Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 901-913

  Murphy, Erin ^a   Shibuya, Kazuko ^a   Hosken, Nancy ^a   Openshaw, Peter ^b   Maino, Vernon ^c   Davis, Kenneth ^c   Murphy, Kenneth ^d   O'Garra, Anne ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c BD Technologies   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 4 ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CELL CLONING; CONTROLLED STUDY; FEMALE; HELPER CELL; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; LONG TERM POTENTIATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ALLERGENS; ANIMALS; ANTIGEN-PRESENTING CELLS; AUTOANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CLONE CELLS; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; TIME FACTORS;

EID: 0029965236     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.901     Document Type: Article

References (68)

1. Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348-2357.
2. Mosmann, T.R , and R.L. Coffman. 1989. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv. Immunol. 46:111-147.
3. Sher, A., and R.L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385-409.
4. H2 subsets: doubt no more. Immunol. Today. 12:256-257.
5. Parronchi, P., D. Macchia, M.-P. Piccinni, P. Biswas, C. Simonelli, E. Maggi, M. Ricci, A.A. Ansari, and S. Romagnani. 1991. Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc. Natl. Acad. Sci. USA. 88:4538-4542.
6. Yssel, H., K.E. Johnson, P. Schneider, J. Wideman, A. Terr, R. Kastelein., and J.E. de Vries. 1992. T cell activation epitopes of the house dust mite allergen Der p I. J. Immunol. 148:738-745.
7. Fiorentino, D.F., M.W. Bond, and T.R. Mosmann. 1989. Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081-2095.
8. Fiorentino, D.F., A. Zlotnik, P. Vieira, T.R. Mosmann, M. Howard, K.W. Moore, and A. O'Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146:3444-3451.
9. de Waal Malefyt, R., J. Haanen, H. Yssel, M.-G. Roncarolo, A. te Velde, C. Figdor, K. Johnson, R. Kastelein, H. Spits, and J.E. de Vries. 1991. IL-10 and v-IL-10 strongly reduce antigen-specific human T cell responses by diminishing the antigen presenting capacity of monocytes via downregularion of class II MHC expression. J. Exp. Med. 174:915-924.
10. Hsieh, C.-S., A.B. Heimberger, J.S. Gold, A. O'Garra, and K. Murphy. 1992. Differential regulation of T helper phenotype development by IL-4 and IL-10 in an αβ-transgenic system. Proc. Natl. Acad. Sci. USA. 89:6065-6069.
11. Powrie, F., and R. Coffman. 1993. IL-4 and IL-10 inhibit DTH and IFN-γ production. Eur. J. Immunol. 23:2223-2229.
12. + T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177: 627-636.
13. O'Garra, A., and K. Murphy. 1993. T-cell subsets in autoimmunity. Curr. Opin. Immunol. 5:880-886.
14. Powrie, F., and R.L. Coffman. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol. Today. 14:270-274.
15. Swain, S.L. 1993. IL-4 dictates T-cell differentiation. Res. Immunol. 144:567-651.
16. + T cells through IL-12 produced by Listeria-induced macrophages. Science (Wash. DC). 260:547-549.
17. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
18. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA. 90:10188-10192.
19. Manetti, R., P. Parronchi, M.G. Guidizi, M.-P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing cells. J. Exp. Med. 177:1199-1204.
20. Sadick, M.D., F.P. Heinzel, B.J. Holaday, R.T. Pu, R.S. Dawkins, and R.M. Locksley. 1990. Cure of leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon γ-independent mechanism. J. Exp. Med. 171:115-127.
21. Chatelain, R., K. Varkila, and R.L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182-1187.
22. Murphy, E.E., G. Terres, S.E. Macatonia, C.-S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper cell 1 clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223-233.
23. Manetti, R., F. Gerosa, M.G. Giudici, R. Biagotti, P. Parronchi, M.-P. Piccinni, S. Sampognaro, E. Maggj, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179: 1273-1283.
24. Kubin, M., M. Kamoun, and G. Trinchieri. 1994. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211-222.
25. Sypek, J.P., C.L. Chung, S.E.H. Mayor, J.M. Subramanyam, S.J. Goldman, D.S. Sieburth, S.E. Wolf, and R.G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797-1802.
26. Heinzel, F.P., D.S. Schoenhaut, R.M. Rerko, L.E. Rosser, and M.K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505-1509.
27. Afonso, L.C.C., T.M. Scharton, L.Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science (Wash. DC). 263:235-237.
28. Nabors, G.S., L.C.C. Afonso, J.P. Farrell, and P. Scott. 1995. Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and pentostam. Proc. Natl. Acad. Sci. USA. 92:3142-3146.
29. Correa-Oliveira, R., K. Varkila, and R.L. Coffman. 1995. The adoptive transfer of Leishmania-specific Th1 and Th2 responses can be regulated by IL-4 and IFN-γ. Eur. J. Immunol. In press.
30. Holaday, B.J., M.D. Sadick, Z.E. Wang, S.L. Reiner, F.P. Heinzel, T.G. Parslow, and R.M. Locksley. 1991. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J. Immunol. 147:1653-1658.
31. Mocci, S., and R.L. Coffman. 1995. The induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture. J. Immunol. 154:3779-3787.
32. Parronchi, P., M. De Carli, R. Manetti, C. Simonelli, S. Sampognaro, M.-P. Piccinni, D. Macchia, E. Maggi, G. Del Prete, and S. Romagnani. 1992. IL-4 and IFN (α and γ) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. J. Immunol. 149:2977-2983.
33. Perez, V.L., J.A. Lederer, A.H. Lichtman, and A.K. Abbas. 1995. Stability of Th1 and Th2 populations. Int. Immunol. 7: 869-875.
34. Szabo, S.J., N.G. Jacobson, A.S. Dighe, U. Gubler, and K.M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 Signaling. Immunity. 2:665-675.
35. Openshaw, P., E. Murphy, N.A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182: 1357-1367.
36. + TCR-lo thymocytes in vivo. Science (Wash. DC). 250:1720-1722.
37. Marrack, P., R. Shimonkevitz, C. Hannum, K. Haskins, and J. Kappler. 1983. The major histocompatibility complex-restricted antigen receptor on T cells. J. Exp. Med. 158:1635-1646.
38. Haskins, K., R. Kobo, J. White, M. Pigeon, J. Kappler, and P. Marrack. 1983. The MHC-restricted antigen on T cells. i. Isolation of a monoclonal antibody. J. Exp. Med. 157:1149-1169.
39. Cherwinski, H.M., J.H. Schumacher, K.D. Brown, and T.R. Mosmann. 1987. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166:1229-1244.
40. Tony, H.P., and D.C. Parker. 1985. Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of antiimmunoglobulin presented by small B lymphocytes. J. Exp. Med. 161:223-241.
41. + T cells from TCR-α/β transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int. Immunol. 5: 1119-1128.
42. Abrams, J. 1995. Immunometric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. Current Protocols in Immunology. 13:6.1-15.
43. Abrams, J.S., M.-G. Roncarolo, H. Yssel, U. Andersson, G.J. Gleich, and J.E. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol. Rev. 127:5-24.
44. Schoenhaut, D.S., A.O. Chua, A.G. Wolitzky, P.M. Quinn, C.M. Dwyer, W. McComas, P.C. Familletti, M.K. Gately, and U. Gubler. 1992. Cloning and expression of IL-12. J Immunol. 148:3433-3440.
45. Ohara, J., and W.E. Paul. 1985. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature (Lond.). 315:333-336.
46. Slade, S.J., and J. Langhorne. 1989. Production of interferon-gamma during infection of mice with Plasmodium chabaudi chabaudi. Immunobiology. 179:353-365.
47. Assenmacher, M., J. Schmitz, and A. Radbruch. 1994. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells. Eur. J. Immunol. 24:1097-1101.
48. Ferrick, D.A., M.D. Schrenzel, T. Mulvania, B. Hsieh, W.G. Ferlin, and H. Lepper. 1995. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo. Nature (Lond.). 373: 255-257.
49. Picker, L.J., M.K. Singh, Z. Zdraveski, J.R. Treer, S.L. Waldrop, P.R. Bergstresser, and V.C. Maino. 1995. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood. 86:1408-1419.
50. Bucy, R.P., A. Panoskaltsis-Mortari, G.-q. Huang, J. Li, L. Karr, M. Ross, J.H. Russell, K.M. Murphy, and C.T. Weaver. 1994. Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J. Exp. Med. 180:1251-1262.
51. + cell subset with an unrestricted cytokine profile. J. Immunol. 143:518-525.
52. Kelso, A., and N.M. Gough. 1988. Coexpression of granulocyte-macrophage colony-stimulating factor, γ interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones. Proc. Natl. Acad. Sci. USA. 85:9189-9193.
53. - lymphocyte population. J. Immunol. 154: 4294-4301.
54. Heinzel, F.P., M.D. Sadick, B.J. Holaday, R.L. Coffman, and R.M. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis. J. Exp. Med. 169:59-72.
55. Belosevic, M., D.S. Finbloom, P.H.V.D. Meide, M.V. Slayter, and C.A. Nacy. 1989. Administration of monoclonal anti-IFN-γ antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266-274.
56. Scott, P. 1991. IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of leishmaniasis. J. Immunol. 147:3149-3155.
57. Kamogawa, Y., L.E. Minasi, S.R. Carding, K. Bottomly, and R.A. Flavell. 1993. The relationship of IL-4 and IFN-γ-producing T cells studied by lineage ablation of IL-4 producing cells. Cell. 75:985-995.
58. Scott, P., P. Natovitz, R.L. Coffman, E. Pearce, and A. Sher. 1988. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 168:1675-1684.
59. Carvalho, E.M., R. Badaro, S.G. Reed, T.C. Jones, and W.D. Johnson, Jr. 1985. Absence of γ interferon and interleukin 2 production during active visceral leishmaniasis. J. Clin. Invest. 76:2066-2069.
60. Howard, J.G., C. Hale, and F.Y. Liew. 1980. Genetically determined susceptibility to Leishmania tropica infection is expressed by hemopoietic donor cells in mouse radiation chimeras. Nature (Lond.). 288:161-162.
61. Salgame, P., J.S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R.J. Modlin, and B.R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science (Wash. DC). 254:279-282.
62. Yamamura, M., K. Uyemura, R.J. Deans, K. Weinberg, T.H. Rea, B.R. Bloom, and R.L. Modlin. 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science (Wash. DC). 254:277-279.
63. Pearce, E.J., P. Caspar, J.-M. Grzych, F.A. Lewis, and A. Sher. 1991. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 173:159-166.
64. Alwan, W.H., W.J. Kozlowska, and P.J.M. Openshaw. 1994. Distinct types of lung disease caused by functional subsets of antiviral T cells. J. Exp. Med. 179:81-89.
65. Ando, D.G., J. Clayton, D. Kong, J.L. Urban, and J.L. Sercarz. 1989. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 124:132-143.
66. Powell, M.B., D. Mitchell, J. Lederman, J. Buckmeier, S.S. Zamvil, M. Graham, N.H. Ruddle, and L. Steinman. 1990. Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int. Immunol. 2:539-544
67. Khoury, S.J., W.W. Hancock, and H.L. Weiner. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med. 176: 1355-1364.
68. Katz, J.D., C. Benoist, and D. Mathis. 1995. T helper cell subsets in insulin-dependent diabetes. Science (Wash. DC). 268: 1185-1188.