-
2
-
-
27844596799
-
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
-
Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, Helfand SL (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15, 2063-2068.
-
(2005)
Curr. Biol.
, vol.15
, pp. 2063-2068
-
-
Bauer, J.H.1
Poon, P.C.2
Glatt-Deeley, H.3
Abrams, J.M.4
Helfand, S.L.5
-
3
-
-
0038152845
-
Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
-
Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA (2003) Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301, 215-218.
-
(2003)
Science
, vol.301
, pp. 215-218
-
-
Castrillon, D.H.1
Miao, L.2
Kollipara, R.3
Horner, J.W.4
DePinho, R.A.5
-
4
-
-
67449128222
-
Direct interaction between Nrf2 and p21Cip/WAF1 upregulates the Nrf2-mediated antioxidant response
-
Chen W, Sun Z, Wang X-J, Jiang T, Huang Z, Fang D, Zhang DD (2009) Direct interaction between Nrf2 and p21Cip/WAF1 upregulates the Nrf2-mediated antioxidant response. Mol. Cell 34, 663-673.
-
(2009)
Mol. Cell
, vol.34
, pp. 663-673
-
-
Chen, W.1
Sun, Z.2
Wang, X.-J.3
Jiang, T.4
Huang, Z.5
Fang, D.6
Zhang, D.D.7
-
5
-
-
43649098702
-
Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: relationship with caloric restriction
-
Chiba T, Yamaza H, Komatsu T, Nakayama M, Fujita S, Hayashi H, Higami Y, Shimokawa I (2008) Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: relationship with caloric restriction. Exp. Gerontol. 43, 595-600.
-
(2008)
Exp. Gerontol.
, vol.43
, pp. 595-600
-
-
Chiba, T.1
Yamaza, H.2
Komatsu, T.3
Nakayama, M.4
Fujita, S.5
Hayashi, H.6
Higami, Y.7
Shimokawa, I.8
-
6
-
-
33845892109
-
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
-
Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL (2007) Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat. Genet. 39, 99-105.
-
(2007)
Nat. Genet.
, vol.39
, pp. 99-105
-
-
Choudhury, A.R.1
Ju, Z.2
Djojosubroto, M.W.3
Schienke, A.4
Lechel, A.5
Schaetzlein, S.6
Jiang, H.7
Stepczynska, A.8
Wang, C.9
Buer, J.10
Lee, H.W.11
von Zglinicki, T.12
Ganser, A.13
Schirmacher, P.14
Nakauchi, H.15
Rudolph, K.L.16
-
7
-
-
0031005135
-
Induction of tumor necrosis factor-alpha in vivo by a skin irritant, tributyltin, through activation of transcription factors: its pharmacological modulation by anti-inflammatory drugs
-
Corsini E, Terzoli A, Bruccoleri A, Marinovich M, Galli CL (1997) Induction of tumor necrosis factor-alpha in vivo by a skin irritant, tributyltin, through activation of transcription factors: its pharmacological modulation by anti-inflammatory drugs. J. Invest. Dermatol. 108, 892-896.
-
(1997)
J. Invest. Dermatol.
, vol.108
, pp. 892-896
-
-
Corsini, E.1
Terzoli, A.2
Bruccoleri, A.3
Marinovich, M.4
Galli, C.L.5
-
8
-
-
0037342151
-
Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR
-
Daitoku H, Yamagata K, Matsuzaki H, Hatta M, Fukamizu A (2003) Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 52, 642-649.
-
(2003)
Diabetes
, vol.52
, pp. 642-649
-
-
Daitoku, H.1
Yamagata, K.2
Matsuzaki, H.3
Hatta, M.4
Fukamizu, A.5
-
9
-
-
0028807085
-
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
-
Dorman JB, Albinder B, Shroyer T, Kenyon C (1995) The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141, 1399-1406.
-
(1995)
Genetics
, vol.141
, pp. 1399-1406
-
-
Dorman, J.B.1
Albinder, B.2
Shroyer, T.3
Kenyon, C.4
-
10
-
-
0028918656
-
Lipid peroxidation in rats intoxicated with 3-nitropropionic acid
-
Fu YT, He FS, Zhang SL, Zhang JS (1995) Lipid peroxidation in rats intoxicated with 3-nitropropionic acid. Toxicon 33, 327-331.
-
(1995)
Toxicon
, vol.33
, pp. 327-331
-
-
Fu, Y.T.1
He, F.S.2
Zhang, S.L.3
Zhang, J.S.4
-
11
-
-
17644379936
-
FOXO transcription factors in cell-cycle regulation and the response to oxidative stress
-
Furukawa-Hibi Y, Kobayashi Y, Chen C, Motoyama N (2005) FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. Antioxid. Redox Signal. 7, 752-760.
-
(2005)
Antioxid. Redox Signal.
, vol.7
, pp. 752-760
-
-
Furukawa-Hibi, Y.1
Kobayashi, Y.2
Chen, C.3
Motoyama, N.4
-
12
-
-
4544227785
-
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice
-
Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida-Araki K, Hisatsune H, Nishikawa S, Nakayama K, Nakayama K, Ikeda K, Motoyama N, Mori N (2004) Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J. Biol. Chem. 279, 34741-34749.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34741-34749
-
-
Furuyama, T.1
Kitayama, K.2
Shimoda, Y.3
Ogawa, M.4
Sone, K.5
Yoshida-Araki, K.6
Hisatsune, H.7
Nishikawa, S.8
Nakayama, K.9
Nakayama, K.10
Ikeda, K.11
Motoyama, N.12
Mori, N.13
-
13
-
-
40549111934
-
Protective mechanisms of p53-p21-pRb proteins against DNA damage-induced cell death
-
Garner E, Raj K (2008) Protective mechanisms of p53-p21-pRb proteins against DNA damage-induced cell death. Cell Cycle 7, 277-282.
-
(2008)
Cell Cycle
, vol.7
, pp. 277-282
-
-
Garner, E.1
Raj, K.2
-
14
-
-
0022345539
-
Brain enzyme and clinical alterations induced in rats and mice by nitroaliphatic toxicants
-
Gould DH, Wilson MP, Hamar DW (1985) Brain enzyme and clinical alterations induced in rats and mice by nitroaliphatic toxicants. Toxicol. Lett. 27, 83-89.
-
(1985)
Toxicol. Lett.
, vol.27
, pp. 83-89
-
-
Gould, D.H.1
Wilson, M.P.2
Hamar, D.W.3
-
15
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24, 7410-7425.
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
16
-
-
34848850156
-
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
-
Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, Gygi SP, Brunet A (2007) An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr. Biol. 17, 1646-1656.
-
(2007)
Curr. Biol.
, vol.17
, pp. 1646-1656
-
-
Greer, E.L.1
Dowlatshahi, D.2
Banko, M.R.3
Villen, J.4
Hoang, K.5
Blanchard, D.6
Gygi, S.P.7
Brunet, A.8
-
17
-
-
49649116327
-
Calorie restriction minimizes activation of insulin signaling in response to glucose: potential involvement of the growth hormone-insulin-like growth factor 1 axis
-
Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I (2008) Calorie restriction minimizes activation of insulin signaling in response to glucose: potential involvement of the growth hormone-insulin-like growth factor 1 axis. Exp. Gerontol. 43, 827-832.
-
(2008)
Exp. Gerontol.
, vol.43
, pp. 827-832
-
-
Hayashi, H.1
Yamaza, H.2
Komatsu, T.3
Park, S.4
Chiba, T.5
Higami, Y.6
Nagayasu, T.7
Shimokawa, I.8
-
18
-
-
34249281690
-
Stressing the role of FoxO proteins in lifespan and disease
-
van der Horst A, Burgering BM (2007) Stressing the role of FoxO proteins in lifespan and disease. Nat. Rev. Mol. Cell Biol. 8, 440-450.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 440-450
-
-
van der Horst, A.1
Burgering, B.M.2
-
19
-
-
0036371485
-
Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements
-
Ishii T, Itoh K, Yamamoto M (2002) Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements. Methods Enzymol. 348, 182-190.
-
(2002)
Methods Enzymol.
, vol.348
, pp. 182-190
-
-
Ishii, T.1
Itoh, K.2
Yamamoto, M.3
-
20
-
-
64749108996
-
Tumours with PI3K activation are resistant to dietary restriction
-
Kalaany NY, Sabatini DM (2009) Tumours with PI3K activation are resistant to dietary restriction. Nature 458, 725-731.
-
(2009)
Nature
, vol.458
, pp. 725-731
-
-
Kalaany, N.Y.1
Sabatini, D.M.2
-
21
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan MB, Bartek J (2004) Cell-cycle checkpoints and cancer. Nature 432, 316-323.
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
22
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
23
-
-
33748052967
-
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
-
Kobayashi M, Yamamoto M (2006) Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv. Enzyme Regul. 46, 113-140.
-
(2006)
Adv. Enzyme Regul.
, vol.46
, pp. 113-140
-
-
Kobayashi, M.1
Yamamoto, M.2
-
24
-
-
0032573178
-
The genetics of caloric restriction in Caenorhabditis elegans
-
Lakowski B, Hekimi S (1998) The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U S A 95, 13091-13096.
-
(1998)
Proc. Natl. Acad. Sci. U S A
, vol.95
, pp. 13091-13096
-
-
Lakowski, B.1
Hekimi, S.2
-
26
-
-
22744445281
-
Overview of caloric restriction and ageing
-
Masoro EJ (2005) Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913-922.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 913-922
-
-
Masoro, E.J.1
-
27
-
-
38349006256
-
Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
-
Muniyappa R, Lee S, Chen H, Quon MJ (2007) Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am. J. Physiol. Endocrinol. Metab. 294, E15-E26.
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.294
-
-
Muniyappa, R.1
Lee, S.2
Chen, H.3
Quon, M.J.4
-
28
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA (2007) FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128, 309-323.
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
Kollipara, R.2
Chu, G.3
Ji, H.4
Xiao, Y.5
Ding, Z.6
Miao, L.7
Tothova, Z.8
Horner, J.W.9
Carrasco, D.R.10
Jiang, S.11
Gilliland, D.G.12
Chin, L.13
Wong, W.H.14
Castrillon, D.H.15
DePinho, R.A.16
-
29
-
-
40649108843
-
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
-
Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, de Cabo R (2008) Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc. Natl Acad. Sci. USA 105, 2325-2330.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 2325-2330
-
-
Pearson, K.J.1
Lewis, K.N.2
Price, N.L.3
Chang, J.W.4
Perez, E.5
Cascajo, M.V.6
Tamashiro, K.L.7
Poosala, S.8
Csiszar, A.9
Ungvari, Z.10
Kensler, T.W.11
Yamamoto, M.12
Egan, J.M.13
Longo, D.L.14
Ingram, D.K.15
Navas, P.16
de Cabo, R.17
-
30
-
-
0142243264
-
Dietary calorie restriction, DNA-repair and brain aging
-
Rao KS (2003) Dietary calorie restriction, DNA-repair and brain aging. Mol. Cell. Biochem. 253, 313-318.
-
(2003)
Mol. Cell. Biochem.
, vol.253
, pp. 313-318
-
-
Rao, K.S.1
-
31
-
-
0025788034
-
Influence of diet on fatal neoplastic disease in male Fischer 344 rats
-
Shimokawa I, Yu BP, Masoro EJ (1991) Influence of diet on fatal neoplastic disease in male Fischer 344 rats. J. Gerontol. 46, B228-B232.
-
(1991)
J. Gerontol.
, vol.46
-
-
Shimokawa, I.1
Yu, B.P.2
Masoro, E.J.3
-
32
-
-
0036086818
-
Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model
-
Shimokawa I, Higami Y, Utsuyama M, Tuchiya T, Komatsu T, Chiba T, Yamaza H (2002) Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. Am. J. Pathol. 160, 2259-2265.
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 2259-2265
-
-
Shimokawa, I.1
Higami, Y.2
Utsuyama, M.3
Tuchiya, T.4
Komatsu, T.5
Chiba, T.6
Yamaza, H.7
-
33
-
-
0038380473
-
Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction
-
Shimokawa I, Higami Y, Tsuchiya T, Otani H, Komatsu T, Chiba T, Yamaza H (2003) Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. FASEB J. 17, 1108-1109.
-
(2003)
FASEB J.
, vol.17
, pp. 1108-1109
-
-
Shimokawa, I.1
Higami, Y.2
Tsuchiya, T.3
Otani, H.4
Komatsu, T.5
Chiba, T.6
Yamaza, H.7
-
34
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegue E, DePinho RA, Gilliland DG (2007) FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128, 325-339.
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
McDowell, E.P.7
Lazo-Kallanian, S.8
Williams, I.R.9
Sears, C.10
Armstrong, S.A.11
Passegue, E.12
DePinho, R.A.13
Gilliland, D.G.14
-
35
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA (2002) p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
Hee Park, S.11
Thompson, T.12
Karsenty, G.13
Bradley, A.14
Donehower, L.A.15
-
36
-
-
34047113944
-
Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin
-
Yamaza H, Komatsu T, To K, Toyama H, Chiba T, Higami Y, Shimokawa I (2007) Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin. J. Gerontol. A Biol. Sci. Med. Sci. 62, 27-33.
-
(2007)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.62
, pp. 27-33
-
-
Yamaza, H.1
Komatsu, T.2
To, K.3
Toyama, H.4
Chiba, T.5
Higami, Y.6
Shimokawa, I.7
|