Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Journal of Clinical Investigation

Volumn 125, Issue 1, 2015, Pages 194-207

  Gerriets, Valerie A ^a   Kishton, Rigel J ^a   Nichols, Amanda G ^a   MacIntyre, Andrew N ^a   Inoue, Makoto ^a   Ilkayeva, Olga ^a   Winter, Peter S ^a   Liu, Xiaojing ^b   Priyadharshini, Bhavana ^c   Slawinska, Marta E ^d   Haeberli, Lea ^d   Huck, Catherine ^d   Turka, Laurence A ^c   Wood, Kris C ^a   Hale, Laura P ^e   Smith, Paul A ^d   Schneider, Martin A ^d   MacIver, Nancie J ^a   Locasale, Jason W ^b   Newgard, Christopher B ^a   Shinohara, Mari L ^a   Rathmell, Jeffrey C ^a   more..

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

^e Department of Surgery Massachusetts General Hospital Harvard Medical School ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; GLYCOLYTIC ENZYME; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE 1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; TRANSCRIPTOME;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL DIVISION; CELL FATE; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA REPLICATION; EFFECTOR CELL; ELECTRON TRANSPORT; ENZYME INHIBITION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLYCOLYSIS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIPID OXIDATION; MALE; METABOLOMICS; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATION; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; ANIMAL; C57BL MOUSE; CELL CULTURE; ENERGY METABOLISM; ENZYMOLOGY; IMMUNOLOGY; PHYSIOLOGY;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENERGY METABOLISM; GLYCOLYSIS; MICE, INBRED C57BL; PROTEIN-SERINE-THREONINE KINASES; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSCRIPTOME;

EID: 84920481006     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI76012     Document Type: Article

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