메뉴 건너뛰기




Volumn 16, Issue 12, 2015, Pages 30269-30308

Oxidative stress and inflammation in hepatic diseases: Therapeutic possibilities of N-acetylcysteine

Author keywords

Anti inflammatory; Antioxidant; Biomarkers; Hepatic injury; Liver; N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; CATALASE; GAMMA INTERFERON; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID PEROXIDE; LIPOPOLYSACCHARIDE; LIPOXYGENASE; MALONALDEHYDE; MYELOPEROXIDASE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA; XANTHINE OXIDASE; BIOLOGICAL MARKER;

EID: 84951002164     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms161226225     Document Type: Review
Times cited : (190)

References (257)
  • 1
    • 84920733357 scopus 로고    scopus 로고
    • An overview of effective therapies and recent advances in biomarkers for chronic liver diseases and associated liver cancer
    • [CrossRef] [PubMed]
    • Chatterjee, R.; Mitra, A. An overview of effective therapies and recent advances in biomarkers for chronic liver diseases and associated liver cancer. Int. Immunopharmacol. 2015, 24, 335-345. [CrossRef] [PubMed].
    • (2015) Int. Immunopharmacol , vol.24 , pp. 335-345
    • Chatterjee, R.1    Mitra, A.2
  • 2
    • 84886289571 scopus 로고    scopus 로고
    • Liver auto-immunology: The paradox of autoimmunity in a tolerogenic organ
    • [CrossRef] [PubMed]
    • Invernizzi, P. Liver auto-immunology: The paradox of autoimmunity in a tolerogenic organ. J. Autoimmun. 2013, 46, 1-6. [CrossRef] [PubMed].
    • (2013) J. Autoimmun , vol.46 , pp. 1-6
    • Invernizzi, P.1
  • 3
    • 84937523554 scopus 로고    scopus 로고
    • MicroRNAs in liver tissue engineering-New promises for failing organs
    • [CrossRef] [PubMed]
    • Raschzok, N.; Sallmon, H.; Pratschke, J.; Sauer, I.M. MicroRNAs in liver tissue engineering-New promises for failing organs. Adv. Drug Deliv. Rev. 2015, 88, 67-77. [CrossRef] [PubMed].
    • (2015) Adv. Drug Deliv. Rev , vol.88 , pp. 67-77
    • Raschzok, N.1    Sallmon, H.2    Pratschke, J.3    Sauer, I.M.4
  • 4
    • 84927637736 scopus 로고    scopus 로고
    • Clinical aspects of hepatic disease
    • [CrossRef]
    • Leung, C.C.H.; Young, K.K. Clinical aspects of hepatic disease. Anaesth. Intensive Care Med. 2015, 16, 11-13. [CrossRef].
    • (2015) Anaesth. Intensive Care Med , vol.16 , pp. 11-13
    • Leung, C.C.H.1    Young, K.K.2
  • 5
    • 84887318014 scopus 로고    scopus 로고
    • The Gordian Knot of dysbiosis, obesity and NAFLD
    • [CrossRef] [PubMed]
    • Mehal,W.Z. The Gordian Knot of dysbiosis, obesity and NAFLD. Nat. Rev. Gastroenterol. Hepatol. 2013, 10, 637-644. [CrossRef] [PubMed].
    • (2013) Nat. Rev. Gastroenterol. Hepatol , vol.10 , pp. 637-644
    • Mehal, W.Z.1
  • 6
    • 84936775786 scopus 로고    scopus 로고
    • Epigenetic modifications by histone deacetylases: Biological implications and therapeutic potential in liver fibrosis
    • [CrossRef] [PubMed]
    • Chen, P.J.; Huang, C.; Meng, X.M.; Li, J. Epigenetic modifications by histone deacetylases: Biological implications and therapeutic potential in liver fibrosis. Biochimie 2015, 116, 61-69. [CrossRef] [PubMed].
    • (2015) Biochimie , vol.116 , pp. 61-69
    • Chen, P.J.1    Huang, C.2    Meng, X.M.3    Li, J.4
  • 7
    • 84923054566 scopus 로고    scopus 로고
    • Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis
    • [CrossRef] [PubMed]
    • Duval, F.; Moreno-Cuevas, J.E.; Gonzalez-Garza, M.T.; Rodriguez-Montalvo, C.; Cruz-Vega, D.E. Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis. Chin. Med. 2014, 9, 27. [CrossRef] [PubMed].
    • (2014) Chin. Med , vol.9 , pp. 27
    • Duval, F.1    Moreno-Cuevas, J.E.2    Gonzalez-Garza, M.T.3    Rodriguez-Montalvo, C.4    Cruz-Vega, D.E.5
  • 8
    • 79953036451 scopus 로고    scopus 로고
    • Nitric oxide and redox regulation in the liver: Part II. Redox biology in pathologic hepatocytes and implications for intervention
    • [CrossRef] [PubMed]
    • Diesen, D.L.; Kuo, P.C. Nitric oxide and redox regulation in the liver: Part II. Redox biology in pathologic hepatocytes and implications for intervention. J. Surg. Res. 2011, 167, 96-112. [CrossRef] [PubMed].
    • (2011) J. Surg. Res , vol.167 , pp. 96-112
    • Diesen, D.L.1    Kuo, P.C.2
  • 9
    • 84885093994 scopus 로고    scopus 로고
    • Development of nonalcoholic hepatopathy: Contributions of oxidative stress and advanced glycation end products
    • [CrossRef] [PubMed]
    • Santos, J.C.; Valentim, I.B.; de Araujo, O.R.; Ataide Tda, R.; Goulart, M.O. Development of nonalcoholic hepatopathy: Contributions of oxidative stress and advanced glycation end products. Int. J. Mol. Sci. 2013, 14, 19846-19866. [CrossRef] [PubMed].
    • (2013) Int. J. Mol. Sci , vol.14 , pp. 19846-19866
    • Santos, J.C.1    Valentim, I.B.2    de Araujo, O.R.3    Ataide Tda, R.4    Goulart, M.O.5
  • 10
    • 80052707667 scopus 로고    scopus 로고
    • Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches
    • [CrossRef] [PubMed]
    • Mormone, E.; George, J.; Nieto, N. Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches. Chem. Biol. Interact. 2011, 193, 225-231. [CrossRef] [PubMed].
    • (2011) Chem. Biol. Interact , vol.193 , pp. 225-231
    • Mormone, E.1    George, J.2    Nieto, N.3
  • 12
    • 84929152649 scopus 로고    scopus 로고
    • The role of antioxidants in the chemistry of oxidative stress: A review
    • [CrossRef] [PubMed]
    • Pisoschi, A.M.; Pop, A. The role of antioxidants in the chemistry of oxidative stress: A review. Eur. J. Med. Chem. 2015, 97, 55-74. [CrossRef] [PubMed].
    • (2015) Eur. J. Med. Chem , vol.97 , pp. 55-74
    • Pisoschi, A.M.1    Pop, A.2
  • 13
    • 78049465541 scopus 로고    scopus 로고
    • Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis
    • [CrossRef] [PubMed]
    • Chen, Y.; Johansson, E.; Yang, Y.; Miller, M.L.; Shen, D.; Orlicky, D.J.; Shertzer, H.G.; Vasiliou, V.; Nebert, D.W.; Dalton, T.P. Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis. J. Hepatol. 2010, 53, 1085-1094. [CrossRef] [PubMed].
    • (2010) J. Hepatol , vol.53 , pp. 1085-1094
    • Chen, Y.1    Johansson, E.2    Yang, Y.3    Miller, M.L.4    Shen, D.5    Orlicky, D.J.6    Shertzer, H.G.7    Vasiliou, V.8    Nebert, D.W.9    Dalton, T.P.10
  • 14
    • 84881527586 scopus 로고    scopus 로고
    • Glutathione defense mechanism in liver injury: Insights from animal models
    • [CrossRef] [PubMed]
    • Chen, Y.; Dong, H.; Thompson, D.C.; Shertzer, H.G.; Nebert, D.W.; Vasiliou, V. Glutathione defense mechanism in liver injury: Insights from animal models. Food Chem. Toxicol. 2013, 60, 38-44. [CrossRef] [PubMed].
    • (2013) Food Chem. Toxicol , vol.60 , pp. 38-44
    • Chen, Y.1    Dong, H.2    Thompson, D.C.3    Shertzer, H.G.4    Nebert, D.W.5    Vasiliou, V.6
  • 15
    • 33646382125 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis. 3. Oxidative stress and NASH
    • [CrossRef] [PubMed]
    • Okanoue, T.; Mitsuyoshi, H. Non-alcoholic steatohepatitis. 3. Oxidative stress and NASH. Nihon Naika Gakkai Zasshi 2006, 95, 51-56. [CrossRef] [PubMed].
    • (2006) Nihon Naika Gakkai Zasshi , vol.95 , pp. 51-56
    • Okanoue, T.1    Mitsuyoshi, H.2
  • 17
    • 44349104572 scopus 로고    scopus 로고
    • The Antioxidant Role of Glutathione and N-acetylcysteine Supplements and Exercise-Induced Oxidative Stress
    • [CrossRef] [PubMed]
    • Kerksick, C.;Willoughby, D. The Antioxidant Role of Glutathione and N-acetylcysteine Supplements and Exercise-Induced Oxidative Stress. J. Int. Soc. Sports Nutr. 2005, 9, 38-44. [CrossRef] [PubMed].
    • (2005) J. Int. Soc. Sports Nutr , vol.9 , pp. 38-44
    • Kerksick, C.1    Willoughby, D.2
  • 18
    • 84945956734 scopus 로고    scopus 로고
    • Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?
    • [CrossRef] [PubMed]
    • Moura, F.A.; de Andrade, K.Q.; Dos Santos, J.C.; Araujo, O.R.; Goulart, M.O. Antioxidant therapy for treatment of inflammatory bowel disease: Does it work? Redox Biol. 2015, 6, 617-639. [CrossRef] [PubMed].
    • (2015) Redox Biol , vol.6 , pp. 617-639
    • Moura, F.A.1    de Andrade, K.Q.2    Dos Santos, J.C.3    Araujo, O.R.4    Goulart, M.O.5
  • 19
    • 76749140795 scopus 로고    scopus 로고
    • Protective effects of N-acetylcysteine on the liver of brain-dead Ba-Ma mini pig
    • [CrossRef] [PubMed]
    • Li, J.; Zhang, S.; Wu, Y.; Guo, W.; Zhang, Y.; Zhai, W. Protective effects of N-acetylcysteine on the liver of brain-dead Ba-Ma mini pig. Transplant. Proc. 2010, 42, 195-199. [CrossRef] [PubMed].
    • (2010) Transplant. Proc , vol.42 , pp. 195-199
    • Li, J.1    Zhang, S.2    Wu, Y.3    Guo, W.4    Zhang, Y.5    Zhai, W.6
  • 22
    • 34648813720 scopus 로고    scopus 로고
    • ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
    • [CrossRef] [PubMed]
    • D'Autreaux, B.; Toledano, M.B. ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis. Nat. Rev. Mol. Cell. Biol. 2007, 8, 813-824. [CrossRef] [PubMed].
    • (2007) Nat. Rev. Mol. Cell. Biol , vol.8 , pp. 813-824
    • D'Autreaux, B.1    Toledano, M.B.2
  • 24
    • 84872422812 scopus 로고    scopus 로고
    • Alterations in the redox state and liver damage: Hints from the EASL Basic School of Hepatology
    • [CrossRef] [PubMed]
    • Tell, G.; Vascotto, C.; Tiribelli, C. Alterations in the redox state and liver damage: Hints from the EASL Basic School of Hepatology. J. Hepatol. 2013, 58, 365-374. [CrossRef] [PubMed].
    • (2013) J. Hepatol , vol.58 , pp. 365-374
    • Tell, G.1    Vascotto, C.2    Tiribelli, C.3
  • 25
    • 0742288763 scopus 로고    scopus 로고
    • Metabolic, antioxidant, nutraceutical, probiotic, and herbal therapies relating to the management of hepatobiliary disorders
    • [CrossRef]
    • Center, S.A. Metabolic, antioxidant, nutraceutical, probiotic, and herbal therapies relating to the management of hepatobiliary disorders. Vet. Clin. N. Am. Small Anim. Pract. 2004, 34, 67-172. [CrossRef].
    • (2004) Vet. Clin. N. Am. Small Anim. Pract , vol.34 , pp. 67-172
    • Center, S.A.1
  • 26
    • 84887034371 scopus 로고    scopus 로고
    • Biological markers of oxidative stress: Applications to cardiovascular research and practice
    • [CrossRef] [PubMed]
    • Ho, E.; Karimi Galougahi, K.; Liu, C.C.; Bhindi, R.; Figtree, G.A. Biological markers of oxidative stress: Applications to cardiovascular research and practice. Redox Biol. 2013, 1, 483-491. [CrossRef] [PubMed].
    • (2013) Redox Biol , vol.1 , pp. 483-491
    • Ho, E.1    Karimi Galougahi, K.2    Liu, C.C.3    Bhindi, R.4    Figtree, G.A.5
  • 27
    • 0033044679 scopus 로고    scopus 로고
    • The relative importance of HO. And ONOO-in mediating the toxicity of O
    • [PubMed]
    • Liochev, S.I.; Fridovich, I. The relative importance of HO. and ONOO-in mediating the toxicity of O. Free Radic. Biol. Med. 1999, 26, 777-778. [PubMed].
    • (1999) Free Radic. Biol. Med , vol.26 , pp. 777-778
    • Liochev, S.I.1    Fridovich, I.2
  • 28
    • 84655169624 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    • [CrossRef] [PubMed]
    • Rolo, A.P.; Teodoro, J.S.; Palmeira, C.M. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic. Biol. Med. 2012, 52, 59-69. [CrossRef] [PubMed].
    • (2012) Free Radic. Biol. Med , vol.52 , pp. 59-69
    • Rolo, A.P.1    Teodoro, J.S.2    Palmeira, C.M.3
  • 29
    • 79952667726 scopus 로고    scopus 로고
    • Relações patofisiológicas entre estresse oxidativo e arteriosclerose
    • [CrossRef]
    • Silva, D.C.; Cerchiaro, G.; Honório, K.M. Relações patofisiológicas entre estresse oxidativo e arteriosclerose. Quim. Nova 2011, 34, 300-305. [CrossRef].
    • (2011) Quim. Nova , vol.34 , pp. 300-305
    • Silva, D.C.1    Cerchiaro, G.2    Honório, K.M.3
  • 33
    • 84884520213 scopus 로고    scopus 로고
    • Free radical biology for medicine: Learning from nonalcoholic fatty liver disease
    • [CrossRef] [PubMed]
    • Serviddio, G.; Bellanti, F.; Vendemiale, G. Free radical biology for medicine: Learning from nonalcoholic fatty liver disease. Free Radic. Biol. Med. 2013, 65, 952-968. [CrossRef] [PubMed].
    • (2013) Free Radic. Biol. Med , vol.65 , pp. 952-968
    • Serviddio, G.1    Bellanti, F.2    Vendemiale, G.3
  • 34
    • 36148931348 scopus 로고    scopus 로고
    • Espécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: Principais métodos analíticos para sua determinação
    • [CrossRef]
    • Vasconcelos, S.M.L.; Goulart, M.O.F.; Moura, J.B.F.; Manfredini, V.; Benfato, M.S.; Kubota, L.T. Espécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: Principais métodos analíticos para sua determinação. Quím. Nova 2007, 30, 1323-1338. [CrossRef].
    • (2007) Quím. Nova , vol.30 , pp. 1323-1338
    • Vasconcelos, S.M.L.1    Goulart, M.O.F.2    Moura, J.B.F.3    Manfredini, V.4    Benfato, M.S.5    Kubota, L.T.6
  • 35
    • 84885189573 scopus 로고    scopus 로고
    • Mechanisms of liver involvement in systemic disease
    • [CrossRef] [PubMed]
    • Edwards, L.; Wanless, I.R. Mechanisms of liver involvement in systemic disease. Best Pract. Res. Clin. Gastroenterol. 2013, 27, 471-483. [CrossRef] [PubMed].
    • (2013) Best Pract. Res. Clin. Gastroenterol , vol.27 , pp. 471-483
    • Edwards, L.1    Wanless, I.R.2
  • 37
    • 84902668983 scopus 로고    scopus 로고
    • Pathogenesis of liver cirrhosis
    • [CrossRef] [PubMed]
    • Zhou, W.C.; Zhang, Q.B.; Qiao, L. Pathogenesis of liver cirrhosis. World J. Gastroenterol. 2014, 20, 7312-7324. [CrossRef] [PubMed].
    • (2014) World J. Gastroenterol , vol.20 , pp. 7312-7324
    • Zhou, W.C.1    Zhang, Q.B.2    Qiao, L.3
  • 38
    • 67349205002 scopus 로고    scopus 로고
    • Kupffer cells in non-alcoholic fatty liver disease: The emerging view
    • [CrossRef] [PubMed]
    • Baffy, G. Kupffer cells in non-alcoholic fatty liver disease: The emerging view. J. Hepatol. 2009, 51, 212-223. [CrossRef] [PubMed].
    • (2009) J. Hepatol , vol.51 , pp. 212-223
    • Baffy, G.1
  • 39
    • 84987802508 scopus 로고    scopus 로고
    • Role of toll-like receptors in immune activation and tolerance in the liver
    • [CrossRef] [PubMed]
    • Nakamoto, N.; Kanai, T. Role of toll-like receptors in immune activation and tolerance in the liver. Front. Immunol. 2014, 5, 221. [CrossRef] [PubMed].
    • (2014) Front. Immunol , vol.5 , pp. 221
    • Nakamoto, N.1    Kanai, T.2
  • 40
    • 84877828545 scopus 로고    scopus 로고
    • The chemistry and biological activities of N-acetylcysteine
    • [CrossRef] [PubMed]
    • Samuni, Y.; Goldstein, S.; Dean, O.M.; Berk, M. The chemistry and biological activities of N-acetylcysteine. Biochim. Biophys. Acta 2013, 1830, 4117-4129. [CrossRef] [PubMed].
    • (2013) Biochim. Biophys. Acta , vol.1830 , pp. 4117-4129
    • Samuni, Y.1    Goldstein, S.2    Dean, O.M.3    Berk, M.4
  • 41
    • 0035996583 scopus 로고    scopus 로고
    • Oxygen homeostas is, thiol equilibrium and redox regulation of signalling transcription factors in the alveolar epithelium
    • [CrossRef]
    • Haddad, J.J. Oxygen homeostas is, thiol equilibrium and redox regulation of signalling transcription factors in the alveolar epithelium. Cell Signal. 2002, 14, 799-810. [CrossRef].
    • (2002) Cell Signal , vol.14 , pp. 799-810
    • Haddad, J.J.1
  • 42
    • 78349265397 scopus 로고    scopus 로고
    • Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation
    • [CrossRef] [PubMed]
    • Bhogal, R.H.; Curbishley, S.M.; Weston, C.J.; Adams, D.H.; Afford, S.C. Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation. Liver Transpl. 2010, 16, 1303-1313. [CrossRef] [PubMed].
    • (2010) Liver Transpl , vol.16 , pp. 1303-1313
    • Bhogal, R.H.1    Curbishley, S.M.2    Weston, C.J.3    Adams, D.H.4    Afford, S.C.5
  • 43
    • 84896826716 scopus 로고    scopus 로고
    • Hepatic inflammation and progressive liver fibrosis in chronic liver disease
    • [CrossRef] [PubMed]
    • Czaja, A.J. Hepatic inflammation and progressive liver fibrosis in chronic liver disease. World J. Gastroenterol. 2014, 20, 2515-2532. [CrossRef] [PubMed].
    • (2014) World J. Gastroenterol , vol.20 , pp. 2515-2532
    • Czaja, A.J.1
  • 45
    • 78049370987 scopus 로고    scopus 로고
    • Oxidative stress, inflammation, and cancer: How are they linked?
    • [CrossRef] [PubMed]
    • Reuter, S.; Gupta, S.C.; Chaturvedi, M.M.; Aggarwal, B.B. Oxidative stress, inflammation, and cancer: How are they linked? Free Radic. Biol. Med. 2010, 49, 1603-1616. [CrossRef] [PubMed].
    • (2010) Free Radic. Biol. Med , vol.49 , pp. 1603-1616
    • Reuter, S.1    Gupta, S.C.2    Chaturvedi, M.M.3    Aggarwal, B.B.4
  • 46
    • 84918823093 scopus 로고    scopus 로고
    • S100A4 promotes liver fibrosis via activation of hepatic stellate cells
    • [CrossRef] [PubMed]
    • Chen, L.; Li, J.; Zhang, J.; Dai, C.; Liu, X.; Wang, J.; Gao, Z.; Guo, H.; Wang, R.; Lu, S.; et al. S100A4 promotes liver fibrosis via activation of hepatic stellate cells. J. Hepatol. 2015, 62, 156-164. [CrossRef] [PubMed].
    • (2015) J. Hepatol , vol.62 , pp. 156-164
    • Chen, L.1    Li, J.2    Zhang, J.3    Dai, C.4    Liu, X.5    Wang, J.6    Gao, Z.7    Guo, H.8    Wang, R.9    Lu, S.10
  • 47
    • 84922753298 scopus 로고    scopus 로고
    • The importance of the interaction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation
    • [CrossRef] [PubMed]
    • Giraudi, P.J.; Becerra, V.J.; Marin, V.; Chavez-Tapia, N.C.; Tiribelli, C.; Rosso, N. The importance of the interaction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation. Exp. Mol. Pathol. 2015, 98, 85-92. [CrossRef] [PubMed].
    • (2015) Exp. Mol. Pathol , vol.98 , pp. 85-92
    • Giraudi, P.J.1    Becerra, V.J.2    Marin, V.3    Chavez-Tapia, N.C.4    Tiribelli, C.5    Rosso, N.6
  • 48
    • 84855860915 scopus 로고    scopus 로고
    • A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation
    • [CrossRef] [PubMed]
    • Pelz, S.; Stock, P.; Bruckner, S.; Christ, B. A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation. Exp. Cell. Res. 2012, 318, 276-287. [CrossRef] [PubMed].
    • (2012) Exp. Cell. Res , vol.318 , pp. 276-287
    • Pelz, S.1    Stock, P.2    Bruckner, S.3    Christ, B.4
  • 49
    • 80054758173 scopus 로고    scopus 로고
    • Current status of novel antifibrotic therapies in patients with chronic liver disease
    • [CrossRef] [PubMed]
    • Cohen-Naftaly, M.; Friedman, S.L. Current status of novel antifibrotic therapies in patients with chronic liver disease. Ther. Adv. Gastroenterol. 2011, 4, 391-417. [CrossRef] [PubMed].
    • (2011) Ther. Adv. Gastroenterol , vol.4 , pp. 391-417
    • Cohen-Naftaly, M.1    Friedman, S.L.2
  • 50
    • 34548072307 scopus 로고    scopus 로고
    • N-acetylcysteine-A safe antidote for cysteine/glutathione deficiency
    • [CrossRef] [PubMed]
    • Atkuri, K.R.; Mantovani, J.J.; Herzenberg, L.A.; Herzenberg, L.A. N-acetylcysteine-A safe antidote for cysteine/glutathione deficiency. Curr. Opin. Pharmacol. 2007, 7, 355-359. [CrossRef] [PubMed].
    • (2007) Curr. Opin. Pharmacol , vol.7 , pp. 355-359
    • Atkuri, K.R.1    Mantovani, J.J.2    Herzenberg, L.A.3    Herzenberg, L.A.4
  • 52
    • 84891883913 scopus 로고    scopus 로고
    • Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits
    • [CrossRef] [PubMed]
    • Rushworth, G.F.; Megson, I.L. Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol. Ther. 2014, 141, 150-159. [CrossRef] [PubMed].
    • (2014) Pharmacol. Ther , vol.141 , pp. 150-159
    • Rushworth, G.F.1    Megson, I.L.2
  • 53
    • 53449091546 scopus 로고    scopus 로고
    • The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women
    • [CrossRef] [PubMed]
    • Arranz, L.; Fernandez, C.; Rodriguez, A.; Ribera, J.M.; de la Fuente, M. The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women. Free Radic. Biol. Med. 2008, 45, 1252-1262. [CrossRef] [PubMed].
    • (2008) Free Radic. Biol. Med , vol.45 , pp. 1252-1262
    • Arranz, L.1    Fernandez, C.2    Rodriguez, A.3    Ribera, J.M.4    de la Fuente, M.5
  • 54
    • 54749129969 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis
    • [PubMed]
    • Baumgardner, J.N.; Shankar, K.; Hennings, L.; Albano, E.; Badger, T.M.; Ronis, M.J.J. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. J. Nutr. 2008, 138, 1872-1879. [PubMed].
    • (2008) J. Nutr , vol.138 , pp. 1872-1879
    • Baumgardner, J.N.1    Shankar, K.2    Hennings, L.3    Albano, E.4    Badger, T.M.5    Ronis, M.J.J.6
  • 56
    • 77954477402 scopus 로고    scopus 로고
    • The Use of N-acetylcysteine in Intensive Care
    • Atkinson, M.C. The Use of N-acetylcysteine in Intensive Care. Lit. Rev. 2002, 4, 21-27.
    • (2002) Lit. Rev , vol.4 , pp. 21-27
    • Atkinson, M.C.1
  • 57
    • 33644905318 scopus 로고    scopus 로고
    • N-acetylcysteine-Passe-partout or much ado about nothing?
    • [CrossRef] [PubMed]
    • Aitio, M.L. N-acetylcysteine-Passe-partout or much ado about nothing? Br. J. Clin. Pharmacol. 2005, 61, 5-15. [CrossRef] [PubMed].
    • (2005) Br. J. Clin. Pharmacol , vol.61 , pp. 5-15
    • Aitio, M.L.1
  • 58
    • 0034212604 scopus 로고    scopus 로고
    • Population, acid-base, and redox properties of N-acetylcysteine conformers
    • [CrossRef] [PubMed]
    • Noszál, B.; Visky, D.; Kraszni, M. Population, acid-base, and redox properties of N-acetylcysteine conformers. J. Med. Chem. 2000, 43, 2176-2182. [CrossRef] [PubMed].
    • (2000) J. Med. Chem , vol.43 , pp. 2176-2182
    • Noszál, B.1    Visky, D.2    Kraszni, M.3
  • 59
    • 33750484015 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo dose-effects: A review
    • [CrossRef] [PubMed]
    • Sadowska, A.M.; Manuel, Y.K.B.; de Backer, W.A. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo dose-effects: A review. Pulm Pharmacol. Ther. 2007, 20, 9-22. [CrossRef] [PubMed].
    • (2007) Pulm Pharmacol. Ther , vol.20 , pp. 9-22
    • Sadowska, A.M.1    Manuel, Y.K.B.2    de Backer, W.A.3
  • 61
    • 84896740612 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers
    • [CrossRef] [PubMed]
    • Kasperczyk, S.; Dobrakowski, M.; Kasperczyk, A.; Machnik, G.; Birkner, E. Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers. Environ. Toxicol. Pharmacol. 2014, 37, 638-647. [CrossRef] [PubMed].
    • (2014) Environ. Toxicol. Pharmacol , vol.37 , pp. 638-647
    • Kasperczyk, S.1    Dobrakowski, M.2    Kasperczyk, A.3    Machnik, G.4    Birkner, E.5
  • 62
    • 84939616634 scopus 로고    scopus 로고
    • Zinc and N-acetylcysteine modify mercury distribution and promote increase in hepatic metallothionein levels
    • [CrossRef] [PubMed]
    • Oliveira, V.A.; Oliveira, C.S.; Mesquita, M.; Pedroso, T.F.; Costa, L.M.; Fiuza Tda, L.; Pereira, M.E. Zinc and N-acetylcysteine modify mercury distribution and promote increase in hepatic metallothionein levels. J. Trace Elem. Med. Biol. 2015, 32, 183-188. [CrossRef] [PubMed].
    • (2015) J. Trace Elem. Med. Biol , vol.32 , pp. 183-188
    • Oliveira, V.A.1    Oliveira, C.S.2    Mesquita, M.3    Pedroso, T.F.4    Costa, L.M.5    Fiuza Tda, L.6    Pereira, M.E.7
  • 63
    • 0346788873 scopus 로고    scopus 로고
    • Kinetics of superoxide scavenging by glutathione: An evaluation of its role in the removal of mitochondrial superoxide
    • [CrossRef] [PubMed]
    • Jones, C.M.; Lawrence, A.; Wardman, P.; Burkitt, M.J. Kinetics of superoxide scavenging by glutathione: An evaluation of its role in the removal of mitochondrial superoxide. Biochem Soc. Trans. 2003, 31, 1337-1339. [CrossRef] [PubMed].
    • (2003) Biochem Soc. Trans , vol.31 , pp. 1337-1339
    • Jones, C.M.1    Lawrence, A.2    Wardman, P.3    Burkitt, M.J.4
  • 64
    • 0344224201 scopus 로고    scopus 로고
    • N,N1-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-Is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents
    • [PubMed]
    • Sarnstrand, B.; Jansson, A.H.; Matuseviciene, G.; Scheynius, A.; Pierrou, S.; Bergstrand, H. N,N1-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-Is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. J. Pharmacol. Exp. Ther. 1999, 288, 1174-1184. [PubMed].
    • (1999) J. Pharmacol. Exp. Ther , vol.288 , pp. 1174-1184
    • Sarnstrand, B.1    Jansson, A.H.2    Matuseviciene, G.3    Scheynius, A.4    Pierrou, S.5    Bergstrand, H.6
  • 65
    • 57649148545 scopus 로고    scopus 로고
    • N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility
    • [CrossRef] [PubMed]
    • Dodd, S.; Dean, O.; Copolov, D.L.; Malhi, G.S.; Berk, M. N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility. Expert Opin. Biol. Ther. 2008, 8, 1955-1962. [CrossRef] [PubMed].
    • (2008) Expert Opin. Biol. Ther , vol.8 , pp. 1955-1962
    • Dodd, S.1    Dean, O.2    Copolov, D.L.3    Malhi, G.S.4    Berk, M.5
  • 66
    • 44149127234 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats
    • [PubMed]
    • Zhang, S.; Chai, F.Y.; Yan, H.; Guo, Y.; Harding, J.J. Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats. Mol. Vis. 2008, 14, 862-870. [PubMed].
    • (2008) Mol. Vis , vol.14 , pp. 862-870
    • Zhang, S.1    Chai, F.Y.2    Yan, H.3    Guo, Y.4    Harding, J.J.5
  • 67
    • 0345654274 scopus 로고
    • Glutathione: Interorgan translocation, turnover, and metabolism
    • [CrossRef] [PubMed]
    • Griffith, O.W.; Meister, A. Glutathione: Interorgan translocation, turnover, and metabolism. Proc. Natl. Acad. Sci. USA 1979, 76, 5606-5610. [CrossRef] [PubMed].
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 5606-5610
    • Griffith, O.W.1    Meister, A.2
  • 68
    • 84951135101 scopus 로고    scopus 로고
    • A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development
    • [CrossRef] [PubMed]
    • Lasram, M.M.; Dhouib, I.B.; Annabi, A.; El Fazaa, S.; Gharbi, N. A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development. Clin. Biochem. 2015. [CrossRef] [PubMed].
    • (2015) Clin. Biochem
    • Lasram, M.M.1    Dhouib, I.B.2    Annabi, A.3    El Fazaa, S.4    Gharbi, N.5
  • 69
    • 0019119442 scopus 로고
    • Toxicological, pharmacokinetic and metabolic studies on acetylcysteine
    • [PubMed]
    • Bonanomi, L.; Gazzaniga, A. Toxicological, pharmacokinetic and metabolic studies on acetylcysteine. Eur. J. Respir. Dis. Suppl. 1980, 111, 45-51. [PubMed].
    • (1980) Eur. J. Respir. Dis. Suppl , vol.111 , pp. 45-51
    • Bonanomi, L.1    Gazzaniga, A.2
  • 71
    • 0022869818 scopus 로고
    • Pharmacokinetics of N-acetylcysteine in man
    • [CrossRef] [PubMed]
    • Borgström, L.; Kågedal, B.; Paulsen, O. Pharmacokinetics of N-acetylcysteine in man. Eur. J. Clin. Pharmacol. 1986, 31, 217-222. [CrossRef] [PubMed].
    • (1986) Eur. J. Clin. Pharmacol , vol.31 , pp. 217-222
    • Borgström, L.1    Kågedal, B.2    Paulsen, O.3
  • 75
    • 60949099470 scopus 로고    scopus 로고
    • Use of N-acetylcysteine to reduce post-cardiothoracic surgery complications: A meta-analysis
    • [CrossRef] [PubMed]
    • Baker,W.L.; Anglade, M.W.; Baker, E.L.; White, C.M.; Kluger, J.; Coleman, C.I. Use of N-acetylcysteine to reduce post-cardiothoracic surgery complications: A meta-analysis. Eur. J. Cardiothorac. Surg. 2009, 35, 521-527. [CrossRef] [PubMed].
    • (2009) Eur. J. Cardiothorac. Surg , vol.35 , pp. 521-527
    • Baker, W.L.1    Anglade, M.W.2    Baker, E.L.3    White, C.M.4    Kluger, J.5    Coleman, C.I.6
  • 76
    • 0026588635 scopus 로고
    • HIV-induced cysteine deficiency and T-cell dysfunction-A rationale for treatment with N-acetylcysteine
    • [CrossRef]
    • Dröge, W.; Eck, H.P.; Mihm, S. HIV-induced cysteine deficiency and T-cell dysfunction-A rationale for treatment with N-acetylcysteine. Immunol. Today 1992, 13, 211-214. [CrossRef].
    • (1992) Immunol. Today , vol.13 , pp. 211-214
    • Dröge, W.1    Eck, H.P.2    Mihm, S.3
  • 77
    • 84874652458 scopus 로고    scopus 로고
    • The promise of N-acetylcysteine in neuropsychiatry
    • [CrossRef] [PubMed]
    • Berk, M.; Malhi, G.S.; Gray, L.J.; Dean, O.M. The promise of N-acetylcysteine in neuropsychiatry. Trends Pharmacol. Sci. 2013, 34, 167-177. [CrossRef] [PubMed].
    • (2013) Trends Pharmacol. Sci , vol.34 , pp. 167-177
    • Berk, M.1    Malhi, G.S.2    Gray, L.J.3    Dean, O.M.4
  • 78
    • 0347951068 scopus 로고    scopus 로고
    • The effect of N-acetylcysteine (NAC) on liver and renal tissue inducible nitric oxide synthase (iNOS) and tissue lipid peroxidation in obstructive jaundice stimulated by lipopolysaccharide (LPS)
    • [CrossRef] [PubMed]
    • Çağlıkülekci, M.; Pata, C.; Apa, D.D.; Dirlik, M.; Tamer, L.; Yaylak, F.; Kanik, A.; Aydin, S. The effect of N-acetylcysteine (NAC) on liver and renal tissue inducible nitric oxide synthase (iNOS) and tissue lipid peroxidation in obstructive jaundice stimulated by lipopolysaccharide (LPS). Pharmacol. Res. 2004, 49, 227-238. [CrossRef] [PubMed].
    • (2004) Pharmacol. Res , vol.49 , pp. 227-238
    • Çağlıkülekci, M.1    Pata, C.2    Apa, D.D.3    Dirlik, M.4    Tamer, L.5    Yaylak, F.6    Kanik, A.7    Aydin, S.8
  • 80
    • 84880919496 scopus 로고    scopus 로고
    • N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling
    • [CrossRef] [PubMed]
    • Hou, Y.; Wang, L.; Yi, D.; Ding, B.; Yang, Z.; Li, J.; Chen, X.; Qiu, Y.; Wu, G. N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling. Amino Acids 2013, 45, 513-522. [CrossRef] [PubMed].
    • (2013) Amino Acids , vol.45 , pp. 513-522
    • Hou, Y.1    Wang, L.2    Yi, D.3    Ding, B.4    Yang, Z.5    Li, J.6    Chen, X.7    Qiu, Y.8    Wu, G.9
  • 81
    • 84895499566 scopus 로고    scopus 로고
    • Protective effects of N-acetylcysteine against monosodium glutamate-induced astrocytic cell death
    • [CrossRef] [PubMed]
    • Park, E.; Yu, K.H.; Kim do, K.; Kim, S.; Sapkota, K.; Kim, S.J.; Kim, C.S.; Chun, H.S. Protective effects of N-acetylcysteine against monosodium glutamate-induced astrocytic cell death. Food Chem. Toxicol. 2014, 67, 1-9. [CrossRef] [PubMed].
    • (2014) Food Chem. Toxicol , vol.67 , pp. 1-9
    • Park, E.1    Yu, K.H.2    Kim do, K.3    Kim, S.4    Sapkota, K.5    Kim, S.J.6    Kim, C.S.7    Chun, H.S.8
  • 83
    • 0031550256 scopus 로고    scopus 로고
    • Reactive oxygen species participate in peroxynitrite-induced apoptosis in HL-60 cells
    • [CrossRef] [PubMed]
    • Lin, K.T.; Xue, J.Y.; Sun, F.F.; Wong, P.Y. Reactive oxygen species participate in peroxynitrite-induced apoptosis in HL-60 cells. Biochem. Biophys. Res. Commun. 1997, 230, 115-119. [CrossRef] [PubMed].
    • (1997) Biochem. Biophys. Res. Commun , vol.230 , pp. 115-119
    • Lin, K.T.1    Xue, J.Y.2    Sun, F.F.3    Wong, P.Y.4
  • 84
    • 0343941539 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine and deferoxamine on endogenous antioxidant defense system gene expression in a rat hepatocyte model of cocaine cytotoxicity
    • [CrossRef]
    • Zaragoza, A.; Díez-Fernándeza, C.; Alvarezb, A.M.; Andrésa, D.; Cascales, M. Effect of N-acetylcysteine and deferoxamine on endogenous antioxidant defense system gene expression in a rat hepatocyte model of cocaine cytotoxicity. Biochim. Biophys. Acta 2000, 1496, 183-195. [CrossRef].
    • (2000) Biochim. Biophys. Acta , vol.1496 , pp. 183-195
    • Zaragoza, A.1    Díez-Fernándeza, C.2    Alvarezb, A.M.3    Andrésa, D.4    Cascales, M.5
  • 85
    • 79952737427 scopus 로고    scopus 로고
    • Alteration of immune functions and Th1/Th2 cytokine balance in nicotine-induced murine macrophages: Immunomodulatory role of eugenol and N-acetylcysteine
    • [CrossRef] [PubMed]
    • Mahapatra, S.K.; Bhattacharjee, S.; Chakraborty, S.P.; Majumdar, S.; Roy, S. Alteration of immune functions and Th1/Th2 cytokine balance in nicotine-induced murine macrophages: Immunomodulatory role of eugenol and N-acetylcysteine. Int. Immunopharmacol. 2011, 11, 485-495. [CrossRef] [PubMed].
    • (2011) Int. Immunopharmacol , vol.11 , pp. 485-495
    • Mahapatra, S.K.1    Bhattacharjee, S.2    Chakraborty, S.P.3    Majumdar, S.4    Roy, S.5
  • 86
    • 84951179749 scopus 로고    scopus 로고
    • High dose N-acetyl cysteine improves inflammatory response and outcome in patients with COPD exacerbations
    • [CrossRef]
    • Hafiz, A.M.A.E.; Wakeel, L.M.E.; Hady, H.M.E.; Mourad, A.E.R. High dose N-acetyl cysteine improves inflammatory response and outcome in patients with COPD exacerbations. Egypt. J. Chest Dis. Tuberc. 2013, 62, 51-57. [CrossRef].
    • (2013) Egypt. J. Chest Dis. Tuberc , vol.62 , pp. 51-57
    • Hafiz, A.M.A.E.1    Wakeel, L.M.E.2    Hady, H.M.E.3    Mourad, A.E.R.4
  • 87
    • 0037278466 scopus 로고    scopus 로고
    • Molecular mechanisms of N-acetylcysteine actions
    • [CrossRef] [PubMed]
    • Zafarullah, M.; Li, W.Q.; Sylvester, J.; Ahmad, M. Molecular mechanisms of N-acetylcysteine actions. Cell. Mol. Life Sci. 2003, 60, 6-20. [CrossRef] [PubMed].
    • (2003) Cell. Mol. Life Sci , vol.60 , pp. 6-20
    • Zafarullah, M.1    Li, W.Q.2    Sylvester, J.3    Ahmad, M.4
  • 88
    • 84899488034 scopus 로고    scopus 로고
    • Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis
    • [CrossRef] [PubMed]
    • Afford, S.C.; Humphreys, E.H.; Reid, D.T.; Russell, C.L.; Banz, V.M.; Oo, Y.; Vo, T.; Jenne, C.; Adams, D.H.; Eksteen, B. Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis. Hepatology 2014, 59, 1932-1943. [CrossRef] [PubMed].
    • (2014) Hepatology , vol.59 , pp. 1932-1943
    • Afford, S.C.1    Humphreys, E.H.2    Reid, D.T.3    Russell, C.L.4    Banz, V.M.5    Oo, Y.6    Vo, T.7    Jenne, C.8    Adams, D.H.9    Eksteen, B.10
  • 89
    • 84858082210 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine treatment on oxidative stress and inflammation after severe burn
    • [CrossRef] [PubMed]
    • Csontos, C.; Rezman, B.; Foldi, V.; Bogar, L.; Drenkovics, L.; Roth, E.; Weber, G.; Lantos, J. Effect of N-acetylcysteine treatment on oxidative stress and inflammation after severe burn. Burns 2012, 38, 428-437. [CrossRef] [PubMed].
    • (2012) Burns , vol.38 , pp. 428-437
    • Csontos, C.1    Rezman, B.2    Foldi, V.3    Bogar, L.4    Drenkovics, L.5    Roth, E.6    Weber, G.7    Lantos, J.8
  • 90
    • 0344676399 scopus 로고    scopus 로고
    • The effect of N-acetylcysteine on nuclear factor-kB activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis
    • [CrossRef] [PubMed]
    • Paterson, R.L.; Galley, H.F.; Webster, N.R. The effect of N-acetylcysteine on nuclear factor-kB activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis. Crit. Care Med. 2003, 31, 2574-2578. [CrossRef] [PubMed].
    • (2003) Crit. Care Med , vol.31 , pp. 2574-2578
    • Paterson, R.L.1    Galley, H.F.2    Webster, N.R.3
  • 91
    • 33646044648 scopus 로고    scopus 로고
    • Antioxidant α-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kB ligand and tumor necrosis factor-α
    • [CrossRef] [PubMed]
    • Kim, H.J.; Chang, E.J.; Kim, H.M.; Lee, S.B.; Kim, H.D.; Su Kim, G.; Kim, H.H. Antioxidant α-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kB ligand and tumor necrosis factor-α. Free Radic. Biol. Med. 2006, 40, 1483-1493. [CrossRef] [PubMed].
    • (2006) Free Radic. Biol. Med , vol.40 , pp. 1483-1493
    • Kim, H.J.1    Chang, E.J.2    Kim, H.M.3    Lee, S.B.4    Kim, H.D.5    Su Kim, G.6    Kim, H.H.7
  • 92
    • 0037087050 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine inhibits 26S proteasome function: Implications for effects on NF-kB activation
    • [CrossRef]
    • Pajonk, F.; Riess, K.; Sommer, A.; McBride, W.H. N-acetyl-L-cysteine inhibits 26S proteasome function: Implications for effects on NF-kB activation. Free Radic. Biol. Med. 2002, 32, 536-543. [CrossRef].
    • (2002) Free Radic. Biol. Med , vol.32 , pp. 536-543
    • Pajonk, F.1    Riess, K.2    Sommer, A.3    McBride, W.H.4
  • 93
    • 0034724653 scopus 로고    scopus 로고
    • N-acetylcysteine suppresses TNF-induced NF-kB activation through inhibition of IkB kinases
    • [CrossRef]
    • Oka, S.; Kamata, H.; Kamata, K.; Yagisawa, H.; Hirata, H. N-acetylcysteine suppresses TNF-induced NF-kB activation through inhibition of IkB kinases. FEBS Lett. 2000, 472, 196-202. [CrossRef].
    • (2000) FEBS Lett , vol.472 , pp. 196-202
    • Oka, S.1    Kamata, H.2    Kamata, K.3    Yagisawa, H.4    Hirata, H.5
  • 95
    • 4344632537 scopus 로고    scopus 로고
    • Role of nitric oxide increase on induced programmed cell death during early stages of rat liver regeneration
    • [CrossRef] [PubMed]
    • Ronco, M.T.; Alvarez Mde, L.; Monti, J.A.; Carrillo, M.C.; Pisani, G.B.; Lugano, M.C.; Carnovale, C.E. Role of nitric oxide increase on induced programmed cell death during early stages of rat liver regeneration. Biochim. Biophys. Acta 2004, 1690, 70-76. [CrossRef] [PubMed].
    • (2004) Biochim. Biophys. Acta , vol.1690 , pp. 70-76
    • Ronco, M.T.1    Alvarez Mde, L.2    Monti, J.A.3    Carrillo, M.C.4    Pisani, G.B.5    Lugano, M.C.6    Carnovale, C.E.7
  • 96
    • 34047213199 scopus 로고    scopus 로고
    • Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes
    • [CrossRef] [PubMed]
    • Rabkin, S.W.; Klassen, S.S. Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes. Nitric Oxide 2007, 16, 339-347. [CrossRef] [PubMed].
    • (2007) Nitric Oxide , vol.16 , pp. 339-347
    • Rabkin, S.W.1    Klassen, S.S.2
  • 97
    • 84876149257 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence
    • [CrossRef] [PubMed]
    • Mohd Hanafiah, K.; Groeger, J.; Flaxman, A.D.; Wiersma, S.T. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013, 57, 1333-1342. [CrossRef] [PubMed].
    • (2013) Hepatology , vol.57 , pp. 1333-1342
    • Mohd Hanafiah, K.1    Groeger, J.2    Flaxman, A.D.3    Wiersma, S.T.4
  • 99
    • 0033869778 scopus 로고    scopus 로고
    • Pathogenesis of liver fibrosis: Role of oxidative stress
    • [CrossRef]
    • Poli, G. Pathogenesis of liver fibrosis: Role of oxidative stress. Mol. Asp. Med. 2000, 21, 49-98. [CrossRef].
    • (2000) Mol. Asp. Med , vol.21 , pp. 49-98
    • Poli, G.1
  • 101
    • 23844446272 scopus 로고    scopus 로고
    • Blood micronutrient, oxidative stress, and viral load in patients with chronic hepatitis C
    • [PubMed]
    • Ko, W.S.; Guo, C.H.; Yeh, M.S.; Lin, L.Y.; Hsu, G.S.; Chen, P.C.; Luo, M.C.; Lin, C.Y. Blood micronutrient, oxidative stress, and viral load in patients with chronic hepatitis C. World J. Gastroenterol. 2005, 11, 4697-4702. [PubMed].
    • (2005) World J. Gastroenterol , vol.11 , pp. 4697-4702
    • Ko, W.S.1    Guo, C.H.2    Yeh, M.S.3    Lin, L.Y.4    Hsu, G.S.5    Chen, P.C.6    Luo, M.C.7    Lin, C.Y.8
  • 102
    • 84928956747 scopus 로고    scopus 로고
    • Prevention of hepatocellular carcinoma: Focusing on antioxidant therapy
    • [CrossRef] [PubMed]
    • Miyanishi, K.; Hoki, T.; Tanaka, S.; Kato, J. Prevention of hepatocellular carcinoma: Focusing on antioxidant therapy. World J. Hepatol. 2015, 7, 593-599. [CrossRef] [PubMed].
    • (2015) World J. Hepatol , vol.7 , pp. 593-599
    • Miyanishi, K.1    Hoki, T.2    Tanaka, S.3    Kato, J.4
  • 103
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kB
    • [CrossRef] [PubMed]
    • Gong, G.; Waris, G.; Tanveer, R.; Siddiqui, A. Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kB. Proc. Natl. Acad. Sci. USA 2001, 98, 9599-9604. [CrossRef] [PubMed].
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4
  • 104
    • 16244405250 scopus 로고    scopus 로고
    • Hepatitis C virus, ER stress, and oxidative stress
    • [CrossRef] [PubMed]
    • Tardif, K.D.; Waris, G.; Siddiqui, A. Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol. 2005, 13, 159-163. [CrossRef] [PubMed].
    • (2005) Trends Microbiol , vol.13 , pp. 159-163
    • Tardif, K.D.1    Waris, G.2    Siddiqui, A.3
  • 105
    • 84930905101 scopus 로고    scopus 로고
    • Lipoic acid: Its antioxidant and anti-inflammatory role and clinical applications
    • [CrossRef] [PubMed]
    • Moura, F.A.; de Andrade, K.Q.; dos Santos, J.C.; Goulart, M.F.O. Lipoic acid: Its antioxidant and anti-inflammatory role and clinical applications. Curr. Top. Med. Chem. 2015, 15, 458-483. [CrossRef] [PubMed].
    • (2015) Curr. Top. Med. Chem , vol.15 , pp. 458-483
    • Moura, F.A.1    de Andrade, K.Q.2    dos Santos, J.C.3    Goulart, M.F.O.4
  • 106
    • 0031980673 scopus 로고    scopus 로고
    • Role of iron in the natural history and clinical course of hepatitis C disease
    • [PubMed]
    • Shedlofsky, S.I. Role of iron in the natural history and clinical course of hepatitis C disease. Hepatogastroenterology 1998, 45, 349-355. [PubMed].
    • (1998) Hepatogastroenterology , vol.45 , pp. 349-355
    • Shedlofsky, S.I.1
  • 107
    • 1442350427 scopus 로고    scopus 로고
    • Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection
    • [CrossRef] [PubMed]
    • Metwally, M.A.; Zein, C.O.; Zein, N.N. Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection. Am. J. Gastroenterol. 2004, 99, 286-291. [CrossRef] [PubMed].
    • (2004) Am. J. Gastroenterol , vol.99 , pp. 286-291
    • Metwally, M.A.1    Zein, C.O.2    Zein, N.N.3
  • 108
    • 0035675885 scopus 로고    scopus 로고
    • Hepatitis C patients in puerto rico have an altered iron balance
    • [CrossRef]
    • Rojas, C.; Matos, B.; Santiago, N.; Reymunde, A.; Matta, J.L. Hepatitis C patients in puerto rico have an altered iron balance. Biol. Trace Elem. Res. 2001, 84, 239-245. [CrossRef].
    • (2001) Biol. Trace Elem. Res , vol.84 , pp. 239-245
    • Rojas, C.1    Matos, B.2    Santiago, N.3    Reymunde, A.4    Matta, J.L.5
  • 109
    • 14944342277 scopus 로고    scopus 로고
    • Association of hepatitis C virus infection with serum iron status: Analysis of data from the third National Health and Nutrition Examination Survey
    • [CrossRef] [PubMed]
    • Shan, Y.; Lambrecht, R.W.; Bonkovsky, H.L. Association of hepatitis C virus infection with serum iron status: Analysis of data from the third National Health and Nutrition Examination Survey. Clin. Infect. Dis. 2005, 40, 834-841. [CrossRef] [PubMed].
    • (2005) Clin. Infect. Dis , vol.40 , pp. 834-841
    • Shan, Y.1    Lambrecht, R.W.2    Bonkovsky, H.L.3
  • 111
    • 85042249412 scopus 로고    scopus 로고
    • Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy
    • [CrossRef] [PubMed]
    • Bitetto, D.; Bortolotti, N.; Falleti, E.; Vescovo, S.; Fabris, C.; Fattovich, G.; Cussigh, A.; Cmet, S.; Fornasiere, E.; Ceriani, E.; et al. Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy. Hepatology 2013, 57, 925-933. [CrossRef] [PubMed].
    • (2013) Hepatology , vol.57 , pp. 925-933
    • Bitetto, D.1    Bortolotti, N.2    Falleti, E.3    Vescovo, S.4    Fabris, C.5    Fattovich, G.6    Cussigh, A.7    Cmet, S.8    Fornasiere, E.9    Ceriani, E.10
  • 112
    • 84929011936 scopus 로고    scopus 로고
    • Role of vitamins in gastrointestinal diseases
    • [CrossRef] [PubMed]
    • Masri, O.A.; Chalhoub, J.M.; Sharara, A.I. Role of vitamins in gastrointestinal diseases. World J. Gastroenterol. 2015, 21, 5191-5209. [CrossRef] [PubMed].
    • (2015) World J. Gastroenterol , vol.21 , pp. 5191-5209
    • Masri, O.A.1    Chalhoub, J.M.2    Sharara, A.I.3
  • 113
    • 84923129530 scopus 로고    scopus 로고
    • Oxidative stress response in patients infected by diverse hepatitis C virus genotypes
    • [CrossRef] [PubMed]
    • Khadem Ansari, M.H.; Omrani, M.D.; Kheradmand, F. Oxidative stress response in patients infected by diverse hepatitis C virus genotypes. Hepat. Mon. 2015, 15, e22069. [CrossRef] [PubMed].
    • (2015) Hepat. Mon , vol.15
    • Khadem Ansari, M.H.1    Omrani, M.D.2    Kheradmand, F.3
  • 114
    • 84941079687 scopus 로고    scopus 로고
    • Prediction of fibrosis in hepatitis C patients: Assessment using hydroxyproline and oxidative stress biomarkers
    • [CrossRef] [PubMed]
    • Gabr, S.A.; Alghadir, A.H. Prediction of fibrosis in hepatitis C patients: Assessment using hydroxyproline and oxidative stress biomarkers. Virusdisease 2014, 25, 91-100. [CrossRef] [PubMed].
    • (2014) Virusdisease , vol.25 , pp. 91-100
    • Gabr, S.A.1    Alghadir, A.H.2
  • 115
    • 84929048427 scopus 로고    scopus 로고
    • Effects of vitamin E on chronic hepatitis C genotype 3: A randomized, double-blind, placebo-controlled study
    • Bunchorntavakul, C.; Wootthananont, T.; Atsawarungruangkit, A. Effects of vitamin E on chronic hepatitis C genotype 3: A randomized, double-blind, placebo-controlled study. J. Med. Assoc. Thail. 2014, 97, 31-40.
    • (2014) J. Med. Assoc. Thail , vol.97 , pp. 31-40
    • Bunchorntavakul, C.1    Wootthananont, T.2    Atsawarungruangkit, A.3
  • 116
    • 84885112550 scopus 로고    scopus 로고
    • Immunological mechanisms in the pathophysiology of non-alcoholic steatohepatitis
    • [CrossRef] [PubMed]
    • Vonghia, L.; Michielsen, P.; Francque, S. Immunological mechanisms in the pathophysiology of non-alcoholic steatohepatitis. Int. J. Mol. Sci. 2013, 14, 19867-19890. [CrossRef] [PubMed].
    • (2013) Int. J. Mol. Sci , vol.14 , pp. 19867-19890
    • Vonghia, L.1    Michielsen, P.2    Francque, S.3
  • 117
    • 84919848147 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • [CrossRef]
    • Trépo, C.; Chan, H.L.Y.; Lok, A. Hepatitis B virus infection. Lancet 2014, 384, 2053-2063. [CrossRef].
    • (2014) Lancet , vol.384 , pp. 2053-2063
    • Trépo, C.1    Chan, H.L.Y.2    Lok, A.3
  • 118
    • 77954650414 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis B
    • [CrossRef] [PubMed]
    • McMahon, B.J. Natural history of chronic hepatitis B. Clin. Liver Dis. 2010, 14, 381-396. [CrossRef] [PubMed].
    • (2010) Clin. Liver Dis , vol.14 , pp. 381-396
    • McMahon, B.J.1
  • 119
    • 61349140665 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on alcohol abstinence and alcohol-induced adverse effects in rats
    • [CrossRef] [PubMed]
    • Seiva, F.R.F.; Amauchi, J.F.; Rocha, K.K.R.; Souza, G.A.; Ebaid, G.X.; Burneiko, R.M.; Novelli, E.L. Effects of N-acetylcysteine on alcohol abstinence and alcohol-induced adverse effects in rats. Alcohol 2009, 43, 127-135. [CrossRef] [PubMed].
    • (2009) Alcohol , vol.43 , pp. 127-135
    • Seiva, F.R.F.1    Amauchi, J.F.2    Rocha, K.K.R.3    Souza, G.A.4    Ebaid, G.X.5    Burneiko, R.M.6    Novelli, E.L.7
  • 120
    • 44649161902 scopus 로고    scopus 로고
    • Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model
    • [CrossRef] [PubMed]
    • Tong, A.;Wu, L.; Lin, Q.; Lau, Q.C.; Zhao, X.; Li, J.; Chen, P.; Chen, L.; Tang, H.; Huang, C.;Wei, Y.Q. Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model. Proteomics 2008, 8, 2012-2023. [CrossRef] [PubMed].
    • (2008) Proteomics , vol.8 , pp. 2012-2023
    • Tong, A.1    Wu, L.2    Lin, Q.3    Lau, Q.C.4    Zhao, X.5    Li, J.6    Chen, P.7    Chen, L.8    Tang, H.9    Huang, C.10    Wei, Y.Q.11
  • 121
    • 23044439383 scopus 로고    scopus 로고
    • cDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV
    • [CrossRef] [PubMed]
    • Hajjou, M.; Norel, R.; Carver, R.; Marion, P.; Cullen, J.; Rogler, L.E.; Rogler, C.E. cDNA microarray analysis of HBV transgenic mouse liver identifies genes in lipid biosynthetic and growth control pathways affected by HBV. J. Med. Virol. 2005, 77, 57-65. [CrossRef] [PubMed].
    • (2005) J. Med. Virol , vol.77 , pp. 57-65
    • Hajjou, M.1    Norel, R.2    Carver, R.3    Marion, P.4    Cullen, J.5    Rogler, L.E.6    Rogler, C.E.7
  • 122
    • 84923009315 scopus 로고    scopus 로고
    • The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment
    • [CrossRef] [PubMed]
    • Li, H.; Zhu,W.; Zhang, L.; Lei, H.;Wu, X.; Guo, L.; Chen, X.; Wang, Y.; Tang, H. The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment. Sci. Rep. 2015, 5, 8421. [CrossRef] [PubMed].
    • (2015) Sci. Rep , vol.5 , pp. 8421
    • Li, H.1    Zhu, W.2    Zhang, L.3    Lei, H.4    Wu, X.5    Guo, L.6    Chen, X.7    Wang, Y.8    Tang, H.9
  • 123
    • 84922688324 scopus 로고    scopus 로고
    • Reactive oxygen species promote heat shock protein 90-mediated HBV capsid assembly
    • [CrossRef] [PubMed]
    • Kim, Y.S.; Seo, H.W.; Jung, G. Reactive oxygen species promote heat shock protein 90-mediated HBV capsid assembly. Biochem. Biophys. Res. Commun. 2015, 457, 328-333. [CrossRef] [PubMed].
    • (2015) Biochem. Biophys. Res. Commun , vol.457 , pp. 328-333
    • Kim, Y.S.1    Seo, H.W.2    Jung, G.3
  • 124
    • 69249086613 scopus 로고    scopus 로고
    • Investigation of oxidative stress and antioxidant defense in patients with hepatitis B virus infection and the effect of interferon-α plus lamivudine combination therapy on oxidative stress
    • Acar, A.; Gorenek, L.; Aydin, A.; Eyigun, C.P.; Eken, A.; Sayal, A.; Pahsa, A. Investigation of oxidative stress and antioxidant defense in patients with hepatitis B virus infection and the effect of interferon-α plus lamivudine combination therapy on oxidative stress. Mikrobiyol. Bulteni 2009, 43, 411-423.
    • (2009) Mikrobiyol. Bulteni , vol.43 , pp. 411-423
    • Acar, A.1    Gorenek, L.2    Aydin, A.3    Eyigun, C.P.4    Eken, A.5    Sayal, A.6    Pahsa, A.7
  • 126
    • 29144475091 scopus 로고    scopus 로고
    • Investigation of oxidative stress and some antioxidants in patients with acute and chronic viral hepatitis B and the effect of interferon-α treatment
    • [CrossRef] [PubMed]
    • Dikici, I.; Mehmetoglu, I.; Dikici, N.; Bitirgen, M.; Kurban, S. Investigation of oxidative stress and some antioxidants in patients with acute and chronic viral hepatitis B and the effect of interferon-α treatment. Clin. Biochem. 2005, 38, 1141-1144. [CrossRef] [PubMed].
    • (2005) Clin. Biochem , vol.38 , pp. 1141-1144
    • Dikici, I.1    Mehmetoglu, I.2    Dikici, N.3    Bitirgen, M.4    Kurban, S.5
  • 127
    • 84859183283 scopus 로고    scopus 로고
    • Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis
    • [CrossRef] [PubMed]
    • Duygu, F.; Karsen, H.; Aksoy, N.; Taskin, A. Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis. Ann. Lab. Med. 2012, 32, 113-118. [CrossRef] [PubMed].
    • (2012) Ann. Lab. Med , vol.32 , pp. 113-118
    • Duygu, F.1    Karsen, H.2    Aksoy, N.3    Taskin, A.4
  • 128
    • 84928999912 scopus 로고    scopus 로고
    • Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful?
    • [CrossRef] [PubMed]
    • Takaki, A.; Yamamoto, K. Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful? World J. Hepatol. 2015, 7, 968-979. [CrossRef] [PubMed].
    • (2015) World J. Hepatol , vol.7 , pp. 968-979
    • Takaki, A.1    Yamamoto, K.2
  • 129
    • 73449123375 scopus 로고    scopus 로고
    • Alcoholic liver disease
    • [PubMed]
    • O'Shea, R.S.; Dasarathy, S.; McCullough, A.J.; Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology 2010, 51, 307-328. [PubMed].
    • (2010) Hepatology , vol.51 , pp. 307-328
    • O'Shea, R.S.1    Dasarathy, S.2    McCullough, A.J.3
  • 130
    • 67649116613 scopus 로고    scopus 로고
    • Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders
    • [CrossRef]
    • Rehm, J.; Mathers, C.; Popova, S.; Thavorncharoensap, M.; Teerawattananon, Y.; Patra, J. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 2009, 373, 2223-2233. [CrossRef].
    • (2009) Lancet , vol.373 , pp. 2223-2233
    • Rehm, J.1    Mathers, C.2    Popova, S.3    Thavorncharoensap, M.4    Teerawattananon, Y.5    Patra, J.6
  • 131
    • 0023025701 scopus 로고
    • Histologic spectrum of alcoholic liver disease
    • [CrossRef] [PubMed]
    • MacSween, R.N.; Burt, A.D. Histologic spectrum of alcoholic liver disease. Semin. Liver Dis. 1986, 6, 221-232. [CrossRef] [PubMed].
    • (1986) Semin. Liver Dis , vol.6 , pp. 221-232
    • McSween, R.N.1    Burt, A.D.2
  • 132
    • 77956476652 scopus 로고    scopus 로고
    • Acetaldehyde adducts in alcoholic liver disease
    • [CrossRef] [PubMed]
    • Setshedi, M.;Wands, J.R.; Monte, S.M. Acetaldehyde adducts in alcoholic liver disease. Oxid. Med. Cell Longev. 2010, 3, 178-185. [CrossRef] [PubMed].
    • (2010) Oxid. Med. Cell Longev , vol.3 , pp. 178-185
    • Setshedi, M.1    Wands, J.R.2    Monte, S.M.3
  • 133
    • 80051955211 scopus 로고    scopus 로고
    • Alcohol and the liver
    • [CrossRef]
    • Forrest, E.; Reed, E. Alcohol and the liver. Medicine 2011, 39, 532-535. [CrossRef].
    • (2011) Medicine , vol.39 , pp. 532-535
    • Forrest, E.1    Reed, E.2
  • 134
    • 84929668893 scopus 로고    scopus 로고
    • Changes in tumor necrosis factor-α, heat shock protein 70, malondialdehyde, and superoxide dismutase in patients with different severities of alcoholic fatty liver disease: A prospective observational study
    • [CrossRef] [PubMed]
    • Qu, B.G.; Wang, H.; Jia, Y.G.; Su, J.L.; Wang, Z.D.; Wang, Y.F.; Han, X.H.; Liu, Y.X.; Pan, J.D.; Ren, G.Y. Changes in tumor necrosis factor-α, heat shock protein 70, malondialdehyde, and superoxide dismutase in patients with different severities of alcoholic fatty liver disease: A prospective observational study. Medicine 2015, 94, e643. [CrossRef] [PubMed].
    • (2015) Medicine , vol.94
    • Qu, B.G.1    Wang, H.2    Jia, Y.G.3    Su, J.L.4    Wang, Z.D.5    Wang, Y.F.6    Han, X.H.7    Liu, Y.X.8    Pan, J.D.9    Ren, G.Y.10
  • 136
    • 84929250642 scopus 로고    scopus 로고
    • Oxidative stress during alcohol withdrawal and its relationship with withdrawal severity
    • [PubMed]
    • Parthasarathy, R.; Kattimani, S.; Sridhar, M.G. Oxidative stress during alcohol withdrawal and its relationship with withdrawal severity. Indian J. Psychol. Med. 2015, 37, 175-180. [PubMed].
    • (2015) Indian J. Psychol. Med , vol.37 , pp. 175-180
    • Parthasarathy, R.1    Kattimani, S.2    Sridhar, M.G.3
  • 137
    • 84984532221 scopus 로고    scopus 로고
    • Ethanol inhibits α-aminolevulinate dehydratase and glutathione peroxidase activities in mice liver: Protective effects of ebselen and N-acetylcysteine
    • [CrossRef] [PubMed]
    • Pivetta, L.A.; Pereira, R.P.; Farinon, M.; de Bem, A.F.; Perottoni, J.; Soares, J.C.; Duarte, M.M.; Zeni, G.; Rocha, J.B.; Farina, M. Ethanol inhibits α-aminolevulinate dehydratase and glutathione peroxidase activities in mice liver: Protective effects of ebselen and N-acetylcysteine. Environ. Toxicol. Pharmacol. 2006, 21, 338-343. [CrossRef] [PubMed].
    • (2006) Environ. Toxicol. Pharmacol , vol.21 , pp. 338-343
    • Pivetta, L.A.1    Pereira, R.P.2    Farinon, M.3    de Bem, A.F.4    Perottoni, J.5    Soares, J.C.6    Duarte, M.M.7    Zeni, G.8    Rocha, J.B.9    Farina, M.10
  • 138
    • 84924944118 scopus 로고    scopus 로고
    • N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically
    • [CrossRef] [PubMed]
    • Caro, A.A.; Bell, M.; Ejiofor, S.; Zurcher, G.; Petersen, D.R.; Ronis, M.J. N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically. Alcohol. Clin. Exp. Res. 2014, 38, 2896-2906. [CrossRef] [PubMed].
    • (2014) Alcohol. Clin. Exp. Res , vol.38 , pp. 2896-2906
    • Caro, A.A.1    Bell, M.2    Ejiofor, S.3    Zurcher, G.4    Petersen, D.R.5    Ronis, M.J.6
  • 140
    • 34948823454 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis
    • [CrossRef] [PubMed]
    • Thong-Ngam, D.; Samuhasaneeto, S.; Kulaputana, O.; Klaikeaw, N. N-acetylcysteine attenuates oxidative stress and liver pathology in rats with non-alcoholic steatohepatitis. World J. Gastroenterol. 2007, 13, 5127-5132. [CrossRef] [PubMed].
    • (2007) World J. Gastroenterol , vol.13 , pp. 5127-5132
    • Thong-Ngam, D.1    Samuhasaneeto, S.2    Kulaputana, O.3    Klaikeaw, N.4
  • 143
    • 0035449657 scopus 로고    scopus 로고
    • Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: Effect of N-acetylcysteine and interferon-α
    • [CrossRef] [PubMed]
    • Vendemiale, G.; Grattagliano, I.; Caruso, M.L.; Serviddio, G.; Valentini, A.M.; Pirrelli, M.; Altomare, E. Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: Effect of N-acetylcysteine and interferon-α. Toxicol. Appl. Pharmacol. 2001, 175, 130-139. [CrossRef] [PubMed].
    • (2001) Toxicol. Appl. Pharmacol , vol.175 , pp. 130-139
    • Vendemiale, G.1    Grattagliano, I.2    Caruso, M.L.3    Serviddio, G.4    Valentini, A.M.5    Pirrelli, M.6    Altomare, E.7
  • 145
    • 84863138767 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats
    • Lei, S.; Liu, Y.; Liu, H.; Yu, H.; Wang, H.; Xia, Z. Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats. Yonsei Med. J. 2012, 53, 294-303.
    • (2012) Yonsei Med. J , vol.53 , pp. 294-303
    • Lei, S.1    Liu, Y.2    Liu, H.3    Yu, H.4    Wang, H.5    Xia, Z.6
  • 147
    • 84912141161 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury
    • [CrossRef] [PubMed]
    • Sun, Y.; Pu, L.Y.; Lu, L.; Wang, X.H.; Zhang, F.; Rao, J.H. N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury. World J. Gastroenterol. 2014, 20, 15289-15298. [CrossRef] [PubMed].
    • (2014) World J. Gastroenterol , vol.20 , pp. 15289-15298
    • Sun, Y.1    Pu, L.Y.2    Lu, L.3    Wang, X.H.4    Zhang, F.5    Rao, J.H.6
  • 148
    • 84888620795 scopus 로고    scopus 로고
    • Reestablishment of ischemia-reperfusion liver injury by N-acetylcysteine administration prior to a preconditioning iron protocol
    • [CrossRef] [PubMed]
    • Fernandez, V.; Vargas, R.; Castillo, V.; Cadiz, N.; Bastias, D.; Roman, S.; Tapia, G.; Videla, L.A. Reestablishment of ischemia-reperfusion liver injury by N-acetylcysteine administration prior to a preconditioning iron protocol. Sci. World J. 2013, 2013, 1-9. [CrossRef] [PubMed].
    • (2013) Sci. World J , vol.2013 , pp. 1-9
    • Fernandez, V.1    Vargas, R.2    Castillo, V.3    Cadiz, N.4    Bastias, D.5    Roman, S.6    Tapia, G.7    Videla, L.A.8
  • 149
    • 0032575363 scopus 로고    scopus 로고
    • Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury
    • [CrossRef]
    • Demir, S.; Inal-Erden, M. Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury. Clin. Chim. Acta 1998, 275, 127-135. [CrossRef].
    • (1998) Clin. Chim. Acta , vol.275 , pp. 127-135
    • Demir, S.1    Inal-Erden, M.2
  • 150
    • 0037414397 scopus 로고    scopus 로고
    • Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion
    • [CrossRef]
    • Sener, G.; Tosun, O.; Sehirli, A.Ö.; Kaçmaz, A.; Arbak, S.; Ersoy, Y.; Ayanoğlu-Dülger, G. Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci. 2003, 72, 2707-2718. [CrossRef].
    • (2003) Life Sci , vol.72 , pp. 2707-2718
    • Sener, G.1    Tosun, O.2    Sehirli, A.Ö.3    Kaçmaz, A.4    Arbak, S.5    Ersoy, Y.6    Ayanoğlu-Dülger, G.7
  • 151
    • 84924403072 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway
    • [CrossRef] [PubMed]
    • Wang, C.; Chen, K.; Xia, Y.; Dai, W.; Wang, F.; Shen, M.; Cheng, P.; Wang, J.; Lu, J.; Zhang, Y.; et al. N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway. PLoS ONE 2014, 9, e108855. [CrossRef] [PubMed].
    • (2014) PLoS ONE , vol.9
    • Wang, C.1    Chen, K.2    Xia, Y.3    Dai, W.4    Wang, F.5    Shen, M.6    Cheng, P.7    Wang, J.8    Lu, J.9    Zhang, Y.10
  • 152
    • 84884898261 scopus 로고    scopus 로고
    • Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse
    • [CrossRef] [PubMed]
    • Lin, H.; Liu, X.B.; Yu, J.J.; Hua, F.; Hu, Z.W. Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. PLoS ONE 2013, 8, e74130. [CrossRef] [PubMed].
    • (2013) PLoS ONE , vol.8
    • Lin, H.1    Liu, X.B.2    Yu, J.J.3    Hua, F.4    Hu, Z.W.5
  • 153
    • 84939943461 scopus 로고    scopus 로고
    • Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis
    • [CrossRef] [PubMed]
    • Tian, Y.; Kuo, C.F.; Sir, D.; Wang, L.; Govindarajan, S.; Petrovic, L.M.; Ou, J.H. Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis. Cell. Death Differ. 2015, 22, 1025-1034. [CrossRef] [PubMed].
    • (2015) Cell. Death Differ , vol.22 , pp. 1025-1034
    • Tian, Y.1    Kuo, C.F.2    Sir, D.3    Wang, L.4    Govindarajan, S.5    Petrovic, L.M.6    Ou, J.H.7
  • 154
    • 84855869948 scopus 로고    scopus 로고
    • Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model
    • [CrossRef] [PubMed]
    • Galicia-Moreno, M.; Favari, L.; Muriel, P. Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model. Eur. J. Gastroenterol. Hepatol. 2012, 24, 179-185. [CrossRef] [PubMed].
    • (2012) Eur. J. Gastroenterol. Hepatol , vol.24 , pp. 179-185
    • Galicia-Moreno, M.1    Favari, L.2    Muriel, P.3
  • 156
    • 77954084245 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: Antioxidant and anti-inflammatory mechanisms
    • [CrossRef] [PubMed]
    • Bemeur, C.; Vaquero, J.; Desjardins, P.; Butterworth, R.F. N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: Antioxidant and anti-inflammatory mechanisms. Metab. Brain Dis. 2010, 25, 241-249. [CrossRef] [PubMed].
    • (2010) Metab. Brain Dis , vol.25 , pp. 241-249
    • Bemeur, C.1    Vaquero, J.2    Desjardins, P.3    Butterworth, R.F.4
  • 157
    • 79956101516 scopus 로고    scopus 로고
    • Schistosoma mansoni: N-acetylcysteine downregulates oxidative stress and enhances the antischistosomal activity of artemether in mice
    • [CrossRef] [PubMed]
    • Seif el-Din, S.H.; Al-Hroob, A.M.; Ebeid, F.A. Schistosoma mansoni: N-acetylcysteine downregulates oxidative stress and enhances the antischistosomal activity of artemether in mice. Exp. Parasitol. 2011, 128, 230-235. [CrossRef] [PubMed].
    • (2011) Exp. Parasitol , vol.128 , pp. 230-235
    • Seif el-Din, S.H.1    Al-Hroob, A.M.2    Ebeid, F.A.3
  • 158
    • 33749528921 scopus 로고    scopus 로고
    • Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats
    • [CrossRef] [PubMed]
    • Hsu, B.G.; Lee, R.P.; Yang, F.L.; Harn, H.J.; Chen, H.I. Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats. Life Sci. 2006, 79, 2010-2016. [CrossRef] [PubMed].
    • (2006) Life Sci , vol.79 , pp. 2010-2016
    • Hsu, B.G.1    Lee, R.P.2    Yang, F.L.3    Harn, H.J.4    Chen, H.I.5
  • 160
    • 81855221836 scopus 로고    scopus 로고
    • Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis
    • [CrossRef] [PubMed]
    • Setshedi, M.; Longato, L.; Petersen, D.R.; Ronis, M.; Chen, W.C.; Wands, J.R.; de la Monte, S.M. Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis. Alcohol. Clin. Exp. Res. 2011, 35, 2139-2151. [CrossRef] [PubMed].
    • (2011) Alcohol. Clin. Exp. Res , vol.35 , pp. 2139-2151
    • Setshedi, M.1    Longato, L.2    Petersen, D.R.3    Ronis, M.4    Chen, W.C.5    Wands, J.R.6    de la Monte, S.M.7
  • 161
    • 4344576889 scopus 로고    scopus 로고
    • Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: Protection by N-acetyl cysteine
    • [CrossRef] [PubMed]
    • Bajt, M.L.; Knight, T.R.; Lemasters, J.J.; Jaeschke, H. Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: Protection by N-acetyl cysteine. Toxicol. Sci. 2004, 80, 343-349. [CrossRef] [PubMed].
    • (2004) Toxicol. Sci , vol.80 , pp. 343-349
    • Bajt, M.L.1    Knight, T.R.2    Lemasters, J.J.3    Jaeschke, H.4
  • 163
    • 77956020728 scopus 로고    scopus 로고
    • Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat
    • [CrossRef] [PubMed]
    • Acharya, M.; Lau-Cam, C.A. Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat. J. Biomed. Sci. 2010, 17 (Suppl. S1), 1-11. [CrossRef] [PubMed].
    • (2010) J. Biomed. Sci , vol.17 , pp. 1-11
    • Acharya, M.1    Lau-Cam, C.A.2
  • 164
    • 37549052936 scopus 로고    scopus 로고
    • Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose
    • [CrossRef] [PubMed]
    • Terneus, M.V.; Brown, J.M.; Carpenter, A.B.; Valentovic, M.A. Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose. Toxicology 2008, 244, 25-34. [CrossRef] [PubMed].
    • (2008) Toxicology , vol.244 , pp. 25-34
    • Terneus, M.V.1    Brown, J.M.2    Carpenter, A.B.3    Valentovic, M.A.4
  • 165
    • 0027995496 scopus 로고
    • Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes
    • [CrossRef]
    • Rafeiro, E.; Barr, S.G.; Harrison, J.J.; Racz,W.J. Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes. Toxicology 1994, 93, 209-224. [CrossRef].
    • (1994) Toxicology , vol.93 , pp. 209-224
    • Rafeiro, E.1    Barr, S.G.2    Harrison, J.J.3    Racz, W.J.4
  • 166
    • 0036197307 scopus 로고    scopus 로고
    • Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: A study of Hep3B cells
    • [CrossRef] [PubMed]
    • Manov, I.; Hirsh, M.; Iancu, T.C. Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: A study of Hep3B cells. Exp. Toxicol. Pathol. 2002, 53, 489-500. [CrossRef] [PubMed].
    • (2002) Exp. Toxicol. Pathol , vol.53 , pp. 489-500
    • Manov, I.1    Hirsh, M.2    Iancu, T.C.3
  • 167
    • 0030852822 scopus 로고    scopus 로고
    • Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol
    • [CrossRef]
    • Al-Mustafa, Z.H.; Al-Ali, A.K.; Qaw, F.S.; Abdul-Cader, Z. Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol. Toxicology 1997, 121, 223-228. [CrossRef].
    • (1997) Toxicology , vol.121 , pp. 223-228
    • Al-Mustafa, Z.H.1    Al-Ali, A.K.2    Qaw, F.S.3    Abdul-Cader, Z.4
  • 168
    • 84922756226 scopus 로고    scopus 로고
    • Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells
    • [CrossRef] [PubMed]
    • Tobwala, S.; Khayyat, A.; Fan, W.; Ercal, N. Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells. Exp. Biol. Med. 2015, 240, 261-272. [CrossRef] [PubMed].
    • (2015) Exp. Biol. Med , vol.240 , pp. 261-272
    • Tobwala, S.1    Khayyat, A.2    Fan, W.3    Ercal, N.4
  • 169
    • 33644780110 scopus 로고    scopus 로고
    • Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats
    • [PubMed]
    • Rana, S.V.; Attri, S.; Vaiphei, K.; Pal, R.; Attri, A.; Singh, K. Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats. World J. Gastroenterol. 2006, 12, 287-291. [PubMed].
    • (2006) World J. Gastroenterol , vol.12 , pp. 287-291
    • Rana, S.V.1    Attri, S.2    Vaiphei, K.3    Pal, R.4    Attri, A.5    Singh, K.6
  • 170
    • 0037398812 scopus 로고    scopus 로고
    • A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine
    • [CrossRef]
    • Raza, M.; Ahmad, M.; Gado, A.; Al-Shabanah, O.A. A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine. Comp. Biochem. Physiol. Part C Toxicol. Pharmacol. 2003, 134, 451-456. [CrossRef].
    • (2003) Comp. Biochem. Physiol. Part C Toxicol. Pharmacol , vol.134 , pp. 451-456
    • Raza, M.1    Ahmad, M.2    Gado, A.3    Al-Shabanah, O.A.4
  • 171
    • 2942714874 scopus 로고    scopus 로고
    • The toxicity of N-methyl-α-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine
    • [PubMed]
    • Carvalho, M.; Remiao, F.; Milhazes, N.; Borges, F.; Fernandes, E.; Carvalho, F.; Bastos, M.L. The toxicity of N-methyl-α-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine. Toxicology 2004, 200, 193-203. [PubMed].
    • (2004) Toxicology , vol.200 , pp. 193-203
    • Carvalho, M.1    Remiao, F.2    Milhazes, N.3    Borges, F.4    Fernandes, E.5    Carvalho, F.6    Bastos, M.L.7
  • 172
    • 38349057749 scopus 로고    scopus 로고
    • The protective effect of N-acetylcysteine against cyclosporine A-induced hepatotoxicity in rats
    • [CrossRef] [PubMed]
    • Kaya, H.; Koc, A.; Sogut, S.; Duru, M.; Yilmaz, H.R.; Uz, E.; Durgut, R. The protective effect of N-acetylcysteine against cyclosporine A-induced hepatotoxicity in rats. J. Appl. Toxicol. 2008, 28, 15-20. [CrossRef] [PubMed].
    • (2008) J. Appl. Toxicol , vol.28 , pp. 15-20
    • Kaya, H.1    Koc, A.2    Sogut, S.3    Duru, M.4    Yilmaz, H.R.5    Uz, E.6    Durgut, R.7
  • 173
    • 84983571372 scopus 로고    scopus 로고
    • Protective Effects of N-acetylcysteine against the Statins Cytotoxicity in Freshly Isolated Rat Hepatocytes
    • [PubMed]
    • Abdoli, N.; Azarmi, Y.; Eghbal, M.A. Protective Effects of N-acetylcysteine against the Statins Cytotoxicity in Freshly Isolated Rat Hepatocytes. Adv. Pharm. Bull. 2014, 4, 249-254. [PubMed].
    • (2014) Adv. Pharm. Bull , vol.4 , pp. 249-254
    • Abdoli, N.1    Azarmi, Y.2    Eghbal, M.A.3
  • 174
    • 84905845192 scopus 로고    scopus 로고
    • Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats
    • [CrossRef] [PubMed]
    • Akbulut, S.; Elbe, H.; Eris, C.; Dogan, Z.; Toprak, G.; Otan, E.; Erdemli, E.; Turkoz, Y. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World J. Gastroenterol. 2014, 20, 10158-10165. [CrossRef] [PubMed].
    • (2014) World J. Gastroenterol , vol.20 , pp. 10158-10165
    • Akbulut, S.1    Elbe, H.2    Eris, C.3    Dogan, Z.4    Toprak, G.5    Otan, E.6    Erdemli, E.7    Turkoz, Y.8
  • 175
    • 84897497566 scopus 로고    scopus 로고
    • Hepatoprotective and antioxidant activity of N-acetyl cysteine in carbamazepine-administered rats
    • [CrossRef] [PubMed]
    • Maheswari, E.; Saraswathy, G.R.; Santhranii, T. Hepatoprotective and antioxidant activity of N-acetyl cysteine in carbamazepine-administered rats. Indian J. Pharmacol. 2014, 46, 211-215. [CrossRef] [PubMed].
    • (2014) Indian J. Pharmacol , vol.46 , pp. 211-215
    • Maheswari, E.1    Saraswathy, G.R.2    Santhranii, T.3
  • 176
    • 84902547989 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory effects of N-acetylcysteine against malathion-induced liver damages and immunotoxicity in rats
    • [CrossRef] [PubMed]
    • Lasram, M.M.; Lamine, A.J.; Dhouib, I.B.; Bouzid, K.; Annabi, A.; Belhadjhmida, N.; Ahmed, M.B.; El Fazaa, S.; Abdelmoula, J.; Gharbi, N. Antioxidant and anti-inflammatory effects of N-acetylcysteine against malathion-induced liver damages and immunotoxicity in rats. Life Sci. 2014, 107, 50-58. [CrossRef] [PubMed].
    • (2014) Life Sci , vol.107 , pp. 50-58
    • Lasram, M.M.1    Lamine, A.J.2    Dhouib, I.B.3    Bouzid, K.4    Annabi, A.5    Belhadjhmida, N.6    Ahmed, M.B.7    El Fazaa, S.8    Abdelmoula, J.9    Gharbi, N.10
  • 177
    • 84875059392 scopus 로고    scopus 로고
    • Protective effect of NAC against malathion-induced oxidative stress in freshly isolated rat hepatocytes
    • [PubMed]
    • Mostafalou, S.; Abdollahi, M.; Eghbal, M.A.; Saeedi Kouzehkonani, N. Protective effect of NAC against malathion-induced oxidative stress in freshly isolated rat hepatocytes. Adv. Pharm. Bull. 2012, 2, 79-88. [PubMed].
    • (2012) Adv. Pharm. Bull , vol.2 , pp. 79-88
    • Mostafalou, S.1    Abdollahi, M.2    Eghbal, M.A.3    Saeedi Kouzehkonani, N.4
  • 178
    • 84870844654 scopus 로고    scopus 로고
    • Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb-and paraquat-induced hepatotoxicity in rats
    • [CrossRef] [PubMed]
    • Ahmad, I.; Shukla, S.; Kumar, A.; Singh, B.K.; Kumar, V.; Chauhan, A.K.; Singh, D.; Pandey, H.P.; Singh, C. Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb-and paraquat-induced hepatotoxicity in rats. Chem. Biol. Interact. 2013, 201, 9-18. [CrossRef] [PubMed].
    • (2013) Chem. Biol. Interact , vol.201 , pp. 9-18
    • Ahmad, I.1    Shukla, S.2    Kumar, A.3    Singh, B.K.4    Kumar, V.5    Chauhan, A.K.6    Singh, D.7    Pandey, H.P.8    Singh, C.9
  • 179
    • 84890814960 scopus 로고    scopus 로고
    • In vitro effect of N-acetylcysteine on hepatocyte injury caused by dichlorodiphenyltrichloroethane and its metabolites
    • [CrossRef] [PubMed]
    • Van Tonder, J.J.; Gulumian, M.; Cromarty, A.D.; Steenkamp, V. In vitro effect of N-acetylcysteine on hepatocyte injury caused by dichlorodiphenyltrichloroethane and its metabolites. Hum. Exp. Toxicol. 2014, 33, 41-53. [CrossRef] [PubMed].
    • (2014) Hum. Exp. Toxicol , vol.33 , pp. 41-53
    • Van Tonder, J.J.1    Gulumian, M.2    Cromarty, A.D.3    Steenkamp, V.4
  • 180
    • 84951106355 scopus 로고    scopus 로고
    • Anti-inflammatory Effects of N-acetylcysteine against Carbosulfan-induced Hepatic Impairment in Male Rats
    • [CrossRef]
    • Dhouib, I.E.-B.; Annabi, A.; Lasram, M.M.; Gharbi, N.; El-Fazaa, S. Anti-inflammatory Effects of N-acetylcysteine against Carbosulfan-induced Hepatic Impairment in Male Rats. Recent Adv. Biol. Med. 2015, 1, 29-40. [CrossRef].
    • (2015) Recent Adv. Biol. Med , vol.1 , pp. 29-40
    • Dhouib, I.E.-B.1    Annabi, A.2    Lasram, M.M.3    Gharbi, N.4    El-Fazaa, S.5
  • 181
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • [CrossRef] [PubMed]
    • Yamaguchi, K.; Yang, L.; McCall, S.; Huang, J.; Yu, X.X.; Pandey, S.K.; Bhanot, S.; Monia, B.P.; Li, Y.X.; Diehl, A.M. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007, 45, 1366-1374. [CrossRef] [PubMed].
    • (2007) Hepatology , vol.45 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3    Huang, J.4    Yu, X.X.5    Pandey, S.K.6    Bhanot, S.7    Monia, B.P.8    Li, Y.X.9    Diehl, A.M.10
  • 182
    • 37849004297 scopus 로고    scopus 로고
    • Protective effect of N-acetylcysteine against radiation induced DNA damage and hepatic toxicity in rats
    • [CrossRef] [PubMed]
    • Mansour, H.H.; Hafez, H.F.; Fahmy, N.M.; Hanafi, N. Protective effect of N-acetylcysteine against radiation induced DNA damage and hepatic toxicity in rats. Biochem. Pharmacol. 2008, 75, 773-780. [CrossRef] [PubMed].
    • (2008) Biochem. Pharmacol , vol.75 , pp. 773-780
    • Mansour, H.H.1    Hafez, H.F.2    Fahmy, N.M.3    Hanafi, N.4
  • 183
    • 84898027741 scopus 로고    scopus 로고
    • N-acetyl cysteine and selenium protects mercuric chloride-induced oxidative stress and antioxidant defense system in liver and kidney of rats: A histopathological approach
    • [CrossRef] [PubMed]
    • Joshi, D.; Mittal, D.K.; Shukla, S.; Srivastav, A.K.; Srivastav, S.K. N-acetyl cysteine and selenium protects mercuric chloride-induced oxidative stress and antioxidant defense system in liver and kidney of rats: A histopathological approach. J. Trace Elem. Med. Biol. 2014, 28, 218-226. [CrossRef] [PubMed].
    • (2014) J. Trace Elem. Med. Biol , vol.28 , pp. 218-226
    • Joshi, D.1    Mittal, D.K.2    Shukla, S.3    Srivastav, A.K.4    Srivastav, S.K.5
  • 185
    • 84879882560 scopus 로고    scopus 로고
    • Effect of N-acetyl cysteine (NAC), an organosulfur compound from Allium plants, on experimentally induced hepatic prefibrogenic events in Wistar rat
    • [CrossRef] [PubMed]
    • Nissar, A.U.; Farrukh, M.R.; Kaiser, P.J.; Rafiq, R.A.; Afnan, Q.; Bhushan, S.; Adil, H.S.; Subhash, B.C.; Tasduq, S.A. Effect of N-acetyl cysteine (NAC), an organosulfur compound from Allium plants, on experimentally induced hepatic prefibrogenic events in Wistar rat. Phytomedicine 2013, 20, 828-833. [CrossRef] [PubMed].
    • (2013) Phytomedicine , vol.20 , pp. 828-833
    • Nissar, A.U.1    Farrukh, M.R.2    Kaiser, P.J.3    Rafiq, R.A.4    Afnan, Q.5    Bhushan, S.6    Adil, H.S.7    Subhash, B.C.8    Tasduq, S.A.9
  • 186
    • 85013015764 scopus 로고    scopus 로고
    • N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway
    • [PubMed]
    • Cai, Z.; Lou, Q.;Wang, F.; Li, E.; Sun, J.; Fang, H.; Xi, J.; Ju, L. N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway. Int. J. Clin. Exp. Pathol. 2015, 8, 8655-8662. [PubMed].
    • (2015) Int. J. Clin. Exp. Pathol , vol.8 , pp. 8655-8662
    • Cai, Z.1    Lou, Q.2    Wang, F.3    Li, E.4    Sun, J.5    Fang, H.6    Xi, J.7    Ju, L.8
  • 187
    • 78751668372 scopus 로고    scopus 로고
    • Protective effects of N-acetylcysteine against cadmium-induced damage in cultured rat normal liver cells
    • [CrossRef] [PubMed]
    • Odewumi, C.O.; Badisa, V.L.; Le, U.T.; Latinwo, L.M.; Ikediobi, C.O.; Badisa, R.B.; Darling-Reed, S.F. Protective effects of N-acetylcysteine against cadmium-induced damage in cultured rat normal liver cells. Int. J. Mol. Med. 2011, 27, 243-248. [CrossRef] [PubMed].
    • (2011) Int. J. Mol. Med , vol.27 , pp. 243-248
    • Odewumi, C.O.1    Badisa, V.L.2    Le, U.T.3    Latinwo, L.M.4    Ikediobi, C.O.5    Badisa, R.B.6    Darling-Reed, S.F.7
  • 188
    • 84923205953 scopus 로고    scopus 로고
    • N-acetylcysteine protects against cadmium-induced oxidative stress in rat hepatocytes
    • [CrossRef] [PubMed]
    • Wang, J.; Zhu, H.; Liu, X.; Liu, Z. N-acetylcysteine protects against cadmium-induced oxidative stress in rat hepatocytes. J. Vet. Sci. 2014, 15, 485. [CrossRef] [PubMed].
    • (2014) J. Vet. Sci , vol.15 , pp. 485
    • Wang, J.1    Zhu, H.2    Liu, X.3    Liu, Z.4
  • 189
    • 71249123078 scopus 로고    scopus 로고
    • Calcium-dependent nitric oxide production is involved in the cytoprotective properties of N-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes
    • [CrossRef] [PubMed]
    • Gonzalez-Rubio, S.; Linares, C.I.; Bello, R.I.; Gonzalez, R.; Ferrin, G.; Hidalgo, A.B.; Munoz-Gomariz, E.; Rodriguez, B.A.; Barrera, P.; Ranchal, I.; et al. Calcium-dependent nitric oxide production is involved in the cytoprotective properties of N-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes. Toxicol. Appl. Pharmacol. 2010, 242, 165-172. [CrossRef] [PubMed].
    • (2010) Toxicol. Appl. Pharmacol , vol.242 , pp. 165-172
    • Gonzalez-Rubio, S.1    Linares, C.I.2    Bello, R.I.3    Gonzalez, R.4    Ferrin, G.5    Hidalgo, A.B.6    Munoz-Gomariz, E.7    Rodriguez, B.A.8    Barrera, P.9    Ranchal, I.10
  • 190
    • 0032849141 scopus 로고    scopus 로고
    • Protective effect of N-acetylcysteine on reduced glutathione, reduced glutathione-related enzymes and lipid peroxidation in methanol intoxication
    • [CrossRef]
    • Skrzydlewska, E.; Farbiszewski, R. Protective effect of N-acetylcysteine on reduced glutathione, reduced glutathione-related enzymes and lipid peroxidation in methanol intoxication. Drug Alcohol. Depend. 1999, 57, 61-67. [CrossRef].
    • (1999) Drug Alcohol. Depend , vol.57 , pp. 61-67
    • Skrzydlewska, E.1    Farbiszewski, R.2
  • 191
    • 84886248481 scopus 로고    scopus 로고
    • N-acetylcysteine protects against fluoride-induced oxidative damage in primary rat hepatocytes
    • [CrossRef] [PubMed]
    • Pawlowska-Goral, K.; Kurzeja, E.; Stec, M. N-acetylcysteine protects against fluoride-induced oxidative damage in primary rat hepatocytes. Toxicol. Vitro 2013, 27, 2279-2282. [CrossRef] [PubMed].
    • (2013) Toxicol. Vitro , vol.27 , pp. 2279-2282
    • Pawlowska-Goral, K.1    Kurzeja, E.2    Stec, M.3
  • 192
    • 79551583880 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates dimethylnitrosamine induced oxidative stress in rats
    • [CrossRef] [PubMed]
    • Sathish, P.; Paramasivan, V.; Palani, V.; Sivanesan, K. N-acetylcysteine attenuates dimethylnitrosamine induced oxidative stress in rats. Eur. J. Pharmacol. 2011, 654, 181-186. [CrossRef] [PubMed].
    • (2011) Eur. J. Pharmacol , vol.654 , pp. 181-186
    • Sathish, P.1    Paramasivan, V.2    Palani, V.3    Sivanesan, K.4
  • 193
    • 33748142432 scopus 로고    scopus 로고
    • Co-administration of zinc and N-acetylcysteine prevents arsenic-induced tissue oxidative stress in male rats
    • [CrossRef] [PubMed]
    • Modi, M.; Kaul, R.K.; Kannan, G.M.; Flora, S.J. Co-administration of zinc and N-acetylcysteine prevents arsenic-induced tissue oxidative stress in male rats. J. Trace Elem. Med. Biol. 2006, 20, 197-204. [CrossRef] [PubMed].
    • (2006) J. Trace Elem. Med. Biol , vol.20 , pp. 197-204
    • Modi, M.1    Kaul, R.K.2    Kannan, G.M.3    Flora, S.J.4
  • 194
    • 78650278965 scopus 로고    scopus 로고
    • Inhibition of hepatic delta-aminolevulinate dehydratase activity induced by mercuric chloride is potentiated by N-acetylcysteine in vitro
    • [CrossRef] [PubMed]
    • Brandao, R.; Nogueira, C.W. Inhibition of hepatic delta-aminolevulinate dehydratase activity induced by mercuric chloride is potentiated by N-acetylcysteine in vitro. Food Chem. Toxicol. 2011, 49, 305-308. [CrossRef] [PubMed].
    • (2011) Food Chem. Toxicol , vol.49 , pp. 305-308
    • Brandao, R.1    Nogueira, C.W.2
  • 195
    • 84855448266 scopus 로고    scopus 로고
    • The effects of N-acetylcysteine on hepatic function during isoflurane anaesthesia for laparoscopic surgery patients
    • [CrossRef] [PubMed]
    • Beyaz, S.G.; Yelken, B.; Kanbak, G. The effects of N-acetylcysteine on hepatic function during isoflurane anaesthesia for laparoscopic surgery patients. Indian J. Anaesth. 2011, 55, 567-572. [CrossRef] [PubMed].
    • (2011) Indian J. Anaesth , vol.55 , pp. 567-572
    • Beyaz, S.G.1    Yelken, B.2    Kanbak, G.3
  • 196
    • 34547936148 scopus 로고    scopus 로고
    • Protective effects of melatonin and N-acetylcysteine on hepatic injury in a rat cardiopulmonary bypass model
    • [CrossRef] [PubMed]
    • Huang, H.; Yin, R.; Zhu, J.; Feng, X.; Wang, C.; Sheng, Y.; Dong, G.; Li, D.; Jing, H. Protective effects of melatonin and N-acetylcysteine on hepatic injury in a rat cardiopulmonary bypass model. J. Surg. Res. 2007, 142, 153-161. [CrossRef] [PubMed].
    • (2007) J. Surg. Res , vol.142 , pp. 153-161
    • Huang, H.1    Yin, R.2    Zhu, J.3    Feng, X.4    Wang, C.5    Sheng, Y.6    Dong, G.7    Li, D.8    Jing, H.9
  • 197
    • 84928521784 scopus 로고    scopus 로고
    • The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues
    • [CrossRef] [PubMed]
    • Altinoz, E.; Turkoz, Y.; Vardi, N. The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues. Bratisl. Lek. Listy 2015, 116, 252-258. [CrossRef] [PubMed].
    • (2015) Bratisl. Lek. Listy , vol.116 , pp. 252-258
    • Altinoz, E.1    Turkoz, Y.2    Vardi, N.3
  • 198
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
    • [CrossRef] [PubMed]
    • Williams, C.D.; Stengel, J.; Asike, M.I.; Torres, D.M.; Shaw, J.; Contreras, M.; Landt, C.L.; Harrison, S.A. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study. Gastroenterology 2011, 140, 124-131. [CrossRef] [PubMed].
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3    Torres, D.M.4    Shaw, J.5    Contreras, M.6    Landt, C.L.7    Harrison, S.A.8
  • 199
    • 35348900749 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • [CrossRef] [PubMed]
    • Adams, L.A.; Lindor, K.D. Nonalcoholic fatty liver disease. Ann. Epidemiol. 2007, 17, 11. [CrossRef] [PubMed].
    • (2007) Ann. Epidemiol , vol.17 , pp. 11
    • Adams, L.A.1    Lindor, K.D.2
  • 200
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • [CrossRef] [PubMed]
    • Vernon, G.; Baranova, A.; Younossi, Z.M. Systematic review: The epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther. 2011, 34, 274-285. [CrossRef] [PubMed].
    • (2011) Aliment. Pharmacol. Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 201
    • 84944358185 scopus 로고    scopus 로고
    • Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease?-A mechanistic hypothesis
    • [CrossRef] [PubMed]
    • De Medeiros, I.C.; de Lima, J.G. Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease?-A mechanistic hypothesis. Med. Hypotheses 2015, 85, 148-152. [CrossRef] [PubMed].
    • (2015) Med. Hypotheses , vol.85 , pp. 148-152
    • De Medeiros, I.C.1    de Lima, J.G.2
  • 202
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • [CrossRef]
    • Day, C.P.; James, O.F. Steatohepatitis: A tale of two "hits"? Gastroenterology 1998, 114, 842-845. [CrossRef].
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 203
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • [CrossRef] [PubMed]
    • Houstis, N.; Rosen, E.D.; Lander, E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440, 944-948. [CrossRef] [PubMed].
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 204
    • 84925507275 scopus 로고    scopus 로고
    • The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA)
    • [CrossRef] [PubMed]
    • Al Rifai, M.; Silverman, M.G.; Nasir, K.; Budoff, M.J.; Blankstein, R.; Szklo, M.; Katz, R.; Blumenthal, R.S.; Blaha, M.J. The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 2015, 239, 629-633. [CrossRef] [PubMed].
    • (2015) Atherosclerosis , vol.239 , pp. 629-633
    • Al Rifai, M.1    Silverman, M.G.2    Nasir, K.3    Budoff, M.J.4    Blankstein, R.5    Szklo, M.6    Katz, R.7    Blumenthal, R.S.8    Blaha, M.J.9
  • 205
    • 84893903196 scopus 로고    scopus 로고
    • The relationship between advanced oxidation protein products (AOPP) and biochemical and histopathological findings in patients with nonalcoholic steatohepatitis
    • [CrossRef] [PubMed]
    • Ozenirler, S.; Erkan, G.; Konca Degertekin, C.; Ercin, U.; Cengiz, M.; Bilgihan, A.; Yilmaz, G.; Akyol, G. The relationship between advanced oxidation protein products (AOPP) and biochemical and histopathological findings in patients with nonalcoholic steatohepatitis. J. Dig. Dis. 2014, 15, 131-136. [CrossRef] [PubMed].
    • (2014) J. Dig. Dis , vol.15 , pp. 131-136
    • Ozenirler, S.1    Erkan, G.2    Konca Degertekin, C.3    Ercin, U.4    Cengiz, M.5    Bilgihan, A.6    Yilmaz, G.7    Akyol, G.8
  • 206
    • 33845390864 scopus 로고    scopus 로고
    • Protein adducts generated from products of lipid oxidation: Focus on HNE and one
    • [CrossRef] [PubMed]
    • Sayre, L.M.; Lin, D.; Yuan, Q.; Zhu, X.; Tang, X. Protein adducts generated from products of lipid oxidation: Focus on HNE and one. Drug Metabol. Rev. 2006, 38, 651-675. [CrossRef] [PubMed].
    • (2006) Drug Metabol. Rev , vol.38 , pp. 651-675
    • Sayre, L.M.1    Lin, D.2    Yuan, Q.3    Zhu, X.4    Tang, X.5
  • 207
    • 84915803580 scopus 로고    scopus 로고
    • Oral coenzyme Q10 supplementation in patients with nonalcoholic fatty liver disease: Effects on serum vaspin, chemerin, pentraxin 3, insulin resistance and oxidative stress
    • [CrossRef] [PubMed]
    • Farhangi, M.A.; Alipour, B.; Jafarvand, E.; Khoshbaten, M. Oral coenzyme Q10 supplementation in patients with nonalcoholic fatty liver disease: Effects on serum vaspin, chemerin, pentraxin 3, insulin resistance and oxidative stress. Arch. Med. Res. 2014, 45, 589-595. [CrossRef] [PubMed].
    • (2014) Arch. Med. Res , vol.45 , pp. 589-595
    • Farhangi, M.A.1    Alipour, B.2    Jafarvand, E.3    Khoshbaten, M.4
  • 208
    • 28044466416 scopus 로고    scopus 로고
    • Measurement of the total antioxidant response using a novel automated method in subjects with nonalcoholic steatohepatitis
    • [CrossRef] [PubMed]
    • Horoz, M.; Bolukbas, C.; Bolukbas, F.F.; Sabuncu, T.; Aslan, M.; Sarifakiogullari, S.; Gunaydin, N.; Erel, O. Measurement of the total antioxidant response using a novel automated method in subjects with nonalcoholic steatohepatitis. BMC Gastroenterol. 2005, 5, 35. [CrossRef] [PubMed].
    • (2005) BMC Gastroenterol , vol.5 , pp. 35
    • Horoz, M.1    Bolukbas, C.2    Bolukbas, F.F.3    Sabuncu, T.4    Aslan, M.5    Sarifakiogullari, S.6    Gunaydin, N.7    Erel, O.8
  • 209
    • 1442300220 scopus 로고    scopus 로고
    • Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis
    • [PubMed]
    • Koruk, M.; Taysi, S.; Savas, M.C.; Yilmaz, O.; Akcay, F.; Karakok, M. Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis. Ann. Clin. Lab. Sci. 2004, 34, 57-62. [PubMed].
    • (2004) Ann. Clin. Lab. Sci , vol.34 , pp. 57-62
    • Koruk, M.1    Taysi, S.2    Savas, M.C.3    Yilmaz, O.4    Akcay, F.5    Karakok, M.6
  • 210
    • 84930860402 scopus 로고    scopus 로고
    • Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: An update
    • [PubMed]
    • Athyros, V.G.; Tziomalos, K.; Katsiki, N.; Doumas, M.; Karagiannis, A.; Mikhailidis, D.P. Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease: An update. World J. Gastroenterol. 2015, 21, 6820-6834. [PubMed].
    • (2015) World J. Gastroenterol , vol.21 , pp. 6820-6834
    • Athyros, V.G.1    Tziomalos, K.2    Katsiki, N.3    Doumas, M.4    Karagiannis, A.5    Mikhailidis, D.P.6
  • 211
    • 84945931788 scopus 로고    scopus 로고
    • The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease
    • [PubMed]
    • Linhart, K.B.; Glassen, K.; Peccerella, T.;Waldherr, R.; Linhart, H.; Bartsch, H.; Seitz, H.K. The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease. Hepatobiliary Surg. Nutr. 2015, 4, 117-123. [PubMed].
    • (2015) Hepatobiliary Surg. Nutr , vol.4 , pp. 117-123
    • Linhart, K.B.1    Glassen, K.2    Peccerella, T.3    Waldherr, R.4    Linhart, H.5    Bartsch, H.6    Seitz, H.K.7
  • 212
    • 29644435115 scopus 로고    scopus 로고
    • The role of Keap1 in cellular protective responses
    • [CrossRef] [PubMed]
    • Dinkova-Kostova, A.T.; Holtzclaw,W.D.; Kensler, T.W. The role of Keap1 in cellular protective responses. Chem. Res. Toxicol. 2005, 18, 1779-1791. [CrossRef] [PubMed].
    • (2005) Chem. Res. Toxicol , vol.18 , pp. 1779-1791
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Kensler, T.W.3
  • 213
    • 84863138767 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats
    • [CrossRef] [PubMed]
    • Lei, S.; Liu, Y.; Liu, H.; Yu, H.; Wang, H.; Xia, Z. Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats. Yonsei Med. J. 2012, 53, 294-303. [CrossRef] [PubMed].
    • (2012) Yonsei Med. J , vol.53 , pp. 294-303
    • Lei, S.1    Liu, Y.2    Liu, H.3    Yu, H.4    Wang, H.5    Xia, Z.6
  • 214
    • 70349762427 scopus 로고    scopus 로고
    • A critical role of STAT1 in streptozotocin-induced diabetic liver injury in mice: Controlled by ATF3
    • [CrossRef] [PubMed]
    • Kim, J.Y.; Lee, S.H.; Song, E.H.; Park, Y.M.; Lim, J.Y.; Kim, D.J.; Choi, K.H.; Park, S.I.; Gao, B.; Kim,W.H. A critical role of STAT1 in streptozotocin-induced diabetic liver injury in mice: Controlled by ATF3. Cell Signal. 2009, 21, 1758-1767. [CrossRef] [PubMed].
    • (2009) Cell Signal , vol.21 , pp. 1758-1767
    • Kim, J.Y.1    Lee, S.H.2    Song, E.H.3    Park, Y.M.4    Lim, J.Y.5    Kim, D.J.6    Choi, K.H.7    Park, S.I.8    Gao, B.9    Kim, W.H.10
  • 215
    • 84872155454 scopus 로고    scopus 로고
    • Ulcerative colitis-induced hepatic damage in mice: Studies on inflammation, fibrosis, oxidative DNA damage and GST-P expression
    • [CrossRef] [PubMed]
    • Trivedi, P.P.; Jena, G.B. Ulcerative colitis-induced hepatic damage in mice: Studies on inflammation, fibrosis, oxidative DNA damage and GST-P expression. Chem. Biol. Interact. 2013, 201, 19-30. [CrossRef] [PubMed].
    • (2013) Chem. Biol. Interact , vol.201 , pp. 19-30
    • Trivedi, P.P.1    Jena, G.B.2
  • 216
    • 84937576853 scopus 로고    scopus 로고
    • Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease
    • [CrossRef] [PubMed]
    • Jiang,W.;Wu, N.;Wang, X.; Chi, Y.; Zhang, Y.; Qiu, X.; Hu, Y.; Li, J.; Liu, Y. Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease. Sci. Rep. 2015, 5, 8096. [CrossRef] [PubMed].
    • (2015) Sci. Rep , vol.5 , pp. 8096
    • Jiang, W.1    Wu, N.2    Wang, X.3    Chi, Y.4    Zhang, Y.5    Qiu, X.6    Hu, Y.7    Li, J.8    Liu, Y.9
  • 217
    • 84880339863 scopus 로고    scopus 로고
    • Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: Studies on inflammation, oxidative stress, DNA damage and fibrosis
    • [CrossRef] [PubMed]
    • Trivedi, P.P.; Jena, G.B. Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: Studies on inflammation, oxidative stress, DNA damage and fibrosis. Food Chem. Toxicol. 2013, 59, 339-355. [CrossRef] [PubMed].
    • (2013) Food Chem. Toxicol , vol.59 , pp. 339-355
    • Trivedi, P.P.1    Jena, G.B.2
  • 220
    • 84908029914 scopus 로고    scopus 로고
    • Obesity and the liver: Nonalcoholic fatty liver disease
    • [CrossRef] [PubMed]
    • Koppe, S.W. Obesity and the liver: Nonalcoholic fatty liver disease. Transl. Res. 2014, 164, 312-322. [CrossRef] [PubMed].
    • (2014) Transl. Res , vol.164 , pp. 312-322
    • Koppe, S.W.1
  • 221
    • 84880036121 scopus 로고    scopus 로고
    • Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease
    • [CrossRef] [PubMed]
    • Sourianarayanane, A.; Garg, G.; Smith, T.H.; Butt, M.I.; McCullough, A.J.; Shen, B. Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease. J. Crohns Colitis 2013, 7, e279-e285. [CrossRef] [PubMed].
    • (2013) J. Crohns Colitis , vol.7 , pp. e279-e285
    • Sourianarayanane, A.1    Garg, G.2    Smith, T.H.3    Butt, M.I.4    McCullough, A.J.5    Shen, B.6
  • 222
    • 41849123475 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: Implications for treatment
    • [CrossRef] [PubMed]
    • Carter-Kent, C.; Zein, N.N.; Feldstein, A.E. Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: Implications for treatment. Am. J. Gastroenterol. 2008, 103, 1036-1042. [CrossRef] [PubMed].
    • (2008) Am. J. Gastroenterol , vol.103 , pp. 1036-1042
    • Carter-Kent, C.1    Zein, N.N.2    Feldstein, A.E.3
  • 223
    • 84942821013 scopus 로고    scopus 로고
    • Drug-induced liver injury: Interactions between drug properties and host factors
    • [CrossRef] [PubMed]
    • Chen, M.; Suzuki, A.; Borlak, J.; Andrade, R.J.; Lucena, M.I. Drug-induced liver injury: Interactions between drug properties and host factors. J. Hepatol. 2015, 63, 503-514. [CrossRef] [PubMed].
    • (2015) J. Hepatol , vol.63 , pp. 503-514
    • Chen, M.1    Suzuki, A.2    Borlak, J.3    Andrade, R.J.4    Lucena, M.I.5
  • 224
    • 84884942175 scopus 로고    scopus 로고
    • Drug-induced liver injury from antiepileptic drugs
    • [CrossRef] [PubMed]
    • Au, J.S.; Pockros, P.J. Drug-induced liver injury from antiepileptic drugs. Clin. Liver Dis. 2013, 17, 687-697. [CrossRef] [PubMed].
    • (2013) Clin. Liver Dis , vol.17 , pp. 687-697
    • Au, J.S.1    Pockros, P.J.2
  • 225
    • 84884989156 scopus 로고    scopus 로고
    • Mechanisms of drug-induced liver injury
    • [CrossRef] [PubMed]
    • Yuan, L.; Kaplowitz, N. Mechanisms of drug-induced liver injury. Clin. Liver Dis. 2013, 17, 507-518. [CrossRef] [PubMed].
    • (2013) Clin. Liver Dis , vol.17 , pp. 507-518
    • Yuan, L.1    Kaplowitz, N.2
  • 226
    • 84878325626 scopus 로고    scopus 로고
    • Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland
    • [CrossRef] [PubMed]
    • Björnsson, E.S.; Bergmann, O.M.; Björnsson, H.K.; Kvaran, R.B.; Olafsson, S. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology 2013, 144, 1419-1425. [CrossRef] [PubMed].
    • (2013) Gastroenterology , vol.144 , pp. 1419-1425
    • Björnsson, E.S.1    Bergmann, O.M.2    Björnsson, H.K.3    Kvaran, R.B.4    Olafsson, S.5
  • 228
    • 84924907912 scopus 로고    scopus 로고
    • A Review of Drug-induced Liver Injury
    • [CrossRef]
    • Amirana, S.; Babby, J. A Review of Drug-induced Liver Injury. J. Nurs. Pract. 2015, 11, 270-271. [CrossRef].
    • (2015) J. Nurs. Pract , vol.11 , pp. 270-271
    • Amirana, S.1    Babby, J.2
  • 229
    • 84921874747 scopus 로고    scopus 로고
    • Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury
    • [CrossRef] [PubMed]
    • Tan, C.Y.; Saw, T.Y.; Fong, C.W.; Ho, H.K. Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury. Redox Biol. 2015, 4, 308-320. [CrossRef] [PubMed].
    • (2015) Redox Biol , vol.4 , pp. 308-320
    • Tan, C.Y.1    Saw, T.Y.2    Fong, C.W.3    Ho, H.K.4
  • 230
    • 0030302618 scopus 로고    scopus 로고
    • Assessing the Impact of Pesticides on Lumbricid Populations: An Individual Based Modelling Approach
    • [CrossRef]
    • Baveco, J.M.; Roos, A.M.D. Assessing the Impact of Pesticides on Lumbricid Populations: An Individual Based Modelling Approach. J. Appl. Ecol. 1996, 33, 1451-1468. [CrossRef].
    • (1996) J. Appl. Ecol , vol.33 , pp. 1451-1468
    • Baveco, J.M.1    Roos, A.M.D.2
  • 231
    • 84883764273 scopus 로고    scopus 로고
    • Evaluation of DNA damage and cytotoxicity induced by three commonly used organophosphate pesticides individually and in mixture, in rat tissues
    • [CrossRef] [PubMed]
    • Ojha, A.; Yaduvanshi, S.K.; Pant, S.C.; Lomash, V.; Srivastava, N. Evaluation of DNA damage and cytotoxicity induced by three commonly used organophosphate pesticides individually and in mixture, in rat tissues. Environ. Toxicol. 2013, 28, 543-552. [CrossRef] [PubMed].
    • (2013) Environ. Toxicol , vol.28 , pp. 543-552
    • Ojha, A.1    Yaduvanshi, S.K.2    Pant, S.C.3    Lomash, V.4    Srivastava, N.5
  • 232
    • 0026487266 scopus 로고
    • Hepatotoxicity of trichlorfon and dichlorvos in isolated rat hepatocytes
    • [CrossRef]
    • Yamano, T.; Morita, S. Hepatotoxicity of trichlorfon and dichlorvos in isolated rat hepatocytes. Toxicology 1992, 76, 69-77. [CrossRef].
    • (1992) Toxicology , vol.76 , pp. 69-77
    • Yamano, T.1    Morita, S.2
  • 233
    • 0025325099 scopus 로고
    • Protective effects of antioxidants against endrin-induced lipid peroxidation, glutathione depletion, and lethality in rats
    • [CrossRef] [PubMed]
    • Numan, I.T.; Hassan, M.Q.; Stohs, S.J. Protective effects of antioxidants against endrin-induced lipid peroxidation, glutathione depletion, and lethality in rats. Arch. Environ. Contam. Toxicol. 1990, 19, 302-306. [CrossRef] [PubMed].
    • (1990) Arch. Environ. Contam. Toxicol , vol.19 , pp. 302-306
    • Numan, I.T.1    Hassan, M.Q.2    Stohs, S.J.3
  • 234
    • 0025824465 scopus 로고
    • Endrin-induced histopathological changes and lipid peroxidation in livers and kidneys of rats, mice, guinea pigs and hamsters
    • [CrossRef] [PubMed]
    • Hassan, M.Q.; Numan, I.T.; Al-Nasiri, N.; Stohs, S.J. Endrin-induced histopathological changes and lipid peroxidation in livers and kidneys of rats, mice, guinea pigs and hamsters. Toxicol. Pathol. 1991, 19, 108-114. [CrossRef] [PubMed].
    • (1991) Toxicol. Pathol , vol.19 , pp. 108-114
    • Hassan, M.Q.1    Numan, I.T.2    Al-Nasiri, N.3    Stohs, S.J.4
  • 235
    • 61449200235 scopus 로고    scopus 로고
    • Carbon tetrachloride-induced liver damage in asialoglycoprotein receptor-deficient mice
    • [CrossRef] [PubMed]
    • Dalton, S.R.; Lee, S.M.; King, R.N.; Nanji, A.A.; Kharbanda, K.K.; Casey, C.A.; McVicker, B.L. Carbon tetrachloride-induced liver damage in asialoglycoprotein receptor-deficient mice. Biochem. Pharmacol. 2009, 77, 1283-1290. [CrossRef] [PubMed].
    • (2009) Biochem. Pharmacol , vol.77 , pp. 1283-1290
    • Dalton, S.R.1    Lee, S.M.2    King, R.N.3    Nanji, A.A.4    Kharbanda, K.K.5    Casey, C.A.6    McVicker, B.L.7
  • 236
    • 73349136974 scopus 로고    scopus 로고
    • Role of free radicals in liver diseases
    • [CrossRef] [PubMed]
    • Muriel, P. Role of free radicals in liver diseases. Hepatol. Int. 2009, 3, 526-536. [CrossRef] [PubMed].
    • (2009) Hepatol. Int , vol.3 , pp. 526-536
    • Muriel, P.1
  • 239
  • 240
    • 34547768785 scopus 로고    scopus 로고
    • Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress
    • [CrossRef] [PubMed]
    • Fukuda, K.; Asoh, S.; Ishikawa, M.; Yamamoto, Y.; Ohsawa, I.; Ohta, S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem. Biophys. Res. Commun. 2007, 361, 670-674. [CrossRef] [PubMed].
    • (2007) Biochem. Biophys. Res. Commun , vol.361 , pp. 670-674
    • Fukuda, K.1    Asoh, S.2    Ishikawa, M.3    Yamamoto, Y.4    Ohsawa, I.5    Ohta, S.6
  • 241
    • 84873714923 scopus 로고    scopus 로고
    • Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis
    • [CrossRef] [PubMed]
    • Kireev, R.; Bitoun, S.; Cuesta, S.; Tejerina, A.; Ibarrola, C.; Moreno, E.; Vara, E.; Tresguerres, J.A. Melatonin treatment protects liver of Zucker rats after ischemia/reperfusion by diminishing oxidative stress and apoptosis. Eur. J. Pharmacol. 2013, 701, 185-193. [CrossRef] [PubMed].
    • (2013) Eur. J. Pharmacol , vol.701 , pp. 185-193
    • Kireev, R.1    Bitoun, S.2    Cuesta, S.3    Tejerina, A.4    Ibarrola, C.5    Moreno, E.6    Vara, E.7    Tresguerres, J.A.8
  • 243
    • 84926361584 scopus 로고    scopus 로고
    • As2O3 induces apoptosis in human hepatocellular carcinoma HepG2 cells through a ROS-mediated mitochondrial pathway and activation of caspases
    • [PubMed]
    • Jiang, L.; Wang, L.; Chen, L.; Cai, G.H.; Ren, Q.Y.; Chen, J.Z.; Shi, H.J.; Xie, Y.H. As2O3 induces apoptosis in human hepatocellular carcinoma HepG2 cells through a ROS-mediated mitochondrial pathway and activation of caspases. Int. J. Clin. Exp. Med. 2015, 8, 2190-2196. [PubMed].
    • (2015) Int. J. Clin. Exp. Med , vol.8 , pp. 2190-2196
    • Jiang, L.1    Wang, L.2    Chen, L.3    Cai, G.H.4    Ren, Q.Y.5    Chen, J.Z.6    Shi, H.J.7    Xie, Y.H.8
  • 244
    • 84950978174 scopus 로고    scopus 로고
    • Liver disease and hepatocellular carcinoma in alcoholics: The role of anticraving therapy
    • Borro, P.; Leone, S.; Testino, G. Liver disease and hepatocellular carcinoma in alcoholics: The role of anticraving therapy. Curr. Drug Targets 2015, 16, 13.
    • (2015) Curr. Drug Targets , vol.16 , pp. 13
    • Borro, P.1    Leone, S.2    Testino, G.3
  • 245
    • 56149115918 scopus 로고    scopus 로고
    • Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
    • [CrossRef] [PubMed]
    • Miura, K.; Taura, K.; Kodama, Y.; Schnabl, B.; Brenner, D.A. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 2008, 48, 1420-1429. [CrossRef] [PubMed].
    • (2008) Hepatology , vol.48 , pp. 1420-1429
    • Miura, K.1    Taura, K.2    Kodama, Y.3    Schnabl, B.4    Brenner, D.A.5
  • 246
    • 67049087682 scopus 로고    scopus 로고
    • Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation
    • [CrossRef] [PubMed]
    • Nishikawa, T.; Nakajima, T.; Katagishi, T.; Okada, Y.; Jo, M.; Kagawa, K.; Okanoue, T.; Itoh, Y.; Yoshikawa, T. Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation. Liver Int. 2009, 29, 846-856. [CrossRef] [PubMed].
    • (2009) Liver Int , vol.29 , pp. 846-856
    • Nishikawa, T.1    Nakajima, T.2    Katagishi, T.3    Okada, Y.4    Jo, M.5    Kagawa, K.6    Okanoue, T.7    Itoh, Y.8    Yoshikawa, T.9
  • 248
    • 46749095883 scopus 로고    scopus 로고
    • Oxidative stress in ulcerative colitis-associated carcinogenesis
    • [CrossRef] [PubMed]
    • Roessner, A.; Kuester, D.; Malfertheiner, P.; Schneider-Stock, R. Oxidative stress in ulcerative colitis-associated carcinogenesis. Pathol. Res. Pract. 2008, 204, 511-524. [CrossRef] [PubMed].
    • (2008) Pathol. Res. Pract , vol.204 , pp. 511-524
    • Roessner, A.1    Kuester, D.2    Malfertheiner, P.3    Schneider-Stock, R.4
  • 249
    • 84894477345 scopus 로고    scopus 로고
    • Cisplatin otoprotection using transtympanic L-N-acetylcysteine: A pilot randomized study in head and neck cancer patients
    • [CrossRef] [PubMed]
    • Yoo, J.; Hamilton, S.J.; Angel, D.; Fung, K.; Franklin, J.; Parnes, L.S.; Lewis, D.; Venkatesan, V.;Winquist, E. Cisplatin otoprotection using transtympanic L-N-acetylcysteine: A pilot randomized study in head and neck cancer patients. Laryngoscope 2014, 124, E87-E94. [CrossRef] [PubMed].
    • (2014) Laryngoscope , vol.124 , pp. E87-E94
    • Yoo, J.1    Hamilton, S.J.2    Angel, D.3    Fung, K.4    Franklin, J.5    Parnes, L.S.6    Lewis, D.7    Venkatesan, V.8    Winquist, E.9
  • 250
    • 33646464224 scopus 로고    scopus 로고
    • N-acetylcysteine has neuroprotective effects against oxaliplatin-based adjuvant chemotherapy in colon cancer patients: Preliminary data
    • [CrossRef] [PubMed]
    • Lin, P.C.; Lee, M.Y.; Wang, W.S.; Yen, C.C.; Chao, T.C.; Hsiao, L.T.; Yang, M.H.; Chen, P.M.; Lin, K.P.; Chiou, T.J. N-acetylcysteine has neuroprotective effects against oxaliplatin-based adjuvant chemotherapy in colon cancer patients: Preliminary data. Support. Care Cancer 2006, 14, 484-487. [CrossRef] [PubMed].
    • (2006) Support. Care Cancer , vol.14 , pp. 484-487
    • Lin, P.C.1    Lee, M.Y.2    Wang, W.S.3    Yen, C.C.4    Chao, T.C.5    Hsiao, L.T.6    Yang, M.H.7    Chen, P.M.8    Lin, K.P.9    Chiou, T.J.10
  • 251
    • 84889575198 scopus 로고    scopus 로고
    • Modulation of oxidative stress as an anticancer strategy
    • [CrossRef] [PubMed]
    • Gorrini, C.; Harris, I.S.; Mak, T.W. Modulation of oxidative stress as an anticancer strategy. Nat. Rev. Drug Discov. 2013, 12, 931-947. [CrossRef] [PubMed].
    • (2013) Nat. Rev. Drug Discov , vol.12 , pp. 931-947
    • Gorrini, C.1    Harris, I.S.2    Mak, T.W.3
  • 252
    • 80755126040 scopus 로고    scopus 로고
    • Administration of substances to laboratory animals: Routes of administration and factors to consider
    • [PubMed]
    • Turner, P.V.; Brabb, T.; Pekow, C.; Vasbinder, M.A. Administration of substances to laboratory animals: Routes of administration and factors to consider. J. Am. Assoc. Lab. Anim. Sci. 2011, 50, 600-613. [PubMed].
    • (2011) J. Am. Assoc. Lab. Anim. Sci , vol.50 , pp. 600-613
    • Turner, P.V.1    Brabb, T.2    Pekow, C.3    Vasbinder, M.A.4
  • 253
    • 0015122797 scopus 로고
    • The route of absorption of intraperitoneally administered compounds
    • [PubMed]
    • Lukas, G.; Brindle, S.D.; Greengard, P. The route of absorption of intraperitoneally administered compounds. J. Pharmacol. Exp. Ther. 1971, 178, 562-564. [PubMed].
    • (1971) J. Pharmacol. Exp. Ther , vol.178 , pp. 562-564
    • Lukas, G.1    Brindle, S.D.2    Greengard, P.3
  • 254
    • 0029064248 scopus 로고    scopus 로고
    • The role of the diaphragm in lymphatic absorption from the peritoneal cavity
    • [PubMed]
    • Abu-Hijleh, M.F.; Habbal, O.A.; Moqattash, S.T. The role of the diaphragm in lymphatic absorption from the peritoneal cavity. J. Anat. 1995, 186 Pt 3, 453-467. [PubMed].
    • J. Anat. 1995, 186 Pt 3 , pp. 453-467
    • Abu-Hijleh, M.F.1    Habbal, O.A.2    Moqattash, S.T.3
  • 255
    • 84938890732 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study
    • [CrossRef] [PubMed]
    • Schmitt, B.; Vicenzi, M.; Garrel, C.; Denis, F.M. Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study. Redox Biol. 2015, 6, 198-205. [CrossRef] [PubMed].
    • (2015) Redox Biol , vol.6 , pp. 198-205
    • Schmitt, B.1    Vicenzi, M.2    Garrel, C.3    Denis, F.M.4
  • 256
    • 84923675740 scopus 로고    scopus 로고
    • Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress
    • [CrossRef] [PubMed]
    • Kadiiska, M.B.; Peddada, S.; Herbert, R.A.; Basu, S.; Hensley, K.; Jones, D.P.; Hatch, G.E.; Mason, R.P. Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress. Free Radic. Biol. Med. 2015, 81, 100-106. [CrossRef] [PubMed].
    • (2015) Free Radic. Biol. Med , vol.81 , pp. 100-106
    • Kadiiska, M.B.1    Peddada, S.2    Herbert, R.A.3    Basu, S.4    Hensley, K.5    Jones, D.P.6    Hatch, G.E.7    Mason, R.P.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.