The effects of N-acetylcysteine on hepatic function during isoflurane anaesthesia for laparoscopic surgery patients

Indian Journal of Anaesthesia

Volumn 55, Issue 6, 2011, Pages 567-572

  Beyaz, Serbülent Gökhan ^a   Yelken, Birgul ^b   Kanbak, Güngor ^b  

^a SAKARYA UNIVERSITY   (Turkey)

^b OSMANGAZI UNIVERSITY MEDICAL FACULTY   (Turkey)

Author keywords

Isoflurane; Liver function tests; N acetylcysteine

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ATROPINE; EPHEDRINE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE TRANSFERASE; ISOFLURANE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NITRIC OXIDE; OXYGEN; PHENIRAMINE; PLACEBO; THIOPENTAL; VECURONIUM;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANESTHESIA INDUCTION; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; COUGHING; DRUG DOSE REDUCTION; DRUG EFFECT; FEMALE; FLUSHING; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GYNECOLOGIC SURGERY; HUMAN; HYPOTENSION; INTERNATIONAL NORMALIZED RATIO; LACTATE DEHYDROGENASE BLOOD LEVEL; LAPAROSCOPIC SURGERY; LIVER FUNCTION; LIVER FUNCTION TEST; NAUSEA; PARTIAL THROMBOPLASTIN TIME; PERIOPERATIVE PERIOD; PROTHROMBIN TIME; SIDE EFFECT; SURGICAL PATIENT; URTICARIA;

EID: 84855448266     PISSN: 00195049     EISSN: None     Source Type: Journal    
DOI: 10.4103/0019-5049.90610     Document Type: Article

References (34)

1. Kharasch ED. Adverse drug reactions with halogenated anesthetics. Clin Pharmacol Ther 2008;84:158-162. Back to cited text no. 1 [PUBMED] [FULLTEXT]
2. Reichle FM, Conzen PF. Halogenated inhalational anaesthetics. Best Pract Res Clin Anaesthesiol 2003;17:29-46. Back to cited text no. 2 [PUBMED]
3. Bedirli N, Ofluoglu E, Kerem M, Utebey G, Alper M, Yilmazer D, et al. Hepatic energy metabolism and the differential protective effects of sevoflurane and isoflurane anesthesia in a rat hepatic ischemia-reperfusion injury model. Anesth Analg 2008;106:830-837. Back to cited text no. 3 [PUBMED] [FULLTEXT]
4. Wark HJ. Hepatic failure after cardiopulmonary bypass is unlikely to be isoflurane hepatitis. Anesthesiology 2002;97:1323-1324. Back to cited text no. 4 [PUBMED] [FULLTEXT]
5. Ihtiyar E, Algin C, Haciolu A, Isiksoy S. Fatal isoflurane hepatotoxicity without re-exposure. Indian J Gastroenterol 2006;25:41-42. Back to cited text no. 5 [PUBMED]
6. Lu CC, Tsai CS, Hu OY, Chen RM, Chen TL, Ho ST. Pharmacokinetics of isoflurane in human blood. Pharmacology 2008;81:344-349. Back to cited text no. 6 [PUBMED] [FULLTEXT]
7. Lee SA, Choi JG, Zuo Z. Volatile anesthetics attenuate oxidative stress-reduced activity of glutamate transporter type 3. Anesth Analg 2009;109:1506-1510. Back to cited text no. 7 [PUBMED] [FULLTEXT]
8. Njoku DB, Shrestha S, Soloway R, Duray PR, Tsokos M, Abu-Asab MS, et al. Subcellular localization of trifluoroacetylated liver proteins in association with hepatitis following isoflurane. Anesthesiology 2002;96:757-761. Back to cited text no. 8 [PUBMED] [FULLTEXT]
9. Picker O, Beck C, Pannen B. Liver protection in the perioperative setting. Best Pract Res Clin Anaesthesiol 2008;22:209-24. Back to cited text no. 9 [PUBMED]
10. Hynninen MS, Niemi TT, Pöyhiä R, Raininko EI, Salmenperä MT, Lepäntalo MJ, et al. N-acetylcysteine for the prevention of kidney injury in abdominal aortic surgery: A randomized, double-blind, placebo-controlled trial. Anesth Analg 2006;102:1638-1645. Back to cited text no. 10
11. Naughton F, Wijeysundera D, Karkouti K, Tait G, Beattie WS. N-acetylcysteine to reduce renal failure after cardiac surgery: A systematic review and meta-analysis. Can J Anaesth 2008;55:827-835. Back to cited text no. 11 [PUBMED] [FULLTEXT]
12. Oliveira DM, Gomes ES, Mussivand T, Fiorelli AI, Gomes OM. Effects of n-acetylcysteine on ischemic preconditioning: Study in isolated rat hearts. Rev Bras Cir Cardiovasc 2009;24:23-30. Back to cited text no. 12 [PUBMED] [FULLTEXT]
13. Warholm M, Guthenberg C, von Bahr C, Mannervik B. Glutathione transferases from human liver. Methods Enzymol 1985;113:499-504. Back to cited text no. 13 [PUBMED]
14. Ceylan BG, Yilmaz F, Eroglu F, Yavuz L, Gulmen S, Vural H. Oxidant and antioxidant activities of different anesthetic techniques. Propofol versus desflurane. Saudi Med J 2009;30:371-376. Back to cited text no. 14 [PUBMED]
15. th ed. Chapter 25, Philadelphia: Elsevier Churchill Livingstone; 2005. p.928-998. Back to cited text no. 15
16. Toker A, Girgin NK, Turker G, Kutlay O. [Are preoperative routine laboratory tests necessary in minor and moderate surgical procedures?]. Dicle Med J 2008;35:120-127. Back to cited text no. 16
17. Nishiyama T, Yokoyama T, Hanaoka K. Effects of sevoflurane and isoflurane anesthesia on arterial ketone body ratio and liver function. Acta Anaesthesiol Scand 1999;43:347-351. Back to cited text no. 17 [PUBMED] [FULLTEXT]
18. Soma LR, Tierney WJ, Hogan GK, Satoh N. The Effects of multiple administrationsevoflurane to Cynomolgus Monkeys: Clinical pathologic, hematologic and pathologic study. AnesthAnalg 1995;81:347-351. Back to cited text no. 18
19. Wissing H, Kuhn I. The Effect of desflurane on liver function markers in infants and children. Acta Anaesth Scand 2000;44:1149-1157. Back to cited text no. 19 [PUBMED] [FULLTEXT]
20. Kharasch ED, Thummel KE. Identification of cytocrome P450 2E1 as the predominant enzyme catalysing human liver microzomal desfluorinasation of sevoflurane, isoflurane and metoxyflurane. Anesthesiology 1993;79:795-779. Back to cited text no. 20 [PUBMED] [FULLTEXT]
21. Frink EJ. The hepatic effects of sevoflurane. Anesth Analg 1995;81:46-52. Back to cited text no. 21
22. Nishiyama T, Yokoyama T, Hanaoka K. Liver function after sevoflurane or isoflurane anaesthesia in neurosurgical patients. Can J Anaesth 1998;45:753-756. Back to cited text no. 22 [PUBMED] [FULLTEXT]
23. De Gasperi A, Corti A, Mazza E, Prosperi M, Amici O, Bettinelli L. Acute liver failure: Managing coagulopathy and the bleeding diathesis. Transplant Proc 2009;41:1256-1259. Back to cited text no. 23 [PUBMED] [FULLTEXT]
24. Tanaka KA, Key NS, Levy JH. Blood coagulation: Hemostasisand thrombin regulation. Anesth Analg 2009;108:1433-1446. Back to cited text no. 24 [PUBMED] [FULLTEXT]
25. Beaussier M, Deriaz H, Abdelahim Z, Aissa F, Lienhart A. Comparative effects of desflurane and isoflurane on recovery after long lasting anaesthesia. Can J Anaesth 1998;45:429-434. Back to cited text no. 25 [PUBMED] [FULLTEXT]
26. Itoh Y, Yano T, Sendo T, Oishi R. Clinical and experimental evidence for prevention of acute renal failure induced by radiographic contrast media. J Pharmacol Sci 2005;97:473-88. Back to cited text no. 26 [PUBMED] [FULLTEXT]
27. Tepel M, van der Giet M, Schwarzfeld C, Laufer U, Liermann D, Zidek W. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 2000;343:180-184. Back to cited text no. 27 [PUBMED] [FULLTEXT]
28. Frink EJ Jr, Morgan SE, Coetzee A, Conzen PF, Brown BR Jr. The effects ofsevoflurane, halothane, enflurane and isoflurane on hepatic blood flow oxygenisation in chronically. Anesth Analg 1992;76:85-91. Back to cited text no. 28
29. Conzen PF, Vollmar B, Habazettl H, Frink EJ, Peter K, Messmer K. Systemic and regional hemodynamic of isoflurane and sevoflurane in rats. AnesthAnalg 1992;74:79. Back to cited text no. 29
30. Bernard JM, Doursout MF, Wouters P, Hartley CJ, Merin RG, Chelly JE. Effects of sevoflurane and isoflurane on hepatic circulation in the chronically instrumented dog. Anesthesiology 1992;77:541-545. Back to cited text no. 30 [PUBMED] [FULLTEXT]
31. Pohorecki R, Howard BJ, Matsushita M, Stemmer PM, Becker GL, Landers DF. Isoflurane isomers differ in preservation of ATP in anoxic rat hepatocytes. J Pharmacol Exp Ther 1994;268:625-628. Back to cited text no. 31 [PUBMED] [FULLTEXT]
32. Howard BJ, Pohorecki R, Becker GL, Landers DF. Energy status in anoxic rat hepatocytes: Effects of isoflurane, solution composition, and hypothermia. Liver Transpl Surg 1995;1:220-224. Back to cited text no. 32
33. Eger EI, Johnson BH, Strum DP, Ferell LD. Studies of the toxicity of I-653, halothane and isoflurane in enzyme induced hypoxic rats. AnesthAnalg 1987;66:1227-129. Back to cited text no. 33
34. Gelman S, Riverman V, Fowler KC, Bishop SP, Bradley EL. The effect of halothane, isoflurane and blood loss on hepatotoxicity and hepatic oxygen availability in phenobarbital pre treated hypoxic rats. AnesthAnalg 1984;63:965-972. Back to cited text no. 34