathogenesis of Werner syndrome Nat. Genet. 36 2004 877 882
-
(2004)
Nat. Genet.
, vol.36
, pp. 877-882
-
-
Chang, S.1
Multani, A.S.2
Cabrera, N.G.3
Naylor, M.L.4
Laud, P.5
Lombard, D.6
Pathak, S.7
Guarente, L.8
Depinho, R.A.9
-
24
-
-
4043164343
-
Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells
-
C.H. Chiu, W.D. Lin, S.Y. Huang, and Y.H. Lee Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells Genes Dev. 18 2004 1970 1975
-
(2004)
Genes Dev.
, vol.18
, pp. 1970-1975
-
-
Chiu, C.H.1
Lin, W.D.2
Huang, S.Y.3
Lee, Y.H.4
-
25
-
-
0035815414
-
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
-
D.J. Clancy, D. Gems, L.G. Harshman, S. Oldham, H. Stocker, E. Hafen, S.J. Leevers, and L. Partridge Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein Science 292 2001 104 106
-
(2001)
Science
, vol.292
, pp. 104-106
-
-
Clancy, D.J.1
Gems, D.2
Harshman, L.G.3
Oldham, S.4
Stocker, H.5
Hafen, E.6
Leevers, S.J.7
Partridge, L.8
-
26
-
-
0037066518
-
Dietary restriction in long-lived dwarf flies
-
D.J. Clancy, D. Gems, E. Hafen, S.J. Leevers, and L. Partridge Dietary restriction in long-lived dwarf flies Science 296 2002 319
-
(2002)
Science
, vol.296
, pp. 319
-
-
Clancy, D.J.1
Gems, D.2
Hafen, E.3
Leevers, S.J.4
Partridge, L.5
-
27
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
H.Y. Cohen, C. Miller, K.J. Bitterman, N.R. Wall, B. Hekking, B. Kessler, K.T. Howitz, M. Gorospe, R. de Cabo, and D.A. Sinclair Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science 305 2004 390 392
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
De Cabo, R.9
Sinclair, D.A.10
-
28
-
-
0041419437
-
Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span
-
K.T. Coschigano, A.N. Holland, M.E. Riders, E.O. List, A. Flyvbjerg, and J.J. Kopchick Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span Endocrinology 144 2003 3799 3810
-
(2003)
Endocrinology
, vol.144
, pp. 3799-3810
-
-
Coschigano, K.T.1
Holland, A.N.2
Riders, M.E.3
List, E.O.4
Flyvbjerg, A.5
Kopchick, J.J.6
-
29
-
-
3042750643
-
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
-
H. Daitoku, M. Hatta, H. Matsuzaki, S. Aratani, T. Ohshima, M. Miyagishi, T. Nakajima, and A. Fukamizu Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity Proc. Natl. Acad. Sci. USA 101 2004 10042 10047
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 10042-10047
-
-
Daitoku, H.1
Hatta, M.2
Matsuzaki, H.3
Aratani, S.4
Ohshima, T.5
Miyagishi, M.6
Nakajima, T.7
Fukamizu, A.8
-
30
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
P.F. Dijkers, R.H. Medema, J.W. Lammers, L. Koenderman, and P.J. Coffer Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1 Curr. Biol. 10 2000 1201 1204
-
(2000)
Curr. Biol.
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
Medema, R.H.2
Lammers, J.W.3
Koenderman, L.4
Coffer, P.J.5
-
31
-
-
0037174629
-
Timing requirements for insulin/IGF-1 signaling in C. elegans
-
A. Dillin, D.K. Crawford, and C. Kenyon Timing requirements for insulin/IGF-1 signaling in C. elegans Science 298 2002 830 834
-
(2002)
Science
, vol.298
, pp. 830-834
-
-
Dillin, A.1
Crawford, D.K.2
Kenyon, C.3
-
32
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
A. Dillin, A.L. Hsu, N. Arantes-Oliveira, J. Lehrer-Graiwer, H. Hsin, A.G. Fraser, R.S. Kamath, J. Ahringer, and C. Kenyon Rates of behavior and aging specified by mitochondrial function during development Science 298 2002 2398 2401
-
(2002)
Science
, vol.298
, pp. 2398-2401
-
-
Dillin, A.1
Hsu, A.L.2
Arantes-Oliveira, N.3
Lehrer-Graiwer, J.4
Hsin, H.5
Fraser, A.G.6
Kamath, R.S.7
Ahringer, J.8
Kenyon, C.9
-
33
-
-
0021200211
-
Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity
-
J.E. Eigenmann, D.F. Patterson, and E.R. Froesch Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity Acta Endocrinol. (Copenh.) 106 1984 448 453
-
(1984)
Acta Endocrinol. (Copenh.)
, vol.106
, pp. 448-453
-
-
Eigenmann, J.E.1
Patterson, D.F.2
Froesch, E.R.3
-
34
-
-
0037280096
-
SOD2 functions downstream of Sch9 to extend longevity in yeast
-
P. Fabrizio, L.L. Liou, V.N. Moy, A. Diaspro, J. SelverstoneValentine, E.B. Gralla, and V.D. Longo SOD2 functions downstream of Sch9 to extend longevity in yeast Genetics 163 2003 35 46
-
(2003)
Genetics
, vol.163
, pp. 35-46
-
-
Fabrizio, P.1
Liou, L.L.2
Moy, V.N.3
Diaspro, A.4
Selverstonevalentine, J.5
Gralla, E.B.6
Longo, V.D.7
-
35
-
-
0033118981
-
CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans
-
S. Felkai, J.J. Ewbank, J. Lemieux, J.C. Labbe, G.G. Brown, and S. Hekimi CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans EMBO J. 18 1999 1783 1792
-
(1999)
EMBO J.
, vol.18
, pp. 1783-1792
-
-
Felkai, S.1
Ewbank, J.J.2
Lemieux, J.3
Labbe, J.C.4
Brown, G.G.5
Hekimi, S.6
-
36
-
-
0035515923
-
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
-
J. Feng, F. Bussiere, and S. Hekimi Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans Dev. Cell 1 2001 633 644
-
(2001)
Dev. Cell
, vol.1
, pp. 633-644
-
-
Feng, J.1
Bussiere, F.2
Hekimi, S.3
-
37
-
-
0036132447
-
The Snell dwarf mutation Pit1(dw) can increase life span in mice
-
K. Flurkey, J. Papaconstantinou, and D.E. Harrison The Snell dwarf mutation Pit1(dw) can increase life span in mice Mech. Ageing Dev. 123 2002 121 130
-
(2002)
Mech. Ageing Dev.
, vol.123
, pp. 121-130
-
-
Flurkey, K.1
Papaconstantinou, J.2
Harrison, D.E.3
-
38
-
-
0023831256
-
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
-
D.B. Friedman, and T.E. Johnson A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility Genetics 118 1988 75 86
-
(1988)
Genetics
, vol.118
, pp. 75-86
-
-
Friedman, D.B.1
Johnson, T.E.2
-
39
-
-
0036021375
-
Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation
-
D. Garigan, A.L. Hsu, A.G. Fraser, R.S. Kamath, J. Ahringer, and C. Kenyon Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation Genetics 161 2002 1101 1112
-
(2002)
Genetics
, vol.161
, pp. 1101-1112
-
-
Garigan, D.1
Hsu, A.L.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Kenyon, C.6
-
40
-
-
0038047438
-
Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens
-
D.A. Garsin, J.M. Villanueva, J. Begun, D.H. Kim, C.D. Sifri, S.B. Calderwood, G. Ruvkun, and F.M. Ausubel Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens Science 300 2003 1921
-
(2003)
Science
, vol.300
, pp. 1921
-
-
Garsin, D.A.1
Villanueva, J.M.2
Begun, J.3
Kim, D.H.4
Sifri, C.D.5
Calderwood, S.B.6
Ruvkun, G.7
Ausubel, F.M.8
-
41
-
-
0344198603
-
Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan
-
B.J. Geesaman, E. Benson, S.J. Brewster, L.M. Kunkel, H. Blanche, G. Thomas, T.T. Perls, M.J. Daly, and A.A. Puca Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan Proc. Natl. Acad. Sci. USA 100 2003 14115 14120
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14115-14120
-
-
Geesaman, B.J.1
Benson, E.2
Brewster, S.J.3
Kunkel, L.M.4
Blanche, H.5
Thomas, G.6
Perls, T.T.7
Daly, M.J.8
Puca, A.A.9
-
42
-
-
0034036321
-
Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans
-
D. Gems, and D.L. Riddle Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans Genetics 154 2000 1597 1610
-
(2000)
Genetics
, vol.154
, pp. 1597-1610
-
-
Gems, D.1
Riddle, D.L.2
-
43
-
-
0031685525
-
Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans
-
D. Gems, A.J. Sutton, M.L. Sundermeyer, P.S. Albert, K.V. King, M.L. Edgley, P.L. Larsen, and D. Riddle Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans Genetics 150 1998 129 155
-
(1998)
Genetics
, vol.150
, pp. 129-155
-
-
Gems, D.1
Sutton, A.J.2
Sundermeyer, M.L.3
Albert, P.S.4
King, K.V.5
Edgley, M.L.6
Larsen, P.L.7
Riddle, D.8
-
44
-
-
2342420089
-
Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues
-
B. Gerisch, and A. Antebi Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues Development 131 2004 1765 1776
-
(2004)
Development
, vol.131
, pp. 1765-1776
-
-
Gerisch, B.1
Antebi, A.2
-
45
-
-
4143050290
-
The interaction between FOXO and SIRT1: Tipping the balance towards survival
-
M.E. Giannakou, and L. Partridge The interaction between FOXO and SIRT1: tipping the balance towards survival Trends Cell Biol. 14 2004 408 412
-
(2004)
Trends Cell Biol.
, vol.14
, pp. 408-412
-
-
Giannakou, M.E.1
Partridge, L.2
-
46
-
-
3142749712
-
Long-lived Drosophila with overexpressed dFOXO in adult fat body
-
M.E. Giannakou, M. Goss, M.A. Junger, E. Hafen, S.J. Leevers, and L. Partridge Long-lived Drosophila with overexpressed dFOXO in adult fat body Science 305 2004 361
-
(2004)
Science
, vol.305
, pp. 361
-
-
Giannakou, M.E.1
Goss, M.2
Junger, M.A.3
Hafen, E.4
Leevers, S.J.5
Partridge, L.6
-
47
-
-
13944253348
-
Calorie restriction - The SIR2 connection
-
L. Guarente, and F. Picard Calorie restriction - the SIR2 connection this issue Cell 120 2005 473 482
-
(2005)
Cell
, vol.120
, pp. 473-482
-
-
Guarente, L.1
Picard, F.2
-
48
-
-
0001001689
-
Effects of food restriction on aging: Separation of food intake and adiposity
-
D.E. Harrison, J.R. Archer, and C.M. Astle Effects of food restriction on aging: separation of food intake and adiposity Proc. Natl. Acad. Sci. USA 81 1984 1835 1838
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, pp. 1835-1838
-
-
Harrison, D.E.1
Archer, J.R.2
Astle, C.M.3
-
49
-
-
0036809333
-
SHsps and their role in the chaperone network
-
M. Haslbeck sHsps and their role in the chaperone network Cell. Mol. Life Sci. 59 2002 1649 1657
-
(2002)
Cell. Mol. Life Sci.
, vol.59
, pp. 1649-1657
-
-
Haslbeck, M.1
-
50
-
-
0035846604
-
Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
-
S.T. Henderson, and T.E. Johnson daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans Curr. Biol. 11 2001 1975 1980
-
(2001)
Curr. Biol.
, vol.11
, pp. 1975-1980
-
-
Henderson, S.T.1
Johnson, T.E.2
-
51
-
-
0038826959
-
Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress
-
M.J. Hercus, V. Loeschcke, and S.I. Rattan Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress Biogerontology 4 2003 149 156
-
(2003)
Biogerontology
, vol.4
, pp. 149-156
-
-
Hercus, M.J.1
Loeschcke, V.2
Rattan, S.I.3
-
52
-
-
0037167855
-
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
-
L.A. Herndon, P.J. Schmeissner, J.M. Dudaronek, P.A. Brown, K.M. Listner, Y. Sakano, M.C. Paupard, D.H. Hall, and M. Driscoll Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans Nature 419 2002 808 814
-
(2002)
Nature
, vol.419
, pp. 808-814
-
-
Herndon, L.A.1
Schmeissner, P.J.2
Dudaronek, J.M.3
Brown, P.A.4
Listner, K.M.5
Sakano, Y.6
Paupard, M.C.7
Hall, D.H.8
Driscoll, M.9
-
53
-
-
11144355021
-
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
-
M. Hertweck, C. Gobel, and R. Baumeister C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span Dev. Cell 6 2004 577 588
-
(2004)
Dev. Cell
, vol.6
, pp. 577-588
-
-
Hertweck, M.1
Gobel, C.2
Baumeister, R.3
-
54
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
M. Holzenberger, J. Dupont, B. Ducos, P. Leneuve, A. Geloen, P.C. Even, P. Cervera, and Y. Le Bouc IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice Nature 421 2003 182 187
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Geloen, A.5
Even, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
55
-
-
0032782364
-
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
-
Y. Honda, and S. Honda The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans FASEB J. 13 1999 1385 1393
-
(1999)
FASEB J.
, vol.13
, pp. 1385-1393
-
-
Honda, Y.1
Honda, S.2
-
56
-
-
0027467912
-
Oxygen-dependent perturbation of life span and aging rate in the nematode
-
S. Honda, N. Ishii, K. Suzuki, and M. Matsuo Oxygen-dependent perturbation of life span and aging rate in the nematode J. Gerontol. 48 1993 B57 B61
-
(1993)
J. Gerontol.
, vol.48
-
-
Honda, S.1
Ishii, N.2
Suzuki, K.3
Matsuo, M.4
-
57
-
-
0042886011
-
Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans
-
K. Houthoofd, B.P. Braeckman, T.E. Johnson, and J.R. Vanfleteren Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans Exp. Gerontol. 38 2003 947 954
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 947-954
-
-
Houthoofd, K.1
Braeckman, B.P.2
Johnson, T.E.3
Vanfleteren, J.R.4
-
58
-
-
0033609291
-
Signals from the reproductive system regulate the lifespan of C. elegans
-
H. Hsin, and C. Kenyon Signals from the reproductive system regulate the lifespan of C. elegans Nature 399 1999 362 366
-
(1999)
Nature
, vol.399
, pp. 362-366
-
-
Hsin, H.1
Kenyon, C.2
-
59
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
-
A.L. Hsu, C.T. Murphy, and C. Kenyon Regulation of aging and age-related disease by DAF-16 and heat-shock factor Science 300 2003 1142 1145
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
60
-
-
2942563805
-
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
-
D.S. Hwangbo, B. Gersham, M.P. Tu, M. Palmer, and M. Tatar Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body Nature 429 2004 562 566
-
(2004)
Nature
, vol.429
, pp. 562-566
-
-
Hwangbo, D.S.1
Gersham, B.2
Tu, M.P.3
Palmer, M.4
Tatar, M.5
-
61
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
K. Inoki, M.N. Corradetti, and K.L. Guan Dysregulation of the TSC-mTOR pathway in human disease Nat. Genet. 37 2005 19 24
-
(2005)
Nat. Genet.
, vol.37
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.L.3
-
62
-
-
0032514466
-
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes
-
N. Ishii, M. Fujii, P.S. Hartman, M. Tsuda, K. Yasuda, N. Senoo-Matsuda, S. Yanase, D. Ayusawa, and K. Suzuki A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes Nature 394 1998 694 697
-
(1998)
Nature
, vol.394
, pp. 694-697
-
-
Ishii, N.1
Fujii, M.2
Hartman, P.S.3
Tsuda, M.4
Yasuda, K.5
Senoo-Matsuda, N.6
Yanase, S.7
Ayusawa, D.8
Suzuki, K.9
-
63
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
K. Jia, D. Chen, and D.L. Riddle The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span Development 131 2004 3897 3906
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
64
-
-
2642530948
-
Long lifespan in worms with long telomeric DNA
-
K.S. Joeng, E.J. Song, K.J. Lee, and J. Lee Long lifespan in worms with long telomeric DNA Nat. Genet. 36 2004 607 611
-
(2004)
Nat. Genet.
, vol.36
, pp. 607-611
-
-
Joeng, K.S.1
Song, E.J.2
Lee, K.J.3
Lee, J.4
-
65
-
-
0035895199
-
A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants
-
T. Jonassen, P.L. Larsen, and C.F. Clarke A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants Proc. Natl. Acad. Sci. USA 98 2001 421 426
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 421-426
-
-
Jonassen, T.1
Larsen, P.L.2
Clarke, C.F.3
-
66
-
-
0034892172
-
Changes in gene expression associated with developmental arrest and longevity in Caenorhabditis elegans
-
S.J. Jones, D.L. Riddle, A.T. Pouzyrev, V.E. Velculescu, L. Hillier, S.R. Eddy, S.L. Stricklin, D.L. Baillie, R. Waterston, and M.A. Marra Changes in gene expression associated with developmental arrest and longevity in Caenorhabditis elegans Genome Res. 11 2001 1346 1352
-
(2001)
Genome Res.
, vol.11
, pp. 1346-1352
-
-
Jones, S.J.1
Riddle, D.L.2
Pouzyrev, A.T.3
Velculescu, V.E.4
Hillier, L.5
Eddy, S.R.6
Stricklin, S.L.7
Baillie, D.L.8
Waterston, R.9
Marra, M.A.10
-
67
-
-
0242539698
-
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
-
M.A. Junger, F. Rintelen, H. Stocker, J.D. Wasserman, M. Vegh, T. Radimerski, M.E. Greenberg, and E. Hafen The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling J. Biol. 2 2003 20
-
(2003)
J. Biol.
, vol.2
, pp. 20
-
-
Junger, M.A.1
Rintelen, F.2
Stocker, H.3
Wasserman, J.D.4
Vegh, M.5
Radimerski, T.6
Greenberg, M.E.7
Hafen, E.8
-
68
-
-
19344374925
-
Sir2-independent life span extension by calorie restriction in yeast
-
10.1371/journal.pbio.0020296
-
M. Kaeberlein, K.T. Kirkland, S. Fields, and B.K. Kennedy Sir2-independent life span extension by calorie restriction in yeast PLoS Biol. 2 2004 e296 10.1371/journal.pbio.0020296
-
(2004)
PLoS Biol.
, vol.2
, pp. 296
-
-
Kaeberlein, M.1
Kirkland, K.T.2
Fields, S.3
Kennedy, B.K.4
-
69
-
-
0032972559
-
Positive correlation between mammalian life span and cellular resistance to stress
-
P. Kapahi, M.E. Boulton, and T.B. Kirkwood Positive correlation between mammalian life span and cellular resistance to stress Free Radic. Biol. Med. 26 1999 495 500
-
(1999)
Free Radic. Biol. Med.
, vol.26
, pp. 495-500
-
-
Kapahi, P.1
Boulton, M.E.2
Kirkwood, T.B.3
-
70
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
P. Kapahi, B.M. Zid, T. Harper, D. Koslover, V. Sapin, and S. Benzer Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway Curr. Biol. 14 2004 885 890
-
(2004)
Curr. Biol.
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
71
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
C. Kenyon, J. Chang, E. Gensch, A. Rudner, and R. Tabtiang A C. elegans mutant that lives twice as long as wild type Nature 366 1993 461 464
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
72
-
-
0030813398
-
Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
K.D. Kimura, H.A. Tissenbaum, Y. Liu, and G. Ruvkun daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans Science 277 1997 942 946
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
73
-
-
0032947552
-
Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
-
P.A. Kirchman, S. Kim, C.Y. Lai, and S.M. Jazwinski Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae Genetics 152 1999 179 190
-
(1999)
Genetics
, vol.152
, pp. 179-190
-
-
Kirchman, P.A.1
Kim, S.2
Lai, C.Y.3
Jazwinski, S.M.4
-
74
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
G.J. Kops, T.B. Dansen, P.E. Polderman, I. Saarloos, K.W. Wirtz, P.J. Coffer, T.T. Huang, J.L. Bos, R.H. Medema, and B.M. Burgering Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress Nature 419 2002 316 321
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
Saarloos, I.4
Wirtz, K.W.5
Coffer, P.J.6
Huang, T.T.7
Bos, J.L.8
Medema, R.H.9
Burgering, B.M.10
-
75
-
-
0032573178
-
The genetics of caloric restriction in Caenorhabditis elegans
-
B. Lakowski, and S. Hekimi The genetics of caloric restriction in Caenorhabditis elegans Proc. Natl. Acad. Sci. USA 95 1998 13091 13096
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13091-13096
-
-
Lakowski, B.1
Hekimi, S.2
-
76
-
-
0027515616
-
Aging and resistance to oxidative damage in Caenorhabditis elegans
-
P.L. Larsen Aging and resistance to oxidative damage in Caenorhabditis elegans Proc. Natl. Acad. Sci. USA 90 1993 8905 8909
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8905-8909
-
-
Larsen, P.L.1
-
77
-
-
0037016442
-
Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q
-
P.L. Larsen, and C.F. Clarke Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q Science 295 2002 120 123
-
(2002)
Science
, vol.295
, pp. 120-123
-
-
Larsen, P.L.1
Clarke, C.F.2
-
78
-
-
0035846601
-
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
-
R.Y. Lee, J. Hench, and G. Ruvkun Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway Curr. Biol. 11 2001 1950 1957
-
(2001)
Curr. Biol.
, vol.11
, pp. 1950-1957
-
-
Lee, R.Y.1
Hench, J.2
Ruvkun, G.3
-
79
-
-
0037466652
-
DAF-16 target genes that control C. elegans life-span and metabolism
-
S.S. Lee, S. Kennedy, A.C. Tolonen, and G. Ruvkun DAF-16 target genes that control C. elegans life-span and metabolism Science 300 2003 644 647
-
(2003)
Science
, vol.300
, pp. 644-647
-
-
Lee, S.S.1
Kennedy, S.2
Tolonen, A.C.3
Ruvkun, G.4
-
80
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
-
S.S. Lee, R.Y. Lee, A.G. Fraser, R.S. Kamath, J. Ahringer, and G. Ruvkun A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity Nat. Genet. 33 2002 40 48
-
(2002)
Nat. Genet.
, vol.33
, pp. 40-48
-
-
Lee, S.S.1
Lee, R.Y.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Ruvkun, G.6
-
81
-
-
0037380570
-
Daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway
-
W. Li, S.G. Kennedy, and G. Ruvkun daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway Genes Dev. 17 2003 844 858
-
(2003)
Genes Dev.
, vol.17
, pp. 844-858
-
-
Li, W.1
Kennedy, S.G.2
Ruvkun, G.3
-
82
-
-
0345447590
-
Tissue-specific activities of the C. elegans DAF-16 protein in the regulation of lifespan
-
N. Libina, J.R. Berman, and C. Kenyon Tissue-specific activities of the C. elegans DAF-16 protein in the regulation of lifespan Cell 115 2003 489 502
-
(2003)
Cell
, vol.115
, pp. 489-502
-
-
Libina, N.1
Berman, J.R.2
Kenyon, C.3
-
83
-
-
0030657540
-
Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
K. Lin, J.B. Dorman, A. Rodan, and C. Kenyon daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans Science 278 1997 1319 1322
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
84
-
-
0034967720
-
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
-
K. Lin, H. Hsin, N. Libina, and C. Kenyon Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling Nat. Genet. 28 2001 139 145
-
(2001)
Nat. Genet.
, vol.28
, pp. 139-145
-
-
Lin, K.1
Hsin, H.2
Libina, N.3
Kenyon, C.4
-
85
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
S.J. Lin, M. Kaeberlein, A.A. Andalis, L.A. Sturtz, P.A. Defossez, V.C. Culotta, G.R. Fink, and L. Guarente Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration Nature 418 2002 344 348
-
(2002)
Nature
, vol.418
, pp. 344-348
-
-
Lin, S.J.1
Kaeberlein, M.2
Andalis, A.A.3
Sturtz, L.A.4
Defossez, P.A.5
Culotta, V.C.6
Fink, G.R.7
Guarente, L.8
-
86
-
-
0035855939
-
Receptors and transduction in taste
-
B. Lindemann Receptors and transduction in taste Nature 413 2001 219 225
-
(2001)
Nature
, vol.413
, pp. 219-225
-
-
Lindemann, B.1
-
87
-
-
0029123058
-
Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress
-
G.J. Lithgow, T.M. White, S. Melov, and T.E. Johnson Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress Proc. Natl. Acad. Sci. USA 92 1995 7540 7544
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7540-7544
-
-
Lithgow, G.J.1
White, T.M.2
Melov, S.3
Johnson, T.E.4
-
88
-
-
0038687689
-
The Ras and Sch9 pathways regulate stress resistance and longevity
-
V.D. Longo The Ras and Sch9 pathways regulate stress resistance and longevity Exp. Gerontol. 38 2003 807 811
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 807-811
-
-
Longo, V.D.1
-
89
-
-
0037238644
-
Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans
-
D. McCulloch, and D. Gems Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans Exp. Gerontol. 38 2003 129 136
-
(2003)
Exp. Gerontol.
, vol.38
, pp. 129-136
-
-
McCulloch, D.1
Gems, D.2
-
90
-
-
7244238167
-
Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
-
J.J. McElwee, E. Schuster, E. Blanc, J.H. Thomas, and D. Gems Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance J. Biol. Chem. 279 2004 44533 44543
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 44533-44543
-
-
McElwee, J.J.1
Schuster, E.2
Blanc, E.3
Thomas, J.H.4
Gems, D.5
-
91
-
-
0042691506
-
Autophagy genes are essential for dauer development and life-span extension in C. elegans
-
A. Melendez, Z. Talloczy, M. Seaman, E.L. Eskelinen, D.H. Hall, and B. Levine Autophagy genes are essential for dauer development and life-span extension in C. elegans Science 301 2003 1387 1391
-
(2003)
Science
, vol.301
, pp. 1387-1391
-
-
Melendez, A.1
Talloczy, Z.2
Seaman, M.3
Eskelinen, E.L.4
Hall, D.H.5
Levine, B.6
-
92
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
M.D. Michael, R.N. Kulkarni, C. Postic, S.F. Previs, G.I. Shulman, M.A. Magnuson, and C.R. Kahn Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction Mol. Cell 6 2000 87 97
-
(2000)
Mol. Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
Previs, S.F.4
Shulman, G.I.5
Magnuson, M.A.6
Kahn, C.R.7
-
93
-
-
0742323000
-
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
-
J.F. Morley, and R.I. Morimoto Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones Mol. Biol. Cell 15 2004 657 664
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 657-664
-
-
Morley, J.F.1
Morimoto, R.I.2
-
94
-
-
0036678146
-
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
-
J.F. Morley, H.R. Brignull, J.J. Weyers, and R.I. Morimoto The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans Proc. Natl. Acad. Sci. USA 99 2002 10417 10422
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10417-10422
-
-
Morley, J.F.1
Brignull, H.R.2
Weyers, J.J.3
Morimoto, R.I.4
-
95
-
-
0029768753
-
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
-
J.Z. Morris, H.A. Tissenbaum, and G. Ruvkun A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans Nature 382 1996 536 539
-
(1996)
Nature
, vol.382
, pp. 536-539
-
-
Morris, J.Z.1
Tissenbaum, H.A.2
Ruvkun, G.3
-
96
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
M.C. Motta, N. Divecha, M. Lemieux, C. Kamel, D. Chen, W. Gu, Y. Bultsma, M. McBurney, and L. Guarente Mammalian SIRT1 represses forkhead transcription factors Cell 116 2004 551 563
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
Bultsma, Y.7
McBurney, M.8
Guarente, L.9
-
97
-
-
0030014296
-
A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans
-
S. Murakami, and T.E. Johnson A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans Genetics 143 1996 1207 1218
-
(1996)
Genetics
, vol.143
, pp. 1207-1218
-
-
Murakami, S.1
Johnson, T.E.2
-
98
-
-
0035797913
-
The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans
-
S. Murakami, and T.E. Johnson The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans Curr. Biol. 11 2001 1517 1523
-
(2001)
Curr. Biol.
, vol.11
, pp. 1517-1523
-
-
Murakami, S.1
Johnson, T.E.2
-
99
-
-
0042092531
-
Genes that act downstream of DAF-16 tp influence the lifespan of C. elegans
-
C.T. Murphy, S. McCarroll, C.I. Bargmann, A. Fraser, R.S. Kamath, J. Ahringer, H. Li, and C. Kenyon Genes that act downstream of DAF-16 tp influence the lifespan of C. elegans Nature 424 2003 277 283
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
100
-
-
0037192473
-
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
-
S. Nemoto, and T. Finkel Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway Science 295 2002 2450 2452
-
(2002)
Science
, vol.295
, pp. 2450-2452
-
-
Nemoto, S.1
Finkel, T.2
-
101
-
-
0032238299
-
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
-
S. Ogg, and G. Ruvkun The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway Mol. Cell 2 1998 887 893
-
(1998)
Mol. Cell
, vol.2
, pp. 887-893
-
-
Ogg, S.1
Ruvkun, G.2
-
102
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
S. Ogg, S. Paradis, S. Gottlieb, G.I. Patterson, L. Lee, H.A. Tissenbaum, and G. Ruvkun The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature 389 1997 994 999
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
103
-
-
0037418579
-
Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans
-
S. Ookuma, M. Fukuda, and E. Nishida Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans Curr. Biol. 13 2003 427 431
-
(2003)
Curr. Biol.
, vol.13
, pp. 427-431
-
-
Ookuma, S.1
Fukuda, M.2
Nishida, E.3
-
104
-
-
0032529189
-
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
-
S. Paradis, and G. Ruvkun Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor Genes Dev. 12 1998 2488 2498
-
(1998)
Genes Dev.
, vol.12
, pp. 2488-2498
-
-
Paradis, S.1
Ruvkun, G.2
-
105
-
-
0033151613
-
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
-
S. Paradis, M. Ailion, A. Toker, J.H. Thomas, and G. Ruvkun A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans Genes Dev. 13 1999 1438 1452
-
(1999)
Genes Dev.
, vol.13
, pp. 1438-1452
-
-
Paradis, S.1
Ailion, M.2
Toker, A.3
Thomas, J.H.4
Ruvkun, G.5
-
106
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
F. Picard, M. Kurtev, N. Chung, A. Topark-Ngarm, T. Senawong, R. Machado De Oliveira, M. Leid, M.W. McBurney, and L. Guarente Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma Nature 429 2004 771 776
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
MacHado De Oliveira, R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
107
-
-
0035868890
-
Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
-
S.B. Pierce, M. Costa, R. Wisotzkey, S. Devahdhar, S.A. Homburger, R. Buchman, and G. Ruvkun Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family Genes Dev. 15 2001 672 686
-
(2001)
Genes Dev.
, vol.15
, pp. 672-686
-
-
Pierce, S.B.1
Costa, M.2
Wisotzkey, R.3
Devahdhar, S.4
Homburger, S.A.5
Buchman, R.6
Ruvkun, G.7
-
108
-
-
0036773552
-
Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis
-
M.M. Ramsey, R.L. Ingram, A.B. Cashion, A.H. Ng, J.M. Cline, A.F. Parlow, and W.E. Sonntag Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis Endocrinology 143 2002 4139 4142
-
(2002)
Endocrinology
, vol.143
, pp. 4139-4142
-
-
Ramsey, M.M.1
Ingram, R.L.2
Cashion, A.B.3
Ng, A.H.4
Cline, J.M.5
Parlow, A.F.6
Sonntag, W.E.7
-
109
-
-
7744224162
-
Effect of extrinsic mortality on the evolution of senescence in guppies
-
D.N. Reznick, M.J. Bryant, D. Roff, C.K. Ghalambor, and D.E. Ghalambor Effect of extrinsic mortality on the evolution of senescence in guppies Nature 431 2004 1095 1099
-
(2004)
Nature
, vol.431
, pp. 1095-1099
-
-
Reznick, D.N.1
Bryant, M.J.2
Roff, D.3
Ghalambor, C.K.4
Ghalambor, D.E.5
-
110
-
-
0004282618
-
-
Cold Spring Harbor Laboratory Press Plainview, NY
-
D.L. Riddle C. elegans II 1997 Cold Spring Harbor Laboratory Press Plainview, NY
-
(1997)
C. Elegans II
-
-
Riddle, D.L.1
-
111
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
B. Rogina, and S.L. Helfand Sir2 mediates longevity in the fly through a pathway related to calorie restriction Proc. Natl. Acad. Sci. USA 101 2004 15998 16003
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
112
-
-
0034671596
-
Extended life-span conferred by cotransporter gene mutations in drosophila
-
B. Rogina, R.A. Reenan, S.P. Nilsen, and S.L. Helfand Extended life-span conferred by cotransporter gene mutations in drosophila Science 290 2000 2137 2140
-
(2000)
Science
, vol.290
, pp. 2137-2140
-
-
Rogina, B.1
Reenan, R.A.2
Nilsen, S.P.3
Helfand, S.L.4
-
113
-
-
18744416824
-
Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction
-
B. Rogina, S.L. Helfand, and S. Frankel Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction Science 298 2002 1745
-
(2002)
Science
, vol.298
, pp. 1745
-
-
Rogina, B.1
Helfand, S.L.2
Frankel, S.3
-
114
-
-
13944274395
-
PPARgamma as a metabolic regulator: Insights from genomics and pharmacology
-
D.B. Savage PPARgamma as a metabolic regulator: insights from genomics and pharmacology Expert Rev. Mol. Med. 2005 2005 1 16
-
(2005)
Expert Rev. Mol. Med.
, vol.2005
, pp. 1-16
-
-
Savage, D.B.1
-
115
-
-
1642332084
-
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
J. Seoane, H.V. Le, L. Shen, S.A. Anderson, and J. Massague Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation Cell 117 2004 211 223
-
(2004)
Cell
, vol.117
, pp. 211-223
-
-
Seoane, J.1
Le H., V.2
Shen, L.3
Anderson, S.A.4
Massague, J.5
-
116
-
-
0033601345
-
A delayed wave of death from reproduction in Drosophila
-
C.M. Sgro, and L. Partridge A delayed wave of death from reproduction in Drosophila Science 286 1999 2521 2524
-
(1999)
Science
, vol.286
, pp. 2521-2524
-
-
Sgro, C.M.1
Partridge, L.2
-
117
-
-
0037470439
-
Steroid control of longevity in Drosophila melanogaster
-
A.F. Simon, C. Shih, A. Mack, and S. Benzer Steroid control of longevity in Drosophila melanogaster Science 299 2003 1407 1410
-
(2003)
Science
, vol.299
, pp. 1407-1410
-
-
Simon, A.F.1
Shih, C.2
MacK, A.3
Benzer, S.4
-
118
-
-
0032908347
-
FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
-
J. Sun, and J. Tower FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies Mol. Cell. Biol. 19 1999 216 228
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 216-228
-
-
Sun, J.1
Tower, J.2
-
119
-
-
0035989388
-
Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster
-
J. Sun, D. Folk, T.J. Bradley, and J. Tower Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster Genetics 161 2002 661 672
-
(2002)
Genetics
, vol.161
, pp. 661-672
-
-
Sun, J.1
Folk, D.2
Bradley, T.J.3
Tower, J.4
-
120
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
-
M. Tatar, A. Kopelman, D. Epstein, M.P. Tu, C.M. Yin, and R.S. Garofalo A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function Science 292 2001 107 110
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
Tu, M.P.4
Yin, C.M.5
Garofalo, R.S.6
-
121
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
M. Tatar, A. Bartke, and A. Antebi The endocrine regulation of aging by insulin-like signals Science 299 2003 1346 1351
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
122
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
H.A. Tissenbaum, and L. Guarente Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans Nature 410 2001 227 230
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
123
-
-
0037134040
-
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
-
H. Tran, A. Brunet, J.M. Grenier, S.R. Datta, A.J. Fornace Jr., P.S. DiStefano, L.W. Chiang, and M.E. Greenberg DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein Science 296 2002 530 534
-
(2002)
Science
, vol.296
, pp. 530-534
-
-
Tran, H.1
Brunet, A.2
Grenier, J.M.3
Datta, S.R.4
Fornace Jr., A.J.5
Distefano, P.S.6
Chiang, L.W.7
Greenberg, M.E.8
-
124
-
-
0013356701
-
The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico
-
M.P. Tu, D. Epstein, and M. Tatar The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico Aging Cell 1 2002 75 80
-
(2002)
Aging Cell
, vol.1
, pp. 75-80
-
-
Tu, M.P.1
Epstein, D.2
Tatar, M.3
-
125
-
-
0001039666
-
Impaired ovarian ecdysone synthesis of Drosophila melanogaster insulin receptor mutants
-
M.P. Tu, C.M. Yin, and M. Tatar Impaired ovarian ecdysone synthesis of Drosophila melanogaster insulin receptor mutants Aging Cell 1 2002 158 160
-
(2002)
Aging Cell
, vol.1
, pp. 158-160
-
-
Tu, M.P.1
Yin, C.M.2
Tatar, M.3
-
126
-
-
0037011958
-
P53 mutant mice that display early ageing-associated phenotypes
-
S.D. Tyner, S. Venkatachalam, J. Choi, S. Jones, N. Ghebranious, H. Igelmann, X. Lu, G. Soron, B. Cooper, and C. Brayton p53 mutant mice that display early ageing-associated phenotypes Nature 415 2002 45 53
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
-
127
-
-
0033613204
-
Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate
-
W.A. Van Voorhies, and S. Ward Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate Proc. Natl. Acad. Sci. USA 96 1999 11399 11403
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11399-11403
-
-
Van Voorhies, W.A.1
Ward, S.2
-
128
-
-
0028803718
-
The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans
-
J.R. Vanfleteren, and A. De Vreese The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans FASEB J. 9 1995 1355 1361
-
(1995)
FASEB J.
, vol.9
, pp. 1355-1361
-
-
Vanfleteren, J.R.1
De Vreese, A.2
-
129
-
-
0041507039
-
Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals
-
G.A. Walker, and G.J. Lithgow Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals Aging Cell 2 2003 131 140
-
(2003)
Aging Cell
, vol.2
, pp. 131-140
-
-
Walker, G.A.1
Lithgow, G.J.2
-
130
-
-
0034682285
-
Evolution of lifespan in C. elegans
-
D.W. Walker, G. McColl, N.L. Jenkins, J. Harris, and G.J. Lithgow Evolution of lifespan in C. elegans Nature 405 2000 296 297
-
(2000)
Nature
, vol.405
, pp. 296-297
-
-
Walker, D.W.1
McColl, G.2
Jenkins, N.L.3
Harris, J.4
Lithgow, G.J.5
-
131
-
-
0034953956
-
Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans
-
G.A. Walker, T.M. White, G. McColl, N.L. Jenkins, S. Babich, E.P. Candido, T.E. Johnson, and G.J. Lithgow Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans J. Gerontol. A Biol. Sci. Med. Sci. 56 2001 B281 B287
-
(2001)
J. Gerontol. a Biol. Sci. Med. Sci.
, vol.56
-
-
Walker, G.A.1
White, T.M.2
McColl, G.3
Jenkins, N.L.4
Babich, S.5
Candido, E.P.6
Johnson, T.E.7
Lithgow, G.J.8
-
132
-
-
0242362732
-
JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
-
M.C. Wang, D. Bohmann, and H. Jasper JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila Dev. Cell 5 2003 811 816
-
(2003)
Dev. Cell
, vol.5
, pp. 811-816
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
133
-
-
4344591769
-
Multiple-stress analysis for isolation of Drosophila longevity genes
-
H.D. Wang, P. Kazemi-Esfarjani, and S. Benzer Multiple-stress analysis for isolation of Drosophila longevity genes Proc. Natl. Acad. Sci. USA 101 2004 12610 12615
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 12610-12615
-
-
Wang, H.D.1
Kazemi-Esfarjani, P.2
Benzer, S.3
-
134
-
-
9644278037
-
Insulin regulation of heart function in aging fruit flies
-
R.J. Wessells, E. Fitzgerald, J.R. Cypser, M. Tatar, and R. Bodmer Insulin regulation of heart function in aging fruit flies Nat. Genet. 36 2004 1275 1281
-
(2004)
Nat. Genet.
, vol.36
, pp. 1275-1281
-
-
Wessells, R.J.1
Fitzgerald, E.2
Cypser, J.R.3
Tatar, M.4
Bodmer, R.5
-
135
-
-
0034613164
-
Regulation of C. elegans life-span by insulinlike signaling in the nervous system
-
C.A. Wolkow, K.D. Kimura, M.S. Lee, and G. Ruvkun Regulation of C. elegans life-span by insulinlike signaling in the nervous system Science 290 2000 147 150
-
(2000)
Science
, vol.290
, pp. 147-150
-
-
Wolkow, C.A.1
Kimura, K.D.2
Lee, M.S.3
Ruvkun, G.4
-
136
-
-
0346668317
-
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway
-
C.A. Wolkow, M.J. Munoz, D.L. Riddle, and G. Ruvkun Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway J. Biol. Chem. 277 2002 49591 49597
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49591-49597
-
-
Wolkow, C.A.1
Munoz, M.J.2
Riddle, D.L.3
Ruvkun, G.4
|