Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition

Free Radical Biology and Medicine

Volumn 39, Issue 5, 2005, Pages 619-630

  Ronis, Martin J J ^a,b,f   Butura, Angelica ^c   Sampey, Brante P ^d   Shankar, Kartik ^a,b   Prior, Ronald L ^a   Korourian, Sohelia ^b   Albano, Emanuele ^e   Ingelman Sundberg, Magnus ^c   Petersen, Dennis R ^d   Badger, Thomas M ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^f U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Adducts; Alcohol; Cytokines; Hepatotoxicity; Lipid peroxidation; N Acetylcysteine

Indexed keywords

4 HYDROXYNONENAL; ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALCOHOL; ANTIBODY; BIOLOGICAL MARKER; CD14 ANTIGEN; CYTOCHROME P450 2E1; ENDOTOXIN; GLUTATHIONE; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MALONALDEHYDE; MESSENGER RNA; RADICAL; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL INTOXICATION; ALCOHOL LIVER CIRRHOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE MARKER; DRUG EFFECT; ENTERIC FEEDING; ENZYME INDUCTION; ENZYME RELEASE; FATTY LIVER; GENE EXPRESSION REGULATION; INFLAMMATORY INFILTRATE; KUPFFER CELL; LIPID PEROXIDATION; LIVER CYTOSOL; LIVER INJURY; LIVER LEVEL; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RNA ANALYSIS; SCORING SYSTEM; STATISTICAL SIGNIFICANCE;

ACETYLCYSTEINE; ALDEHYDES; ANIMALS; ANTIGENS, CD14; ANTIOXIDANTS; CATTLE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOCHROME P-450 CYP2E1; CYTOKINES; CYTOSOL; ENTERAL NUTRITION; ETHANOL; GLUTATHIONE; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KUPFFER CELLS; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; LIVER; LYMPHOTOXIN-ALPHA; MALE; MALONDIALDEHYDE; NECROSIS; OXIDANTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 23444439192     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.04.011     Document Type: Article

References (57)

1. R.G. Thurman Alcoholic liver injury involves activation of Kupffer cells by endotoxins Am. J. Physiol. 275 1998 G605 G611
2. H. Tilg, and A.M. Diehl N. Engl. J. Med. 343 2000 1467 1476
3. E. Albano C.D.I.N. Sherman V.R. Preedy R.R. Watson Ethanol and the Liver 2002 Taylor & Francis London 153 190
4. G.E. Arteel Oxidants and antioxidants in alcohol-induced liver disease Gastroenterology 124 2003 778 790
5. H. Tsukamoto, S.J. Towner, L.M. Ciofalo, and S.W. French Ethanol-induced liver fibrosis in rats fed high fat diets Hepatology 6 1986 814 822
6. A.A. Nanji, U. Khetty, S.M. Sadrzadeh, and T. Yamanaka Severity of liver injury in experimental alcoholic liver disease: correlation with plasma endotoxin, prostaglandin E2, leukotriene B4 and thromboxane Am. J. Pathol. 142 1993 367 373
7. K.O. Lindros, and H.A. Jarvelainen A new oral low-carbohydrate alcohol liquid diet producing liver lesions: a preliminary account Alcohol Alcoholism 33 1998 347 353
8. V. Paradis, M. Kollinger, M. Fabre, A. Holstege, T. Poynard, and P. Bedossa In situ detection of lipid peroxidation of lipid peroxidation by-products in chronic liver diseases Hepatology 26 1997 135 142
9. K.T. Knecht, B.U. Bradford, R.P. Mason, and R.G. Thurman In vivo formation of a free radical metabolite of ethanol Mol. Pharmacol. 38 1990 26 30
10. E. Albano, P. Clot, M. Morimoto, A. Tomasi, M. Ingelman-Sundberg, and S.W. French Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol Hepatology 23 1996 155 163
11. A.A. Caro, and A.I. Cederbaum Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1 Mol. Pharmacol. 60 2001 742 752
12. Y. Iimuro, B.U. Bradford, S. Yamashina, I. Rusyn, M. Nakagami, N. Enomoto, H. Kono, W. Frey, D. Forman, D. Brenner, and R.G. Thurman The glutathione precursor l-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat Hepatology 31 2000 391 398
13. S. McKim, A. Konno, E. Gabele, T. Uesugi, M. Froh, H. Sies, R.G. Thurman, and G. Arteel Cocoa extract protects against early alcohol-induced liver injury in the rat Arch. Biochem. Biophys. 406 2002 40 46
14. G.E. Arteel, T. Uesugi, L.N. Bevan, E. Gabele, M.D. Wheeler, S.E. McKim, and R.G. Thurman Green tea extract protects against early alcohol-induced liver injury in rats Biol. Chem. 383 2002 663 670
15. M.D. Wheeler, H. Knon, M. Yin, I. Rusyn, M. Froh, H.D. Connor, R.P. Mason, R.J. Samulski, and R.G. Thurman Delivery of Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats Gastroenterology 120 2001 1241 1250
16. M.D. Wheeler, M. Nakagami, B.U. Bradford, T. Uesugi, R.P. Mason, H.D. Connor, A. Dikalova, M. Kadiiska, and R.G. Thurman Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat J. Biol. Chem. 276 2001 36664 36672
17. N. Enomoto, K. Ikejima, B. Bradford, C. Rivera, H. Kono, D.A. Brenner, and R.G. Thurman Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin Gastroenterology 115 1998 443 451
18. M.D. Wheeler, and R.G. Thurman Up-regulation of CD14 in liver caused by acute ethanol involves oxidant-dependent AP-1 pathway J. Biol. Chem. 278 2003 8435 8441
19. S. Korourian, R. Hakkak, M.J.J. Ronis, S.R. Shelnutt, J. Waldran, M. Ingelman-Sundberg, and T.M. Badger Diet and risk of ethanol-induced hepatotoxicity: carbohydrate-fat relationships in rats Toxicol. Sci. 47 1999 110 117
20. M.J.J. Ronis, S. Korourian, M. Zipperman, R. Hakkak, and T.M. Badger Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition J. Nutr. 134 2004 904 912
21. M.J.J. Ronis, R. Hakkak, S. Korourian, E. Albano, S. Yoon, M. Ingelman-Sundberg, K.O. Lindros, and T.M. Badger Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate diets Exp. Biol. Med. 229 2004 351 360
22. M.J.J. Ronis, S. Korourian, S. Yoon, M. Ingelman-Sundberg, E. Albano, K.O. Lindros, and T.M. Badger Lack of sexual dimorphism in alcohol-induced liver damage (ALD) in rats treated chronically with ethanol-containing low carbohydrate diets: The role of ethanol metabolism and endotoxin Life Sci. 75 2004 469 483
23. C. Ioannedes, D.E. Hall, D.E. Mulder, C.M. Steele, J. Spickett, M. Delaforge, and D.V. Parke A comparison of the protective effects of N-acetyl cysteine and S-carboxymethylcysteine against paracetamol-induced hepatotoxicity Toxicology 28 1983 313 321
24. N.A. Buckley, I.M. Whyte, D.L. O'Connell, and A.H. Dawson Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? J. Toxicol. 37 1999 759 767
25. C.S. Lieber Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases Adv. Pharmacol. 38 1997 601 628
26. T.M. Badger, M.J.J. Ronis, C.K. Lumpkin Jr., C.K. Valentine, M. Shahare, D. Irby, J. Huang, C. Mercado, P.E. Thomas, M. Ingelman-Sundberg, and J. Crouch Effects of chronic ethanol on growth hormone secretion and hepatic P450 isozymes of the rat J. Pharmacol. Exp. Ther. 264 1993 438 447
27. M.J.J. Ronis, J. Crouch, C. Mercado, D. Irby, C.R. Valentine, C.K. Lumpkin Jr., M. Ingelman-Sundberg, and T.M. Badger Cytochrome P450 CYP 2E1 Induction during chronic alcohol exposure occurs by a two step mechanism associated with blood alcohol concentrations in rats J. Pharmacol. Exp. Ther. 264 1993 944 950
28. I. Johansson, and M. Ingelman-Sundberg Carbon tetrachloride-induced lipid peroxidation dependent on an ethanol-inducible form of rabbit liver microsomal cytochrome P450 FEBS Lett. 183 1985 2467 2471
29. G. Cao, and R.L. Prior Measurement of oxygen radical absorbance capacity in biological samples Methods Enzymol. 99 1992 50 62
30. FL)) of plasma and other biological and food samples J. Agric. Food Chem. 51 2003 3273 3279
31. B.P. Sampey, S. Korourian, M.J.J. Ronis, T.M. Badger, and D.R. Petersen Immunohistochemical characterization of hepatic malondialdehyde and 4-hydroxynonenal modified proteins during early stages of ethanol-induced liver injury Alcohol Clin. Exp. Res. 27 2003 1015 1022
32. E. Mottaran, S.F. Stewart, R. Rolla, D. Vay, V. Cipriani, M.G. Moretti, M. Vidali, M. Sartori, C. Rigamonti, C.P. Day, and E. Albano Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease Free Radic. Biol. Med. 32 2002 38 45
33. K. Shankar, M. Hidestrand, B. Yarberri, R. Xiao, F.A. Simmen, T.M. Badger, and M.J.J. Ronis Microarray-based analysis of nutrition ethanol interactions during gestation The Toxicologist 84 2005 57
34. T.M. Badger, J. Crouch, D. Irby, R. Hakkak, and M. Shahare Episodic excretion of ethanol during chronic intragastric ethanol infusion in rats J. Pharmacol. Exp. Ther. 264 1993 938 943
35. W.-H. Fang, Y.-M. Yao, Z.-G. Shi, Y. Yu, Y. Wu, L.-R. Lu, and Z.-Y. Sheng Effect of recombinant bactericidal/permeability-increasing protein on endotoxin translocation and lipopolysaccharide-binding protein/CD14 expression in rats after thermal injury Crit. Care Med. 29 2001 1452 1459
36. N. Enomoto, S. Yamashina, P. Schemmer, C.A. Rivera, B.U. Bradford, A. Enomoto, D.A. Brenner, and R.G. Thurman Estriol sensitizes rat Kupffer cells via gut-derived endotoxin Am. J. Physiol. 277 1999 G671 G677
37. H. Kono, I. Rusyn, M. Yin, E. Gabele, S. Yamashina, A. Dikalova, M.B. Kadiska, H.D. Connor, R.P. Mason, B.H. Segal, B.U. Bradford, S.M. Holland, and R.G. Thurman NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease J. Clin. Invest. 106 2000 867 872
38. M.J.J. Ronis, K.O. Lindros, and M. Ingelman-Sundberg The CYP2E1 subfamily C. Ioannides Cytochromes P450: metabolic and toxicological aspects 1996 CRC Press Boca Raton, FL 211 239
39. A.A. Caro, and A.I. Cederbaum Oxidative stress, toxicology and pharmacology of CYP2E1 Annu. Rev. Pharmacol. Toxicol. 44 2004 27 42
40. M. Morimoto, A.-L. Hagbjork, Y.J. Wan, P.C. Fu, P. Clot, E. Albano, M. Ingelman-Sundberg, and S.W. French Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors Hepatology 21 1995 1610 1617
41. C. Fang, K.O. Lindros, T.M. Badger, M.J.J. Ronis, and M. Ingelman-Sundberg Zonated expression of cytokines in rat liver. Effect of chronic ethanol and the cytochrome P450 2E1 inhibitor chlormethiazole Hepatology 27 1998 1304 1310
42. G. Poli Pathogenesis of liver fibrosis: role of oxidative stress Mol. Aspects Med. 21 2000 49 98
43. A.A. Nanji, S. Zhao, S.M.H. Sadrzaheh, and D.J. Waxman Markedly enhanced P450 2E1 induction and lipid peroxidation is associated with severe liver in fish-oil-ethanol-fed rats Alcohol Clin. Exp. Res. 18 1994 1280 1285
44. A.A. Nanji, K. Jokelainen, G.L. Tipoe, A. Rehemtulla, and A.J. Dannenberg Dietary saturated fatty acids reverse inflammatory changes in rat liver despite continued ethanol administration J. Pharmacol. Exp. Ther. 299 2001 638 644
45. R.J. Schauer, H. Zollner, and H. Esterbauer Biological effects of aldehydes with particular attention to 4-hydroxynonenal and malondialdehyde C. Vigo-Pelfrey Membrane Lipid Peroxidation vol. 3 1990 CRC Press Boca Raton, FL 141 163
46. G. Poli, and R.J. Schauer 4-Hydroxynonenal in the pathomehanisms of oxidative stress IUBMB Life 50 2000 315 321
47. K. Okada, C. Wangpoengtrakul, T. Osawa, S. Toyokuni, K. Tanaka, and K. Uchida 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress: indentification of proteosomes as target molecules J. Biol. Chem. 274 1999 23787 23793
48. L.E. Nagy Molecular aspects of alcohol metabolism: Transcription factors involved in early ethanol-induced liver injury Annu. Rev. Nutr. 24 2004 55 678
49. D.A. Stoyanovsky, D. Wu, and A.I. Cederbaum Interaction of 1-hydroxyethyl radical with glutathione, ascorbic acid and alpha-tocopherol Free Radic. Biol. Med. 24 1998 132 138
50. D.R. Dufour, J.A. Lott, F.S. Nolte, D.R. Gretch, R.S. Koff, and L.B. Seef Diagnosis and monitoring of hepatic injury: II. Recommendations for use of laboratory tests in screening diagnosis and monitoring Clin. Chem. 46 2000 2050 2068
51. M. Yin, M.D. Wheeler, H. Kono, B.U. Bradford, R.M. Gallucci, M.I. Luster, and R.G. Thurman Essential role of tumor necrosis factor α in alcohol-induced liver injury Gastroenterology 117 1999 942 952
52. Z. Zhou, L. Wang, Z. Song, J.C. Lambert, C.J. McClain, and Y.J. Kang A critical involvement of oxidative stress in acute alcohol-induced hepatic TNFα production Am. J. Pathol. 163 2003 1137 1146
53. C.J. McClain, S. Barve, I. Deaciuc, M. Kugelmas, and D. Hill Tumor necrosis factor and alcoholic liver disease Semin. Liver Dis. 19 1999 205 219
54. C. Ji, Q. Deng, and N. Kaplowitz Role of TNFα in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury Hepatology 40 2004 442 451
55. S.M.H. Sadrzadeh, and A.A. Nanji The 21-aminosterolid 16-desmethyl-tirilazad mesylate prevents necroinflammatory changes in experimental alcoholic liver disease J. Pharmacol. Exp. Ther. 284 1998 406 412
56. S.F. Stewart, M. Vidali, C.P. Day, E. Albano, and D.E.J. Jones Oxidative stress as a trigger for cellular immune response in patients with alcoholic liver disease Hepatology 39 2004 197 203
57. P. Clot, M. Parola, G. Bellomo, U. Dianzani, R. Carini, M. Tabone, S. Aricò, M. Ingelman-Sundberg, and E. Albano Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol Gastroenterology 113 1997 265 276