The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

Molecular Cell

Volumn 14, Issue 3, 2004, Pages 395-403

  Stitt, Trevor N ^a   Drujan, Doreen ^a   Clarke, Brian A ^a   Panaro, Frank ^a   Timofeyva, Yekatarina ^a   Kline, William O ^a   Gonzalez, Michael ^a   Yancopoulos, George D ^a   Glass, David J ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN MAFBX; PROTEIN MURF1; SOMATOMEDIN BINDING PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CATABOLISM; CATABOLITE REPRESSION; ENZYME INHIBITION; MOUSE; MUSCLE ATROPHY; MUSCLE HYPERTROPHY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; DENERVATION; DEXAMETHASONE; FORKHEAD TRANSCRIPTION FACTORS; GLUCOCORTICOIDS; INSULIN-LIKE GROWTH FACTOR I; MICE; MUSCLE FIBERS; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

ANIMALIA;

EID: 2042425906     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(04)00211-4     Document Type: Article

References (35)

1. Adams G.R., McCue S.A. Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. J. Appl. Physiol. 84:1998;1716-1722
2. Bodine S.C., Latres E., Baumhueter S., Lai V.K., Nunez L., Clarke B.A., Poueymirou W.T., Panaro F.J., Na E., Dharmarajan K., et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 294:2001;1704-1708. a
3. Bodine S.C., Stitt T.N., Gonzalez M., Kline W.O., Stover G.L., Bauerlein R., Zlotchenko E., Scrimgeour A., Lawrence J.C., Glass D.J., et al. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol. 3:2001;1014-1019. b
4. Bois P.R., Grosveld G.C. FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts. EMBO J. 22:2003;1147-1157
5. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., Greenberg M.E. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96:1999;857-868
6. Cantley L.C. The phosphoinositide 3-kinase pathway. Science. 296:2002;1655-1657
7. Carlsson P., Mahlapuu M. Forkhead transcription factors. key players in development and metabolism Dev. Biol. 250:2002;1-23
8. Coleman M.E., DeMayo F., Yin K.C., Lee H.M., Geske R., Montgomery C., Schwartz R.J. Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J. Biol. Chem. 270:1995;12109-12116
9. Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 378:1995;785-789
10. Datta S.R., Brunet A., Greenberg M.E. Cellular survival. a play in three Akts Genes Dev. 13:1999;2905-2927
11. DeVol D.L., Rotwein P., Sadow J.L., Novakofski J., Bechtel P.J. Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. Am. J. Physiol. 259:1990;E89-E95
12. Du J., Mitch W.E., Wang X., Price S.R. Glucocorticoids induce proteasome C3 subunit expression in L6 muscle cells by opposing the suppression of its transcription by NF-kappa B. J. Biol. Chem. 275:2000;19661-19666
13. Florini J.R., Ewton D.Z., Coolican S.A. Growth hormone and the insulin-like growth factor system in myogenesis. Endocr. Rev. 17:1996;481-517
14. Glass D.J. Signalling pathways that mediate skeletal muscle hypertrophy and atrophy. Nat. Cell Biol. 5:2003;87-90
15. Goldspink D.F., Garlick P.J., McNurlan M.A. Protein turnover measured in vivo and in vitro in muscles undergoing compensatory growth and subsequent denervation atrophy. Biochem. J. 210:1983;89-98
16. Gomes M.D., Lecker S.H., Jagoe R.T., Navon A., Goldberg A.L. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc. Natl. Acad. Sci. USA. 98:2001;14440-14445
17. Hasselgren P.O. Glucocorticoids and muscle catabolism. Curr. Opin. Clin. Nutr. Metab. Care. 2:1999;201-205
18. Hong D.H., Forsberg N.E. Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures. Mol. Cell. Endocrinol. 108:1995;199-209
19. Hribal M.L., Nakae J., Kitamura T., Shutter J.R., Accili D. Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. J. Cell Biol. 162:2003;535-541
20. Jagoe R.T., Goldberg A.L. What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? Curr. Opin. Clin. Nutr. Metab. Care. 4:2001;183-190
21. Kops G.J., de Ruiter N.D., De Vries-Smits A.M., Powell D.R., Bos J.L., Burgering B.M. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature. 398:1999;630-634
22. Mitch W.E., Goldberg A.L. Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N. Engl. J. Med. 335:1996;1897-1905
23. Murgia M., Serrano A.L., Calabria E., Pallafacchina G., Lomo T., Schiaffino S. Ras is involved in nerve-activity-dependent regulation of muscle genes. Nat. Cell Biol. 2:2000;142-147
24. Musaro A., McCullagh K., Paul A., Houghton L., Dobrowolny G., Molinaro M., Barton E.R., Sweeney H.L., Rosenthal N. Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nat. Genet. 27:2001;195-200
25. Nave B.T., Ouwens M., Withers D.J., Alessi D.R., Shepherd P.R. Mammalian target of rapamycin is a direct target for protein kinase B. identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation Biochem. J. 344:1999;427-431
26. Pallafacchina G., Calabria E., Serrano A.L., Kalhovde J.M., Schiaffino S. A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc. Natl. Acad. Sci. USA. 99:2002;9213-9218
27. Reynolds T.H. 4th, Bodine S.C., Lawrence J.C. Jr. Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J. Biol. Chem. 277:2002;17657-17662
28. Rommel C., Clarke B.A., Zimmermann S., Nunez L., Rossman R., Reid K., Moelling K., Yancopoulos G.D., Glass D.J. Differentiation stage-specific inhibition of the raf-MEK-ERK pathway by Akt. Science. 286:1999;1738-1741
29. Rommel C., Bodine S.C., Clarke B.A., Rossman R., Nunez L., Stitt T.N., Yancopoulos G.D., Glass D.J. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat. Cell Biol. 3:2001;1009-1013
30. Sandri M., Sandri C., Gilbert A., Skurk C., Calabria E., Picard A., Walsh K., Schiaffino S., Lecker S.H., Goldberg A.L. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 117:2004;399-412
31. Scott P.H., Lawrence J.C. Jr. Attenuation of mammalian target of rapamycin activity by increased cAMP in 3T3-L1 adipocytes. J. Biol. Chem. 273:1998;34496-34501
32. Tran, H., Brunet, A., Griffith, E.C., and Greenberg, M.E. (2003). The many forks in FOXO's road. Sci. STKE 2003, RE5.
33. Vivanco I., Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer. 2:2002;489-501
34. Wang L., Luo G.J., Wang J.J., Hasselgren P.O. Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes. Shock. 10:1998;298-306
35. Wray C.J., Mammen J.M., Hershko D.D., Hasselgren P.O. Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle. Int. J. Biochem. Cell Biol. 35:2003;698-705