Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

World Journal of Gastroenterology

Volumn 12, Issue 2, 2006, Pages 287-291

  Rana, S V ^a   Attri, S ^a   Vaiphei, K ^a   Pal, R ^a   Attri, A ^b   Singh, K ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b GOVERNMENT MEDICAL COLLEGE AND HOSPITAL   (India)

Author keywords

Hepatoprotection; N acetylcysteine; Rifampicin

Indexed keywords

ACETYLCYSTEINE; CATALASE; CYTOCHROME P450; GLUTATHIONE PEROXIDASE; LIPID; OXIDOREDUCTASE; RIFAMPICIN; SUPEROXIDE DISMUTASE; THIOL; TRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG MECHANISM; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER; LIVER INJURY; LIVER PROTECTION; LIVER WEIGHT; MALE; NONHUMAN; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION;

EID: 33644780110     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i2.287     Document Type: Article

References (30)

1. Gajalakshmi V, Peto R, Kanaka TS, Jha P. Smoking and mortality from tuberculosis and other diseases in India: retrospective study of 43000 adult male deaths and 35000 controls. Lancet 2003; 362: 507-515
2. Steel MA, Burk RF, Desprez RM. Toxic hepatitis with isoniazid and rifampicin. A meta analysis Chest 1991; 99:465-471
3. Bachs L, Parez A, Elena M, Piera C, Rodes J. Effect of long term rifampicin administration in primary biliary cirrhosis. Gastroenterol 1992; 102: 2077-2080
4. Gangadharan PRJ. Isoniazid, rifampicin and hepatotoxicity. Ann Rev Respir Dis 1986; 133: 963-965
5. Sodhi CP, Rana SV, Attari S, Metha S, Vaiphei K, Metha SK. Oxidative hepatic injury of isoniazid-rifampicin in young rats subjected to protein energy malnutrition. Drug Chem Toxicol 1998; 21: 305-317
6. Farrell GC. Biochemical mechanisms. In : Khullar S, Hunter S drug induced eds. Liver disease. New York: Churchill Livingstone 1994: 247-255
7. Meyer A, Buhul R, Kampf S, Magnussen H. Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fibrosis and normal. Am J Resp Crit Care Med 1995; 152: 1055-1060
8. Nakano H, Boudjema K, Jaeck D, Alexandre E, Imbs P, Chenerd MP, Nagaski H, Kumuda K, Wolf P, Cinqualbre J. Amelioration of hepatocellular integrity and inhibition of sinusoidal oxidative stress by N-acetylcysteine pre-treatment in cold ischemia reperfussion injury of rats liver. Eur Surg Res 1996; 25: 245-255
9. Bahri AK, Chiang CS, Timbrell JA. Acetylhydrazine hepatotoxicity. Toxicol Appl Pharmacol 1981; 60: 561-569
10. Sedlak PA, Lindsay RH. Estimation of total, protein bound and non-protein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968; 25: 192-205
11. Ohkawa H, Ohishi N, Yagi K, Maggirwar.D.N. Dhanraj, S.M.Somani and V.Rajkumar. Adenosine acts as an endogenous activator of the cellular antioxidants defense system. Biochem Biophys Res Commun 1994; 201: 508-512
12. Omura T, Sato R. The carbon monoxide binding pigment of liver microsomes II. Solubilization, purification and properties. J Biol Chem 1964; 239: 2370-2378
13. Konno Y. Generation of Superoxide radical during autooxidation of dyhydroxylamine and an assay for Superoxide dismutase. Arch Biochem Biophys 1978; 186:189-195
14. Luck H. Catalase estimation: In 'Methods in enzyme Analysis. Academic Press, New York & London 1971; 886-889
15. Flohe L, Gungler WA. Assay of glutathione peroxidase. Methods Enzymol 1984; 105:114-126
16. Carlberg I, Mannervik B. Purification by chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH dependent reduction of the mixed disulfide of CoA and glutathione. Biochem Biopsy Acta 1977; 484: 267-274
17. Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferases. The first step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-7139
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-275
19. Zitkowa L, Stastna J, Dobrousky K, Tousak J. Causes for rifampicin hepatoxicity: An experimental study. Czechosolvak Med 1982; 5: 210-217
20. Pelikan EW. Cited by Bushly SRM. Toxicity in chemotherapy. In: Schmitzer RJ and Hawking F, eds. Experimental chemotherapy. New York: Academic Press 1963; 25-52
21. 14) acetylhydrazine-derived covalent binding. Biochem Pharmacol 1982; 31: 4031-4034
22. Sinha BK. Activation of hydrazine derivatives of free radicals in the per fused rat liver: a spin trapping study. Biochem Biopsy Acta 1987; 924: 261-269
23. Umemura T Hasegava R, Sai-Kato K, Nisikawa A, Furukawa F, Toyokami S, Uchida K, Inoue K, Kurokawa Y., Prevention by 2-mercaptoethane sulfonate and N-acetylcysteine of renal oxidative damage in rats treated with ferric nitrotriacetate. Jpn J Cancer Res 1966; 87: 882-886
24. Ercal N, Treeraphan P, Hammond TC, Matthews RH, Graneman NH, Spitz.H. In vivo indexes of oxidative stress in lead exposed C57 BL/6 mice are reduced by treatment with meso-9, 3-dimercaptosuccinic acid or N-acetylcysteine. Free Radicals Biol Med 1996; 21: 157-161
25. Blech DM, Borders CI. Hydroperoxide anion HO2, is an affinity reagent for the inactivation of yeast Cu, Zn, superoxide dismutase: modification of one histidine per subunit. Arch Biochem Biophy 1983; 224:579.
26. Jaya DS, Augustine J, Menon VP. Protective role of N-acetylcysteine against alcohol and paracetamol induced toxicity. Ind J Clin Biochem 1994; 9: 64-71.
27. Yao WB, Zhao YQ, Abe T, Ohta J, Ubuka T. Effect of N-acetylcysteine administration on cystein and glutathione contents in liver and kidney and in perfused liver of intact and diethylmaleate treated rats. Amino Acids 1994; 7:255-266.
28. Adachi Y, Nanno T, Yamashita M, Veshima S, Yamamoto T. Induction of rat liver bilirubin conjugating enzymes and glutathione S - transferase by rifampicin. Gastroentrol Jap 1985; 20: 104-110.
29. Mitchell JR, Zimmerman HJ, Ishak KG, Throgenirsson OP, Timbrell JA, Snodgrass WR, Nelson SD. Isoniazid liver injury: Clinical spectrum, pathology and probable pathogenesis. Ann Intern Med 1976; 84: 181-192.
30. Attari S, Rana SV, Vaiphei K, Sodhi CP, Katyal R, Goel RC, Nain CK, Singh K (2000). Isoniazid and rifampicin induced oxidative hepatic injury -protection by N-acetyl cysteine. Hum Exper Toxicol 2000; 19: 517-524.