N-acetyl cysteine and selenium protects mercuric chloride-induced oxidative stress and antioxidant defense system in liver and kidney of rats: A histopathological approach

Journal of Trace Elements in Medicine and Biology

Volumn 28, Issue 2, 2014, Pages 218-226

  Joshi, Deepmala ^a,b   Mittal, Deepak Kumar ^b   Shukla, Sangeeta ^b   Srivastav, Ajai Kumar ^a   Srivastav, Sunil Kumar ^a  

^a D D U GORAKHPUR UNIVERSITY   (India)

^b JIWAJI UNIVERSITY   (India)

Author keywords

Histology; Mercuric chloride; N acetyl cysteine; Oxidative stress; Selenium

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CATALASE; CHOLESTEROL; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; LACTATE DEHYDROGENASE; MERCURIC CHLORIDE; NITROGEN; SELENIUM; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UREA; URIC ACID; ANTIOXIDANT; BIOLOGICAL MARKER; PROTECTIVE AGENT;

ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BIOACCUMULATION; CHOLESTEROL BLOOD LEVEL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER PROTECTION; MALE; MERCURIALISM; MONOTHERAPY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RENAL PROTECTION; TISSUE LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; ADULT; KIDNEY; LIVER; URIC ACID BLOOD LEVEL; ANIMAL; DRUG EFFECTS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY;

ANIMALIA; RATTUS;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; CATALASE; GLUTATHIONE; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; MERCURIC CHLORIDE; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; SELENIUM; SUPEROXIDE DISMUTASE;

EID: 84898027741     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2013.12.006     Document Type: Article

References (57)

1. World Health Organization Inorganic mercury. Environmental health criteria 118 1991, 1-168. World Health Organization, Geneva.
2. Clarkson T.W. The toxicology of mercury. Crit Rev Clin Lab Sci 1997, 34:369-373.
3. Papp A., Nagymajtenyi L., Vezer T. Subchronic mercury treatment of rats in different phases of ontogenesis: functional effects on the central and peripheral nervous system. Food Chem Toxicol 2005, 43:77-85.
4. Perottoni J., Lobato L.P., Silveira A., Rocha J.B., Emanuelli T. Effects of mercury and selenite on daminolevulinate dehydratase activity and on selected oxidative stress parameters in rats. Environ Res 2004, 95:166-173.
5. Ganote C.E., Reimer K.A., Jennings R.B. Acute mercuric chloride nephrotoxicity: an electron microscopic and metabolic study. Lab Invest 1974, 31:633-647.
6. Zalups R.K., Diamond G.L. Mercuric chloride-induced nephrotoxicity in the rat following unilateral nephrectomy and compensatory renal growth. Virchows Arch B 1987, 53:336-346.
7. Kalia K., Flora S.J.S. Strategies for safe and effective therapeutic measure for chronic arsenic and lead poisoning. J Occup Health 2005, 47:1-21.
8. Arakawa M., Ito Y. N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology. Cerebellum 2007, 19:1-7.
9. Saricaoglu F., Dal D., Salman A.E., Atay O.A., Doral M.N., Salman M.A., Kilinç K., Aypar U. Effect of low-dose N-acetylcysteine infusion on tourniquet-induced ischaemia-reperfusion injury in arthroscopic knee surgery. Acta Anaesthesiol Scand 2005, 49:847-851.
10. Stadtman T.C. Selenium-dependent enzymes. Annu Rev Biochem 1980, 49:93-110.
11. Stajn A., Zikic R.V., Ognjanovic B., Saicic Z.S., Pavlovic S.Z., KosticMM, Petrovic V.M. Effect of cadmium and selenium on the antioxidant defence system in rat kidneys. Comp Biochem Physiol 1997, 117C:167-172.
12. Agarwal R., Goel S.K., Behari J.R. Detoxification and antoxidant effects of curcumin in rats experimentally exposed to mercury. J Appl Toxicol 2010, 30:457-468.
13. Giradi E., Elias M. Effect of different glutathione levels on renal mercury deposition and excretion in the rat. Toxicology 1993, 81:57-67.
14. Johri S., Shukla S., Sharma P. Role of antioxidant and chelating agent against beryllium induced toxicity. Indian J Exp Biol 2002, 40:575-582.
15. Reitman S., Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957, 28:56-63.
16. Wroblewski F., La Due J.S. Colorimetric method for LDH. Microanalysis in medical biochemistry 1955, vol. 104:115-118. JA Churchill Ltd., Gloucester. 4th ed.
17. Fiske C.H., Subbarow Y. The colorimetric determination of phosphates. J Biol Chem 1925, 66:375-380.
18. Sharma S.K. Krishna Murti CR. Production of lipidperoxides by brain. J Neurochem 1968, 15:147-149.
19. Brehe J.E., Burch H.B. Enzymatic assay for glutathione. Anal Biochem 1976, 74:189-195.
20. Misra H.P., Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972, 247:3170-3175.
21. Sinha A.K. Colorimetric assay of catalase. Anal Biochem 1972, 47:389-394.
22. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin-Phenol reagent. J Biol Chem 1951, 193:265-275.
23. Skare I. Microdetermination of mercury in biological samples part III automated determination of mercury in urine, fish and blood samples. Analyst 1972, 97:148-155.
24. Domingo J.L. Prevention by chelating agents of metal induced developmental toxicity. Reprod Toxicol 1995, 9:105-113.
25. Carvalho C.M.L., Lu J., Xu Z., Arner E.S.J., Holmgren A. Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. FASEB J 2011, 25:370-381.
26. Miller O.M., Lund B.O., Woods J.S. Reactivity of Hg (II) with superoxide: evidence for the catalytic dismutation of superoxide by Hg (II). J Biochem Toxicol 1999, 6:293-298.
27. Hussain S.A., Atkinson S.J., Thompson A., Khan A.T. Accumulation of mercury and its effect on antioxidant enzymes in brain, liver and kidneys of mice. J Environ Sci Health 1999, 34:645-660.
28. Benov L.C., Benchev I.C., Monovich O.H. Thiol antidotes effect on lipid peroxidation in mercury poisoned rats. Chem Biol Interact 1990, 76:321-332.
29. Liss G., Greenberg R.A., Tamburro C.H. Use of serum bile acids in the identification of vinyl chloride hepatotoxicity. Am J Med 1985, 78:68-76.
30. Plaa G.L., Hewitt W.R. Detection and evaluation of chemically induced liver injury. Principles and methods of toxicology 1986, 401-441. Raven Press, New York. A.W. Hayes (Ed.).
31. Sharma M.K., Madhu Kumar, Ashok Kumar Protection against mercury-induced renal damage in Swiss albino mice by Ocimum sanctum. Environ Toxicol Phrmacol 2005, 19:161-167.
32. Winterbourn C.C. Superoxide as an intracellular sink. Free Radic Biol Med 1993, 14:85-90.
33. El-Shenawy S.M.A., Hassan N.S. Comparative evaluation of the protective effect of selenium and garlic against liver and kidney damage induced by mercury chloride in the rats. Pharmacol Rep 2008, 60:199-208.
34. Harper H.A., Rodwell V.W., Mayes P.A. Review of physiological chemistry 1979, Lange Medical Publications, Los Altos, CA USA.
35. Prasada Rao P.V.V., Jordan S.A., Bhatnager M.K. Ultra structure of kidney of ducks exposed to methylmercury, lead and cadmium in combination. J Environ Pathol Toxicol Oncol 1989, 9:19-44.
36. Bhadauria M., Shukla S., Mathur R., Agrawal O.P., Shrivastava S., Johri S., Joshi D., Singh V. Hepatic endogenous defense potential of propolis after mercury intoxication. Integr Zool 2008, 4:311-321.
37. Sharma M.K., Kumar M., Kumar A. Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian J Exp Biol 2002, 40:1079-1082.
38. Huang Y.L., Cheng S.L., Lin T.H. Lipid peroxidation in rats administrated with mercuric chloride. Biol Trace Elem Res 1996, 52:193-196.
39. Hijova E., Nistiar F., Sipulova A. Changes in ascorbic acid and malondialdehyde in rats after exposure to mercury. Bratisl Lek Listy 2005, 106:248-251.
40. Rao M.V., Purohit A.R. Neuroprotection by melatonin on mercury induced toxicity in the rat brain. Pharmacol Pharm 2011, 2:375-385.
41. Jagadeesan G. Mercury poisoning and its antidotes. Biochem Cell Arch 2004, 4:5-60.
42. Shanmugasundaram P., Venkataraman S. Hepato protective and antioxidant effects of Hygrophila auriculata (K. Schum) Heine Acanthaceae root extract. J Ethnopharmacol 2006, 104:124-128.
43. Ketterer B., Coles B., Meyer D.J. The role of glutathione in detoxification. Environ Health Perspect 1983, 49:59-69.
44. Meister A., Anderson M.E. Glutathione. Annu Rev Biochem 1983, 52:711-760.
45. Zalups R.K., Lash L.H. Interactions between glutathione and mercury in the kidney, liver and blood. Toxicology of metals 1996, 145. CRC Press, Boca Raton. L.W. Chang (Ed.).
46. Zalups R.K. Early aspects of the intrarenal distribution of mercury after intravenous administration of mercuric chloride. Toxicology 1993, 79:215-228.
47. Perottni J., Rodrigues O.E.D., Paixao M.W., zeni G., Lobato L.P., Braga A.L., Rocha J.B.T., Emanuelli T. Renal and hepatic ALA-D activity and selected oxidative stress parameters of rats exposed to inorganic mercury and organoselenium compounds. Food Chem Toxicol 2004, 42:17-18.
48. Emanuelli T., Rocha J.B.T., Pereira M.E., Porciuncula L.O., Morsch V.M., Martins A.F., Souza D.O.G. Effect of mercury chloride intoxication and dimercaprol treatment on delta-aminolevulinate dehydratase from brain, liver and kidney of adult mice. Pharmacol Toxicol 1996, 79:136-143.
49. Cotgreave I.A. N-acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol 1997, 38:205-227.
50. Halliwell B. Oxidative stress and neurodegeneration: where are we now. J Neurochem 2006, 97:1634-1658.
51. Borgstrom L., Kagedal B., Paulsen O. Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol 1986, 31:217-222.
52. Zimet I. Acetylcysteine: a drug that is much more than a mucokinetic. Biomed Pharmacother 1988, 42:513-520.
53. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Haffman D.G., Hoekstra W.G. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:558-560.
54. Xia L., Novdman T., Olsson J.M., Damdimopoulos A., Bjorkhem-Dergman L., Nalvaste I., Eriksson L.C., Arner E.S.J., Spyrou G., Bjornstedt M. The mammalian selenoenzyme thioredoxin reductase reduces ubiquinone: a novel mechanism for defence against oxidative stress. J Biol Chem 2002, 278:2141-2146.
55. Cuvin-Aralar M.L.A., Furness R.W. Mercury and selenium interaction: a review. Ecotoxicol Environ Saf 1991, 21:348-364.
56. Fang S.C. Interaction of selenium and mercury in rat. Chem Biol Interact 1977, 17:25-40.
57. Naganuma A., Ishii Y., Imura N. Effect of administration sequence of mercuric chloride and sodium selenite on their fates and toxicities in mice. Ecotoxicol Environ Saf 1984, 8:572-580.