메뉴 건너뛰기




Volumn 121, Issue 1, 2005, Pages 115-125

JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; SOMATOMEDIN BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FOXO;

EID: 17044408768     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.02.030     Document Type: Article
Times cited : (464)

References (59)
  • 1
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • D. Accili, and K.C. Arden FoxOs at the crossroads of cellular metabolism, differentiation, and transformation Cell 117 2004 421 426
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 2
    • 0031962486 scopus 로고    scopus 로고
    • Small stress proteins: Chaperones that act as regulators of intracellular redox state and programmed cell death
    • A.P. Arrigo Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death Biol. Chem. 379 1998 19 26
    • (1998) Biol. Chem. , vol.379 , pp. 19-26
    • Arrigo, A.P.1
  • 3
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • K.B. Beckman, and B.N. Ames The free radical theory of aging matures Physiol. Rev. 78 1998 547 581
    • (1998) Physiol. Rev. , vol.78 , pp. 547-581
    • Beckman, K.B.1    Ames, B.N.2
  • 4
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • M. Bluher, B.B. Kahn, and C.R. Kahn Extended longevity in mice lacking the insulin receptor in adipose tissue Science 299 2003 572 574
    • (2003) Science , vol.299 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 6
    • 0036484062 scopus 로고    scopus 로고
    • Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
    • J.S. Britton, W.K. Lockwood, L. Li, S.M. Cohen, and B.A. Edgar Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions Dev. Cell 2 2002 239 249
    • (2002) Dev. Cell , vol.2 , pp. 239-249
    • Britton, J.S.1    Lockwood, W.K.2    Li, L.3    Cohen, S.M.4    Edgar, B.A.5
  • 7
    • 0035916357 scopus 로고    scopus 로고
    • An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    • W. Brogiolo, H. Stocker, T. Ikeya, F. Rintelen, R. Fernandez, and E. Hafen An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control Curr. Biol. 11 2001 213 221
    • (2001) Curr. Biol. , vol.11 , pp. 213-221
    • Brogiolo, W.1    Stocker, H.2    Ikeya, T.3    Rintelen, F.4    Fernandez, R.5    Hafen, E.6
  • 11
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • S.R. Datta, A. Brunet, and M.E. Greenberg Cellular survival: a play in three Akts Genes Dev. 13 1999 2905 2927
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 12
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • R.J. Davis Signal transduction by the JNK group of MAP kinases Cell 103 2000 239 252
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 14
    • 0036584593 scopus 로고    scopus 로고
    • Genetic analysis of insulin signaling in Drosophila
    • R.S. Garofalo Genetic analysis of insulin signaling in Drosophila Trends Endocrinol. Metab. 13 2002 156 162
    • (2002) Trends Endocrinol. Metab. , vol.13 , pp. 156-162
    • Garofalo, R.S.1
  • 16
    • 0141922962 scopus 로고    scopus 로고
    • The functions of insulin signaling: Size isn't everything, even in Drosophila
    • D.C. Goberdhan, and C. Wilson The functions of insulin signaling: size isn't everything, even in Drosophila Differentiation 71 2003 375 397
    • (2003) Differentiation , vol.71 , pp. 375-397
    • Goberdhan, D.C.1    Wilson, C.2
  • 17
    • 0034626747 scopus 로고    scopus 로고
    • Genetic pathways that regulate ageing in model organisms
    • L. Guarente, and C. Kenyon Genetic pathways that regulate ageing in model organisms Nature 408 2000 255 262
    • (2000) Nature , vol.408 , pp. 255-262
    • Guarente, L.1    Kenyon, C.2
  • 18
    • 0037470539 scopus 로고    scopus 로고
    • Genetics and the specificity of the aging process
    • S. Hekimi, and L. Guarente Genetics and the specificity of the aging process Science 299 2003 1351 1354
    • (2003) Science , vol.299 , pp. 1351-1354
    • Hekimi, S.1    Guarente, L.2
  • 19
    • 0035846604 scopus 로고    scopus 로고
    • Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • S.T. Henderson, and T.E. Johnson daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans Curr. Biol. 11 2001 1975 1980
    • (2001) Curr. Biol. , vol.11 , pp. 1975-1980
    • Henderson, S.T.1    Johnson, T.E.2
  • 22
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • A.L. Hsu, C.T. Murphy, and C. Kenyon Regulation of aging and age-related disease by DAF-16 and heat-shock factor Science 300 2003 1142 1145
    • (2003) Science , vol.300 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 23
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • D.S. Hwangbo, B. Gersham, M.P. Tu, M. Palmer, and M. Tatar Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body Nature 429 2004 562 566
    • (2004) Nature , vol.429 , pp. 562-566
    • Hwangbo, D.S.1    Gersham, B.2    Tu, M.P.3    Palmer, M.4    Tatar, M.5
  • 24
    • 0037031147 scopus 로고    scopus 로고
    • Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
    • T. Ikeya, M. Galic, P. Belawat, K. Nairz, and E. Hafen Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila Curr. Biol. 12 2002 1293 1300
    • (2002) Curr. Biol. , vol.12 , pp. 1293-1300
    • Ikeya, T.1    Galic, M.2    Belawat, P.3    Nairz, K.4    Hafen, E.5
  • 26
    • 0242539698 scopus 로고    scopus 로고
    • The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    • M.A. Jünger, F. Rintelen, H. Stocker, J.D. Wasserman, M. Vegh, T. Radimerski, M.E. Greenberg, and E. Hafen The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling J. Biol. 2 2003 20
    • (2003) J. Biol. , vol.2 , pp. 20
    • Jünger, M.A.1    Rintelen, F.2    Stocker, H.3    Wasserman, J.D.4    Vegh, M.5    Radimerski, T.6    Greenberg, M.E.7    Hafen, E.8
  • 27
    • 0037119417 scopus 로고    scopus 로고
    • Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
    • H. Kaneto, G. Xu, N. Fujii, S. Kim, S. Bonner-Weir, and G.C. Weir Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression J. Biol. Chem. 277 2002 30010 30018
    • (2002) J. Biol. Chem. , vol.277 , pp. 30010-30018
    • Kaneto, H.1    Xu, G.2    Fujii, N.3    Kim, S.4    Bonner-Weir, S.5    Weir, G.C.6
  • 28
    • 0035917440 scopus 로고    scopus 로고
    • A conserved regulatory system for aging
    • C. Kenyon A conserved regulatory system for aging Cell 105 2001 165 168
    • (2001) Cell , vol.105 , pp. 165-168
    • Kenyon, C.1
  • 29
    • 0035971422 scopus 로고    scopus 로고
    • Drosophila AP-1: Lessons from an invertebrate
    • L. Kockel, J.G. Homsy, and D. Bohmann Drosophila AP-1: lessons from an invertebrate Oncogene 20 2001 2347 2364
    • (2001) Oncogene , vol.20 , pp. 2347-2364
    • Kockel, L.1    Homsy, J.G.2    Bohmann, D.3
  • 31
    • 0037312020 scopus 로고    scopus 로고
    • How does calorie restriction work?
    • J. Koubova, and L. Guarente How does calorie restriction work? Genes Dev. 17 2003 313 321
    • (2003) Genes Dev. , vol.17 , pp. 313-321
    • Koubova, J.1    Guarente, L.2
  • 33
    • 0037474274 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
    • Y.H. Lee, J. Giraud, R.J. Davis, and M.F. White c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade J. Biol. Chem. 278 2003 2896 2902
    • (2003) J. Biol. Chem. , vol.278 , pp. 2896-2902
    • Lee, Y.H.1    Giraud, J.2    Davis, R.J.3    White, M.F.4
  • 34
    • 0037380570 scopus 로고    scopus 로고
    • Daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway
    • W. Li, S.G. Kennedy, and G. Ruvkun daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway Genes Dev. 17 2003 844 858
    • (2003) Genes Dev. , vol.17 , pp. 844-858
    • Li, W.1    Kennedy, S.G.2    Ruvkun, G.3
  • 35
    • 0345447590 scopus 로고    scopus 로고
    • Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    • N. Libina, J.R. Berman, and C. Kenyon Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan Cell 115 2003 489 502
    • (2003) Cell , vol.115 , pp. 489-502
    • Libina, N.1    Berman, J.R.2    Kenyon, C.3
  • 36
    • 0030657540 scopus 로고    scopus 로고
    • Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • K. Lin, J.B. Dorman, A. Rodan, and C. Kenyon daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans Science 278 1997 1319 1322
    • (1997) Science , vol.278 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 37
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • K. Lin, H. Hsin, N. Libina, and C. Kenyon Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling Nat. Genet. 28 2001 139 145
    • (2001) Nat. Genet. , vol.28 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 38
    • 0032519787 scopus 로고    scopus 로고
    • Puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
    • E. Martin-Blanco, A. Gampel, J. Ring, K. Virdee, N. Kirov, A.M. Tolkovsky, and A. Martinez-Arias puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila Genes Dev. 12 1998 557 570
    • (1998) Genes Dev. , vol.12 , pp. 557-570
    • Martin-Blanco, E.1    Gampel, A.2    Ring, J.3    Virdee, K.4    Kirov, N.5    Tolkovsky, A.M.6    Martinez-Arias, A.7
  • 39
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • M.P. Mattson Pathways towards and away from Alzheimer's disease Nature 430 2004 631 639
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 40
    • 0034976004 scopus 로고    scopus 로고
    • The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
    • M. Miron, J. Verdu, P.E. Lachance, M.J. Birnbaum, P.F. Lasko, and N. Sonenberg The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila Nat. Cell Biol. 3 2001 596 601
    • (2001) Nat. Cell Biol. , vol.3 , pp. 596-601
    • Miron, M.1    Verdu, J.2    Lachance, P.E.3    Birnbaum, M.J.4    Lasko, P.F.5    Sonenberg, N.6
  • 42
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • S. Ogg, S. Paradis, S. Gottlieb, G.I. Patterson, L. Lee, H.A. Tissenbaum, and G. Ruvkun The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature 389 1997 994 999
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6    Ruvkun, G.7
  • 43
    • 0036713481 scopus 로고    scopus 로고
    • The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels
    • S. Oldham, H. Stocker, M. Laffargue, F. Wittwer, M. Wymann, and E. Hafen The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels Development 129 2002 4103 4109
    • (2002) Development , vol.129 , pp. 4103-4109
    • Oldham, S.1    Stocker, H.2    Laffargue, M.3    Wittwer, F.4    Wymann, M.5    Hafen, E.6
  • 44
    • 0042161896 scopus 로고    scopus 로고
    • Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway
    • O. Puig, M.T. Marr, M.L. Ruhf, and R. Tjian Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway Genes Dev. 17 2003 2006 2020
    • (2003) Genes Dev. , vol.17 , pp. 2006-2020
    • Puig, O.1    Marr, M.T.2    Ruhf, M.L.3    Tjian, R.4
  • 45
    • 0037052544 scopus 로고    scopus 로고
    • Ablation of insulin-producing neurons in flies: Growth and diabetic phenotypes
    • E.J. Rulifson, S.K. Kim, and R. Nusse Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes Science 296 2002 1118 1120
    • (2002) Science , vol.296 , pp. 1118-1120
    • Rulifson, E.J.1    Kim, S.K.2    Nusse, R.3
  • 46
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • A.R. Saltiel, and C.R. Kahn Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 2001 799 806
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 47
    • 0033229835 scopus 로고    scopus 로고
    • Stress signaling in Drosophila
    • B.E. Stronach, and N. Perrimon Stress signaling in Drosophila Oncogene 18 1999 6172 6182
    • (1999) Oncogene , vol.18 , pp. 6172-6182
    • Stronach, B.E.1    Perrimon, N.2
  • 48
    • 0035062236 scopus 로고    scopus 로고
    • Slow aging during insect reproductive diapause: Why butterflies, grasshoppers and flies are like worms
    • M. Tatar, and C. Yin Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms Exp. Gerontol. 36 2001 723 738
    • (2001) Exp. Gerontol. , vol.36 , pp. 723-738
    • Tatar, M.1    Yin, C.2
  • 49
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • M. Tatar, A. Kopelman, D. Epstein, M.P. Tu, C.M. Yin, and R.S. Garofalo A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function Science 292 2001 107 110
    • (2001) Science , vol.292 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.P.4    Yin, C.M.5    Garofalo, R.S.6
  • 50
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • M. Tatar, A. Bartke, and A. Antebi The endocrine regulation of aging by insulin-like signals Science 299 2003 1346 1351
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 52
    • 0013356701 scopus 로고    scopus 로고
    • The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico
    • M.P. Tu, D. Epstein, and M. Tatar The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico Aging Cell 1 2002 75 80
    • (2002) Aging Cell , vol.1 , pp. 75-80
    • Tu, M.P.1    Epstein, D.2    Tatar, M.3
  • 53
    • 0242362732 scopus 로고    scopus 로고
    • JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
    • M.C. Wang, D. Bohmann, and H. Jasper JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila Dev. Cell 5 2003 811 816
    • (2003) Dev. Cell , vol.5 , pp. 811-816
    • Wang, M.C.1    Bohmann, D.2    Jasper, H.3
  • 54
    • 0033828645 scopus 로고    scopus 로고
    • Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye
    • U. Weber, N. Paricio, and M. Mlodzik Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye Development 127 2000 3619 3629
    • (2000) Development , vol.127 , pp. 3619-3629
    • Weber, U.1    Paricio, N.2    Mlodzik, M.3
  • 55
    • 0031849099 scopus 로고    scopus 로고
    • Small heat-shock protein family: Function in health and disease
    • M.J. Welsh, and M. Gaestel Small heat-shock protein family: function in health and disease Ann. N Y Acad. Sci. 851 1998 28 35
    • (1998) Ann. N Y Acad. Sci. , vol.851 , pp. 28-35
    • Welsh, M.J.1    Gaestel, M.2
  • 58
    • 0032841759 scopus 로고    scopus 로고
    • Thorax closure in Drosophila: Involvement of Fos and the JNK pathway
    • J. Zeitlinger, and D. Bohmann Thorax closure in Drosophila: involvement of Fos and the JNK pathway Development 126 1999 3947 3956
    • (1999) Development , vol.126 , pp. 3947-3956
    • Zeitlinger, J.1    Bohmann, D.2
  • 59
    • 0242363614 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-Jun NH2-terminal kinase in pancreatic beta-cells
    • B. Zhang, M. Hosaka, Y. Sawada, S. Torii, S. Mizutani, M. Ogata, T. Izumi, and T. Takeuchi Parathyroid hormone-related protein induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-Jun NH2-terminal kinase in pancreatic beta-cells Diabetes 52 2003 2720 2730
    • (2003) Diabetes , vol.52 , pp. 2720-2730
    • Zhang, B.1    Hosaka, M.2    Sawada, Y.3    Torii, S.4    Mizutani, S.5    Ogata, M.6    Izumi, T.7    Takeuchi, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.