Mechanisms underlying lineage commitment and plasticity of helper CD4 + T cells

Science

Volumn 327, Issue 5969, 2010, Pages 1098-1102

  O'Shea, John ^a   Paul, William E ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; PROTEIN BCL 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3;

CYTOLOGY; DISEASE TREATMENT; IMMUNE SYSTEM; PATHOGEN; PROTEIN;

CD4+ T LYMPHOCYTE; CELL FATE; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL POLARITY; CELL SPECIFICITY; COMPLEX FORMATION; CYTOKINE PRODUCTION; EPIGENETICS; GENE EXPRESSION; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LYMPHOCYTE DIFFERENTIATION; NATURAL KILLER T CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 77649220954     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1178334     Document Type: Review

References (50)

1. T. R. Mosmann, H. Cherwinski, M. W. Bond, M. A. Giedlin, R. L. Coffman, ;.J. Immunol. 136, 2348 (1986).
2. A. K. Abbas, K. M. Murphy, A. Sher, Nature 383, 787 (1996).
3. C. Dong, R. A. Flavell, Sci STKE 2000, pe1 (2000).
4. E. M. Shevach, Nat. Rev. Immunol. 2, 389 (2002).
5. S. Sakaguchi, T. Yamaguchi, T. Nomura, M. Ono, Cell 133, 775 (2008).
6. S. Z. Josefowicz, A. Rudensky, Immunity 30, 616 (2009).
7. B. Stockinger, M. Veldhoen, B. Martin, Semin. Immunol. 19, 353 (2007).
8. P. Miossec, T. Korn, V. K. Kuchroo, N. Engl J. Med. 361, 888 (2009).
9. Y. K. Lee, R. Mukasa, R. D. Hatton, C. T. Weaver, Curr. Opin. Immunol. 21, 274 (2009).
10. L Zhou, M. M. Chong, D. R. Littman, Immunity 30, 646 (2009).
11. N. Fazilleau, L. Mark, L. J. McHeyzer-Williams, M. G. McHeyzer-Williams, Immunity 30, 324 (2009).
12. C. King, S. G. Tangye, C. R. Mackay, Annu. Rev. Immunol. 26, 741 (2008).
13. A. Awasthi, V. K. Kuchroo, Science 325, 953 (2009).
14. R. J. Johnston et al, Science 325, 1006 (2009).
15. R. I. Nurieva et al, Science 325, 1001 (2009).
16. X. Zhou, S. Bailey-Bucktrout, L. T. Jeker, J. A. Bluestone, Curr. Opin. Immunol. 21, 281 (2009).
17. M. Veldhoen et al., Nat. Immunol. 9, 1341 (2008).
18. W. Elyaman et al, Proc. Natl. Acad. Sci. U.S.A 106, 12885 (2009).
19. N. J. Wilson et al, Nat. Immunol. 8, 950 (2007).
20. Z. Chen, C. M. Tato, L. Muul, A. Laurence, J. J. O'Shea, Arthritis Rheum. 56, 2936 (2007).
21. Y. K. Lee et at., Immunity 30, 92 (2009).
22. D. Bending et al, J. Clin. Investig. 119, 565 (2009).
23. G. Shi et al, J. Immunol. 181, 7205 (2008).
24. N. Hayashi et al, Proc. Natl. Acad. Sci. U.S.A. 104, 14765 (2007).
25. T. Duhen, R. Geiger, D. Jarrossay, A. Lanzavecchia, F. Sallusto, Nat. Immunol. 10, 857 (2009).
26. S. Trifari, C. D. Kaplan, E. H. Tran, N. K. Crellin, H. Spits, Nat. Immunol. 10, 864 (2009).
27. M. Löhning et al, J. Exp. Med. 205, 53 (2008).
28. X. Zhou et al, Nat. Immunol. 10, 1000 (2009).
29. L. Xu, A. Kitani, I. Fuss, W. Strober, J. Immunol. 178, 6725 (2007).
30. G. Wei et al, Immunity 30, 155 (2009).
31. N. Komatsu et al, Proc. Natl. Acad. Sci. U.S.A. 106, 1903 (2009).
32. M. A. Koch et al, Nat. Immunol. 10, 595 (2009).
33. L. Zhou et al, Nature 453, 236 (2008).
34. F. Zhang, G. Meng, W. Strober, Nat. Immunol. 9, 1297 (2008).
35. M. Tsuji et al, Science 323, 1488 (2009).
36. K. R. Cordes et al, Nature 460, 705 (2009).
37. C. B. Wilson, E. Rowell, M. Sekimata, Nat. Rev. Immunol. 9, 91 (2009).
38. S. Floess et al, PLoS Biol. 5, e38 (2007).
39. S. Yamanaka, Philos. Trans. R. Soc. London Ser. B 363, 2079 (2008).
40. Q. Zhou, D. A. Melton, Cell Stem Cell 3, 382 (2008).
41. B. E. Bernstein et al, Cell 125, 315 (2006).
42. X. Zhou et al, J. Exp. Med. 205, 1983 (2008).
43. R. J. Johnston et al, Science 325, 1006 (2009).
44. J. Zhu et al, Nat. Immunol. 5, 1157 (2004).
45. A. A. Lighvani et al, Proc. Natl. Acad. Sci. U.S.A. 98, 15137 (2001).
46. V. T. Thieu et al, Immunity 29, 679 (2008).
47. C. Georgescu et al, Proc. Natl. Acad. Sci. U.S.A. 105, 20100 (2008).
48. E. V. Rothenberg, J. E. Moore, M. A. Yui, Nat Rev. Immunol. 8, 9 (2008).
49. A. Barski et al, Cell 129, 823 (2007).
50. J.O'S. and W.E.P. are supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Institute of Allergy and Infectious Disease intramural research programs, respectively.