Preferential generation of follicular B helper T cells from Foxp3 + T cells in gut Peyer's patches

Science

Volumn 323, Issue 5920, 2009, Pages 1488-1492

  Tsuji, Masayuki ^a   Komatsu, Noriko ^a   Kawamoto, Shimpei ^a,c   Suzuki, Keiichiro ^a   Kanagawa, Osami ^b   Honjo, Tasuku ^c   Hori, Shohei ^a   Fagarasan, Sidonia ^a  

^a RIKEN   (Japan)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

BLOOD; PROTEIN; RODENT;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL INTERACTION; CELL LINE; CONTROLLED STUDY; HELPER CELL; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD40; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DENDRITIC CELLS; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; GERMINAL CENTER; IMMUNOGLOBULIN A, SECRETORY; INTESTINE, SMALL; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; PEYER'S PATCHES; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 62449202866     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1169152     Document Type: Article

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31. We thank Y. Doi, A. Yagisawa, T. Miyao, and H. Fujimoto for technical assistance; B. Malissen and K. Itoh for mice; D. Littman and A. Coutinho for inspiring discussions; I. Taniuchi for discussion and for critically reading of the manuscript. This work is supported in part by Grants-in-Aid for Scientific Research in Priority Areas (S.F., S.H.) and for Young Scientists (A) (S.H.), and by the Uehara Memorial Foundation (S.H.). S.H. and S.F. contributed as senior authors.