A pathway that links reproductive status to lifespan in Caenorhabditis elegans

Annals of the New York Academy of Sciences

Volumn 1204, Issue , 2010, Pages 156-162

  Kenyon, Cynthia ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

aging; DAF 12; germ cells; nuclear hormone receptor

Indexed keywords

EID: 77956244148     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05640.x     Document Type: Conference Paper

References (32)

1. Kenyon, C.J. 2010. The genetics of aging. Nature 464 : 504 512. Review.
2. Bartke, A. 2008. Insulin and aging. Cell Cycle 7 : 3338 3343.
3. Kleemann, G.A. C.T. Murphy. 2009. The endocrine regulation of aging in Caenorhabditis elegans. Mol. Cell. Endocrinol. 299 : 51 57.
4. Panowski, S.H. A. Dillin. 2009. Signals of youth: endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol. Metab. 20 : 259 264.
5. Tatar, M., A. Bartke A. Antebi. 2003. The endocrine regulation of aging by insulin-like signals. Science 299 : 1346 1351.
6. Kenyon, C. 2005. The plasticity of aging: insights from long-lived mutants. Cell 120 : 449 460.
7. Ayyadevara, S., R. Alla, J.J. Thaden R.J. Shmookler Reis. 2008. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell 7 : 13 22.
8. Willcox, B.J. et al. 2008. FOXO3A genotype is strongly associated with human longevity. Proc. Natl. Acad. Sci. USA 105 : 13987 13992.
9. Anselmi, C.V. et al. 2009. Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation Res. 12 : 95 104.
10. Pawlikowska, L. et al. 2009. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8 : 460 472.
11. Flachsbart, F. et al. 2009. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc. Natl. Acad. Sci. USA 106 : 2700 2705.
12. Flatt, T. et al. 2008. Drosophila germ-line modulation of insulin signaling and lifespan. Proc. Natl. Acad. Sci. USA 105 : 6368 6373.
13. Hsin, H. C. Kenyon. 1999. Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399 : 362 366.
14. Arantes-Oliveira, N., J. Apfeld, A. Dillin C. Kenyon. 2002. Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295 : 502 505.
15. Partridge, L., D. Gems D.J. Withers. 2005. Sex and death: what is the connection? Cell 120 : 461 472.
16. Gerisch, B. et al. 2001. A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev. Cell 1 : 841 851.
17. Gerisch, B. et al. 2007. A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc. Natl. Acad. Sci. USA 104 : 5014 5019.
18. Berman, J.R. C. Kenyon. 2006. Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling. Cell 124 : 1055 1068.
19. Libina, N., J.R. Berman C. Kenyon. 2003. Tissue-specific activities of the C. elegans DAF-16 protein in the regulation of lifespan. Cell 115 : 489 502.
20. Murphy, C.T. et al. 2003. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424 : 277 283.
21. Bluher, M., B.B. Kahn C.R. Kahn. 2003. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 : 572 574.
22. Wang, M.C., E.J. O'Rourke G. Ruvkun. 2008. Fat metabolism links germline stem cells and longevity in C. elegans. Science 322 : 957 960.
23. Henderson, S.T. T.E. Johnson. 2001. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11 : 1975 1980.
24. Lin, K., H. Hsin, L. Libina C. Kenyon. 2001. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28 : 139 145.
25. Lee, R.Y., J. Hench G. Ruvkun. 2001. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11 : 1950 1957.
26. Gems, D. et al. 1998. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150 : 129 155.
27. Ghazi, A. C. Kenyon. 2009. A transcription elongation factor that links signals from the reproductive system to lifespan extension in C. elegans. PLoS Genet. 5 : e1000639. Epub 2009 Sep 11. PMID: 19749979.
28. Yamawaki, T.M. et al. 2008. Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans longevity. Genetics 178 : 513 526.
29. Barnes, A.I. et al. 2006. No extension of lifespan by ablation of germ line in Drosophila. Proc. Biol. Sci. 273 : 939 947.
30. Cargill, S.L., J.R. Carey, H.G. Müller G. Anderson. 2003. Age of ovary determines remaining life expectancy in old ovariectomized mice. Aging Cell 2 : 185 190.
31. Mason, J.B., S.L. Cargill, G.B. Anderson J.R. Carey. 2009. Transplantation of young ovaries to old mice increased life span in transplant recipients. J. Gerontol. A Biol. Sci. Med. Sci. 64 : 1207 1211.
32. Parker, W.H. et al. 2009. Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study. Obstet. Gynecol. 113 : 1027 1037.