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Volumn 494, Issue 7437, 2013, Pages 323-327

FOXO3A directs a protective autophagy program in haematopoietic stem cells

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PROTEIN P53; TRANSCRIPTION FACTOR FKHRL1;

EID: 84874192375     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11895     Document Type: Article
Times cited : (505)

References (39)
  • 1
    • 33745614062 scopus 로고    scopus 로고
    • Stem cells, ageing and the quest for immortality
    • Rando, T. A. Stem cells, ageing and the quest for immortality. Nature 441, 1080-1086 (2006).
    • (2006) Nature , vol.441 , pp. 1080-1086
    • Rando, T.A.1
  • 2
    • 39349096526 scopus 로고    scopus 로고
    • Hematopoiesis: An evolving paradigmfor stem cell biology
    • Orkin, S. H. & Zon, L. I. Hematopoiesis: An evolving paradigmfor stem cell biology. Cell 132, 631-644 (2008).
    • (2008) Cell , vol.132 , pp. 631-644
    • Orkin, S.H.1    Zon, L.I.2
  • 3
    • 39149086121 scopus 로고    scopus 로고
    • Stems cells and the pathways to aging and cancer
    • Rossi, D. J., Jamieson, C. H. M. & Weissman, I. L. Stems cells and the pathways to aging and cancer. Cell 132, 681-696 (2008).
    • (2008) Cell , vol.132 , pp. 681-696
    • Rossi, D.J.1    Jamieson, C.H.M.2    Weissman, I.L.3
  • 4
    • 80053541022 scopus 로고    scopus 로고
    • Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies. Wiley Interdiscip
    • Warr, M. R., Pietras, E. M. & Passegué, E. Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies. Wiley Interdiscip. Rev. Syst. Biol. Med. 3, 681-701 (2011).
    • (2011) Rev. Syst. Biol. Med. , vol.3 , pp. 681-701
    • Warr, M.R.1    Pietras, E.M.2    Passegué, E.3
  • 5
    • 34249798692 scopus 로고    scopus 로고
    • Autophagic and apoptotic response to stress signals in mammalian cells
    • Ferraro, E. & Cecconi, F. Autophagic and apoptotic response to stress signals in mammalian cells. Arch. Biochem. Biophys. 462, 210-219 (2007).
    • (2007) Arch. Biochem. Biophys. , vol.462 , pp. 210-219
    • Ferraro, E.1    Cecconi, F.2
  • 6
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He, C. & Klionsky, D. J. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 43, 67-93 (2009).
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 7
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial, N. N. & Korsmeyer, S. J. Cell death: critical control points. Cell 116, 205-219 (2004).
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 8
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri, M. C., Zalckvar, E., Kimchi, A. & Kroemer, G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nature ev.Mol. Cell Biol. 8, 741-752 (2007).
    • (2007) Nature ev.Mol. Cell Biol. , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 9
    • 22344444616 scopus 로고    scopus 로고
    • Does autophagy contribute to cell death?
    • Debnath, J., Baehrecke, E. H. & Kroemer, G. Does autophagy contribute to cell death? Autophagy 1, 66-74 (2005).
    • (2005) Autophagy , vol.1 , pp. 66-74
    • Debnath, J.1    Baehrecke, E.H.2    Kroemer, G.3
  • 10
    • 34648813587 scopus 로고    scopus 로고
    • Life and death in hematopoietic stem cells
    • Oguro, H. & Iwana, A. Life and death in hematopoietic stem cells. Curr. Opin. Immunol. 19, 503-509 (2007).
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 503-509
    • Oguro, H.1    Iwana, A.2
  • 11
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy inimmunity and inflammation
    • Levine, B., Mizushima, N.&Virgin, H. W. Autophagy inimmunity and inflammation. Nature 469, 323-335 (2011).
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 12
    • 33846461678 scopus 로고    scopus 로고
    • A critical role for the autophagy gene Atg5 in T cell survival and proliferation
    • Pua, H. H., Dzhagalov, I., Chuck, M., Mizushima, N. & He, Y. W. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J. Exp. Med. 204, 25-31 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 25-31
    • Pua, H.H.1    Dzhagalov, I.2    Chuck, M.3    Mizushima, N.4    He, Y.W.5
  • 13
    • 41449106674 scopus 로고    scopus 로고
    • The autophagy geneATG5 plays an essential role inBlymphocyte development
    • Miller, B. C. et al. The autophagy geneATG5 plays an essential role inBlymphocyte development. Autophagy 4, 309-314 (2008).
    • (2008) Autophagy , vol.4 , pp. 309-314
    • Miller, B.C.1
  • 14
    • 51649124519 scopus 로고    scopus 로고
    • Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
    • Kundu, M. et al. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 112, 1493-1502 (2008).
    • (2008) Blood , vol.112 , pp. 1493-1502
    • Kundu, M.1
  • 15
    • 76249127368 scopus 로고    scopus 로고
    • Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo
    • Mortensen, M. et al. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc. Natl Acad. Sci. USA 107, 832-837 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 832-837
    • Mortensen, M.1
  • 16
    • 78649689953 scopus 로고    scopus 로고
    • FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
    • Liu, F. et al. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood 116, 4806-4814 (2010).
    • (2010) Blood , vol.116 , pp. 4806-4814
    • Liu, F.1
  • 17
    • 79952728102 scopus 로고    scopus 로고
    • The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
    • Mortensen, M. et al. The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance. J. Exp. Med. 208, 455-467 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 455-467
    • Mortensen, M.1
  • 18
    • 84855885803 scopus 로고    scopus 로고
    • Cell cycle regulationinhematopoietic stem cells
    • Pietras, E. M.,Warr, M. R.&Passegué, E.Cell cycle regulationinhematopoietic stem cells. J. Cell Biol. 195, 709-720 (2011).
    • (2011) J. Cell Biol. , vol.195 , pp. 709-720
    • Pietras, E.M.1    Warr, M.R.2    Passegué, E.3
  • 19
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response tonutrient starvation using transgenic mice expressinga fluorescent autophagosome marker
    • Mizushima, N., Yamamoto, A.,Matsui, M., Yoshimori, T.&Ohsumi, Y. In vivo analysis of autophagy in response tonutrient starvation using transgenic mice expressinga fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101-1111 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 20
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima, N., Yoshimori, T. & Levine, B. Methods in mammalian autophagy research. Cell 140, 313-326 (2010).
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 21
    • 46849121421 scopus 로고    scopus 로고
    • Utilizing flow cytometry to monitor autophagy in living mammalian cells
    • Shvets, E., Fass, E. & Elazar, Z. Utilizing flow cytometry to monitor autophagy in living mammalian cells. Autophagy 4, 621-628 (2008).
    • (2008) Autophagy , vol.4 , pp. 621-628
    • Shvets, E.1    Fass, E.2    Elazar, Z.3
  • 22
    • 77955637249 scopus 로고    scopus 로고
    • ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death
    • Radoshevich, L. et al. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 142, 590-600 (2010).
    • (2010) Cell , vol.142 , pp. 590-600
    • Radoshevich, L.1
  • 23
    • 77956251480 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis
    • Mohrin, M. et al. Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis. Cell Stem Cell 7, 174-185 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 174-185
    • Mohrin, M.1
  • 24
    • 0034508217 scopus 로고    scopus 로고
    • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
    • Lindsten, T. et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6, 1389-1399 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 1389-1399
    • Lindsten, T.1
  • 25
    • 36448940798 scopus 로고    scopus 로고
    • FoxO3 controls autophagy in skeletal muscle in vivo
    • Mammucari, C. et al. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab. 6, 458-471 (2007).
    • (2007) Cell Metab. , vol.6 , pp. 458-471
    • Mammucari, C.1
  • 26
    • 77951243028 scopus 로고    scopus 로고
    • Autophagy regulation by p53
    • Maiuri, M. C. et al. Autophagy regulation by p53. Curr. Opin. Cell Biol. 22, 181-185 (2010).
    • (2010) Curr. Opin. Cell Biol. , vol.22 , pp. 181-185
    • Maiuri, M.C.1
  • 27
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are criticalmediators of hematopoietic stemcell resistance to physiologic oxidative stress
    • Tothova, Z. et al. FoxOs are criticalmediators of hematopoietic stemcell resistance to physiologic oxidative stress. Cell 128, 325-339 (2007).
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1
  • 29
    • 75549090275 scopus 로고    scopus 로고
    • MTORregulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen, C., Liu, Y.&Zheng, P.mTORregulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal. 2, ra75 (2009).
    • (2009) Sci. Signal. , vol.2
    • Chen, C.1    Liu, Y.2    Zheng, P.3
  • 30
    • 84858649330 scopus 로고    scopus 로고
    • Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing
    • Ergen, A. V., Boles, N. C. & Goodell, M. A. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood 119, 2500-2509 (2012).
    • (2012) Blood , vol.119 , pp. 2500-2509
    • Ergen, A.V.1    Boles, N.C.2    Goodell, M.A.3
  • 31
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum, J. J. et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248 (2005).
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1
  • 32
    • 71849114718 scopus 로고    scopus 로고
    • Balancing dormant and self-renewing hematopoietic stem cells
    • Wilson, A., Laurenti, E. & Trumpp, A. Balancing dormant and self-renewing hematopoietic stem cells. Curr. Opin. Genet. Dev. 19, 461-468 (2009).
    • (2009) Curr. Opin. Genet. Dev. , vol.19 , pp. 461-468
    • Wilson, A.1    Laurenti, E.2    Trumpp, A.3
  • 33
    • 34249882777 scopus 로고    scopus 로고
    • Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    • Miyamoto, K. et al. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1, 101-112 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 101-112
    • Miyamoto, K.1
  • 34
    • 0038152845 scopus 로고    scopus 로고
    • Suppression of ovarian follicle activation in mice by the transcription factor FoxO3a
    • Castrillon, D. H., Miao, L., Kollipara, R., Horner, J. W. & DePinho, R. A. Suppression of ovarian follicle activation in mice by the transcription factor FoxO3a. Science 301, 215-218 (2003).
    • (2003) Science , vol.301 , pp. 215-218
    • Castrillon, D.H.1    Miao, L.2    Kollipara, R.3    Horner, J.W.4    DePinho, R.A.5
  • 35
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221 (1992).
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1
  • 36
    • 23844433945 scopus 로고    scopus 로고
    • Essential role ofBAX,BAK inBcell homeostasis and prevention of autoimmune disease
    • Takeuchi, O. et al. Essential role ofBAX,BAK inBcell homeostasis and prevention of autoimmune disease. Proc. Natl Acad. Sci. USA 102, 11272-11277 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 11272-11277
    • Takeuchi, O.1
  • 37
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kuhn, R., Schwenk, F., Aguet, M. & Rajewsky, K. Inducible gene targeting in mice. Science 269, 1427-1429 (1995).
    • (1995) Science , vol.269 , pp. 1427-1429
    • Kuhn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4
  • 38
    • 63249095562 scopus 로고    scopus 로고
    • JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting selfrenewal
    • Santaguida, M. et al. JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting selfrenewal. Cancer Cell 15, 341-352 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 341-352
    • Santaguida, M.1
  • 39
    • 78751511180 scopus 로고    scopus 로고
    • Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
    • Lock, R. et al. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol. Biol. Cell 22, 165-178 (2011).
    • (2011) Mol. Biol. Cell , vol.22 , pp. 165-178
    • Lock, R.1


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