Helper T cell differentiation is controlled by the cell cycle

Immunity

Volumn 9, Issue 2, 1998, Pages 229-237

  Bird, Jennifer J ^a,b   Brown, Daniel R ^b   Mullen, Alan C ^b   Moskowitz, Naomi H ^a,b   Mahowald, Michael A ^a,b   Sider, Jenny R ^a,b   Gajewski, Thomas F ^a   Wang, Chyung Ru ^a,b   Reiner, Steven L ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; CELL CYCLE; CYTOKINE PRODUCTION; GENE EXPRESSION; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0032143821     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80605-6     Document Type: Article

References (77)

1. Abbas, A.K., Murphy, K.M., and Sher, A. (1996). Functional diversity of helper T lymphocytes. Nature 383, 787-793.
2. Aparicio, O.M., and Gottschling, D.E. (1994). Overcoming telomeric silencing: a frans-activator competes to establish gene expression in a cell cycle-dependent way. Genes Dev. 8, 1133-1146.
3. Barton, M.C., and Emerson, B.M. (1994). Regulated expression of the β-globin gene locus in synthetic nuclei. Genes Dev. 8, 2453-2465.
4. Berton, M.T., and Vitetta, E.S. (1990). Interleukin 4 induces changes in the chromatin structure of the γ1 switch region in resting B cells before switch recombination. J. Exp. Med. 172, 375-378.
5. Bhattacharya, S., Eckner, R., Grossman, S., Oldread, E., Arany, Z., D'Andre, A., and Livingston, D.M. (1996). Cooperation of Stat2 and p300/CBP in signaling induced by interferon-a. Nature 383, 344-347.
6. Bluestone, J.A. (1995). New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2, 555-559.
7. Bretscher, P.A., Wei, G., Menon, J.N., and Bielefeldt-Ohmann, H. (1992). Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 257, 539-542.
8. Brown, D.R., Moskowitz, N.H., Killeen, N., and Reiner, S.L. (1997a). A role for CD4 in peripheral T cell differentiation. J. Exp. Med. 186, 101-107.
9. Brown, K.E., Guest, S.S., Smale, ST., Hahm, K., Merkenschlager, M., and Fisher, A.G. (1997b). Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91, 845-854.
10. +T-cell phenotype development. Proc. Natl. Acad. Sci. USA 92, 7565-7569.
11. Burger, C., and Radbruch, A. (1990). Protective methylation of immunoglobulin and T cell receptor (TcR) gene loci prior to induction of class switch and TcR recombination. Eur. J. Immunol. 20, 2285-2291.
12. WAF1. Science 277, 1996-2000.
13. Chuvpilo, S., Schomberg, C., Gerwig, R., Heinfling, A., Reeves, R., Frummt, F., and Serfling, E. (1993). Multiple closely-linked NFAT/ octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res. 21, 5694-5704.
14. Corcoran, A.E., Riddell, A., Krooshoop, D., and Venkitaraman, A.R. (1998). Impaired immunglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature 391, 904-907.
15. Corry, D.B., Reiner, S.L., Linsley, P.S., and Locksley, R.M. (1994). Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153, 4142-4148.
16. Dent, A.L., Shaffer, A.L., Yu, X., Allman, D., and Staudt, L.M. (1997). Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276, 589-592.
17. Dhordain, P., Albagli, O., Lin, R.J., Ansieau, S., Quief, S., Leutz, A., Kerckaert, J.-P., Evans, R.M., and Leprince, D. (1997). Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Proc. Natl. Acad. Sci. USA 94, 10762-10767.
18. Firpo, E.J., Koff, A., Solomon, M.J., and Roberts, J.M. (1994). Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mol. Cell. Biol. 14, 4889-4901.
19. Fowell, D.J., Magram, J., Turck, C.W., Killeen, N., and Locksley, R.M. (1997). Impaired Th2 subset development in the absence of CD4. Immunity 6, 559-569.
20. Gajewski, T.F., Joyce, J., and Fitch, F.W. (1989). Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-γ. J. Immunol. 143, 15-22.
21. Guery, J.C., Galbiati, F., Smiroldo, S., and Adorini, L. (1997). Non-MHC-linked Th2 cell development induced by soluble protein administration predicts susceptibility to Leishmania major infection. J. Immunol. 159, 2147-2153.
22. Güler, M.L., Gorham, J.D., Hsieh, C.-S., Mackey, A.J., Steen, R.G., Dietrich, W.F., and Murphy, K.M. (1996). Genetic susceptibility to leishmania: IL-12 responsiveness in TH1 cell development. Science 271, 984-987.
23. Heinzel, F.P., Rerko, R.M., Hatam, F., and Locksley, R.M. (1993). IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J. Immunol. 150, 3924-3931.
24. Henkel, G., and Brown, M.A. (1994). PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Proc. Natl. Acad. Sci. USA 91, 7737-7741.
25. Ho, I.-C., Hodge, M.R., Rooney, J.W., and Glimcher, LH. (1996). The proto-oncogene c-maf is responsible fortissue-specific expression of interleukin-4. Cell 85, 973-983.
26. Hodgkin, P.D., Lee, J.-H., and Lyons, A.B. (1996). B cell differentiation and isotype switching is related to division cycle number. J. Exp. Med. 184, 277-281.
27. Holländer, G.A., Zuklys, S., Morel, C., Mizoguchi, E., Mobisson, K., Simpson, S., Terhorst, C., Wishart, W., Golan, D.E., Bhan, A.K., and Burakoff, SJ. (1998). Monoallelic expression of the interleukin-2 locus. Science 279, 2118-2121.
28. Horvai, A.E., Xu, L., Korzus, E., Brard, G., Kalafus, D., Mullen, T-M., Rose, D.W., Rosenfeld, M.G., and Glass, C.K. (1997). Nuclear integration of JAK/STAT and Ras/AP1 signaling by CBP and p300. Proc. Natl. Acad. Sci. USA 94, 1074-1079.
29. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. 182, 1579-1584.
30. + T cells, interleukin 4 production is cytokine-autonomous, whereas Interferon γ production is cytokine-dependent. Proc. Natl. Acad. Sci. USA 94, 3189-3194.
31. Huang, H., Hu-Li, J., Chen, H., Ben-Sasson, S.Z., and Paul, W.E. (1997). IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent. J. Immunol. 159, 3731-3738.
32. Ikegami, S., Taguchi, T., Ohashi, M., Oguro, M., Nagano, M., and Mano, Y. (1978). Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α. Nature 275, 458-460.
33. Jones, P.A., and Taylor, S.M. (1980). Cellular differentiation, cytidine analogs, and DNA methylation. Cell 20, 85-93.
34. Kadonaga, J.T. (1998). Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines. Cell 92, 307-313.
35. Kang, C-J., Sheridan, C., and Koshland, M.E. (1998). Astage-specific enhancer of immunoglobulin J chain gene is induced by interleukin-2 in a presecretor B cell stage. Immunity 8, 285-295.
36. Kaplan, M.H., Schindler, U., Smiley, S.T, , and Grusby, M.J. (1996). State is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4, 313-319.
37. Keane-Myers, A., Gause, W.C., Linsley, P.S., Chen, S.J., and Wills-Karp, M. (1997). B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens. J. Immunol. 158, 2042-2049.
38. Klein-Hessling, S., Schneider, G., Heinfling, A., Chuvpilo, S., and Serfling, E. (1996). HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells. Proc. Natl. Acad. Sci. USA 93, 15311-15316.
39. Korzus, E., Torchia, J., Rose, D.W., Xu, L., Kurokawa, R., McInerney, E.M., Mullen, T.M., Glass, C.K., and Rosenfeld, M.G. (1998). Transcription factor-specific requirementsforcoactivators and their acetyltransferase functions. Science 279, 703-707.
40. Kruh, J. (1982). Effects of sodium butyrate, a new pharmacological agent, on cells in culture. Mol. Cell. Biochem. 42, 65-82.
41. Kubo, M., Ransom, J., Webb, D., Hashimoto, Y., Tada, T., and Nakayama, T. (1997). T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J. 16, 4007-4020.
42. Lalande, M. (1990). A reversible arrest point in the late G1 phase of the mammalian cell cycle. Exp. Cell Res. 186, 332-339.
43. Launois, P., Swihart, K.G., Milon, G., and Louis, J.A. (1997). Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J. Immunol. 158, 3317-3324.
44. Le Gros, G., Ben-Sasson, S.Z., Seder, R., Finkelman, F.D., and Paul, W.E. (1990). Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172, 921-929.
45. Lederer, J.A., Perez, V.L., DesRoches, L., Kim, S.M., Abbas, A.K., and Lichtman, A.M. (1996). Cytokine transcriptional events during helper T cell subset differentiation. J. Exp. Med. 184, 397-406.
46. Lee, W.T., Cole-Calkins, J., and Street, N.E. (1996). Memory T cell development in the absence of specific antigen priming. J. Immunol. 157, 5300-5307.
47. Lu, P., Zhou, X., Chen, S.J., Moorman, M., Morris, S.C., Finkelman, F.D., Linsley, P., Urban, J.F., and Gause, W.C. (1994). CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J. Exp. Med. 180, 693-698.
48. Lyons, A.B., and Parish, C.R. (1994). Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171, 131-137.
49. Martinez-Balbás, M.A., Dey, A., Rabindran, S.K., Ozato, K., and Wu, C. (1995). Displacement of sequence-specific transcription factors from mitotic chromatin. Cell 83, 29-38.
50. + T lymphocytes from TCR transgenic mice. J. Immunol. 152, 5220-5225.
51. Melvin, A.J., McGurn, M.E., Bort, S.J., Gibson, C., and Lewis, D.B. (1995). Hypomethylation of the Interferon-γ gene correlates with its expression by primary T-lineage cells. Eur. J. Immunol. 25, 426-430.
52. Mombaerts, P., Iacomini, J., Johnson, R.S., Herrup, K., and Tonegawa, S. (1992). RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
53. Moore, E.G. (1969). The effects of ferrous ion and dithioerythritol on inhibition by hydroxyurea of ribonucleotide reductase. Cancer Res. 29, 291-295.
54. Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A., and Coffman, R.L. (1986). Two types of m urine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
55. lo thymocytes in vivo. Science 250, 1720-1723.
56. Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R.J., Schreiber, S.L., and Evans, R.M. (1997). Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89, 373-380.
57. Nourse, J., Firpo, E., Flanagan, W.M., Coats, S., Polyak, K., Lee, M.H., Massague, J., Crabtree, G.R., and Roberts, J.M. (1994). Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase and inhibitor prevented by rapamycin. Nature 372, 570-573.
58. O'Garra, A. (1998). Cytokines inducethe development of functionally heterogenous T helper cell subsets. Immunity 8, 275-283.
59. Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., and Nakatani, Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959.
60. Openshaw, P., Murphy, E.E., Hosken, N.A., Maino, V., Davis, K., Murphy, K., and O'Garra, A. (1995). Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182, 1357-1367.
61. Rothenberg, E.V., and Ward, S.B. (1996). A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc. Natl. Acad. Sci. USA 93, 9358-9365.
62. Schiff, P.B., and Horwitz, S.B. (1980). Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl. Acad. Sci. USA 77,1561-1565.
63. Schmitz, J., and Radbruch, A. (1989). An interleukin 4-induced DNase I hypersensitive site indicates opening of the γ1 switch region prior to switch recombination. Int. Immunol. 1, 570-575.
64. Seder, R.A., Germain, R.N., Linsley, P.S., and Paul, W.E. (1994). CD28-mediated costimulation of interleukin 2 (IL-2)production plays a critical role in T cell priming for IL-4 and Interferon-γ production. J. Exp. Med. 179, 299-304.
65. Siebenlist, U., Durand, D.B., Bressler, P., Holbrook, N.J., Norris, C.A., Kamoun, M., Kant, J.A., and Crabtree, G.R. (1986). Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells . Mol. Cell. Biol. 6, 3042-3049.
66. Swain, S.L., McKenzie, D.T., Weinberg, A.D., and Hancock, W. (1988). Characterization of T helper 1 and 2 cell cubsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells. J. Immunol. 141, 3445-3455.
67. Thompson, C.B. (1995). Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell 81, 979-982.
68. Wakimoto, B.T. (1998). Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila. Cell 93, 321-324.
69. Weintraub, H., Flint, S.J., Leffak, I.M., Groudine, M., and Grainger, R.M. (1978). The generation and propagation of variegated chromosome structures. Cold Spring Harbor Symp. Quantitative Biol. 42, 401-407.
70. Weiss, A., Waiser, J., Serfling, E., Nebl, G., Samstag, Y., Jáck, H.-M., Gessner, A., Röllinghoff, M., and Lohoff, M. (1997). A dominant mechanism coordinately suppresses the expression of Th2 lymphokines. Int. Immunol. 9, 1347-1353.
71. Wells, A.D., Gudmundsdottir, H., and Turka, L.A. (1997). Following the fate of individual Tcellsthrough activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J. Clin. Invest. 100, 3173-3183.
72. Yoder, J.A., Walsh, C.P., and Bestor, T.H. (1997). Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 13, 335-340.
73. Yoshida, M., Kijima, M., Akita, M., and Beppu, T. (1990). Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 265, 17174-17179.
74. Young, H.A., Ghosh, P., Ye, J., Lederer, J., Lichtman, A., Gerard, J.R., Penix, L., Wilson, C.B., Melvin, A.J., McGurn, M.E., et al. (1994). Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-γ gene. J. Immunol. 153, 3603-3610.
75. Zhang, J.J., Vinkemeier, U., Gu, W., Chakravarti, D., Horvath, C.M., and Darnell, J.E., Jr. (1996). Two contact regions between Stat1 and CBP/p300 in Interferon γ signaling. Proc. Natl. Acad. Sci. USA 93, 15092-15096.
76. Zheng, W.-P., and Flavell, R.A. (1997). The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596.
77. Zieve, G.W., Turnbull, D., Mullins, J.M., and McIntosh, J.R. (1980). Production of large numbers of mitotic mammalian cells by use of the reversible microtublin inhibitor nocodazole. Nocodazole accumulated mitotic cells. Exp. Cell Res. 126, 397-405.