메뉴 건너뛰기




Volumn 187, Issue 8, 2011, Pages 4187-4198

The liver kinase B1 is a central regulator of T cell development, activation, and metabolism

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE LKB1; UNCLASSIFIED DRUG;

EID: 80054726323     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100367     Document Type: Article
Times cited : (197)

References (64)
  • 1
    • 34548014737 scopus 로고    scopus 로고
    • Revving the Engine: Signal Transduction Fuels T Cell Activation
    • DOI 10.1016/j.immuni.2007.07.008, PII S1074761307003676
    • Jones, R. G., and C. B. Thompson. 2007. Revving the engine: signal transduction fuels T cell activation. Immunity 27: 173-178. (Pubitemid 47284920)
    • (2007) Immunity , vol.27 , Issue.2 , pp. 173-178
    • Jones, R.G.1    Thompson, C.B.2
  • 2
    • 0015924743 scopus 로고
    • Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation
    • Roos, D., and J. A. Loos. 1973. Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation. Exp. Cell Res. 77: 127-135.
    • (1973) Exp. Cell Res. , vol.77 , pp. 127-135
    • Roos, D.1    Loos, J.A.2
  • 3
    • 0027474296 scopus 로고
    • Metabolic changes in activated T cells: An NMR study of human peripheral blood lymphocytes
    • Bental, M., and C. Deutsch. 1993. Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes. Magn. Reson. Med. 29: 317-326. (Pubitemid 23114497)
    • (1993) Magnetic Resonance in Medicine , vol.29 , Issue.3 , pp. 317-326
    • Bental, M.1    Deutsch, C.2
  • 4
    • 0033635249 scopus 로고    scopus 로고
    • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
    • Rathmell, J. C., M. G. Vander Heiden, M. H. Harris, K. A. Frauwirth, and C. B. Thompson. 2000. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6: 683-692.
    • (2000) Mol. Cell , vol.6 , pp. 683-692
    • Rathmell, J.C.1    Vander Heiden, M.G.2    Harris, M.H.3    Frauwirth, K.A.4    Thompson, C.B.5
  • 5
    • 44449165597 scopus 로고    scopus 로고
    • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways
    • Jacobs, S. R., C. E. Herman, N. J. Maciver, J. A. Wofford, H. L. Wieman, J. J. Hammen, and J. C. Rathmell. 2008. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J. Immunol. 180: 4476-4486.
    • (2008) J. Immunol. , vol.180 , pp. 4476-4486
    • Jacobs, S.R.1    Herman, C.E.2    Maciver, N.J.3    Wofford, J.A.4    Wieman, H.L.5    Hammen, J.J.6    Rathmell, J.C.7
  • 6
    • 0034750977 scopus 로고    scopus 로고
    • Signaling takes a breath - New quantitative perspectives on bioenergetics and signal transduction
    • DOI 10.1016/S1074-7613(01)00205-9
    • Krauss, S., M. D. Brand, and F. Buttgereit. 2001. Signaling takes a breath - new quantitative perspectives on bioenergetics and signal transduction. Immunity 15: 497-502. (Pubitemid 33016435)
    • (2001) Immunity , vol.15 , Issue.4 , pp. 497-502
    • Krauss, S.1    Brand, M.D.2    Buttgereit, F.3
  • 8
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi, L. Z., R. Wang, G. Huang, P. Vogel, G. Neale, D. R. Green, and H. Chi. 2011. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208: 1367-1376.
    • (2011) J. Exp. Med. , vol.208 , pp. 1367-1376
    • Shi, L.Z.1    Wang, R.2    Huang, G.3    Vogel, P.4    Neale, G.5    Green, D.R.6    Chi, H.7
  • 11
    • 77953785070 scopus 로고    scopus 로고
    • The metabolic life and times of a T-cell
    • Michalek, R. D., and J. C. Rathmell. 2010. The metabolic life and times of a T-cell. Immunol. Rev. 236: 190-202.
    • (2010) Immunol. Rev. , vol.236 , pp. 190-202
    • Michalek, R.D.1    Rathmell, J.C.2
  • 12
    • 79151486083 scopus 로고    scopus 로고
    • Metabolism, migration and memory in cytotoxic T cells
    • Finlay, D., and D. A. Cantrell. 2011. Metabolism, migration and memory in cytotoxic T cells. Nat. Rev. Immunol. 11: 109-117.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 109-117
    • Finlay, D.1    Cantrell, D.A.2
  • 15
    • 0041975825 scopus 로고    scopus 로고
    • Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma
    • DOI 10.1002/eji.200324048
    • Rathmell, J. C., R. L. Elstrom, R. M. Cinalli, and C. B. Thompson. 2003. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur. J. Immunol. 33: 2223-2232. (Pubitemid 37010040)
    • (2003) European Journal of Immunology , vol.33 , Issue.8 , pp. 2223-2232
    • Rathmell, J.C.1    Elstrom, R.L.2    Cinalli, R.M.3    Thompson, C.B.4
  • 16
    • 70350418625 scopus 로고    scopus 로고
    • MTOR signaling at a glance
    • Laplante, M., and D. M. Sabatini. 2009. mTOR signaling at a glance. J. Cell Sci. 122: 3589-3594.
    • (2009) J. Cell Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 17
    • 77957054466 scopus 로고    scopus 로고
    • The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism
    • Powell, J. D., and G. M. Delgoffe. 2010. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity 33: 301-311.
    • (2010) Immunity , vol.33 , pp. 301-311
    • Powell, J.D.1    Delgoffe, G.M.2
  • 19
    • 74649085700 scopus 로고    scopus 로고
    • The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
    • Rao, R. R., Q. Li, K. Odunsi, and P. A. Shrikant. 2010. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 32: 67-78.
    • (2010) Immunity , vol.32 , pp. 67-78
    • Rao, R.R.1    Li, Q.2    Odunsi, K.3    Shrikant, P.A.4
  • 20
    • 77953897189 scopus 로고    scopus 로고
    • Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
    • Lee, K., P. Gudapati, S. Dragovic, C. Spencer, S. Joyce, N. Killeen, M. A. Magnuson, and M. Boothby. 2010. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 32: 743-753.
    • (2010) Immunity , vol.32 , pp. 743-753
    • Lee, K.1    Gudapati, P.2    Dragovic, S.3    Spencer, C.4    Joyce, S.5    Killeen, N.6    Magnuson, M.A.7    Boothby, M.8
  • 21
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia, M., A. Stabilini, and M. G. Roncarolo. 2005. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 105: 4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 22
    • 35748956420 scopus 로고    scopus 로고
    • Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
    • DOI 10.1016/j.intimp.2007.08.027, PII S1567576907002809
    • Kopf, H., G. M. de la Rosa, O. M. Howard, and X. Chen. 2007. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int. Immunopharmacol. 7: 1819-1824. (Pubitemid 350046435)
    • (2007) International Immunopharmacology , vol.7 , Issue.13 , pp. 1819-1824
    • Kopf, H.1    De La, R.G.M.2    Howard, O.M.Z.3    Chen, X.4
  • 28
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada, D., T. L. Saunders, and S. J. Morrison. 2010. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468: 653-658.
    • (2010) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 29
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    • DOI 10.1016/S0092-8674(03)00929-2
    • Inoki, K., T. Zhu, and K. L. Guan. 2003. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590. (Pubitemid 37506046)
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 31
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley, S. A., J. Boudeau, J. L. Reid, K. J. Mustard, L. Udd, T. P. Mäkelä, D. R. Alessi, and D. G. Hardie. 2003. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2: 28.
    • (2003) J. Biol. , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Mäkelä, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 33
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
    • DOI 10.1038/nrm2249, PII NRM2249
    • Hardie, D. G. 2007. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 8: 774-785. (Pubitemid 47462132)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.10 , pp. 774-785
    • Hardie, D.G.1
  • 34
    • 44849141880 scopus 로고    scopus 로고
    • AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function
    • Mayer, A., S. Denanglaire, B. Viollet, O. Leo, and F. Andris. 2008. AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function. Eur. J. Immunol. 38: 948-956.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 948-956
    • Mayer, A.1    Denanglaire, S.2    Viollet, B.3    Leo, O.4    Andris, F.5
  • 35
    • 73849112608 scopus 로고    scopus 로고
    • The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
    • Cao, Y., H. Li, H. Liu, C. Zheng, H. Ji, and X. Liu. 2010. The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression. Cell Res. http://www.ncbi.nlm.nih.gov/ pubmed/2002938920: 99-108.
    • (2010) Cell Res. , pp. 99-108
    • Cao, Y.1    Li, H.2    Liu, H.3    Zheng, C.4    Ji, H.5    Liu, X.6
  • 37
    • 0037068461 scopus 로고    scopus 로고
    • Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
    • DOI 10.1038/nature01045
    • Bardeesy, N., M. Sinha, A. F. Hezel, S. Signoretti, N. A. Hathaway, N. E. Sharpless, M. Loda, D. R. Carrasco, and R. A. DePinho. 2002. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419: 162-167. (Pubitemid 35025443)
    • (2002) Nature , vol.419 , Issue.6903 , pp. 162-167
    • Bardeesy, N.1    Sinha, M.2    Hezel, A.F.3    Signoretti, S.4    Hathaway, N.A.5    Sharpless, N.E.6    Loda, M.7    Carrasco, D.R.8    DePinho, R.A.9
  • 40
    • 0141863388 scopus 로고    scopus 로고
    • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
    • DOI 10.1128/MCB.23.20.7315-7328.2003
    • Rathmell, J. C., C. J. Fox, D. R. Plas, P. S. Hammerman, R. M. Cinalli, and C. B. Thompson. 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol. Cell. Biol. 23: 7315-7328. (Pubitemid 37211011)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.20 , pp. 7315-7328
    • Rathmell, J.C.1    Fox, C.J.2    Plas, D.R.3    Hammerman, P.S.4    Cinalli, R.M.5    Thompson, C.B.6
  • 41
    • 33947619418 scopus 로고    scopus 로고
    • Functional plasticity in memory T helper cell responses
    • Krawczyk, C. M., H. Shen, and E. J. Pearce. 2007. Functional plasticity in memory T helper cell responses. J. Immunol. 178: 4080-4088. (Pubitemid 46492356)
    • (2007) Journal of Immunology , vol.178 , Issue.7 , pp. 4080-4088
    • Krawczyk, C.M.1    Shen, H.2    Pearce, E.J.3
  • 43
    • 34247184208 scopus 로고    scopus 로고
    • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
    • DOI 10.1091/mbc.E06-07-0593
    • Wieman, H. L., J. A. Wofford, and J. C. Rathmell. 2007. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol. Biol. Cell 18: 1437-1446. (Pubitemid 46626638)
    • (2007) Molecular Biology of the Cell , vol.18 , Issue.4 , pp. 1437-1446
    • Wieman, H.L.1    Wofford, J.A.2    Rathmell, J.C.3
  • 44
    • 0035853833 scopus 로고    scopus 로고
    • Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
    • Plas, D. R., S. Talapatra, A. L. Edinger, J. C. Rathmell, and C. B. Thompson. 2001. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem. 276: 12041-12048.
    • (2001) J. Biol. Chem. , vol.276 , pp. 12041-12048
    • Plas, D.R.1    Talapatra, S.2    Edinger, A.L.3    Rathmell, J.C.4    Thompson, C.B.5
  • 45
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford, D. B., and R. J. Shaw. 2009. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer 9: 563-575.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 46
    • 55249114228 scopus 로고    scopus 로고
    • Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
    • Cham, C. M., G. Driessens, J. P. O'Keefe, and T. F. Gajewski. 2008. Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells. Eur. J. Immunol. 38: 2438-2450.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 2438-2450
    • Cham, C.M.1    Driessens, G.2    O'Keefe, J.P.3    Gajewski, T.F.4
  • 47
    • 28844433635 scopus 로고    scopus 로고
    • Medicine: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • DOI 10.1126/science.1120781
    • Shaw, R. J., K. A. Lamia, D. Vasquez, S. H. Koo, N. Bardeesy, R. A. Depinho, M. Montminy, and L. C. Cantley. 2005. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646. (Pubitemid 41780780)
    • (2005) Science , vol.310 , Issue.5754 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.-H.4    Bardeesy, N.5    DePinho, R.A.6    Montminy, M.7    Cantley, L.C.8
  • 53
    • 70249143637 scopus 로고    scopus 로고
    • Homeostatic proliferation and survival of naïve and memory T cells
    • Boyman, O., S. Létourneau, C. Krieg, and J. Sprent. 2009. Homeostatic proliferation and survival of naïve and memory T cells. Eur. J. Immunol. 39: 2088-2094.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2088-2094
    • Boyman, O.1    Létourneau, S.2    Krieg, C.3    Sprent, J.4
  • 54
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naive and memory T cells
    • Surh, C. D., and J. Sprent. 2008. Homeostasis of naive and memory T cells. Immunity 29: 848-862.
    • (2008) Immunity , vol.29 , pp. 848-862
    • Surh, C.D.1    Sprent, J.2
  • 55
    • 80051997049 scopus 로고    scopus 로고
    • The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
    • Yang, K., G. Neale, D. R. Green, W. He, and H. Chi. 2011. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat. Immunol. 12: 888-897.
    • (2011) Nat. Immunol. , vol.12 , pp. 888-897
    • Yang, K.1    Neale, G.2    Green, D.R.3    He, W.4    Chi, H.5
  • 56
    • 80051617288 scopus 로고    scopus 로고
    • The tuberous sclerosis complex-Mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells
    • Wu, Q., Y. Liu, C. Chen, T. Ikenoue, Y. Qiao, C. S. Li, W. Li, K. L. Guan, and P. Zheng. 2011. The tuberous sclerosis complex-Mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J. Immunol. 187: 1106-1112.
    • (2011) J. Immunol. , vol.187 , pp. 1106-1112
    • Wu, Q.1    Liu, Y.2    Chen, C.3    Ikenoue, T.4    Qiao, Y.5    Li, C.S.6    Li, W.7    Guan, K.L.8    Zheng, P.9
  • 58
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag, D., D. Carling, R. D. Stout, and J. Suttles. 2008. Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J. Immunol. 181: 8633-8641.
    • (2008) J. Immunol. , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 59
    • 21244437079 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide ribonucleoside: A novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis
    • Nath, N., S. Giri, R. Prasad, M. L. Salem, A. K. Singh, and I. Singh. 2005. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis. J. Immunol. 175: 566-574. (Pubitemid 40884363)
    • (2005) Journal of Immunology , vol.175 , Issue.1 , pp. 566-574
    • Nath, N.1    Giri, S.2    Prasad, R.3    Salem, M.L.4    Singh, A.K.5    Singh, I.6
  • 60
    • 79956132815 scopus 로고    scopus 로고
    • LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection
    • Cao, Y., H. Li, H. Liu, M. Zhang, Z. Hua, H. Ji, and X. Liu. 2011. LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection. EMBO J. 30: 2083-2093.
    • (2011) EMBO J. , vol.30 , pp. 2083-2093
    • Cao, Y.1    Li, H.2    Liu, H.3    Zhang, M.4    Hua, Z.5    Ji, H.6    Liu, X.7
  • 61
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
    • DOI 10.1016/j.cmet.2005.05.009, PII S155041310500166X
    • Hawley, S. A., D. A. Pan, K. J. Mustard, L. Ross, J. Bain, A. M. Edelman, B. G. Frenguelli, and D. G. Hardie. 2005. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2: 9-19. (Pubitemid 43239821)
    • (2005) Cell Metabolism , vol.2 , Issue.1 , pp. 9-19
    • Hawley, S.A.1    Pan, D.A.2    Mustard, K.J.3    Ross, L.4    Bain, J.5    Edelman, A.M.6    Frenguelli, B.G.7    Hardie, D.G.8
  • 62
    • 23044437445 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
    • DOI 10.1016/j.cmet.2005.06.005, PII S1550413105001701
    • Woods, A., K. Dickerson, R. Heath, S. P. Hong, M. Momcilovic, S. R. Johnstone, M. Carlson, and D. Carling. 2005. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2: 21-33. (Pubitemid 43239822)
    • (2005) Cell Metabolism , vol.2 , Issue.1 , pp. 21-33
    • Woods, A.1    Dickerson, K.2    Heath, R.3    Hong, S.-P.4    Momcilovic, M.5    Johnstone, S.R.6    Carlson, M.7    Carling, D.8
  • 63
    • 54249141095 scopus 로고    scopus 로고
    • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
    • Maciver, N. J., S. R. Jacobs, H. L. Wieman, J. A. Wofford, J. L. Coloff, and J. C. Rathmell. 2008. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J. Leukoc. Biol. 84: 949-957.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 949-957
    • Maciver, N.J.1    Jacobs, S.R.2    Wieman, H.L.3    Wofford, J.A.4    Coloff, J.L.5    Rathmell, J.C.6
  • 64
    • 77951639702 scopus 로고    scopus 로고
    • IL-7 is essential for homeostatic control of T cell metabolism in vivo
    • Jacobs, S. R., R. D. Michalek, and J. C. Rathmell. 2010. IL-7 is essential for homeostatic control of T cell metabolism in vivo. J. Immunol. 184: 3461-3469.
    • (2010) J. Immunol. , vol.184 , pp. 3461-3469
    • Jacobs, S.R.1    Michalek, R.D.2    Rathmell, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.