N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling

Amino Acids

Volumn 45, Issue 3, 2013, Pages 513-522

  Hou, Yongqing ^a   Wang, Lei ^a   Yi, Dan ^a   Ding, Binying ^a   Yang, Zhenguo ^a   Li, Jiao ^a   Chen, Xing ^a   Qiu, Yinsheng ^a   Wu, Guoyao ^b,c  

^a WUHAN POLYTECHNIC UNIVERSITY   (China)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Aquaporin; Epidermal growth factor; Intestinal mucosa; Lipopolysaccharide; N acetylcysteine; Toll like receptor

Indexed keywords

ACETYLCYSTEINE; AQUAPORIN 8; CATALASE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEAT SHOCK PROTEIN 70; HYDROCORTISONE; HYDROGEN PEROXIDE; INTERLEUKIN 6; MALONALDEHYDE; MESSENGER RNA; OXYGEN; PROSTAGLANDIN E2; SUPEROXIDE DISMUTASE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENTERITIS; ENZYME ACTIVITY; FEMALE; JEJUNUM MUCOSA; NONHUMAN; OXIDATION REDUCTION STATE; PIGLET; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANIMALS; DIETARY SUPPLEMENTS; EPIDERMAL GROWTH FACTOR; FEMALE; INFLAMMATION; INTESTINE, SMALL; LIPOPOLYSACCHARIDES; OXIDATION-REDUCTION; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SWINE; TOLL-LIKE RECEPTOR 4;

EID: 84880919496     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1295-x     Document Type: Article

References (64)

1. Beere HM, Wolf BB, Cain K, et al. (2000) Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2:469-475
2. Bergen WG, Wu G (2009) Intestinal nitrogen recycling and utilization in health and disease. J Nutr 139:821-825
3. Blackwell TS, Blackwell TR, Holden EP, et al. (1996) In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J Immunol 157:1630-1637
4. Brosnan JT, Brosnan ME (2012) Glutamate: a truly functional amino acid. Amino Acids. doi: 10.1007/s00726-012-1280-4
5. Dai ZL, Wu G, Zhu WY (2011) Amino acid metabolism in intestinal bacteria: links between gut ecology and host health. Front Biosci 16:1768-1786
6. Dai ZL, Li XL, Xi PB (2012) l-Glutamine regulates amino acid utilization by intestinal bacteria. Amino Acids. doi: 10.1007/s00726-012-1264-4
7. Deng D, Yin YL, Chu WY, et al. (2009) Impaired translation initiation activation and reduced protein synthesis in weaned piglets fed a low-protein diet. J Nutr Biochem 20:544-552
8. Engler JA, Gupta A, Li L, et al. (1999) Inhibition of DNA synthesis in Caco-2 cells by oxidative stress amelioration by epidermal growth factor. Dig Dis Sci 44:1902-1909
9. Fang YZ, Yang S, Wu G (2002) Free radicals, antioxidants, and nutrition. Nutrition 18:872-879
10. Fishbane S, Durham JH, Marzo K, et al. (2004) N-Acetylcysteine in the prevention of radiocontrast-induced nephropathy. J Am Soc Nephrol 15:251-260
11. Fu WJ, Stromberg AJ, Viele K, et al. (2010) Statistics and bioinformatics in nutritional sciences: analysis of complex data in the era of systems biology. J Nutr Biochem 21:561-572
12. Gao KG, Jiang ZY, Lin YC, et al. (2011) Dietary l-arginine supplementation enhances placental growth and reproductive performance in sows. Amino Acids. doi: 10.1007/s00726-011-0960-9
13. Geng MM, Li TJ, Kong XF, et al. (2011) Reduced expression of intestinal N-acetylglutamate synthase in suckling piglets: a novel molecular mechanism for arginine as a nutritionally essential amino acid for neonates. Amino Acids 40:1513-1522
14. Gribar SC, Anand RJ, Sodhi CP, et al. (2008) The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation. J Leukoc Biol 83:493-498
15. Hardin JA, Wallace LE, Wong JF, et al. (2004) Aquaporin expression is downregulated in a murine model of colitis and in patients with ulcerative colitis, Crohn's disease and infectious colitis. Cell Tissue Res 318:313-323
16. Helmrath MA, Shin CE, Erwin CR (1998) Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression. J Pediatr Surg 33:980-985
17. Hou YQ, Wang L, Ding BY, et al. (2010) Dietary α-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets. Amino Acids 39:555-564
18. Hou YQ, Yao K, Wang L, et al. (2011a) Effects of a-ketoglutarate on energy status in the intestinal mucosa of weaned piglets chronically challenged with lipopolysaccharide. Br J Nutr 106:357-363
19. Hou YQ, Wang L, Ding BY, et al. (2011b) Alpha-ketoglutarate and intestinal function. Front Biosci 16:1186-1196
20. Hou YQ, Wang L, Zhang W, et al. (2011c) Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide. Amino Acids. doi: 10.1007/s00726-011-1191-9
21. Kawai T, Akira S (2006) TLR signaling. Cell Death Differ 13:816-825
22. Knight KR, MacPhadyen K, Lepore DA, et al. (1991) Enhancement of ischaemic rabbit skin flap survival with the antioxidant and free-radical scavenger N-acetylcysteine. Clin Sci (Lond) 81:31-36
23. Kregel KC (2002) Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. J Appl Physiol 92:2177-2186
24. Leaphart CL, Cavallo J, Gribar SC, et al. (2007) A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol 179:4808-4820
25. Lehmann GL, Carreras FI, Soria LR, et al. (2008) LPS induces the TNF-alpha-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis. Am J Physiol Gastrointest Liver Physiol 294:G567-G575
26. Li P, Yin YL, Li DF, et al. (2007) Amino acids and immune function. Br J Nutr 98:237-252
27. Li P, Kim SW, Li XL, et al. (2009) Dietary supplementation with cholesterol and docosahexaenoic acid affects concentrations of amino acids in tissues of young pigs. Amino Acids 37:709-716
28. Li FN, Yin YL, Tan BE, et al. (2011a) Leucine nutrition in animals and humans: mTOR signaling and beyond. Amino Acids 41:1185-1193
29. Li XL, Rezaei R, Li P, et al. (2011b) Composition of amino acids in feed ingredients for animal diets. Amino Acids 40:1159-1168
30. Liu Y, Huang J, Hou Y, et al. (2008) Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs. Br J Nutr 100:552-560
31. Lobo SM, De Backer D, Sun Q, et al. (2003) Gut mucosal damage during endotoxic shock is due to mechanisms other than gut ischemia. J Appl Physiol 95:2047-2054
32. Matsuzaki T, Tajika Y, Ablimit A, et al. (2004) Aquaporins in the digestive system. Med Electron Microsc 37:71-80
33. Mercer DW, Smith GS, Cross JM, et al. (1996) Effects of lipopolysaccharide on intestinal injury: potential role of nitric oxide and lipid peroxidation. J Surg Res 63:185-192
34. Nair RR, Warner BB, Warner BW (2008) Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis. Semin Perinatol 32:107-113
35. Ren WK, Luo W, Wu MM, et al. (2011a) Dietary l-glutamine supplementation improves pregnancy outcome in mice infected with type-2 porcine circovirus. Amino Acids. doi: 10.1007/s00726-011-1134-5
36. Ren W, Yin YL, Liu G, et al. (2011b) Effect of dietary arginine supplementation on reproductive performance of mice with porcine circovirus type 2 infection. Amino Acids. doi: 10.1007/s00726-011-0942-y
37. Rezaei R, Knabe DA, Li XL, et al. (2011) Enhanced efficiency of milk utilization for growth in surviving low-birth-weight piglets. J Anim Sci Biotech 2:73-83
38. Rhoads JM, Wu G (2009) Glutamine, arginine, and leucine signaling in the intestine. Amino Acids 37:111-122
39. Ryan CK, Miller JH, Seydel AS, et al. (1997) Epidermal growth factor and neurotensin induce microvillus hypertrophy following massive enterectomy. J Gastrointest Surg 1:467-473
40. Satterfield MC, Dunlap KA, Keisler DH, et al. (2011) Arginine nutrition and fetal brown adipose tissue development in nutrient-restricted sheep. Amino Acids. doi: 10.1007/s00726-011-1168-8
41. Satterfield MC, Dunlap KA, Keisler DH, et al. (2012) Arginine nutrition and fetal brown adipose tissue development in diet-induced obese sheep. Amino Acids. doi: 10.1007/s00726-012-1235-9
42. Takata K, Matsuzaki T, Tajika Y (2004) Aquaporins: water channel proteins of the cell membrane. Prog Histochem Cytochem 39:1-83
43. Tan BE, Yin YL, Liu ZQ, et al. (2009a) Dietary l-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs. Amino Acids 37:169-175
44. Tan BE, Li XG, Kong XF, et al. (2009b) Dietary l-arginine supplementation enhances the immune status in early-weaned piglets. Amino Acids 37:323-331
45. Tan BE, Yin YL, Kong XF, et al. (2010) l-arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells. Amino Acids 38:1227-1235
46. Thomson ABR, Keelan M, Thiesen A, et al. (2001) Small bowel review diseases of the small intestine. Dig Dis Sci 46:2555-2566
47. Wang JJ, Chen LX, Li DF, et al. (2008) Intrauterine growth restriction affects the proteomes of the small intestine, liver and skeletal muscle in newborn pigs. J Nutr 138:60-66
48. Wang XQ, Ou DY, Yin JD, et al. (2009) Proteomic analysis reveals altered expression of proteins related to glutathione metabolism and apoptosis in the small intestine of zinc oxide-supplemented piglets. Amino Acids 37:209-218
49. Wang JJ, Wu ZL, Li DF, et al. (2012) Nutrition, epigenetics, and metabolic syndrome. Antioxid Redox Signal. doi: 10.1089/ars.2011.4381
50. Webel DM, Finck BN, Baker DH, et al. (1997) Time course of increased plasma cytokines, cortisol and urea nitrogen in pigs following intraperitoneal injection of lipopolysaccharide. J Anim Sci 75:1514-1520
51. Wei JW, Carroll RJ, Harden KK, et al. (2012) Comparisons of treatment means when factors do not interact in two-factorial studies. Amino Acids 42:2031-2035
52. Wilson FA, Suryawan A, Orellana RA, et al. (2011) Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigs. Amino Acids 40:157-165
53. Wu G (2009) Amino acids: metabolism, functions, and nutrition. Amino Acids 37:1-17
54. Wu G (2010a) Functional amino acids in growth, reproduction, and health. Adv Nutr 1:31-37
55. Wu G (2010b) Recent advances in swine amino acid nutrition. J Anim Sci Biotechnol 1:49-61
56. Wu G, Fang YZ, Yang S, et al. (2004) Glutathione metabolism and its implications for health. J Nutr 134:489-492
57. Wu G, Bazer FW, Burghardt RC, et al. (2011a) Proline and hydroxyproline metabolism: implications for animal and human nutrition. Amino Acids 40:1053-1063
58. Wu G, Bazer FW, Johnson GA, et al. (2011b) Important roles for l-glutamine in swine nutrition and production. J Anim Sci 89:2017-2030
59. Xi PB, Jiang ZY, Zheng CT, et al. (2011) Regulation of protein metabolism by glutamine: implications for nutrition and health. Front Biosci 16:578-597
60. Yamamoto T, Kuramoto H, Kadowaki M (2007) Downregulation in aquaporin 4 and aquaporin 8 expression of the colon associated with the induction of allergic diarrhea in a mouse model of food allergy. Life Sci 81:115-120
61. Yao C, Purwanti N, Karabasil MR, et al. (2010) Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos. Am J Pathol 177:724-734
62. Yao K, Yin YL, Li XL, et al. (2011) Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells. Amino Acids. doi: 10.1007/s00726-011-1060-6
63. Yu BP (1994) Cellular defenses against damage from reactive oxygen species. Physiol Rev 74:139-162
64. Zafarullah M, Li WQ, Sylvester J, et al. (2003) Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60:6-20