The Methylcytosine Dioxygenase Tet2 Promotes DNA Demethylation and Activation of Cytokine Gene Expression in T Cells

Immunity

Volumn 42, Issue 4, 2015, Pages 613-626

  Ichiyama, Kenji ^a   Chen, Tingting ^b   Wang, Xiaohu ^c   Yan, Xiaowei ^d   Kim, Byung Seok ^e   Tanaka, Shinya ^f   Ndiaye Lobry, Delphine ^g   Deng, Yuhua ^b   Zou, Yanli ^b   Zheng, Pan ^a   Tian, Qiang ^d   Aifantis, Iannis ^g   Wei, Lai ^b   Dong, Chen ^c  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c TSINGHUA UNIVERSITY   (China)

^d INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f OSAKA UNIVERSITY   (Japan)

^g NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; CYTOKINE; CYTOSINE DERIVATIVE; DIOXYGENASE; DNA; E1A ASSOCIATED P300 PROTEIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TET2; UNCLASSIFIED DRUG; 5-HYDROXYMETHYLCYTOSINE; CYTOSINE; DNA BINDING PROTEIN; EP300 PROTEIN, MOUSE; ONCOPROTEIN; STAT4 PROTEIN; STAT4 PROTEIN, MOUSE; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21; TET2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL LINEAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMETHYLATION; DNA DEMETHYLATION; DNA METABOLISM; EFFECTOR CELL; GENE DELETION; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC ASSOCIATION; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; TH1 CELL; TH17 CELL; TRANSCRIPTION REGULATION; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CYTOLOGY; DNA METHYLATION; ENZYMOLOGY; GENETIC EPIGENESIS; GENETICS; GENOME; HUMAN; IMMUNOLOGY; METABOLISM; TRANSGENIC MOUSE;

ANIMALS; CELL DIFFERENTIATION; CYTOKINES; CYTOSINE; DNA; DNA METHYLATION; DNA-BINDING PROTEINS; E1A-ASSOCIATED P300 PROTEIN; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENOME; HUMANS; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS; STAT4 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS; TH1 CELLS; TH17 CELLS;

EID: 84928184771     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.03.005     Document Type: Article

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