Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles

Aging Cell

Volumn 10, Issue 3, 2011, Pages 551-554

  Tazearslan, Cagdas ^a   Huang, Jing ^a,b   Barzilai, Nir ^a   Suh, Yousin ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b AARON DIAMOND AIDS RESEARCH CENTER   (United States)

Author keywords

Gene expression; Genetic variation; Human longevity; Insulin insulin like growth factor 1 signaling

Indexed keywords

CD123 ANTIGEN; EARLY GROWTH RESPONSE FACTOR 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MACROPHAGE COLONY STIMULATING FACTOR 1; PROTEIN KINASE B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; T CELL DEATH ASSOCIATED GENE 51 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE PROGRESSION; CELL FUNCTION; CELL IMMORTALIZATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; INTRACELLULAR SIGNALING; LONGEVITY; LYMPHOCYTE; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TISSUE ENGINEERING;

AGED, 80 AND OVER; ALLELES; ANIMALS; CELL PROLIFERATION; DOWN-REGULATION; EARLY GROWTH RESPONSE PROTEIN 1; FIBROBLASTS; GENOTYPE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-3 RECEPTOR ALPHA SUBUNIT; JEWS; LONGEVITY; MICE; MICE, KNOCKOUT; MUTATION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

INVERTEBRATA; MURINAE;

EID: 79956016645     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00697.x     Document Type: Article

References (9)

1. Cao X, Koski R, Gashler A, McKiernan M, Morris C, Gaffney R, Hay R, Sukhatme V (1990) Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals. Mol. Cell. Biol. 10, 1931-1939.
2. Dupont J, Khan J, Qu B, Metzler P, Helman L, LeRoith D (2001) Insulin and IGF-1 induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: identification by cDNA microarray analysis. Endocrinology 142, 4969-4975.
3. Flachsbart F, Caliebe A, Kleindorp R, Blanche H, von Eller-Eberstein H, Nikolaus S, Schreiber S, Nebel A (2009) Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc. Natl. Acad. Sci. U S A 106, 2700-2705.
4. Kenyon CJ (2010) The genetics of ageing. Nature 464, 504-512.
5. Pawlikowska L, Hu D, Huntsman S, Sung A, Chu C, Chen J, Joyner AH, Schork NJ, Hsueh WC, Reiner AP, Psaty BM, Atzmon G, Barzilai N, Cummings SR, Browner WS, Kwok PY, Ziv E (2009) Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8, 460-472.
6. Sell C, Dumenil G, Deveaud C, Miura M, Coppola D, DeAngelis T, Rubin R, Efstratiadis A, Baserga R (1994) Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol. Cell. Biol. 14, 3604-3612.
7. Soerensen M, Dato S, Christensen K, McGue M, Stevnsner T, Bohr VA, Christiansen L (2010) Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 9, 1010-1017.
8. Suh Y, Atzmon G, Cho M, Hwang D, Liu B, Leahy D, Barzilai N, Cohen P (2008) Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc. Natl. Acad. Sci. U S A 105, 3438-3442.
9. Willcox B, Donlon T, He Q, Chen R, Grove J, Yano K, Masaki K, Willcox D, Rodriguez B, Curb J (2008) FOXO3A genotype is strongly associated with human longevity. Proc. Natl. Acad. Sci. U S A 105, 13987-13992.