Zinc and N-acetylcysteine modify mercury distribution and promote increase in hepatic metallothionein levels

Journal of Trace Elements in Medicine and Biology

Volumn 32, Issue , 2015, Pages 183-188

  Oliveira, Vitor Antunes ^a   Oliveira, Cláudia Sirlene ^a   Mesquita, Mariana ^a   Pedroso, Taise Fonseca ^a   Costa, Lidiane Machado ^a   Fiuza, Tiago da Luz ^a   Pereira, Maria Ester ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Mercury; Metallothionein; Non protein SH; Total SH; Zinc and N acetylcysteine; Aminolevulinic acid dehydratase

Indexed keywords

ACETYLCYSTEINE; ASPARTATE AMINOTRANSFERASE; CREATININE; HYDROCHLORIC ACID; MERCURY; METALLOTHIONEIN; PORPHOBILINOGEN SYNTHASE; THIOL; UREA; ZINC; ZINC CHLORIDE; ALANINE AMINOTRANSFERASE; THIOL DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMICAL COMPOSITION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; LIVER LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; UREA BLOOD LEVEL; URINE LEVEL; ANIMAL; BLOOD; DRUG EFFECTS; KIDNEY; LIVER; METABOLISM; WISTAR RAT;

RATTUS;

ACETYLCYSTEINE; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CREATININE; FEMALE; KIDNEY; LIVER; MERCURY; METALLOTHIONEIN; PORPHOBILINOGEN SYNTHASE; RATS, WISTAR; SULFHYDRYL COMPOUNDS; UREA; ZINC;

EID: 84939616634     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2015.06.006     Document Type: Article

References (44)

1. Hepler L.G., Olofsson G. Mercury thermodynamic properties, chemical equilibria, and standard potentials. Chem Rev. 1975, 75:585-602.
2. Yerga D.M., Garcia M.B.G., Garcia A.C. Electrochemical determination of mercury: a review. Talanta 2013, 116:1091-1104.
3. Berlin M., Zalups R.K., Fowler B.A. Mercury. Handbook on the Toxicology of Metals 2007, 675-729. Elsevier, Amsterdam, Holland. Third edition. G.F. Nordberg, B.A. Fowler, M. Nordberg, L. Friberg (Eds.).
4. Rooney J.P. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 2007, 234:145-156.
5. Gado A.L., Aldahmash B.A. Antioxidant effect of Arabic gum against mercuric chloride-induced nephrotoxicity. Drug Des. Dev. Ther. 2013, 7:1245-1252.
6. Favero A.M., Oliveira C.S., Franciscato C., Oliveira V.A., Pereira J.S.F., Bortoncheli C.M., Luz S.C.A., Dressler V.L., Flores E.M.M., Pereira M.E. Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride. Cell. Biochem. Funct. 2014, 32:420-428.
7. 2 toxicity. J. Trace Elem. Med. Biol. 2014, 29:255-262.
8. 2. J. Trace Elem. Med. Biol. 2014, 28:240-246.
9. 2 δ-ALA-D inhibition and Hg levels in tissues of suckling rats. Toxicol. Lett. 2003, 146:17-25.
10. Peixoto N.C., Serafim M.A., Flores E.M., Bebianno M.J., Pereira M.E. Metallothionein, zinc, and mercury levels in tissues of young rats exposed to zinc and subsequently to mercury. Life Sci. 2007, 81:1264-1271.
11. Sharma M.K., Sharma A., Kumar A., Kumar M. Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Food Chem. Toxicol. 2007, 45:2412-2419.
12. Oliveira C.S., Favero A.M., Franciscato C., da Luz S.C.A., Pereira M.E. Distinct response of lactating and nonlactating rats exposed to inorganic mercury on hepatic δ-aminolevulinic acid dehydratase activity. Biol. Trace Elem. Res. 2014, 158:230-237.
13. El-Desoky G.E., Bashandy S.A., Alhazza I.M., Al-Othman Z.A., Aboul-Soud M.A.M., Yusuf K. Improvement of mercuric chloride-Induced testis injuries and sperm quality deteriorations by spirulina platensis in rats. PLoS One 2013, 8:159-177.
14. 2 depend on the postnatal period of exposure. Int. J. Dev. Neurosci. 2007, 25:39-46.
15. 2. Int. J. Dev. Neurosci. 2009, 27:459-468.
16. Tunali-Akbay T., Sener G., Salvarli H., Sehirli O., Yarat A. Protective effects of Ginkgo biloba extract against mercury (II)-induced cardiovascular oxidative damage in rats. Phytother. Res. 2007, 21:26-31.
17. Girardi G., Elias M.M. Effectiveness of N-acetylcysteine in protecting against mercuric chloride-induced nephrotoxicity. Toxicology 1991, 67:155-164.
18. Falluel-Morel A., Lin L., Sokolowski K., McCandlish E., Buckley B., DiCicco-Bloom E. N-Acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus. J. Neurosci. Res. 2012, 90:743-750.
19. Joshi D., Mittal D.K., Shrivastava S., Shukla S. Protective role of thiol chelators against dimethylmercury induced toxicity in male rats. Bull. Environ. Contam. Toxicol. 2010, 84:613-617.
20. Farshid A.A., Tamaddonfard E., Simaee N., Mansouri S., Najafi S., Asri-Rezaee S., Alavi H. Effects of histidine and N-acetylcysteine on doxorubicin-induced cardiomyopathy in rats. Cardiovasc. Toxicol. 2013, 10.1007/s12012-013-9239-6.
21. Jalilehvand F., Parmar K., Zielke S. Mercury(II) complex formation with N-acetylcysteine. Metallomics 2013, 5:1368-1376.
22. Trümpler S., Nowak S., Meermann B., Wiesmüller G.A., Buscher W., Sperling M., Karst U. Detoxification of mercury species - an in vitro study with antidotes in human whole blood. Anal. Bioanal. Chem. 2009, 395:1929-1935.
23. Becker A., Soliman F.A. The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells. Neuroch. Res. 2009, 34:1677-1684.
24. Kim J.K., Han M., Nili M. Effects of N-acetyl-l-cysteine on fish hepatoma cells treated with mercury chloride and ionizing radiation. Chemosphere 2011, 85:1635-1638.
25. Oteiza P.I. Zinc and the modulation of redox homeostasis. Free Radic. Biol. Med. 2012, 53:1748-1759.
26. Chen J., Shaikh Z.A. Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells. Toxicol. Appl. Pharmacol. 2009, 241:81-89.
27. Sandstead H.H., Au W. Zinc. Handbook on the Toxicology of Metals 2007, 925-947. Elsevier, Amsterdam. 3rd edition. G.F. Nordberg, B.A. Fowler, M. Nordberg, L.T. Friberg (Eds.).
28. Rodenstein D., De Coster A., Gazzaniga A. Pharmacokinetics of oral acetylcysteine: absorption, binding and metabolism in patients with respiratory disorders. Clin. Pharmacokinet. 1978, 3:247-254.
29. Sassa S. Delta-aminolevulinic acid dehydratase assay. Enzyme 1982, 28:133-145.
30. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
31. Thomas L. Alanine aminotransferase (ALT), aspartate aminotranferase (AST). Clinical Laboratory Diagnostics 1998, 55-65. TH-Books, Frankfurt, Verlangsgesellschaft. 1st ed. L. Thomas (Ed.).
32. Ineu R.P., Oliveira C.S., Oliveira V.A., Moraes-Silva L., Luz S.C.A., Pereira M.E. Antioxidant effect of zinc chloride against ethanol-induced gastrointestinal lesions in rats. Food Chem. Toxicol. 2013, 58:522-559.
33. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
34. Clarkson T.W. The toxicology of mercury. Crit. Ver. Clin. Lab. Sci. 1997, 34:369-403.
35. Gibson K.D., Neuberger A., Scott J.J. The purification and properties of delta-aminolevulinic acid dehydratase. Biochem. J. 1955, 61:618-629.
36. Jaffe E.K. Porphobilinogen synthase the first source of heme's asymmetry. J. Bioenerg. Biomembr. 1995, 27:169-179.
37. Farina M., Brandão R., de Lara F.S., Pagliosa L.B., Soares F.A., Souza D.O., Rocha J.B. Profile of nonprotein thiols, lipid peroxidation and delta-aminolevulinate dehydratase activity in mouse kidney and liver in response to acute exposure to mercuric chloride and sodium selenite. Toxicology 2003, 184:179-187.
38. Frassinetti S., Bronzetti G., Caltavuturo L., Cini M., Della-Croce C. The role of zinc in life: a review. J. Environ. Pathol. Toxicol. Oncol. 2006, 25:597-610.
39. Tandon S.K., Singh S., Prasad S., Mathur N. Hepatic and renal metallothionein induction by an oral equimolar dose of zinc, cadmium or mercury in mice. Food Chem. Toxicol. 2001, 39:571-577.
40. Hwang T.L., Chen H.Y., Changchien T.T., Wang C.C., Wu C.M. The cytotoxicity of mercury chloride to the keratinocytes is associated with metallothionein expression. Biomed. Rep. 2013, 3:379-382.
41. Kimura T., Itoh N. Function of metallothionein in gene expression and signal transduction: newly found protective role of metallothionein. J. Health Sci. 2008, 54:251-260.
42. Minami T., Miyata E., Sakamoto Y., Kohama A., Yamazaki H., Ichida S. Expression of metallothionein mRNAs on mouse cerebellum microglia cells by thimerosal and its metabolites. Toxicology 2009, 261:25-32.
43. 2 in newborn rats. Ecotoxicol. Environ. Saf. 2007, 66:441-446.
44. Agarwal R., Goel S.K., Chandra R., Behari J.R. Role of vitamin E in preventing acute mercury toxicity in rat. Environ. Toxicol. Pharmacol. 2010, 29:70-78.