Effect of N-acetyl cysteine (NAC), an organosulfur compound from Allium plants, on experimentally induced hepatic prefibrogenic events in wistar rat

Phytomedicine

Volumn 20, Issue 10, 2013, Pages 828-833

  Nissar, Ashraf U ^a   Farrukh, Mufti R ^a   Kaiser, Peerzada J ^a   Rafiq, Rather A ^a   Afnan, Quadri ^a   Bhushan, Shashi ^a   Adil, Hassan S ^b   Subhash, Bhardjwaj C ^b   Tasduq, Sheikh A ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^b GOVERNMENT MEDICAL COLLEGE   (India)

Author keywords

Allium plants; Carbon tetrachloride; Fibrosis; Liver; N acetyl cysteine from; Thioacetamide; Wistar rat

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANILINE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CATALASE; CYTOCHROME P450 2E1; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROXYPROLINE; PROTECTIVE AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ALLIUM; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; COLORIMETRY; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; HYDROXYLATION; LIPID PEROXIDATION; LIVER; LIVER FIBROSIS; LIVER INJURY; LIVER LEVEL; LIVER MICROSOME; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; SYSTEMATIC REVIEW;

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALP; ALT; ASPARTATE AMINOTRANSFERASE; AST; CARBON TETRACHLORIDE; CAT; CATALASE; CCL(4); CYP2E1; CYTOCHROME P450 2E1; FIBROSIS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GPX; GSH; LIPIDPEROXIDATION; LIVER; LPO; MALONALDEHYDE; MDA; N-ACETYL CYSTEINE FROM ALLIUM PLANTS; N-ACETYLCYSTEINE; NAC; OS; OXIDATIVE STRESS; TAA; THIOACETAMIDE; WISTAR RAT;

ACETYLCYSTEINE; ALLIUM; ANIMALS; CARBON TETRACHLORIDE; DISEASE MODELS, ANIMAL; LIVER CIRRHOSIS; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; RATS; RATS, WISTAR; SULFUR; THIOACETAMIDE;

ALLIUM; RATTUS NORVEGICUS;

EID: 84879882560     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.03.009     Document Type: Article

References (27)

1. I.C. Arthur Hepatoprotective effects of S-adenosyl-l-methionine against alcohol- and cytochrome P450 2E1-induced liver injury World Journal of Gastroenterology 16 11 2010 1366 1376
2. J.N. Baumgardner, K. Shankar, L. Hennings, E. Albano, T.M. Badger, and M.J. Ronis N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis Journal of Nutrition 138 10 2008 1872 1879
3. A. Cahill, C.C. Cunningham, M. Adachi, H. Ishii, S.M. Bailey, B. Fromenty, and A. Davies Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion Alcoholism: Clinical and Experimental Research 26 6 2002 907 915
4. M.C. Carrillo, S. Kanai, M. Nokubo, and K. Kitani (-) deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats Life Sciences 48 6 1991 517 521
5. S.L. Friedman Liver fibrosis: from bench to bedside Journal of Hepatology 38 1 2003 38 53
6. I.S. Jamall, V.N. Finelli, and S.S.Q. Hee A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues Analytical Biochemistry 112 1981 70 75
7. J.H. Jang, K.J. Kang, Y.H. Kim, Y.N. Kang, and I.S. Lee Reevaluation of experimental model of hepatic fibrosis induced by hepatotoxic drugs: an easy, applicable, and reproducible model Transplantation Proceedings 40 8 2008 2700 2703
8. T.N. Johnson, M.S. Tanner, and G.T. Tucker Developmental changes in the expression of enterocytic and hepatic cytochromes P4501A in rat Xenobiotica 32 7 2002 595 604
9. G. Labbe, D. Pessayre, and B. Fromenty Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies Fundamental and Clinical Pharmacology 22 4 2008 335 353
10. R.M. Laethem, M. Balazy, J.R. Falk, C.L. Laethem, and D.R. Koop Formation of 19(S), 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1 Journal of Biological Chemistry 268 17 1993 12912 12918
11. A.M. Larson Acetaminophen hepatotoxicity Clinics in Liver Disease 11 3 2007 525 548
12. K. Linhardt, and K. Walter H.U. Bergemeyer, Methods of Enzymatic Analysis 1963 Academic Press New York 783 785
13. O. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randell Protein measurement with the Folin phenol reagent Journal of Biological Chemistry 193 1 1951 265 275
14. F. Murphy, M. Arthur, and J. Iredale Developing strategies for liver fibrosis treatment Expert Opinion on Investigational Drugs 11 11 2002 1575 1585
15. S.K. Natarajan, S. Thomas, P. Ramamoorthy, J. Basivireddy, A.B. Pulimood, A. Ramachandran, and K.A. Balasubramanian Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models Journal of Gastroenterology and Hepatology 21 6 2006 947 957
16. P.J. O'Brien, and A.D. Rahimtula A peroxidase assay for cytochrome P-450 Methods in Enzymology. LII 52 1978 407 412
17. D. O'Shea, S.N. Davis, R.B. Kim, and G.R. Wilkinson Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity Clinical Pharmacology and Theraupetics 56 4 1994 359 367
18. T. Ohyama, K. Sato, K. Kishimoto, Y. Yamazaki, N. Horiguchi, T. Ichikawa, S. Kakizaki, H. Takagi, T. Izumi, and M. Mori Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence British Journal of Pharmacology 165 4b 2011 1173 1187
19. A. Pastor, P.S. Collado, M. Almar, and J. Gonzalez-Gallego Antioxidant enzyme status in biliary obstructed rats: effects of N-acetylcysteine Journal of Hepatology 27 2 1997 363 370
20. F.G. Pereira, C. Ferreira, A. Schwengber, C. Marroni, C. Zettler, and N. Marroni Role of N-acetylcysteine on fibrosis and oxidative stress in cirrhotic rats Arquivos de Gastroenterologia 45 2 2008 156 162
21. J.L. Raucy, J.M. Lasker, J.C. Kraner, D.E. Salazar, C.S. Lieber, and G.B. Corcoran Induction of cytochrome P450IIE1 in the obese overfed rat Molecular Pharmacology 39 3 1991 275 280
22. S.A. Tasduq, D.M. Mondhe, D.K. Gupta, M. Baleshwar, and R.K. Johri Reversal of fibrogenic events in liver by Emblica officinalis (Fruit), an Indian Natural Drug Biological and Pharmaceutical Bulletin 28 7 2005 1304 1306
23. M. Segawa, K. Kayano, E. Sakaguchi, M. Okamoto, I. Sakaida, and K. Okita Antioxidant, N-acetyl-l-cysteine inhibits the expression of the collagen alpha2 (I) promoter in the activated human hepatic stellate cell line in the absence as well as the presence of transforming growth factor-beta Hepatology Research 24 3 2002 305
24. S.M. Shaarawy, A.A. Tohamy, S.M. Elgendy, Z.Y. Elmageed, A. Bahnasy, M.S. Mohamed, E. kandil, and K. Matrougi Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity International Journal of Biological Sciences 5 6 2009 549 557
25. A.P. Sivaraj, K. Vinoth kumar, S. Sathiyaraj, K. Sundaresan, B. Devi, and Senthilkumar Hepatoprotective potential of Andrographis paniculata aqueous leaf extract on ethanol induced liver toxicity in albino rats Journal of Applied Pharmaceutical Science 1 6 2011 204 208
26. P. Strnad, G.Z. Tao, Q. Zhou, M. Harada, D.M. Toivola, E.M. Brunt, and M.B. Omary Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models Gastroenterology 134 4 2008 1169 1179
27. G. Vendemiale, I. Grattagliano, M.L. Caruso, G. Serviddio, A.M. Valentini, M. Pirrelli, and E. Altomare Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-alpha Toxicology and Applied Pharmacology 175 2 2001 130 139