DAF-16 target genes that control C. elegans Life-span and metabolism

Science

Volumn 300, Issue 5619, 2003, Pages 644-647

  Lee, Siu Sylvia ^a   Kennedy, Scott ^a   Tolonen, Andrew C ^b   Ruvkun, Gary ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ENGINEERING; INSULIN; METABOLISM; RNA;

INSULIN RECEPTORS;

GENES;

GENE PRODUCT; INSULIN RECEPTOR; PROTEIN DAF2; RNA; UNCLASSIFIED DRUG;

LONGEVITY; METABOLISM;

ARTICLE; BINDING SITE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE CONTROL; GENE IDENTIFICATION; GENOMICS; LIFESPAN; LONGEVITY; METABOLISM; NONHUMAN; ORTHOLOGY; PHYLUM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CAENORHABDITIS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; DOWN-REGULATION; DROSOPHILA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, HELMINTH; GENES, INSECT; GENOMICS; INSULIN; LONGEVITY; MUTATION; PROMOTER REGIONS (GENETICS); RECEPTOR, INSULIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UP-REGULATION;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA;

EID: 0037466652     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083614     Document Type: Article

References (35)

1. C. E. Finch, G. Ruvkun, Annu. Rev. Genom. Hum. Genet. 2, 435 (2001).
2. C. Kenyon, J. Chang, E. Gensch, A. Rudner, R. Tabtiang, Nature 366, 461 (1993).
3. K. D. Kimura, H. A. Tissenbaum, Y. Liu, G. Ruvkun, Science 277, 942 (1997).
4. W. G. Wadsworth, D. L. Riddle, Dev. Biol. 132, 167 (1989).
5. S. Ogg et al., Nature 389, 994 (1997).
6. K. Lin, J. B. Dorman, A. Rodan, C. Kenyon, Science 278, 1319 (1997).
7. R. Y. Lee, J. Hench, G. Ruvkun, Curr. Biol. 11, 1950 (2001).
8. Y. Honda, S. Honda, FASEB J. 13, 1385 (1999).
9. H. Yu, P. L. Larsen, J. Mol. Biol. 314, 1017 (2001).
10. K. U. Birkenkamp, P. J. Coffer, Biochem. Soc. Trans. 31, 292 (2003).
11. R. S. Garofalo, Trends Endocrinol. Metab. 13, 156 (2002).
12. J. Nakae et al., Nature Genet. 32, 245 (2002).
13. M. Holzenberger et al., Nature 421, 182 (2003).
14. M. Bluher, B. B. Kahn, C. R. Kahn, Science 299, 572 (2003).
15. T. Furuyama, T. Nakazawa, I. Nakano, N. Mori, Biochem. J. 349, 629 (2000).
16. G. J. Kops et al., Nature 419, 316 (2002).
17. Materials and methods are available as supporting material on Science Online.
18. S. S. Lee, S. Kennedy, A. C. Tolonen, G. Ruvkun, data not shown.
19. S. S. Lee, S. Kennedy, G. Ruvkun, unpublished results.
20. P. B. Tan, M. R. Lackner, S. K. Kim, Cell 93, 569 (1998).
21. C. A. Wolkow, K. D. Kimura, M. S. Lee, G. Ruvkun, Science 290, 147 (2000).
22. L. Timmons, A. Fire, Nature 395, 854 (1998).
23. F. Simmer et al., Curr. Biol. 12, 1317 (2002).
24. D. B. Friedman, T. E. Johnson, Genetics 118, 75 (1988).
25. S. W. Chan, W. Hong, J. Biol. Chem. 276, 28402 (2001).
26. J. J. Gildea, R. Lopez, A. Shearn, Genetics 156, 645 (2000).
27. L. Guarente, Trends Genet. 17, 391 (2001).
28. H. A. Tissenbaum, L Guarente, Nature 410, 227 (2001).
29. F. Knauf, B. Rogina, Z. Jiang, P. S. Aronson, S. L Helfand, Proc. NatL Acad. Sci. U.S.A. 99, 14315 (2002).
30. B. Rogina, R. A. Reenan, S. P. Nilsen, S. L. Helfand, Science 290, 2137 (2000).
31. K. Ashrafi et al., Nature 421, 268 (2003).
32. M. Dean, The Human ATP-Binding Cassette (ABC) Transporter Superfamily (National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, 2002).
33. A. Coghlan, K. H. Wolfe, Genome Res. 12, 857 (2002).
34. M. D. Adams et al., Science 287, 2185 (2000).
35. We thank Y. Grad for the worm and fly ortholog list; R. Kamath, A. Fraser, and J. Ahringer for the RNAi library; K. Ashrafi for assistance with Nile Red; I. Ruvinsky, H. Mak, D. Kim, members of the Ruvkun lab, and B. Weiss for discussions; P. Chisholm for support and encouragement; and the C. elegans Genetics Center for providing strains. Supported by a Damon Runyon postdoctoral fellowship to S.S.L., an NIH postdoctoral fellowship to S.K., and grants from the Ellison Research Foundation and NIH to G.R.