Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

World Journal of Gastroenterology

Volumn , Issue 29, 2014, Pages 10158-10165

  Akbulut, Sami ^a   Elbe, Hulya ^a   Eris, Cengiz ^a   Dogan, Zumrut ^b   Toprak, Gulten ^c   Otan, Emrah ^a   Erdemli, Erman ^a   Turkoz, Yusuf ^a  

^a INONU UNIVERSITY   (Turkey)

^b ADIYAMAN UNIVERSITY   (Turkey)

^c DICLE UNIVERSITY   (Turkey)

Author keywords

Amifostine; Ascorbic acid; Hepatotoxicity; Methotrexate; N acetyl cysteine; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; AMIFOSTINE; ASCORBIC ACID; CATALASE; GLUTATHIONE; MALONALDEHYDE; METHOTREXATE; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE; ANTIOXIDANT; BIOLOGICAL MARKER; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER FUNCTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SINGLE DRUG DOSE; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; LIVER; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME; ANIMAL EXPERIMENT; BODY WEIGHT; DRUG EFFECT; TISSUE SECTION;

ACETYLCYSTEINE; AMIFOSTINE; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BIOLOGICAL MARKERS; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; LIVER; MALE; METHOTREXATE; OXIDATIVE STRESS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 84905845192     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i29.10158     Document Type: Article

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