메뉴 건너뛰기




Volumn 16, Issue 3, 2016, Pages 149-163

Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR;

EID: 84959539367     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2015.18     Document Type: Review
Times cited : (377)

References (203)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone i Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann T. R., Cherwinski H., Bond M. W., Giedlin M. A, & Coffman R. L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357 (1986).
    • (1986) J. Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 2
    • 0025807152 scopus 로고
    • Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
    • Del Prete G. F, et al. Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J. Clin. Invest. 88, 346-350 (1991).
    • (1991) J. Clin. Invest , vol.88 , pp. 346-350
    • Del Prete, G.F.1
  • 3
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas A. K., Murphy K. M, & Sher A. Functional diversity of helper T lymphocytes. Nature. 383, 787-793 (1996).
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 4
    • 84930389636 scopus 로고    scopus 로고
    • Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity
    • Burkett P. R., Meyer zu Horste G, & Kuchroo V. K. Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity. J. Clin. Invest. 125, 2211-2219 (2015).
    • (2015) J. Clin. Invest , vol.125 , pp. 2211-2219
    • Burkett, P.R.1    Meyer, Z.U.2    Horste, G.3    Kuchroo, V.K.4
  • 5
    • 84893707932 scopus 로고    scopus 로고
    • Th9 cells, new players in adaptive immunity
    • Schmitt E., Klein M, & Bopp T. Th9 cells, new players in adaptive immunity. Trends Immunol. 35, 61-68 (2014).
    • (2014) Trends Immunol , vol.35 , pp. 61-68
    • Schmitt, E.1    Klein, M.2    Bopp, T.3
  • 6
    • 84908148200 scopus 로고    scopus 로고
    • Follicular helper cell differentiation, function, and roles in disease
    • Crotty S. T. Follicular helper cell differentiation, function, and roles in disease. Immunity. 41, 529-542 (2014).
    • (2014) Immunity , vol.41 , pp. 529-542
    • Crotty, S.T.1
  • 7
    • 84869046998 scopus 로고    scopus 로고
    • Multiple Treg suppressive modules and their adaptability
    • Wing J. B, & Sakaguchi S. Multiple Treg suppressive modules and their adaptability. Front. Immunol. 3, 178 (2012).
    • (2012) Front. Immunol , vol.3 , pp. 178
    • Wing, J.B.1    Sakaguchi, S.2
  • 8
    • 58849092225 scopus 로고    scopus 로고
    • Epigenetic control of T helper-cell differentiation
    • Wilson C. B., Rowell E, & Sekimata M. Epigenetic control of T helper-cell differentiation. Nat. Rev. Immunol. 9, 91-105 (2009).
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 91-105
    • Wilson, C.B.1    Rowell, E.2    Sekimata, M.3
  • 9
    • 65549115862 scopus 로고    scopus 로고
    • Plasticity of CD4+ T cell lineage differentiation
    • Zhou L., Chong M. M. W, & Littman D. R. Plasticity of CD4+ T cell lineage differentiation. Immunity. 30, 646-655 (2009).
    • (2009) Immunity , vol.30 , pp. 646-655
    • Zhou, L.1    Chong, M.M.W.2    Littman, D.R.3
  • 10
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea J. J, & Paul W. E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science. 327, 1098-1102 (2010).
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 11
    • 77954948735 scopus 로고    scopus 로고
    • Effector T cell plasticity: Flexibility in the face of changing circumstances
    • Murphy K. M, & Stockinger B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat. Immunol. 11, 674-680 (2010).
    • (2010) Nat. Immunol , vol.11 , pp. 674-680
    • Murphy, K.M.1    Stockinger, B.2
  • 13
    • 78149326083 scopus 로고    scopus 로고
    • A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL 17 cytokine and promote the exacerbation of chronic allergic asthma
    • Wang Y. H, et al. A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL 17 cytokine and promote the exacerbation of chronic allergic asthma. J. Exp. Med. 207, 2479-2491 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 2479-2491
    • Wang, Y.H.1
  • 14
    • 79958134797 scopus 로고    scopus 로고
    • Identification of T helper type 1 like Foxp3+ regulatory T cells in human autoimmune disease
    • Dominguez-Villar M., Baecher-Allan C. M, & Hafler D. A. Identification of T helper type 1 like, Foxp3+ regulatory T cells in human autoimmune disease. Nat. Med. 17, 673-675 (2011).
    • (2011) Nat. Med , vol.17 , pp. 673-675
    • Dominguez-Villar, M.1    Baecher-Allan, C.M.2    Hafler, D.A.3
  • 15
    • 84863094021 scopus 로고    scopus 로고
    • Immunophenotyping of circulating T helper cells argues for multiple functions and plasticity of T cells in vivo in humans - Possible role in asthma
    • Malmhäll C, et al. Immunophenotyping of circulating T helper cells argues for multiple functions and plasticity of T cells in vivo in humans - possible role in asthma. PLoS ONE 7, e40012 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e40012
    • Malmhäll, C.1
  • 17
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxp3pos regulatory T cells differentiate into IL 17 producing cells
    • Koenen H. J. P. M, et al. Human CD25highFoxp3pos regulatory T cells differentiate into IL 17 producing cells. Blood. 112, 2340-2352 (2008).
    • (2008) Blood , vol.112 , pp. 2340-2352
    • Koenen, H.J.P.M.1
  • 18
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang X. O, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 29, 44-56 (2008).
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1
  • 19
    • 58149251898 scopus 로고    scopus 로고
    • Late developmental plasticity in the T helper 17 lineage
    • Lee Y. K, et al. Late developmental plasticity in the T helper 17 lineage. Immunity. 30, 92-107 (2009).
    • (2009) Immunity , vol.30 , pp. 92-107
    • Lee, Y.K.1
  • 20
    • 38749121326 scopus 로고    scopus 로고
    • Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors
    • Lohning M, et al. Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J. Exp. Med. 205, 53-61 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 53-61
    • Lohning, M.1
  • 21
    • 67650650890 scopus 로고    scopus 로고
    • Highly purified Th17 cells from BDC2.5NOD mice convert into Th1 like cells in NOD/SCID recipient mice
    • Bending D, et al. Highly purified Th17 cells from BDC2.5NOD mice convert into Th1 like cells in NOD/SCID recipient mice. J. Clin. Invest. 119, 565-572 (2009).
    • (2009) J. Clin. Invest , vol.119 , pp. 565-572
    • Bending, D.1
  • 22
    • 73349109145 scopus 로고    scopus 로고
    • Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jager A., Dardalhon V., Sobel R. A., Bettelli E, & Kuchroo V. K. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 183, 7169-7177 (2009).
    • (2009) J. Immunol , vol.183 , pp. 7169-7177
    • Jager, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 23
    • 84859897308 scopus 로고    scopus 로고
    • The development and fate of follicular helper T cells defined by an IL 21 reporter mouse
    • Lüthje K, et al. The development and fate of follicular helper T cells defined by an IL 21 reporter mouse. Nat. Immunol. 13, 491-498 (2012).
    • (2012) Nat. Immunol , vol.13 , pp. 491-498
    • Lüthje, K.1
  • 24
    • 84856022450 scopus 로고    scopus 로고
    • Rapid in vivo conversion of effector T cells into Th2 Cells during helminth infection
    • Panzer M, et al. Rapid in vivo conversion of effector T cells into Th2 Cells during helminth infection. J. Immunol. 188, 615-623 (2012).
    • (2012) J. Immunol , vol.188 , pp. 615-623
    • Panzer, M.1
  • 26
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X, et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 10, 1000-1007 (2009).
    • (2009) Nat. Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1
  • 27
    • 79951677394 scopus 로고    scopus 로고
    • Fate mapping of IL 17 producing T cells in inflammatory responses
    • Hirota K, et al. Fate mapping of IL 17 producing T cells in inflammatory responses. Nat. Immunol. 12, 255-263 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 255-263
    • Hirota, K.1
  • 28
    • 80054927155 scopus 로고    scopus 로고
    • An IL 9 fate reporter demonstrates the induction of an innate IL 9 response in lung inflammation
    • Wilhelm C, et al. An IL 9 fate reporter demonstrates the induction of an innate IL 9 response in lung inflammation. Nat. Immunol. 12, 1071-1077 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 1071-1077
    • Wilhelm, C.1
  • 29
    • 84908120294 scopus 로고    scopus 로고
    • IL 22 fate reporter reveals origin and control of IL 22 production in homeostasis and infection
    • Ahlfors H, et al. IL 22 fate reporter reveals origin and control of IL 22 production in homeostasis and infection. J. Immunol. 193, 4602-4613 (2014).
    • (2014) J. Immunol , vol.193 , pp. 4602-4613
    • Ahlfors, H.1
  • 30
    • 84921753054 scopus 로고    scopus 로고
    • T cell immunity Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines
    • Becattini S, et al. T cell immunity. Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines. Science. 347, 400-406 (2015).
    • (2015) Science , vol.347 , pp. 400-406
    • Becattini, S.1
  • 31
    • 84903993800 scopus 로고    scopus 로고
    • Linking T cell receptor sequence to functional phenotype at the single-cell level
    • Han A., Glanville J., Hansmann L, & Davis M. M. Linking T cell receptor sequence to functional phenotype at the single-cell level. Nat. Biotechnol. 32, 684-692 (2014).
    • (2014) Nat. Biotechnol , vol.32 , pp. 684-692
    • Han, A.1    Glanville, J.2    Hansmann, L.3    Davis, M.M.4
  • 32
    • 84949196321 scopus 로고    scopus 로고
    • CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity
    • Wang C, et al. CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity. Cell. 163, 1413-1427 (2015).
    • (2015) Cell , vol.163 , pp. 1413-1427
    • Wang, C.1
  • 33
    • 84949252174 scopus 로고    scopus 로고
    • Single-Cell genomics unveils critical regulators of Th17 cell pathogenicity
    • Gaublomme J. T, et al. Single-Cell genomics unveils critical regulators of Th17 cell pathogenicity. Cell. 163, 1400-1412 (2015).
    • (2015) Cell , vol.163 , pp. 1400-1412
    • Gaublomme, J.T.1
  • 34
    • 84921325808 scopus 로고    scopus 로고
    • The JAK-STAT pathway: Impact on human disease and therapeutic intervention
    • O'Shea J. J, et al. The JAK-STAT pathway: impact on human disease and therapeutic intervention. Annu. Rev. Med. 66, 311-328 (2015).
    • (2015) Annu. Rev. Med , vol.66 , pp. 311-328
    • O'Shea, J.J.1
  • 35
    • 74549179138 scopus 로고    scopus 로고
    • Interferons direct Th2 cell reprogramming to generate a stable GATA 3+T bet+ cell subset with combined Th2 and Th1 cell functions
    • Hegazy A. N, et al. Interferons direct Th2 cell reprogramming to generate a stable GATA 3+T bet+ cell subset with combined Th2 and Th1 cell functions. Immunity. 32, 116-128 (2010).
    • (2010) Immunity , vol.32 , pp. 116-128
    • Hegazy, A.N.1
  • 36
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9 producing subset
    • Veldhoen M, et al. Transforming growth factor â 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9 producing subset. Nat. Immunol. 9, 1341-1346 (2008).
    • (2008) Nat. Immunol , vol.9 , pp. 1341-1346
    • Veldhoen, M.1
  • 37
    • 80755136623 scopus 로고    scopus 로고
    • Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells
    • Lu K. T, et al. Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity. 35, 622-632 (2011).
    • (2011) Immunity , vol.35 , pp. 622-632
    • Lu, K.T.1
  • 38
    • 84855832580 scopus 로고    scopus 로고
    • Regulation of CD4+ T cell polarization by suppressor of cytokine signalling proteins
    • Knosp C. A, & Johnston J. A. Regulation of CD4+ T cell polarization by suppressor of cytokine signalling proteins. Immunology. 135, 101-111 (2012).
    • (2012) Immunology , vol.135 , pp. 101-111
    • Knosp, C.A.1    Johnston, J.A.2
  • 39
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 441, 235-238 (2006).
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1
  • 40
    • 43449135305 scopus 로고    scopus 로고
    • TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing ROR?t function
    • Zhou L, et al. TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing ROR?t function. Nature. 453, 236-240 (2008).
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1
  • 41
    • 84929955331 scopus 로고    scopus 로고
    • Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
    • Gagliani N, et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 523, 221-225 (2015).
    • (2015) Nature , vol.523 , pp. 221-225
    • Gagliani, N.1
  • 42
    • 36248951161 scopus 로고    scopus 로고
    • Interleukins 27 and 6 induce STAT3 mediated T cell production of interleukin 10
    • Stumhofer J. S, et al. Interleukins 27 and 6 induce STAT3 mediated T cell production of interleukin 10. Nat. Immunol. 8, 1363-1371 (2007).
    • (2007) Nat. Immunol , vol.8 , pp. 1363-1371
    • Stumhofer, J.S.1
  • 43
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c Maf to promote the differentiation of type 1 regulatory T cells induced by IL 27
    • Apetoh L, et al. The aryl hydrocarbon receptor interacts with c Maf to promote the differentiation of type 1 regulatory T cells induced by IL 27. Nat. Immunol. 11, 854-861 (2010).
    • (2010) Nat. Immunol , vol.11 , pp. 854-861
    • Apetoh, L.1
  • 44
    • 84870873399 scopus 로고    scopus 로고
    • Interleukin 27: Balancing protective and pathological immunity
    • Hunter C. A, & Kastelein R. Interleukin 27: balancing protective and pathological immunity. Immunity. 37, 960-969 (2012).
    • (2012) Immunity , vol.37 , pp. 960-969
    • Hunter, C.A.1    Kastelein, R.2
  • 45
    • 84865367294 scopus 로고    scopus 로고
    • STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease
    • Laurence A, et al. STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease. Immunity. 37, 209-222 (2012).
    • (2012) Immunity , vol.37 , pp. 209-222
    • Laurence, A.1
  • 46
    • 70449532980 scopus 로고    scopus 로고
    • Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
    • Oldenhove G, et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity. 31, 772-786 (2009).
    • (2009) Immunity , vol.31 , pp. 772-786
    • Oldenhove, G.1
  • 47
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch M. A, et al. The transcription factor T bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602 (2009).
    • (2009) Nat. Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1
  • 48
    • 79955028001 scopus 로고    scopus 로고
    • Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
    • McClymont S. A, et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J. Immunol. 186, 3918-3926 (2011).
    • (2011) J. Immunol , vol.186 , pp. 3918-3926
    • McClymont, S.A.1
  • 49
    • 79251500661 scopus 로고    scopus 로고
    • Phenotypical and functional specialization of FOXP3+ regulatory T cells
    • Campbell D. J, & Koch M. A. Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat. Rev. Immunol. 11, 119-130 (2011).
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 119-130
    • Campbell, D.J.1    Koch, M.A.2
  • 50
    • 79958130907 scopus 로고    scopus 로고
    • Interleukin 12 converts Foxp3+ regulatory T cells to interferon-?-producing Foxp3+ T cells that inhibit colitis
    • Feng T., Cao A. T., Weaver C. T., Elson C. O, & Cong Y. Interleukin 12 converts Foxp3+ regulatory T cells to interferon-?-producing Foxp3+ T cells that inhibit colitis. Gastroenterology. 140, 2031-2043 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 2031-2043
    • Feng, T.1    Cao, A.T.2    Weaver, C.T.3    Elson, C.O.4    Cong, Y.5
  • 51
    • 84932082421 scopus 로고    scopus 로고
    • Divergent phenotypes of human regulatory T cells expressing the receptors TIGIT and CD226
    • Fuhrman C. A, et al. Divergent phenotypes of human regulatory T cells expressing the receptors TIGIT and CD226. J. Immunol. 195, 145-155 (2015).
    • (2015) J Immunol , vol.195 , pp. 145-155
    • Fuhrman, C.A.1
  • 52
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin 2 production in the triggering of islet autoimmune destruction
    • Tang Q, et al. Central role of defective interleukin 2 production in the triggering of islet autoimmune destruction. Immunity. 28, 687-697 (2008).
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1
  • 53
    • 84908403082 scopus 로고    scopus 로고
    • Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus
    • Feng Y, et al. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 158, 749-763 (2014).
    • (2014) Cell , vol.158 , pp. 749-763
    • Feng, Y.1
  • 54
    • 84928591321 scopus 로고    scopus 로고
    • The promise of low-dose interleukin 2 therapy for autoimmune and inflammatory diseases
    • Klatzmann D, & Abbas A. K. The promise of low-dose interleukin 2 therapy for autoimmune and inflammatory diseases. Nat. Rev. Immunol. 15, 283-294 (2015).
    • (2015) Nat. Rev. Immunol , vol.15 , pp. 283-294
    • Klatzmann, D.1    Abbas, A.K.2
  • 55
    • 84904443484 scopus 로고    scopus 로고
    • T cell-receptor-dependent signal intensity dominantly controls CD4+ T cell polarization in vivo
    • van Panhuys N., Klauschen F, & Germain R. N. T cell-receptor-dependent signal intensity dominantly controls CD4+ T cell polarization in vivo. Immunity. 41, 63-74 (2014).
    • (2014) Immunity , vol.41 , pp. 63-74
    • Van Panhuys, N.1    Klauschen, F.2    Germain, R.N.3
  • 56
    • 84873696767 scopus 로고    scopus 로고
    • Early signaling events that underlie fate decisions of naive CD4+ T cells toward distinct T helper cell subsets
    • Yamane H, & Paul W. E. Early signaling events that underlie fate decisions of naive CD4+ T cells toward distinct T helper cell subsets. Immunol. Rev. 252, 12-23 (2013).
    • (2013) Immunol. Rev , vol.252 , pp. 12-23
    • Yamane, H.1    Paul, W.E.2
  • 57
    • 62849126473 scopus 로고    scopus 로고
    • The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
    • Fazilleau N., McHeyzer-Williams L. J., Rosen H, & McHeyzer-Williams M. G. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat. Immunol. 10, 375-384 (2009).
    • (2009) Nat. Immunol , vol.10 , pp. 375-384
    • Fazilleau, N.1    McHeyzer-Williams, L.J.2    Rosen, H.3    McHeyzer-Williams, M.G.4
  • 58
    • 84877710866 scopus 로고    scopus 로고
    • Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection
    • Tubo N. J, et al. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell. 153, 785-796 (2013).
    • (2013) Cell , vol.153 , pp. 785-796
    • Tubo, N.J.1
  • 59
    • 45549098562 scopus 로고    scopus 로고
    • T cell receptor signaling controls Foxp3 expression via PI3K Akt, and mTOR
    • Sauer S, et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl Acad. Sci. USA. 105, 7797-7802 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 7797-7802
    • Sauer, S.1
  • 60
    • 77955391804 scopus 로고    scopus 로고
    • TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
    • Gottschalk R. A., Corse E, & Allison J. P. TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J. Exp. Med. 207, 1701-1711 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 1701-1711
    • Gottschalk, R.A.1    Corse, E.2    Allison, J.P.3
  • 61
    • 84862814979 scopus 로고    scopus 로고
    • Selection of regulatory T cells in the thymus
    • Hsieh C. S., Lee H. M, & Lio C. W. Selection of regulatory T cells in the thymus. Nat. Rev. Immunol. 12, 157-167 (2012).
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 157-167
    • Hsieh, C.S.1    Lee, H.M.2    Lio, C.W.3
  • 62
    • 84869148187 scopus 로고    scopus 로고
    • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
    • Ohkura N, et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity. 37, 785-799 (2012).
    • (2012) Immunity , vol.37 , pp. 785-799
    • Ohkura, N.1
  • 63
    • 84921628213 scopus 로고    scopus 로고
    • Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge
    • Nagaoka M., Hatta Y., Kawaoka Y, & Malherbe L. P. Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge. J. Immunol. 193, 2812-2820 (2014).
    • (2014) J. Immunol , vol.193 , pp. 2812-2820
    • Nagaoka, M.1    Hatta, Y.2    Kawaoka, Y.3    Malherbe, L.P.4
  • 64
    • 0037015004 scopus 로고    scopus 로고
    • Functional plasticity of an antigen-specific memory CD4 T cell population
    • Ahmadzadeh M, & Farber D. L. Functional plasticity of an antigen-specific memory CD4 T cell population. Proc. Natl Acad. Sci. USA. 99, 11802-11807 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11802-11807
    • Ahmadzadeh, M.1    Farber, D.L.2
  • 65
    • 84953311457 scopus 로고    scopus 로고
    • Minimal regulatory network of extrinsic and intrinsic factors recovers observed patterns of CD4+ T cell differentiation and plasticity
    • Martinez-Sanchez M. E., Mendoza L., Villarreal C, & Alvarez-Buylla E. R. A. Minimal regulatory network of extrinsic and intrinsic factors recovers observed patterns of CD4+ T cell differentiation and plasticity. PLoS Comput. Biol. 11, e1004324 (2015).
    • (2015) PLoS Comput. Biol , vol.11 , pp. e1004324
    • Martinez-Sanchez, M.E.1    Mendoza, L.2    Villarreal, C.3    Alvarez-Buylla, E.R.A.4
  • 66
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran A. E, et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208, 1279-1289 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1279-1289
    • Moran, A.E.1
  • 67
    • 84908123494 scopus 로고    scopus 로고
    • Continuous requirement for the TCR in regulatory T cell function
    • Levine A. G., Arvey A., Jin W, & Rudensky A. Y. Continuous requirement for the TCR in regulatory T cell function. Nat. Immunol. 15, 1070-1078 (2014).
    • (2014) Nat. Immunol , vol.15 , pp. 1070-1078
    • Levine, A.G.1    Arvey, A.2    Jin, W.3    Rudensky, A.Y.4
  • 68
    • 84912113033 scopus 로고    scopus 로고
    • Continuous T cell receptor signals maintain a functional regulatory T cell pool
    • Vahl J. C, et al. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity. 41, 722-736 (2014).
    • (2014) Immunity , vol.41 , pp. 722-736
    • Vahl, J.C.1
  • 69
    • 0141920662 scopus 로고    scopus 로고
    • Cutting edge: CD28 controls peripheral homeostasis of CD4+ CD25+ regulatory T cells
    • Tang Q, et al. Cutting edge: CD28 controls peripheral homeostasis of CD4+ CD25+ regulatory T cells. J. Immunol. 171, 3348 (2003).
    • (2003) J. Immunol , vol.171 , pp. 3348
    • Tang, Q.1
  • 70
    • 84873337168 scopus 로고    scopus 로고
    • An obligate cell-intrinsic function for CD28 in Tregs
    • Zhang R, et al. An obligate cell-intrinsic function for CD28 in Tregs. J. Clin. Invest. 123, 580-593 (2013).
    • (2013) J. Clin. Invest , vol.123 , pp. 580-593
    • Zhang, R.1
  • 71
    • 84887512828 scopus 로고    scopus 로고
    • Self-Antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response
    • Bailey-Bucktrout S. L, et al. Self-Antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity. 39, 949-962 (2013).
    • (2013) Immunity , vol.39 , pp. 949-962
    • Bailey-Bucktrout, S.L.1
  • 72
    • 84896730389 scopus 로고    scopus 로고
    • Cutting edge: Self-Antigen controls the balance between effector and regulatory T cells in peripheral tissues
    • Gratz I. K, et al. Cutting edge: self-Antigen controls the balance between effector and regulatory T cells in peripheral tissues. J. Immunol. 192, 1351-1355 (2014).
    • (2014) J. Immunol , vol.192 , pp. 1351-1355
    • Gratz, I.K.1
  • 73
    • 84921315205 scopus 로고    scopus 로고
    • Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co stimulation
    • Laky K., Evans S., Perez-Diez A, & Fowlkes B. J. Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co stimulation. Immunity. 42, 80-94 (2015).
    • (2015) Immunity , vol.42 , pp. 80-94
    • Laky, K.1    Evans, S.2    Perez-Diez, A.3    Fowlkes, B.J.4
  • 74
    • 11144357191 scopus 로고    scopus 로고
    • Distinct IL 2 receptor signaling pattern in CD4+CD25+ regulatory T cells
    • Bensinger S. J, et al. Distinct IL 2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J. Immunol. 172, 5287-5296 (2004).
    • (2004) J. Immunol , vol.172 , pp. 5287-5296
    • Bensinger, S.J.1
  • 75
    • 49249133692 scopus 로고    scopus 로고
    • Regulation of T cell responses by PTEN
    • Buckler J. L., Liu X, & Turka L. A. Regulation of T cell responses by PTEN. Immunol. Rev. 224, 239-248 (2008).
    • (2008) Immunol. Rev , vol.224 , pp. 239-248
    • Buckler, J.L.1    Liu, X.2    Turka, L.A.3
  • 76
    • 33847397525 scopus 로고    scopus 로고
    • Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells
    • Crellin N. K., Garcia R. V, & Levings M. K. Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. Blood. 109, 2014-2022 (2007).
    • (2007) Blood , vol.109 , pp. 2014-2022
    • Crellin, N.K.1    Garcia, R.V.2    Levings, M.K.3
  • 77
    • 33748335576 scopus 로고    scopus 로고
    • PTEN inhibits IL 2 receptor-mediated expansion of CD4+ CD25+ Tregs
    • Walsh P. T, et al. PTEN inhibits IL 2 receptor-mediated expansion of CD4+ CD25+ Tregs. J. Clin. Invest. 116, 2521-2531 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 2521-2531
    • Walsh, P.T.1
  • 78
    • 79956221450 scopus 로고    scopus 로고
    • Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells
    • Patterson S. J, et al. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J. Immunol. 186, 5533-5537 (2011).
    • (2011) J. Immunol , vol.186 , pp. 5533-5537
    • Patterson, S.J.1
  • 79
    • 84922917657 scopus 로고    scopus 로고
    • Control of PI( 3) kinase in Treg cells maintains homeostasis and lineage stability
    • Huynh A, et al. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat. Immunol. 16, 188-196 (2015).
    • (2015) Nat. Immunol , vol.16 , pp. 188-196
    • Huynh, A.1
  • 80
    • 84922930171 scopus 로고    scopus 로고
    • Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
    • Shrestha S, et al. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat. Immunol. 16, 178-187 (2015).
    • (2015) Nat. Immunol , vol.16 , pp. 178-187
    • Shrestha, S.1
  • 81
    • 84869872964 scopus 로고    scopus 로고
    • Novel Foxo1 dependent transcriptional programs control Treg cell function
    • Ouyang W, et al. Novel Foxo1 dependent transcriptional programs control Treg cell function. Nature. 491, 554-559 (2012).
    • (2012) Nature , vol.491 , pp. 554-559
    • Ouyang, W.1
  • 82
    • 84884206864 scopus 로고    scopus 로고
    • Stability and function of regulatory T cells is maintained by a neuropilin 1 semaphorin 4a axis
    • Delgoffe G. M, et al. Stability and function of regulatory T cells is maintained by a neuropilin 1 semaphorin 4a axis. Nature. 501, 252-256 (2013).
    • (2013) Nature , vol.501 , pp. 252-256
    • Delgoffe, G.M.1
  • 83
    • 84890137621 scopus 로고    scopus 로고
    • T cell exit from quiescence and differentiation into Th2 cells depend on Raptor mTORC1 mediated metabolic reprogramming
    • Yang K, et al. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor mTORC1 mediated metabolic reprogramming. Immunity. 39, 1043-1056 (2013).
    • (2013) Immunity , vol.39 , pp. 1043-1056
    • Yang, K.1
  • 84
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe G. M, et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 12, 295-303 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 295-303
    • Delgoffe, G.M.1
  • 85
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe G. M, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 30, 832-844 (2009).
    • (2009) Immunity , vol.30 , pp. 832-844
    • Delgoffe, G.M.1
  • 86
    • 77953897189 scopus 로고    scopus 로고
    • Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
    • Lee K, et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 32, 743-753 (2010).
    • (2010) Immunity , vol.32 , pp. 743-753
    • Lee, K.1
  • 87
    • 84861134382 scopus 로고    scopus 로고
    • PI3K Akt mTORC1 S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of ROR?
    • Kurebayashi Y, et al. PI3K Akt mTORC1 S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of ROR?. Cell Rep. 1, 360-373 (2012).
    • (2012) Cell Rep , vol.1 , pp. 360-373
    • Kurebayashi, Y.1
  • 88
    • 84881192927 scopus 로고    scopus 로고
    • MTORC1 couples immune signals and metabolic programming to establish Treg-cell function
    • Zeng H, et al. mTORC1 couples immune signals and metabolic programming to establish Treg-cell function. Nature. 499, 485-490 (2013).
    • (2013) Nature , vol.499 , pp. 485-490
    • Zeng, H.1
  • 89
    • 84860187314 scopus 로고    scopus 로고
    • Inflammation-driven reprogramming of CD4+Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo
    • Yurchenko E, et al. Inflammation-driven reprogramming of CD4+Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS ONE 7, e35572 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e35572
    • Yurchenko, E.1
  • 90
    • 84890040690 scopus 로고    scopus 로고
    • TSC1 regulates the balance between effector and regulatory T cells
    • Park Y, et al. TSC1 regulates the balance between effector and regulatory T cells. J. Clin. Invest. 123, 5165-5178 (2013).
    • (2013) J. Clin. Invest , vol.123 , pp. 5165-5178
    • Park, Y.1
  • 91
    • 84888180619 scopus 로고    scopus 로고
    • The duration of T cell stimulation is a critical determinant of cell fate and plasticity
    • ra97
    • Miskov-Zivanov N., Turner M. S., Kane L. P., Morel P. A, & Faeder J. R. The duration of T cell stimulation is a critical determinant of cell fate and plasticity. Sci. Signal. 6, ra97 (2013).
    • (2013) Sci. Signal , vol.6
    • Miskov-Zivanov, N.1    Turner, M.S.2    Kane, L.P.3    Morel, P.A.4    Faeder, J.R.5
  • 92
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: Insights into metabolism and lymphocyte function
    • Pearce E. L., Poffenberger M. C., Chang C. H, & Jones R. G. Fueling immunity: insights into metabolism and lymphocyte function. Science. 342, 1242454-1242454 (2013).
    • (2013) Science , vol.342 , pp. 1242454
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.H.3    Jones, R.G.4
  • 93
    • 0036069699 scopus 로고    scopus 로고
    • The CD28 signaling pathway regulates glucose metabolism
    • Frauwirth K. A, et al. The CD28 signaling pathway regulates glucose metabolism. Immunity. 16, 769-777 (2002).
    • (2002) Immunity , vol.16 , pp. 769-777
    • Frauwirth, K.A.1
  • 94
    • 84904057246 scopus 로고    scopus 로고
    • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
    • Macintyre A. N, et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell. Metab. 20, 61-72 (2014).
    • (2014) Cell. Metab , vol.20 , pp. 61-72
    • Macintyre, A.N.1
  • 95
    • 84922375253 scopus 로고    scopus 로고
    • Foxp3 mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells
    • Basu S., Hubbard B, & Shevach E. M. Foxp3 mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells. J. Leukocyte Biol. 97, 279-283 (2015).
    • (2015) J. Leukocyte Biol , vol.97 , pp. 279-283
    • Basu, S.1    Hubbard, B.2    Shevach, E.M.3
  • 96
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    • Michalek R. D, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011).
    • (2011) J. Immunol , vol.186 , pp. 3299-3303
    • Michalek, R.D.1
  • 97
    • 84920481006 scopus 로고    scopus 로고
    • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
    • Gerriets V. A, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J. Clin. Invest. 125, 194-207 (2014).
    • (2014) J. Clin. Invest , vol.125 , pp. 194-207
    • Gerriets, V.A.1
  • 98
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Furusawa Y, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 504, 446-450 (2013).
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1
  • 99
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation
    • Arpaia N, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation. Nature. 504, 451-455 (2013).
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1
  • 100
    • 84942850610 scopus 로고    scopus 로고
    • Glutamine-dependent α ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
    • ra97
    • Klysz D, et al. Glutamine-dependent α ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation. Sci. Signal. 8, ra97 (2015).
    • (2015) Sci. Signal , vol.8
    • Klysz, D.1
  • 101
    • 20444429440 scopus 로고    scopus 로고
    • TCR engagement increases hypoxia-inducible factor 1 protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells
    • Nakamura H, et al. TCR engagement increases hypoxia-inducible factor 1 protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells. J. Immunol. 174, 7592-7599 (2005).
    • (2005) J. Immunol , vol.174 , pp. 7592-7599
    • Nakamura, H.1
  • 102
    • 79960369458 scopus 로고    scopus 로고
    • HIF1α dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi L. Z, et al. HIF1α dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1367-1376
    • Shi, L.Z.1
  • 103
    • 84937576224 scopus 로고    scopus 로고
    • E3 ubiquitin ligase VHL regulates hypoxia-inducible factor 1α to maintain regulatory T cell stability and suppressive capacity
    • Lee J. H., Elly C., Park Y, & Liu Y. C. E3 ubiquitin ligase VHL regulates hypoxia-inducible factor 1α to maintain regulatory T cell stability and suppressive capacity. Immunity. 42, 1062-1074 (2015).
    • (2015) Immunity , vol.42 , pp. 1062-1074
    • Lee, J.H.1    Elly, C.2    Park, Y.3    Liu, Y.C.4
  • 104
    • 80052277906 scopus 로고    scopus 로고
    • Control of TH17/Treg balance by hypoxia-inducible factor 1
    • Dang E. V, et Al. Control of TH17/Treg Balance by Hypoxia-inducible Factor 1. Cell. 146, 772-784 (2011).
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1
  • 105
    • 84911132031 scopus 로고    scopus 로고
    • Bcl 6 directly represses the gene program of the glycolysis pathway
    • Oestreich K. J, et al. Bcl 6 directly represses the gene program of the glycolysis pathway. Nat. Immunol. 15, 957-964 (2014).
    • (2014) Nat. Immunol , vol.15 , pp. 957-964
    • Oestreich, K.J.1
  • 106
    • 33745823168 scopus 로고    scopus 로고
    • Regulation of the energy sensor AMP-Activated protein kinase by antigen receptor and Ca2+ in T lymphocytes
    • Tamas P. Regulation of the energy sensor AMP-Activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J. Exp. Med. 203, 1665-1670 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1665-1670
    • Tamas, P.1
  • 107
    • 80054726323 scopus 로고    scopus 로고
    • The liver kinase B1 is a central regulator of T cell development, activation, and metabolism
    • MacIver N. J, et al. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J. Immunol. 187, 4187-4198 (2011).
    • (2011) J. Immunol , vol.187 , pp. 4187-4198
    • MacIver, N.J.1
  • 108
    • 84921309472 scopus 로고    scopus 로고
    • The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo
    • Blagih J, et al. The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity. 42, 41-54 (2015).
    • (2015) Immunity , vol.42 , pp. 41-54
    • Blagih, J.1
  • 109
    • 84872159532 scopus 로고    scopus 로고
    • AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
    • Faubert B, et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell. Metab. 17, 113-124 (2013).
    • (2013) Cell. Metab , vol.17 , pp. 113-124
    • Faubert, B.1
  • 110
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang C. H, et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell. 153, 1239-1251 (2013).
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.H.1
  • 111
    • 84922080059 scopus 로고    scopus 로고
    • De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
    • Berod L, et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat. Med. 20, 1327-1333 (2014).
    • (2014) Nat. Med , vol.20 , pp. 1327-1333
    • Berod, L.1
  • 112
    • 84880119702 scopus 로고    scopus 로고
    • STAT4 and T bet are required for the plasticity of IFN ? Expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation
    • Williams C. L, et al. STAT4 and T bet are required for the plasticity of IFN ? expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation. J. Immunol. 191, 678-687 (2013).
    • (2013) J. Immunol , vol.191 , pp. 678-687
    • Williams, C.L.1
  • 113
    • 84870027825 scopus 로고    scopus 로고
    • STATs shape the active enhancer landscape of T cell populations
    • Vahedi G, et al. STATs shape the active enhancer landscape of T cell populations. Cell. 151, 981-993 (2012).
    • (2012) Cell , vol.151 , pp. 981-993
    • Vahedi, G.1
  • 114
    • 84863010992 scopus 로고    scopus 로고
    • STAT6 dependent regulation of Th9 development
    • Goswami R, et al. STAT6 dependent regulation of Th9 development. J. Immunol. 188, 968-975 (2012).
    • (2012) J. Immunol , vol.188 , pp. 968-975
    • Goswami, R.1
  • 115
    • 84866975037 scopus 로고    scopus 로고
    • Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
    • Samstein R. M, et al. Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell. 151, 153-166 (2012).
    • (2012) Cell , vol.151 , pp. 153-166
    • Samstein, R.M.1
  • 116
    • 84867894231 scopus 로고    scopus 로고
    • Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors
    • Oestreich K. J, & Weinmann A. S. Master regulators or lineage-specifying?. Changing views on CD4+ T cell transcription factors. Nat. Rev. Immunol. 12, 799-804 (2012).
    • (2012) Nat. Rev. Immunol , vol.12 , pp. 799-804
    • Oestreich, K.J.1    Weinmann, A.S.2
  • 117
    • 58149214356 scopus 로고    scopus 로고
    • Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    • Wei G, et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity. 30, 155-167 (2009).
    • (2009) Immunity , vol.30 , pp. 155-167
    • Wei, G.1
  • 118
    • 84905973739 scopus 로고    scopus 로고
    • Transcriptional and epigenetic networks of helper T and innate lymphoid cells
    • Shih H. Y, et al. Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Immunol. Rev. 261, 23-49 (2014).
    • (2014) Immunol. Rev , vol.261 , pp. 23-49
    • Shih, H.Y.1
  • 119
    • 84866533054 scopus 로고    scopus 로고
    • A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
    • Fu W, et al. A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat. Immunol. 13, 972-980 (2012).
    • (2012) Nat. Immunol , vol.13 , pp. 972-980
    • Fu, W.1
  • 120
    • 84875198920 scopus 로고    scopus 로고
    • Transcriptional regulation and its misregulation in disease
    • Lee T. I, & Young R. A. Transcriptional regulation and its misregulation in disease. Cell. 152, 1237-1251 (2013).
    • (2013) Cell , vol.152 , pp. 1237-1251
    • Lee, T.I.1    Young, R.A.2
  • 121
    • 84879685794 scopus 로고    scopus 로고
    • BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis
    • Roychoudhuri R, et al. BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis. Nature. 498, 506-510 (2013).
    • (2013) Nature , vol.498 , pp. 506-510
    • Roychoudhuri, R.1
  • 122
    • 84896402211 scopus 로고    scopus 로고
    • The transcription factors T bet and Runx are required for the ontogeny of pathogenic interferon-? Producing T helper 17 cells
    • Wang Y, et al. The transcription factors T bet and Runx are required for the ontogeny of pathogenic interferon-? producing T helper 17 cells. Immunity. 40, 355-366 (2014).
    • (2014) Immunity , vol.40 , pp. 355-366
    • Wang, Y.1
  • 123
    • 84959544872 scopus 로고    scopus 로고
    • Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells
    • Sekiya T, et al. Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells. J. Exp. Med. 212, 1623-1640 (2015).
    • (2015) J. Exp. Med , vol.212 , pp. 1623-1640
    • Sekiya, T.1
  • 124
    • 84925039113 scopus 로고    scopus 로고
    • Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program
    • Brown C. C, et al. Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program. Immunity. 42, 499-511 (2015).
    • (2015) Immunity , vol.42 , pp. 499-511
    • Brown, C.C.1
  • 125
    • 84941129470 scopus 로고    scopus 로고
    • The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases
    • Park B. V, & Pan F. The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases. Cell. Mol. Immunol. 12, 533-542 (2015).
    • (2015) Cell. Mol. Immunol , vol.12 , pp. 533-542
    • Park, B.V.1    Pan, F.2
  • 126
    • 0032143821 scopus 로고    scopus 로고
    • Helper T cell differentiation is controlled by the cell cycle
    • Bird J, et al. Helper T cell differentiation is controlled by the cell cycle. Immunity. 9, 229-237 (1998).
    • (1998) Immunity , vol.9 , pp. 229-237
    • Bird, J.1
  • 127
    • 0032412441 scopus 로고    scopus 로고
    • Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    • Agarwal S, & Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity. 9, 765-775 (1998).
    • (1998) Immunity , vol.9 , pp. 765-775
    • Agarwal, S.1    Rao, A.2
  • 128
    • 0035070195 scopus 로고    scopus 로고
    • Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
    • Grogan J. L, et al. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 14, 205-215 (2001).
    • (2001) Immunity , vol.14 , pp. 205-215
    • Grogan, J.L.1
  • 129
    • 0036305450 scopus 로고    scopus 로고
    • TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
    • Avni O, et al. TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3, 643-651 (2002).
    • (2002) Nat. Immunol , vol.3 , pp. 643-651
    • Avni, O.1
  • 130
    • 84889573275 scopus 로고    scopus 로고
    • Histone lysine demethylases as targets for anticancer therapy
    • Hojfeldt J. W., Agger K, & Helin K. Histone lysine demethylases as targets for anticancer therapy. Nat. Rev. Drug Discov. 12, 917-930 (2013).
    • (2013) Nat. Rev. Drug Discov , vol.12 , pp. 917-930
    • Hojfeldt, J.W.1    Agger, K.2    Helin, K.3
  • 131
    • 84878260646 scopus 로고    scopus 로고
    • TETonic shift: Biological roles of TET proteins in DNA demethylation and transcription
    • Pastor W. A., Aravind L, & Rao A. TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat. Rev. Mol. Cell Biol. 14, 341-356 (2013).
    • (2013) Nat. Rev. Mol. Cell Biol , vol.14 , pp. 341-356
    • Pastor, W.A.1    Aravind, L.2    Rao, A.3
  • 132
    • 33745022567 scopus 로고    scopus 로고
    • T helper type 1 specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN ? Promoter are Stat4 dependent
    • Zhang F. T helper type 1 specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN ? promoter are Stat4 dependent. J. Exp. Med. 203, 1493-1505 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1493-1505
    • Zhang, F.1
  • 133
    • 39749145198 scopus 로고    scopus 로고
    • Dynamic regulation of nucleosome positioning in the human genome
    • Schones D. E, et al. Dynamic regulation of nucleosome positioning in the human genome. Cell. 132, 887-898 (2008).
    • (2008) Cell , vol.132 , pp. 887-898
    • Schones, D.E.1
  • 134
    • 69449102464 scopus 로고    scopus 로고
    • Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
    • Wang Z, et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell. 138, 1019-1031 (2009).
    • (2009) Cell , vol.138 , pp. 1019-1031
    • Wang, Z.1
  • 135
    • 84928184771 scopus 로고    scopus 로고
    • The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T Cells
    • Ichiyama K, et al. The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T Cells. Immunity. 42, 613-626 (2015).
    • (2015) Immunity , vol.42 , pp. 613-626
    • Ichiyama, K.1
  • 136
    • 84929049155 scopus 로고    scopus 로고
    • Epigenetics of T cells regulated by Polycomb/Trithorax molecules
    • Onodera A, & Nakayama T. Epigenetics of T cells regulated by Polycomb/Trithorax molecules. Trends Mol. Med. 21, 330-340 (2015).
    • (2015) Trends Mol. Med , vol.21 , pp. 330-340
    • Onodera, A.1    Nakayama, T.2
  • 137
    • 55749090506 scopus 로고    scopus 로고
    • Coordinated but physically separable interaction with H3K27 demethylase and H3K4 methyltransferase activities are required for T box protein-mediated activation of developmental gene expression
    • Miller S. A., Huang A. C., Miazgowicz M. M., Brassil M. M, & Weinmann A. S. Coordinated but physically separable interaction with H3K27 demethylase and H3K4 methyltransferase activities are required for T box protein-mediated activation of developmental gene expression. Genes Dev. 22, 2980-2993 (2008).
    • (2008) Genes Dev , vol.22 , pp. 2980-2993
    • Miller, S.A.1    Huang, A.C.2    Miazgowicz, M.M.3    Brassil, M.M.4    Weinmann, A.S.5
  • 138
    • 84861451140 scopus 로고    scopus 로고
    • Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency
    • Bettini M. L, et al. Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity. 36, 717-730 (2012).
    • (2012) Immunity , vol.36 , pp. 717-730
    • Bettini, M.L.1
  • 139
    • 84886875425 scopus 로고    scopus 로고
    • Mbd2 promotes Foxp3 demethylation and T regulatory-cell function
    • Wang L, et al. Mbd2 promotes Foxp3 demethylation and T regulatory-cell function. Mol. Cell. Biol. 33, 4106-4115 (2013).
    • (2013) Mol. Cell. Biol , vol.33 , pp. 4106-4115
    • Wang, L.1
  • 140
    • 84940971884 scopus 로고    scopus 로고
    • Hydrogen sulfide promotes Tet1- and Tet2 mediated Foxp3 demethylation to drive regulatory T cell differentiation and maintain immune homeostasis
    • Yang R, et al. Hydrogen sulfide promotes Tet1- And Tet2 mediated Foxp3 demethylation to drive regulatory T cell differentiation and maintain immune homeostasis. Immunity. 43, 251-263 (2015).
    • (2015) Immunity , vol.43 , pp. 251-263
    • Yang, R.1
  • 141
    • 84907818506 scopus 로고    scopus 로고
    • Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T regulatory cell development and function
    • Liu Y, et al. Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T regulatory cell development and function. Mol. Cell. Biol. 34, 3993-4007 (2014).
    • (2014) Mol. Cell. Biol , vol.34 , pp. 3993-4007
    • Liu, Y.1
  • 142
    • 33646586637 scopus 로고    scopus 로고
    • Crucial role of MLL for the maintenance of memory T helper type 2 cell responses
    • Yamashita M, et al. Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity. 24, 611-622 (2006).
    • (2006) Immunity , vol.24 , pp. 611-622
    • Yamashita, M.1
  • 143
    • 84865425772 scopus 로고    scopus 로고
    • Cutting edge: Influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells
    • Collier S. P., Collins P. L., Williams C. L., Boothby M. R, & Aune T. M. Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J. Immunol. 189, 2084-2088 (2012).
    • (2012) J. Immunol , vol.189 , pp. 2084-2088
    • Collier, S.P.1    Collins, P.L.2    Williams, C.L.3    Boothby, M.R.4    Aune, T.M.5
  • 144
    • 84874025014 scopus 로고    scopus 로고
    • The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-? Locus
    • Gomez J. A, et al. The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-? locus. Cell. 152, 743-754 (2013).
    • (2013) Cell , vol.152 , pp. 743-754
    • Gomez, J.A.1
  • 145
    • 84929689142 scopus 로고    scopus 로고
    • Long noncoding RNA in hematopoiesis and immunity
    • Satpathy A. T, & Chang H. Y. Long noncoding RNA in hematopoiesis and immunity. Immunity. 42, 792-804 (2015).
    • (2015) Immunity , vol.42 , pp. 792-804
    • Satpathy, A.T.1    Chang, H.Y.2
  • 146
    • 84867740388 scopus 로고    scopus 로고
    • Cell division curtails helper phenotype plasticity and expedites helper T cell differentiation
    • van den Ham H. J, & de Boer R. J. Cell division curtails helper phenotype plasticity and expedites helper T cell differentiation. Immunol. Cell Biol. 90, 860-868 (2012).
    • (2012) Immunol. Cell Biol , vol.90 , pp. 860-868
    • Van Den Ham, H.J.1    De Boer, R.J.2
  • 147
    • 84863305310 scopus 로고    scopus 로고
    • De novo DNA methylation is required to restrict T helper lineage plasticity
    • Thomas R. M., Gamper C. J., Ladle B. H., Powell J. D, & Wells A. D. De novo DNA methylation is required to restrict T helper lineage plasticity. J. Biol. Chem. 287, 22900-22909 (2012).
    • (2012) J. Biol. Chem , vol.287 , pp. 22900-22909
    • Thomas, R.M.1    Gamper, C.J.2    Ladle, B.H.3    Powell, J.D.4    Wells, A.D.5
  • 148
    • 77958173509 scopus 로고    scopus 로고
    • The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression
    • Liu B., Tahk S., Yee K. M., Fan G, & Shuai K. The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression. Science. 330, 521-525 (2010).
    • (2010) Science , vol.330 , pp. 521-525
    • Liu, B.1    Tahk, S.2    Yee, K.M.3    Fan, G.4    Shuai, K.5
  • 150
    • 84924077253 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3
    • Wang L, et al. FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3. J. Clin. Invest. 125, 1111-1123 (2015).
    • (2015) J. Clin. Invest , vol.125 , pp. 1111-1123
    • Wang, L.1
  • 151
    • 84901233628 scopus 로고    scopus 로고
    • Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells
    • Arvey A, et al. Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells. Nat. Immunol. 15, 580-587 (2014).
    • (2014) Nat. Immunol , vol.15 , pp. 580-587
    • Arvey, A.1
  • 152
    • 84922999148 scopus 로고    scopus 로고
    • The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation
    • DuPage M, et al. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 42, 227-238 (2015).
    • (2015) Immunity , vol.42 , pp. 227-238
    • DuPage, M.1
  • 153
    • 84887549060 scopus 로고    scopus 로고
    • The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells
    • Tumes D. J, et al. The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells. Immunity. 39, 819-832 (2013).
    • (2013) Immunity , vol.39 , pp. 819-832
    • Tumes, D.J.1
  • 154
    • 84905115376 scopus 로고    scopus 로고
    • The polycomb repressive complex 2 governs life and death of peripheral T cells
    • Zhang Y, et al. The polycomb repressive complex 2 governs life and death of peripheral T cells. Blood. 124, 737-749 (2014).
    • (2014) Blood , vol.124 , pp. 737-749
    • Zhang, Y.1
  • 155
    • 84902682101 scopus 로고    scopus 로고
    • MiR 155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression
    • Escobar T. M, et al. miR 155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity. 40, 865-879 (2014).
    • (2014) Immunity , vol.40 , pp. 865-879
    • Escobar, T.M.1
  • 156
    • 84923347358 scopus 로고    scopus 로고
    • Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation
    • Li Q, et al. Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation. Nat. Commun. 5, 5780 (2014).
    • (2014) Nat. Commun , vol.5 , pp. 5780
    • Li, Q.1
  • 157
    • 84863724616 scopus 로고    scopus 로고
    • An epigenetic silencing pathway controlling T helper 2 cell lineage commitment
    • Allan R. S, et al. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature. 487, 249-253 (2012).
    • (2012) Nature , vol.487 , pp. 249-253
    • Allan, R.S.1
  • 158
    • 84899761239 scopus 로고    scopus 로고
    • Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
    • Antignano F, et al. Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation. J. Clin. Invest. 124, 1945-1955 (2014).
    • (2014) J. Clin. Invest , vol.124 , pp. 1945-1955
    • Antignano, F.1
  • 159
    • 84876803515 scopus 로고    scopus 로고
    • Cutting edge: A novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28
    • Huang C, et al. Cutting edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28. J. Immunol. 190, 4470-4473 (2013).
    • (2013) J Immunol , vol.190 , pp. 4470-4473
    • Huang, C.1
  • 160
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
    • Xu K, et al. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science. 338, 1465-1469 (2012).
    • (2012) Science , vol.338 , pp. 1465-1469
    • Xu, K.1
  • 161
    • 84879000598 scopus 로고    scopus 로고
    • Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
    • Kim E, et al. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell. 23, 839-852 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 839-852
    • Kim, E.1
  • 162
    • 84875424617 scopus 로고    scopus 로고
    • Emerging roles for chromatin as a signal integration and storage platform
    • Badeaux A. I, & Shi Y. Emerging roles for chromatin as a signal integration and storage platform. Nat. Rev. Mol. Cell Biol. 14, 211-224 (2013).
    • (2013) Nat. Rev. Mol. Cell Biol , vol.14 , pp. 211-224
    • Badeaux, A.I.1    Shi, Y.2
  • 163
    • 84883162180 scopus 로고    scopus 로고
    • MicroRNA-mediated regulation of T helper cell differentiation and plasticity
    • Baumjohann D, & Ansel K. M. MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat. Rev. Immunol. 13, 666-678 (2013).
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 666-678
    • Baumjohann, D.1    Ansel, K.M.2
  • 164
    • 77449143100 scopus 로고    scopus 로고
    • Defects in IL 2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+CD25+ regulatory T cells of type 1 diabetic subjects
    • Long S. A, et al. Defects in IL 2R signaling contribute to diminished maintenance of FOXP3 expression in CD4+CD25+ regulatory T cells of type 1 diabetic subjects. Diabetes. 59, 407-415 (2010).
    • (2010) Diabetes , vol.59 , pp. 407-415
    • Long, S.A.1
  • 165
    • 84891887896 scopus 로고    scopus 로고
    • Regulatory T cell proliferative potential is impaired in human autoimmune disease
    • Carbone F, et al. Regulatory T cell proliferative potential is impaired in human autoimmune disease. Nat. Med. 20, 69-74 (2013).
    • (2013) Nat. Med , vol.20 , pp. 69-74
    • Carbone, F.1
  • 166
    • 84907070734 scopus 로고    scopus 로고
    • Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis
    • Bending D, et al. Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis. J. Immunol. 193, 2699-2708 (2014).
    • (2014) J. Immunol , vol.193 , pp. 2699-2708
    • Bending, D.1
  • 167
    • 84925038493 scopus 로고    scopus 로고
    • Regulatory T cell reprogramming toward a Th2 cell-like lineage impairs oral tolerance and promotes food allergy
    • Rivas M. N, et al. Regulatory T cell reprogramming toward a Th2 cell-like lineage impairs oral tolerance and promotes food allergy. Immunity. 42, 512-523 (2015).
    • (2015) Immunity , vol.42 , pp. 512-523
    • Rivas, M.N.1
  • 168
    • 84891838421 scopus 로고    scopus 로고
    • Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
    • Komatsu N, et al. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat. Med. 20, 62-68 (2014).
    • (2014) Nat. Med , vol.20 , pp. 62-68
    • Komatsu, N.1
  • 169
    • 84879401216 scopus 로고    scopus 로고
    • Expression of ROR?t marks a pathogenic regulatory T cell subset in human colon cancer
    • 164ra159
    • Blatner N. R, et al. Expression of ROR?t marks a pathogenic regulatory T cell subset in human colon cancer. Sci. Transl Med. 4, 164ra159 (2012).
    • (2012) Sci. Transl Med , vol.4
    • Blatner, N.R.1
  • 170
    • 60749107176 scopus 로고    scopus 로고
    • The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17 producing effector T helper cells in vivo
    • McGeachy M. J, et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17 producing effector T helper cells in vivo. Nat. Immunol. 10, 314-324 (2009).
    • (2009) Nat. Immunol , vol.10 , pp. 314-324
    • McGeachy, M.J.1
  • 171
    • 84875473675 scopus 로고    scopus 로고
    • Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell- dependent IgA responses
    • Hirota K, et al. Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell- dependent IgA responses. Nat. Immunol. 14, 372-379 (2013).
    • (2013) Nat. Immunol , vol.14 , pp. 372-379
    • Hirota, K.1
  • 172
    • 84905472351 scopus 로고    scopus 로고
    • HTLV 1 induces a Th1 like state in CD4+CCR4+ T cells
    • Araya N, et al. HTLV 1 induces a Th1 like state in CD4+CCR4+ T cells. J. Clin. Invest. 124, 3431-3442 (2014).
    • (2014) J. Clin. Invest , vol.124 , pp. 3431-3442
    • Araya, N.1
  • 173
    • 84929678307 scopus 로고    scopus 로고
    • IL 2: Change structure change function
    • Bluestone J. A., Crellin N, & Trotta E. IL 2: change structure change function. Immunity. 42, 779-781 (2015).
    • (2015) Immunity , vol.42 , pp. 779-781
    • Bluestone, J.A.1    Crellin, N.2    Trotta, E.3
  • 174
    • 0037198420 scopus 로고    scopus 로고
    • Anti CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
    • Herold K. C, et al. Anti CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 346, 1692-1698 (2002).
    • (2002) N. Engl. J. Med , vol.346 , pp. 1692-1698
    • Herold, K.C.1
  • 175
    • 80051931752 scopus 로고    scopus 로고
    • Anti CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells
    • Penaranda C., Tang Q, & Bluestone J. A. Anti CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J. Immunol. 187, 2015-2022 (2011).
    • (2011) J. Immunol , vol.187 , pp. 2015-2022
    • Penaranda, C.1    Tang, Q.2    Bluestone, J.A.3
  • 176
    • 84941343279 scopus 로고    scopus 로고
    • Releasing the brakes on cancer immunotherapy
    • Littman D. R. Releasing the brakes on cancer immunotherapy. Cell. 162, 1186-1190 (2015).
    • (2015) Cell , vol.162 , pp. 1186-1190
    • Littman, D.R.1
  • 177
    • 84865478468 scopus 로고    scopus 로고
    • Rapamycin/IL 2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
    • Long S. A, et al. Rapamycin/IL 2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes. 61, 2340-2348 (2012).
    • (2012) Diabetes , vol.61 , pp. 2340-2348
    • Long, S.A.1
  • 178
    • 84903188335 scopus 로고    scopus 로고
    • Inactivation of PI( 3)K p110d breaks regulatory T cell-mediated immune tolerance to cancer
    • Ali K, et al. Inactivation of PI(3)K p110d breaks regulatory T cell-mediated immune tolerance to cancer. Nature. 510, 407-411 (2014).
    • (2014) Nature , vol.510 , pp. 407-411
    • Ali, K.1
  • 179
    • 62749201002 scopus 로고    scopus 로고
    • Expansion of human regulatory T cells from patients with type 1 diabetes
    • Putnam A. L, et al. Expansion of human regulatory T cells from patients with type 1 diabetes. Diabetes. 58, 652-662 (2009).
    • (2009) Diabetes , vol.58 , pp. 652-662
    • Putnam, A.L.1
  • 180
    • 84875966999 scopus 로고    scopus 로고
    • Cell-based therapeutics: The next pillar of medicine
    • 179ps177
    • Fischbach M. A., Bluestone J. A, & Lim W. A. Cell-based therapeutics: the next pillar of medicine. Sci. Transl Med. 5, 179ps177 (2013).
    • (2013) Sci. Transl Med , vol.5
    • Fischbach, M.A.1    Bluestone, J.A.2    Lim, W.A.3
  • 181
    • 84905996839 scopus 로고    scopus 로고
    • ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
    • Guedan S, et al. ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells. Blood. 124, 1070-1080 (2014).
    • (2014) Blood , vol.124 , pp. 1070-1080
    • Guedan, S.1
  • 182
    • 84928641864 scopus 로고    scopus 로고
    • Normalization of CD4+ T cell metabolism reverses lupus
    • 274ra218
    • Yin Y, et al. Normalization of CD4+ T cell metabolism reverses lupus. Sci. Transl Med. 7, 274ra218 (2015).
    • (2015) Sci. Transl Med , vol.7
    • Yin, Y.1
  • 183
    • 84882683958 scopus 로고    scopus 로고
    • The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
    • Chen Z, et al. The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3. Immunity. 39, 272-285 (2013).
    • (2013) Immunity , vol.39 , pp. 272-285
    • Chen, Z.1
  • 184
    • 84928489333 scopus 로고    scopus 로고
    • Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing ROR?t
    • Yang J, et al. Cutting edge: ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing ROR?t. J. Immunol. 194, 4094-4097 (2015).
    • (2015) J. Immunol , vol.194 , pp. 4094-4097
    • Yang, J.1
  • 185
    • 84878073297 scopus 로고    scopus 로고
    • Lysine 313 of T box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T bet
    • Jang E. J., Park H. R., Hong J. H, & Hwang E. S. Lysine 313 of T box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T bet. J. Immunol. 190, 5764-5770 (2013).
    • (2013) J. Immunol , vol.190 , pp. 5764-5770
    • Jang, E.J.1    Park, H.R.2    Hong, J.H.3    Hwang, E.S.4
  • 186
    • 79952274915 scopus 로고    scopus 로고
    • Sirtuin 1 targeting promotes Foxp3+ T regulatory cell function and prolongs allograft survival
    • Beier U. H, et al. Sirtuin 1 targeting promotes Foxp3+ T regulatory cell function and prolongs allograft survival. Mol. Cell. Biol. 31, 1022-1029 (2011).
    • (2011) Mol. Cell. Biol , vol.31 , pp. 1022-1029
    • Beier, U.H.1
  • 187
    • 84863229506 scopus 로고    scopus 로고
    • Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells
    • Kwon H. S, et al. Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J. Immunol. 188, 2712-2721 (2012).
    • (2012) J. Immunol , vol.188 , pp. 2712-2721
    • Kwon, H.S.1
  • 188
    • 84940110100 scopus 로고    scopus 로고
    • SIRT1 deacetylates ROR?t and enhances Th17 cell generation
    • Lim H. W, et al. SIRT1 deacetylates ROR?t and enhances Th17 cell generation. J. Exp. Med. 212, 607-617 (2015).
    • (2015) J. Exp. Med , vol.212 , pp. 607-617
    • Lim, H.W.1
  • 189
    • 84946912433 scopus 로고    scopus 로고
    • Epigenetic silencing of TH1 type chemokines shapes tumour immunity and immunotherapy
    • Peng D, et al. Epigenetic silencing of TH1 type chemokines shapes tumour immunity and immunotherapy. Nature. 527, 249-253 (2015).
    • (2015) Nature , vol.527 , pp. 249-253
    • Peng, D.1
  • 190
    • 84883767441 scopus 로고    scopus 로고
    • Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity
    • Liu Y, et al. Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity. Nat. Med. 19, 1173-1177 (2013).
    • (2013) Nat. Med , vol.19 , pp. 1173-1177
    • Liu, Y.1
  • 191
    • 84865966132 scopus 로고    scopus 로고
    • Selective inhibition of CD4+ T cell cytokine production and autoimmunity by BET protein and c Myc inhibitors
    • Bandukwala H. S, et al. Selective inhibition of CD4+ T cell cytokine production and autoimmunity by BET protein and c Myc inhibitors. Proc. Natl Acad. Sci. USA. 109, 14532-14537 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 14532-14537
    • Bandukwala, H.S.1
  • 192
    • 84923029507 scopus 로고    scopus 로고
    • Epigenetic modulation of type 1 diabetes via a dual effect on pancreatic macrophages and β cells
    • Fu W, et al. Epigenetic modulation of type 1 diabetes via a dual effect on pancreatic macrophages and β cells. eLife 3, e04631 (2014).
    • (2014) ELife , vol.3 , pp. e04631
    • Fu, W.1
  • 193
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    • Tsuji M, et al. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science. 323, 1488-1492 (2009).
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1
  • 194
    • 84878169329 scopus 로고    scopus 로고
    • An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor Eos
    • Sharma M. D, et al. An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor Eos. Immunity. 38, 998-1012 (2013).
    • (2013) Immunity , vol.38 , pp. 998-1012
    • Sharma, M.D.1
  • 195
    • 84906534462 scopus 로고    scopus 로고
    • Role of Blimp 1 in programing Th effector cells into IL 10 producers
    • Neumann C, et al. Role of Blimp 1 in programing Th effector cells into IL 10 producers. J. Exp. Med. 211, 1807-1819 (2014).
    • (2014) J. Exp. Med , vol.211 , pp. 1807-1819
    • Neumann, C.1
  • 196
    • 79960919901 scopus 로고    scopus 로고
    • Control of TH17 cells occurs in the small intestine
    • Esplugues E, et al. Control of TH17 cells occurs in the small intestine. Nature. 475, 514-518 (2011).
    • (2011) Nature , vol.475 , pp. 514-518
    • Esplugues, E.1
  • 197
    • 84892914133 scopus 로고    scopus 로고
    • Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis
    • Califano D, et al. Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis. J. Clin. Invest. 124, 174-187 (2013).
    • (2013) J. Clin. Invest , vol.124 , pp. 174-187
    • Califano, D.1
  • 198
    • 84900028407 scopus 로고    scopus 로고
    • IL 27 and IL 12 oppose pro-inflammatory IL 23 in CD4+ T cells by inducing Blimp1
    • Heinemann C, et al. IL 27 and IL 12 oppose pro-inflammatory IL 23 in CD4+ T cells by inducing Blimp1. Nat. Commun. 5, 1-13 (2014).
    • (2014) Nat. Commun , vol.5 , pp. 1-13
    • Heinemann, C.1
  • 199
    • 0023803978 scopus 로고
    • Functional heterogeneity among human inducer T cell clones
    • Umetsu D. T, et al. Functional heterogeneity among human inducer T cell clones. J. Immunol. 140, 4211-4216 (1988).
    • (1988) J. Immunol , vol.140 , pp. 4211-4216
    • Umetsu, D.T.1
  • 200
    • 0023723140 scopus 로고
    • Profiles of lymphokine activities and helper function for IgE in human T cell clones
    • Maggi E, et al. Profiles of lymphokine activities and helper function for IgE in human T cell clones. Eur. J. Immunol. 18, 1045-1050 (1988).
    • (1988) Eur. J. Immunol , vol.18 , pp. 1045-1050
    • Maggi, E.1
  • 201
    • 0029965236 scopus 로고    scopus 로고
    • Reversibility of T helper 1 and 2 populations is lost after long-Term stimulation
    • Murphy E, et al. Reversibility of T helper 1 and 2 populations is lost after long-Term stimulation. J. Exp. Med. 183, 901-913 (1996).
    • (1996) J. Exp. Med , vol.183 , pp. 901-913
    • Murphy, E.1
  • 202
    • 60549115770 scopus 로고    scopus 로고
    • Heterogeneity of natural Foxp3+ T cells: A committed regulatory T cell lineage and an uncommitted minor population retaining plasticity
    • Komatsu N, et al. Heterogeneity of natural Foxp3+ T cells: a committed regulatory T cell lineage and an uncommitted minor population retaining plasticity. Proc. Natl Acad. Sci. USA. 106, 1903-1908 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 1903-1908
    • Komatsu, N.1
  • 203
    • 65449125930 scopus 로고    scopus 로고
    • Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
    • Duarte J. H., Zelenay S., Bergman M. L., Martins A. C, & Demengeot J. Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur. J. Immunol. 39, 948-955 (2009).
    • (2009) Eur. J. Immunol , vol.39 , pp. 948-955
    • Duarte, J.H.1    Zelenay, S.2    Bergman, M.L.3    Martins, A.C.4    Demengeot, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.