메뉴 건너뛰기




Volumn 33, Issue 1, 2014, Pages 41-53

In vitro effect of N-acetylcysteine on hepatocyte injury caused by dichlorodiphenyltrichloroethane and its metabolites

Author keywords

apoptosis; DDT; hepatotoxicity; mitochondria; N acetylcysteine; ROS

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE; 1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ACETYLCYSTEINE; CHLORPHENOTANE; REACTIVE OXYGEN METABOLITE;

EID: 84890814960     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327113482954     Document Type: Article
Times cited : (10)

References (60)
  • 1
    • 28044457932 scopus 로고    scopus 로고
    • Impact of DDT re-introduction on malaria transmission in KwaZulu-Natal
    • Maharaj R, Mthembu DJ, Sharp BL. Impact of DDT re-introduction on malaria transmission in KwaZulu-Natal. S Afr Med J. 2005 ; 95 (11). 871-874 (Pubitemid 41684080)
    • (2005) South African Medical Journal , vol.95 , Issue.11 , pp. 871-874
    • Maharaj, R.1    Mthembu, D.J.2    Sharp, B.L.3
  • 2
    • 74949097997 scopus 로고    scopus 로고
    • Global status of DDT and its alternatives for use in vector control to prevent disease
    • van den Berg H. Global status of DDT and its alternatives for use in vector control to prevent disease. Environ Health Perspect. 2009 ; 117 (11). 1656-1663
    • (2009) Environ Health Perspect , vol.117 , Issue.11 , pp. 1656-1663
    • Van Den Berg, H.1
  • 3
    • 79958858355 scopus 로고    scopus 로고
    • DDT and malaria prevention: Addressing the paradox
    • Bouwman H, van den Berg H, Kylin H. DDT and malaria prevention: addressing the paradox. Environ Health Perspect. 2011 ; 119 (6). 744-747
    • (2011) Environ Health Perspect , vol.119 , Issue.6 , pp. 744-747
    • Bouwman, H.1    Van Den Berg, H.2    Kylin, H.3
  • 4
    • 31444439441 scopus 로고    scopus 로고
    • DDT and human health
    • DOI 10.1016/j.scitotenv.2005.02.022, PII S0048969705001749
    • Beard J. DDT and human health. Sci Total Environ. 2006 ; 355 ((1-3)). 78-89 (Pubitemid 43148945)
    • (2006) Science of the Total Environment , vol.355 , Issue.1-3 , pp. 78-89
    • Beard, J.1
  • 5
    • 0012684768 scopus 로고
    • Liver cell alteration and DDT storage in the fat of the rat induced by dietary levels of 1 to 50 P. P. M. DDT
    • Laug EP, Nelson AA, Fitzhugh OG, Kunze ME. Liver cell alteration and DDT storage in the fat of the rat induced by dietary levels of 1 to 50 P. P. M. DDT. J Pharmacol Exp Ther. 1950 ; 98 (3). 268-273
    • (1950) J Pharmacol Exp Ther , vol.98 , Issue.3 , pp. 268-273
    • Laug, E.P.1    Nelson, A.A.2    Fitzhugh, O.G.3    Kunze, M.E.4
  • 7
    • 0029983185 scopus 로고    scopus 로고
    • Early hepatic changes induced in rats by two hepatocarcinogenic organohalogen pesticides: Bromopropylate and DDT
    • DOI 10.1093/carcin/17.3.407
    • Kostka G, Kopec-Szelzak J, Palut D. Early hepatic changes induced in rats by two hepatocarcinogenic organohalogen pesticides: bromopropylate and DDT. Carcinogenesis. 1996 ; 17 (3). 407-412 (Pubitemid 26085318)
    • (1996) Carcinogenesis , vol.17 , Issue.3 , pp. 407-412
    • Kostka, G.1    Kopec-Szlezak, J.2    Palut, D.3
  • 8
    • 0345422704 scopus 로고    scopus 로고
    • Early hepatic changes in rats induced by permethrin in comparison with DDT
    • Kostka G, Palut D, Kopec-Szlezak J, Ludwicki JK. Early hepatic changes in rats induced by permethrin in comparison with DDT. Toxicology. 1999 ; 142 (2). 135-143
    • (1999) Toxicology , vol.142 , Issue.2 , pp. 135-143
    • Kostka, G.1    Palut, D.2    Kopec-Szlezak, J.3    Ludwicki, J.K.4
  • 9
    • 15744384408 scopus 로고    scopus 로고
    • Transcriptional induction of CYP3A4 by o,p′-DDT in HepG2 cells
    • DOI 10.1016/j.toxlet.2005.01.003
    • Medina-Diaz IM, Elizondo G. Transcriptional induction of CYP3A4 by o,p′-DDT in HepG2 cells. Toxicol Lett. 2005 ; 157 (1). 41-47 (Pubitemid 40410611)
    • (2005) Toxicology Letters , vol.157 , Issue.1 , pp. 41-47
    • Medina-Diaz, I.M.1    Elizondo, G.2
  • 10
    • 80052735248 scopus 로고    scopus 로고
    • Hepatoprotective effect of curcumin on lindane-induced oxidative stress in male Wistar rats
    • Singh R, Sharma P. Hepatoprotective effect of curcumin on lindane-induced oxidative stress in male Wistar rats. Toxicol Int. 2011 ; 18 (2). 124-129
    • (2011) Toxicol Int , vol.18 , Issue.2 , pp. 124-129
    • Singh, R.1    Sharma, P.2
  • 12
    • 77952951846 scopus 로고    scopus 로고
    • Effects of insecticides fenitrothion, endosulfan and abamectin on antioxidant parameters of isolated rat hepatocytes
    • El-Shenawy NS. Effects of insecticides fenitrothion, endosulfan and abamectin on antioxidant parameters of isolated rat hepatocytes. Toxicol in Vitro. 2010 ; 24 (4). 1148-1157
    • (2010) Toxicol in Vitro , vol.24 , Issue.4 , pp. 1148-1157
    • El-Shenawy, N.S.1
  • 13
    • 0345018815 scopus 로고    scopus 로고
    • N-acetylcysteine: Pharmacological considerations and experimental and clinical applications
    • Cotgreave IA. N-acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol. 1997 ; 38: 205-227
    • (1997) Adv Pharmacol , vol.38 , pp. 205-227
    • Cotgreave, I.A.1
  • 14
    • 65449172838 scopus 로고    scopus 로고
    • Prolonged treatment with N-acetylcysteine delays liver recovery from acetaminophen hepatotoxicity
    • Yang R, Miki K, He X, Killeen ME, Fink MP. Prolonged treatment with N-acetylcysteine delays liver recovery from acetaminophen hepatotoxicity. Crit Care. 2009 ; 13 (2). R55
    • (2009) Crit Care , vol.13 , Issue.2 , pp. 55
    • Yang, R.1    Miki, K.2    He, X.3    Killeen, M.E.4    Fink, M.P.5
  • 15
    • 81255189019 scopus 로고    scopus 로고
    • Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats
    • Priya S, Vijayalakshmi P, Vivekanandan P, Karthikeyan S. Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats. Toxicol Ind Health. 2011 ; 27 (1). 914-922
    • (2011) Toxicol Ind Health , vol.27 , Issue.1 , pp. 914-922
    • Priya, S.1    Vijayalakshmi, P.2    Vivekanandan, P.3    Karthikeyan, S.4
  • 16
  • 18
    • 34548072307 scopus 로고    scopus 로고
    • N-Acetylcysteine-a safe antidote for cysteine/glutathione deficiency
    • DOI 10.1016/j.coph.2007.04.005, PII S1471489207000896, Cancer/Immunomodulation
    • Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA. N-Acetylcysteine: a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 ; 7: 355-359 (Pubitemid 47289259)
    • (2007) Current Opinion in Pharmacology , vol.7 , Issue.4 , pp. 355-359
    • Atkuri, K.R.1    Mantovani, J.J.2    Herzenberg, L.A.3    Herzenberg, L.A.4
  • 19
    • 0019489555 scopus 로고
    • N-acetylcysteine protection against halothane hepatotoxicity: Experiments in rats
    • Keany NP, Cocking G. N-acetylcysteine protection against halothane hepatotoxicity: experiments in rats. Lancet. 1981 ; 2 (8237). 95 (Pubitemid 11069889)
    • (1981) Lancet , vol.2 , Issue.8237 , pp. 95
    • Keaney, N.P.1    Cocking, G.2
  • 20
    • 77956188701 scopus 로고    scopus 로고
    • Acute chloroform ingestion successfully treated with intravenously administered N-acetylcysteine
    • Dell'Aglio DM, Sutter ME, Schwartz MD, Koch DD, Algren DA, Morgan BW. Acute chloroform ingestion successfully treated with intravenously administered N-acetylcysteine. J Med Toxicol. 2010 ; 6 (2). 143-146
    • (2010) J Med Toxicol , vol.6 , Issue.2 , pp. 143-146
    • Dell'Aglio, D.M.1    Sutter, M.E.2    Schwartz, M.D.3    Koch, D.D.4    Algren, D.A.5    Morgan, B.W.6
  • 21
    • 36048981825 scopus 로고    scopus 로고
    • Clinical toxicology: Part II. Diagnosis and management of uncommon poisonings
    • Worthley LIG. Clinical toxicology: part II. Diagnosis and management of uncommon poisonings. Crit Care Resusc. 2002 ; 4: 216-230
    • (2002) Crit Care Resusc , vol.4 , pp. 216-230
    • Worthley, L.I.G.1
  • 22
    • 70349255591 scopus 로고    scopus 로고
    • Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity
    • Ji L, Liu T, Chen Y, Wang Z. Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity. J Cell Biochem. 2009 ; 108 (2). 424-432
    • (2009) J Cell Biochem , vol.108 , Issue.2 , pp. 424-432
    • Ji, L.1    Liu, T.2    Chen, Y.3    Wang, Z.4
  • 24
    • 0024955695 scopus 로고
    • MEIC: A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests
    • Bondesson I, Ekwall B, Hellberg S, Romert L, Stenberg K, Walum E. MEIC: a new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests. Cell Biol Toxicol. 1989 ; 5: 331-347
    • (1989) Cell Biol Toxicol , vol.5 , pp. 331-347
    • Bondesson, I.1    Ekwall, B.2    Hellberg, S.3    Romert, L.4    Stenberg, K.5    Walum, E.6
  • 28
    • 27644544444 scopus 로고    scopus 로고
    • In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride
    • DOI 10.1016/j.toxlet.2005.07.001, PII S0378427405001967
    • Fotakis G, Timbrell JA. In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett. 2006 ; 160 (2). 171-177 (Pubitemid 41578961)
    • (2006) Toxicology Letters , vol.160 , Issue.2 , pp. 171-177
    • Fotakis, G.1    Timbrell, J.A.2
  • 29
    • 76749101133 scopus 로고    scopus 로고
    • Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells
    • Zhang L, Seitz LC, Abramczyk AM, Chan C. Synergistic effect of cAMP and palmitate in promoting altered mitochondrial function and cell death in HepG2 cells. Exp Cell Res. 2009 ; 316: 716-727
    • (2009) Exp Cell Res , vol.316 , pp. 716-727
    • Zhang, L.1    Seitz, L.C.2    Abramczyk, A.M.3    Chan, C.4
  • 30
    • 79951799432 scopus 로고    scopus 로고
    • Effects of heat processing time on total phenolic content and antioxidant capacity of Ginseng Jung Kwa
    • Oh C-H, Kim G-N, Lee S-H, Lee J-S, Jang H-D. Effects of heat processing time on total phenolic content and antioxidant capacity of Ginseng Jung Kwa. J Ginseng Res. 2010 ; 34 (3). 198-204
    • (2010) J Ginseng Res , vol.34 , Issue.3 , pp. 198-204
    • Oh, C.-H.1    Kim, G.-N.2    Lee, S.-H.3    Lee, J.-S.4    Jang, H.-D.5
  • 31
    • 0032705639 scopus 로고    scopus 로고
    • A rapid method for the evaluation of compounds with mitochondria- protective properties
    • DOI 10.1016/S0165-0270(99)00107-7, PII S0165027099001077
    • Nuydens R, Novalbos J, Dispersyn G, Weber C, Borgers M, Geerts H. A rapid method for the evaluation of compounds with mitochondria-protective properties. J Neurosci Meth. 1999 ; 92: 153-159 (Pubitemid 29518384)
    • (1999) Journal of Neuroscience Methods , vol.92 , Issue.1-2 , pp. 153-159
    • Nuydens, R.1    Novalbos, J.2    Dispersyn, G.3    Weber, C.4    Borgers, M.5    Geerts, H.6
  • 33
    • 79956094953 scopus 로고    scopus 로고
    • Metabolic signatures in apoptotic human cancer cell lines
    • Halama A, Möller G, Adamski J. Metabolic signatures in apoptotic human cancer cell lines. OMICS. 2011 ; 15 (5). 325-335
    • (2011) OMICS , vol.15 , Issue.5 , pp. 325-335
    • Halama, A.1    Möller, G.2    Adamski, J.3
  • 34
    • 1642341471 scopus 로고    scopus 로고
    • Acute cadmium exposure enhances AP-1 DNA binding and induces cytokines expression and heat shock protein 70 in HepG2 cells
    • DOI 10.1016/j.tox.2004.01.006, PII S0300483X04000368
    • Souza V, Escobar Md Mdel C, Gómez-Quiroz L, Bucio L, Hernández E, Cossio EC, et al. Acute cadmium exposure enhances AP-1 DNA binding and induces cytokines expression and heat shock protein 70 in HepG2 cells. Toxicology. 2004 ; 197 (3). 213-228 (Pubitemid 38368115)
    • (2004) Toxicology , vol.197 , Issue.3 , pp. 213-228
    • Souza, V.1    Escobar, Ma.D.C.2    Gomez-Quiroz, L.3    Bucio, L.4    Hernandez, E.5    Cossio, E.C.6    Gutierrez-Ruiz, Ma.C.7
  • 35
    • 0036180407 scopus 로고    scopus 로고
    • Effects of the environmental estrogens bisphenol A, o,p′-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7
    • DOI 10.1016/S0960-0760(01)00173-X, PII S096007600100173X
    • Diel P, Olff S, Schmidt S, Michna H. Effects of the environmental estrogensbisphenol A, o,p′-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 ; 80 (1). 61-70 (Pubitemid 34178411)
    • (2002) Journal of Steroid Biochemistry and Molecular Biology , vol.80 , Issue.1 , pp. 61-70
    • Diel, P.1    Olff, S.2    Schmidt, S.3    Michna, H.4
  • 36
    • 11844265986 scopus 로고    scopus 로고
    • Organochlorine insecticides: Impacts on human HepG2 cytochrome P4501A, 2B activities and glutathione levels
    • DOI 10.1016/j.tiv.2004.10.002, PII S0887233304001523
    • Dehn PF, Allen-Mocherie S, Karek J, Thenappan A. Organochlorine insecticides: impacts on human HepG2 cytochrome P4501A, 2B activities and glutathione levels. Toxicol in Vitro. 2005 ; 19 (2). 261-273 (Pubitemid 40092749)
    • (2005) Toxicology in Vitro , vol.19 , Issue.2 , pp. 261-273
    • Dehn, P.F.1    Allen-Mocherie, S.2    Karek, J.3    Thenappan, A.4
  • 37
    • 79953735504 scopus 로고    scopus 로고
    • DMSO modulates the pathway of apoptosis triggering
    • Banic B, Nipic D, Suput D, Millisav I. DMSO modulates the pathway of apoptosis triggering. Cell Mol Biol Lett. 2011 ; 16 (2). 328-341
    • (2011) Cell Mol Biol Lett , vol.16 , Issue.2 , pp. 328-341
    • Banic, B.1    Nipic, D.2    Suput, D.3    Millisav, I.4
  • 38
    • 38149071685 scopus 로고    scopus 로고
    • O,p′-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver
    • Kiyosawa N, Kwekel JC, Burgoon LD, Williams KJ, Tashiro C. Chittim B, et al. o,p′-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. Toxicol Sci. 2008 ; 101 (2). 350-363
    • (2008) Toxicol Sci , vol.101 , Issue.2 , pp. 350-363
    • Kiyosawa, N.1    Kwekel, J.C.2    Burgoon, L.D.3    Williams, K.J.4    Tashiro, C.5    Chittim, B.6
  • 39
    • 33644905318 scopus 로고    scopus 로고
    • N-acetylcysteine passe-partout or much ado about nothing?
    • Aitio M-L. N-acetylcysteine passe-partout or much ado about nothing?. Br J Clin Pharmacol. 2005 ; 61 (1). 5-15
    • (2005) Br J Clin Pharmacol , vol.61 , Issue.1 , pp. 5-15
    • Aitio, M.-L.1
  • 40
    • 77950349125 scopus 로고    scopus 로고
    • Synergistic genotoxicity caused by low concentration of titanium dioxide nanoparticles and p,p'-DDT in human hepatocytes
    • Shi Y, Zhang J-H, Jiang M, Zhu L-H, Tan H-Q, Lu B. Synergistic genotoxicity caused by low concentration of titanium dioxide nanoparticles and p,p'-DDT in human hepatocytes. Environ Mol Mutagen. 2010 ; 51: 192-204
    • (2010) Environ Mol Mutagen , vol.51 , pp. 192-204
    • Shi, Y.1    Zhang, J.-H.2    Jiang, M.3    Zhu, L.-H.4    Tan, H.-Q.5    Lu, B.6
  • 42
    • 77956175835 scopus 로고    scopus 로고
    • Responses of hepatocytes to DDT and methyl mercury exposure
    • Bussolaro D, Neto FF, Ribeiro CAO. Responses of hepatocytes to DDT and methyl mercury exposure. Toxicol in Vitro. 2010 ; 24: 1491-1497
    • (2010) Toxicol in Vitro , vol.24 , pp. 1491-1497
    • Bussolaro, D.1    Neto, F.F.2    Ribeiro, C.A.O.3
  • 44
    • 36148955117 scopus 로고    scopus 로고
    • Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
    • DOI 10.1016/j.tiv.2007.05.014, PII S0887233307001713
    • Westerink WM, Schoonen WG. Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol in Vitro. 2007 ; 21 (8). 1581-1591 (Pubitemid 350103536)
    • (2007) Toxicology in Vitro , vol.21 , Issue.8 , pp. 1581-1591
    • Westerink, W.M.A.1    Schoonen, W.G.E.J.2
  • 45
    • 55349114755 scopus 로고    scopus 로고
    • Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls
    • Green RM, Hodges NJ, Chipman JK, O'Donovan MR, Graham M. Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls. Mutagenesis. 2008 ; 23 (6). 457-463
    • (2008) Mutagenesis , vol.23 , Issue.6 , pp. 457-463
    • Green, R.M.1    Hodges, N.J.2    Chipman, J.K.3    O'Donovan, M.R.4    Graham, M.5
  • 46
    • 0021815076 scopus 로고
    • Effects of 1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (DDT) on ATPase-linked functions in isolated rat-liver mitochondria
    • DOI 10.1016/0278-6915(85)90185-1
    • Nishihara Y, Utsumi K. Effects of 1,1,1-trichloro-2,2-bis-(p- chlorophenyl)ethane (DDT) on ATPase-linked functions in isolated rat-liver mitochondria. Food Chem Toxicol. 1985 ; 23 (6). 599-602 (Pubitemid 15013603)
    • (1985) Food and Chemical Toxicology , vol.23 , Issue.6 , pp. 599-602
    • Nishihara, Y.1    Utsumi, K.2
  • 47
    • 0025990161 scopus 로고
    • Mitochondrial bioenergetics as affected by DDT
    • Morena AJM, Madeira VMC. Mitochondrial bioenergetics as affected by DDT. Biochim Biophys Acta. 1991 ; 1060 (2). 166-174
    • (1991) Biochim Biophys Acta , vol.1060 , Issue.2 , pp. 166-174
    • Morena, A.J.M.1    Madeira, V.M.C.2
  • 48
    • 79551613557 scopus 로고    scopus 로고
    • Differential effects of p,p′-DDE on testis and liver mitochondria: Implications for reproductive toxicology
    • Mota PC, Cordeiro M, Pereira SP, Oliveira PJ, Moreno AJ, Ramalho-Santos J. Differential effects of p,p′-DDE on testis and liver mitochondria: implications for reproductive toxicology. Reprod Toxicol. 2011 ; 31: 80-85
    • (2011) Reprod Toxicol , vol.31 , pp. 80-85
    • Mota, P.C.1    Cordeiro, M.2    Pereira, S.P.3    Oliveira, P.J.4    Moreno, A.J.5    Ramalho-Santos, J.6
  • 50
    • 0030817783 scopus 로고    scopus 로고
    • Comparative study of the toxic actions of 2,2-bis-(p-chlorophenyl)- 1,1,1-trichloroethane and 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene on the growth and respiratory activity of a microorganism used as a model
    • Donato MM, Jurado AS, Atunes Madeira MC, Madeira VMC. Comparative study of the toxic actions of 2,2-bis-(p-chlorophenyl)-1,1,1-trichloroethane and 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene on the growth and respiratory activity of a microorganism used as a model. Appl Environ Microbiol. 1997 ; 63 (12). 4948-4951 (Pubitemid 27524237)
    • (1997) Applied and Environmental Microbiology , vol.63 , Issue.12 , pp. 4948-4951
    • Donato, M.M.1    Jurado, A.S.2    Antunes-Madeira, M.D.C.3    Madeira, V.M.C.4
  • 52
    • 0038711442 scopus 로고    scopus 로고
    • The voltage-dependent anion channel is a receptor for plasminogen kringle 5 on human endothelial cells
    • DOI 10.1074/jbc.M303172200
    • Gonzalez-Gronow M, Kalfa T, Johnson CE, Gawdi G, Pizzo SV. The voltage-dependent anion channel is a receptor for Plasminogen Kringle 5 on human endothelial cells. J Biol Chem. 2003 ; 278 (29). 27312-27318 (Pubitemid 36876889)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.29 , pp. 27312-27318
    • Gonzalez-Gronow, M.1    Kalfa, T.2    Johnson, C.E.3    Gawdi, G.4    Pizzo, S.V.5
  • 53
    • 79959231078 scopus 로고    scopus 로고
    • Protective effects of liposomal N-acetylcysteine against paraquat-induced cytotoxicity and gene expression
    • Mitsopoulis P, Suntres ZE. Protective effects of liposomal N-acetylcysteine against paraquat-induced cytotoxicity and gene expression. J Toxicol. 2011 ;: Article ID 808967
    • (2011) J Toxicol , pp. 808967
    • Mitsopoulis, P.1    Suntres, Z.E.2
  • 54
    • 0344982948 scopus 로고    scopus 로고
    • DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children
    • DOI 10.1016/S0013-9351(03)00112-9
    • Perez-Maldonado IN, Diaz-Barriga F, De la Fuente H, Gonzalez-Amaro R, Calderon J, Yanez L. DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children. Environ Res. 2004 ; 94: 38-46 (Pubitemid 37468468)
    • (2004) Environmental Research , vol.94 , Issue.1 , pp. 38-46
    • Perez-Maldonado, I.N.1    Diaz-Barriga, F.2    De La Fuente, H.3    Gonzalez-Amaro, R.4    Calderon, J.5    Yanez, L.6
  • 56
    • 0034101175 scopus 로고    scopus 로고
    • The antiestrogen ICI 182,780 abolishes developmental injury for murine embryos exposed in vitro to o, p-DDT
    • Greenlee AR, Quail CA, Berg RL. The antiestrogen ICI 182,780 abolishes developmental injury for murine embryos exposed in vitro to o, p-DDT. Reprod Toxicol. 1999 ; 14: 225-234
    • (1999) Reprod Toxicol , vol.14 , pp. 225-234
    • Greenlee, A.R.1    Quail, C.A.2    Berg, R.L.3
  • 57
    • 68949111877 scopus 로고    scopus 로고
    • P,p′-DDE induces apoptosis of rat Sertoli cells via a FasL-dependent pathway
    • Shi Y, Song Y, Wang Y, Liang X, Hu Y, Guan X, et al. p,p′-DDE induces apoptosis of rat Sertoli cells via a FasL-dependent pathway. J Biomed Biotechnol. 2009 ;: Article ID 181282
    • (2009) J Biomed Biotechnol , pp. 181282
    • Shi, Y.1    Song, Y.2    Wang, Y.3    Liang, X.4    Hu, Y.5    Guan, X.6
  • 58
    • 75949128582 scopus 로고    scopus 로고
    • P,p′-DDE induces testicular apoptosis in prepubertal rats via the Fas/FasL pathway
    • Shi YQ, Wang YP, Song Y, Li HW, Liu CJ. Wu ZG, et al. p,p′-DDE induces testicular apoptosis in prepubertal rats via the Fas/FasL pathway. Toxicol Lett. 2010 ; 193: 79-85
    • (2010) Toxicol Lett , vol.193 , pp. 79-85
    • Shi, Y.Q.1    Wang, Y.P.2    Song, Y.3    Li, H.W.4    Liu, C.J.5    Wu, Z.G.6
  • 59
    • 0034929864 scopus 로고    scopus 로고
    • Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
    • De Flora S, Izzotti A, D'Adostini F, Balansky RM. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis. 2001 ; 22 (7). 999-1013 (Pubitemid 32633597)
    • (2001) Carcinogenesis , vol.22 , Issue.7 , pp. 999-1013
    • De Flora, S.1    Izzotti, A.2    D'Agostini, F.3    Balansky, R.M.4
  • 60
    • 0033776271 scopus 로고    scopus 로고
    • Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
    • Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nature Cell Biol. 2000 ; 2 (6). 318-325
    • (2000) Nature Cell Biol , vol.2 , Issue.6 , pp. 318-325
    • Matsuyama, S.1    Llopis, J.2    Deveraux, Q.L.3    Tsien, R.Y.4    Reed, J.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.