Immunophenotyping of circulating T helper cells argues for multiple functions and plasticity of T cells in vivo in humans - possible role in asthma

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Malmhäll, Carina ^a   Bossios, Apostolos ^a   Rådinger, Madeleine ^a   Sjöstrand, Margareta ^a   Lu, You ^a   Lundbäck, Bo ^a   Lötvall, Jan ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CD28 ANTIBODY; CD3 ANTIBODY; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; KI 67 ANTIGEN; LYMPHOCYTE ANTIBODY; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RETINOID RELATED ORPHAN RECEPTOR GAMMA T; STEROID; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; ASTHMA; CELL STIMULATION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; EOSINOPHIL COUNT; EOSINOPHILIA; FEMALE; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOPHENOTYPING; IMMUNOREGULATION; IN VITRO STUDY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SWEDEN; T LYMPHOCYTE PLASTICITY; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL;

ADOLESCENT; ADULT; AGED; ASTHMA; CASE-CONTROL STUDIES; CELL MOVEMENT; CELL PROLIFERATION; DEMOGRAPHY; EOSINOPHILIA; FEMALE; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE COUNT; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, HELPER-INDUCER; TRANSCRIPTION FACTORS; YOUNG ADULT;

ANIMALIA;

EID: 84863094021     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040012     Document Type: Article

References (29)

1. Wenzel SE, (2006) Asthma: defining of the persistent adult phenotypes. Lancet 368: 804-813.
2. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, et al. (2008) Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 178: 218-224.
3. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, et al. (2010) Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 181: 315-323.
4. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, et al. (2009) T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 180: 388-395.
5. Lötvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, et al. (2011) Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 127: 355-360.
6. Akdis M, (2010) The cellular orchestra in skin allergy; are differences to lung and nose relevant? Curr Opin Allergy Clin Immunol 10: 443-451.
7. Abbas AK, Murphy KM, Sher A, (1996) Functional diversity of helper T lymphocytes. Nature 383: 787-793.
8. Zhou L, Chong MM, Littman DR, (2009) Plasticity of CD4+ T cell lineage differentiation. Immunity 30: 646-655.
9. Locksley RM, (2009) Nine lives: plasticity among T helper cell subsets. J Exp Med 206: 1643-1646.
10. Jameson SC, Masopust D, (2009) Diversity in T cell memory: an embarrassment of riches. Immunity 31: 859-871.
11. O'Shea JJ, Paul WE, (2010) Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327: 1098-1102.
12. Murphy KM, Stockinger B, (2010) Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol 11: 674-680.
13. Durrant DM, Metzger DW, (2010) Emerging roles of T helper subsets in the pathogenesis of asthma. Immunol Invest 39: 526-549.
14. Simon D, Kozlowski E, Simon H, (2009) Natural killer T cells expressing IFN-gamma and IL-4 in lesional skin of atopic eczema. Allergy 64: 1681-1684.
15. Hegazy AN, Peine M, Helmstetter C, Panse I, Frohlich A, et al. (2010) Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity 32: 116-128.
16. Cosmi L, Maggi L, Santarlasci V, Capone M, Cardilicchia E, et al. (2010) Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. J Allergy Clin Immunol 125: 222-230 e221-224.
17. Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, Oldenhove G, et al. (2011) GATA3 controls Foxp3 regulatory T cell fate during inflammation in mice. J Clin Invest 121: 4503-4515.
18. Zhou L, Lopes JE, Chong MM, Ivanov, II, Min R, et al. (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453: 236-240.
19. Lötvall J, Ekerljung L, Rönmark EP, Wennergren G, Linden A, et al. (2009) West Sweden Asthma Study: prevalence trends over the last 18 years argues no recent increase in asthma. Respir Res 10: 94.
20. Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, et al. (2001) Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14: 205-215.
21. Voo KS, Wang YH, Santori FR, Boggiano C, Arima K, et al. (2009) Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A 106: 4793-4798.
22. Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, et al. (2009) The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 10: 595-602.
23. Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, et al. (2010) Stability of the regulatory T cell lineage in vivo. Science 329: 1667-1671.
24. Raymond M, Van VQ, Wakahara K, Rubio M, Sarfati M, (2011) Lung dendritic cells induce T(H)17 cells that produce T(H)2 cytokines, express GATA-3, and promote airway inflammation. J Allergy Clin Immunol 128: 192-201 e196.
25. Smyth LJ, Eustace A, Kolsum U, Blaikely J, Singh D, (2010) Increased airway T regulatory cells in asthmatic subjects. Chest 138: 905-912.
26. Provoost S, Maes T, van Durme YM, Gevaert P, Bachert C, et al. (2009) Decreased FOXP3 protein expression in patients with asthma. Allergy 64: 1539-1546.
27. Matsumoto K, Inoue H, Fukuyama S, Kan OK, Eguchi-Tsuda M, et al. (2009) Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma. Respirology 14: 187-194.
28. Mullen AC, Hutchins AS, Villarino AV, Lee HW, High FA, et al. (2001) Cell cycle controlling the silencing and functioning of mammalian activators. Curr Biol 11: 1695-1699.
29. Finotto S, Glimcher L, (2004) T cell directives for transcriptional regulation in asthma. Springer Semin Immunopathol 25: 281-294.