The toxicity of N-methyl-α-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine

Toxicology

Volumn 200, Issue 2-3, 2004, Pages 193-203

  Carvalho, Márcia ^a   Remião, Fernando ^a   Milhazes, Nuno ^a   Borges, Fernanda ^a   Fernandes, Eduarda ^a   Carvalho, Félix ^a   Bastos, Maria Lourdes ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Antioxidants; Ascorbic acid; Ecstasy; Hepatocytes; N acetylcysteine; N methyl methyldopamine; Oxidative stress; Toxicity

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; ASCORBIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; ISOENZYME; N METHYL ALPHA METHYLDOPAMINE; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL DEATH; CELL ISOLATION; CELL PROTECTION; CELL SUSPENSION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; EVALUATION; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT; TIME;

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CELL SEPARATION; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYEPINEPHRINE; FREE RADICAL SCAVENGERS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HALLUCINOGENS; HEPATOCYTES; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RATS; SPECTROPHOTOMETRY, ULTRAVIOLET;

MEDA;

EID: 2942714874     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.03.016     Document Type: Article

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