Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat

Journal of Biomedical Science

Volumn 17, Issue SUPPL. 1, 2010, Pages

  Acharya, Miteshkumar ^a   Lau Cam, Cesar A ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLCYSTEINE; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HYPOTAURINE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PARACETAMOL; TAURINE; ANALGESIC AGENT; ANTIOXIDANT; DRUG DERIVATIVE; GLUTATHIONE DISULFIDE; SCAVENGER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CHEMICAL PARAMETERS; CONFERENCE PAPER; CONTROLLED STUDY; DECAPITATION; DRUG MECHANISM; IN VITRO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER HOMOGENATE; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; ARTICLE; DRUG EFFECT; HUMAN; LIVER; LIVER DISEASE; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXIC HEPATITIS;

ANIMALIA; RATTUS;

ACETAMINOPHEN; ACETYLCYSTEINE; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIOXIDANTS; DRUG-INDUCED LIVER INJURY; FREE RADICAL SCAVENGERS; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; HUMANS; LIVER; LIVER DISEASES; MALE; MALONDIALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY; TAURINE;

EID: 77956020728     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-17-S1-S35     Document Type: Conference Paper

References (57)

1. Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi. CJ Henderson CR Wolf N Kitteringham H Powell D Otto BK Park, Proc Nat Acad Sci USA 2000 97 12741 12745 10.1073/pnas.220176997 11058152
2. N-Acetyl-p-benzoquinone imine; a cytochrome P-450-mediated oxidation product of acetaminophen. DC Dahlin GT Miwa AYH Lu SD Nelson, Proc Nat Acad Sci U S A 1984 81 1327 1331 10.1073/pnas.81.5.1327
3. Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity. GA Hazelton JJ Hjelle CD Klaassen, J Pharmacol Exp Ther 1986 237 341 349 3958971
4. Toxic doses of acetaminophen suppress hepatic glutathione synthesis in rats. BH Lauterburg JR Mitchell, Hepatology 1982 2 8 12 10.1002/hep.1840020103 7054070
5. Acetaminophen-derived activation of liver microsomal glutathione S-transferase of rats. M Yonamine Y Aniya T Yokomakura T Koyama T Nagamine H Nakanishi, Jpn J Pharmacol 1996 72 175 181 10.1254/jjp.72.175 8912918
6. Acetaminophen-induced hepatotoxicity. LP James PR Mayeux JA Hinson, Drug Metab Dispos 2003 31 1499 1506 10.1124/dmd.31.12.1499 14625346
7. Effect of N-acetylcysteine on acetaminophen toxicity in mice; relationship to reactive nitrogen and cytokine formation. LP James SS McCullough LW Lamps JA Hinson, Toxicol Sci 2003 75 458 467 10.1093/toxsci/kfg181 12883092
8. Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated muse hepatocytes. AB Reid RC Kurten SS McCullough RW Brock JA Hinson, J Pharmacol Exp Ther 2005 312 509 516 10.1124/jpet.104.075945 15466245
9. Mechanism of the formation and disposition of reactive metabolites that can cause acute liver injury. SD Nelson, Drug Metab Rev 1995 27 147 177 10.3109/03602539509029821 7641574
10. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. JGM Bessems NPE Vermeulen, Crit Rev Toxicol 2001 31 55 138 10.1080/20014091111677 11215692
11. Oxidative stress in cultured hepatocytes exposed to acetaminophen. GM Adamson AW Harman, Biochem Pharmacol 1993 45 2289 2294 10.1016/0006-2952(93) 90201-7 8517869
12. Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol. H Jaeschke, J Pharmacol Exp Ther 1990 255 935 941 2262912
13. Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro. T Rouar P Paík O Kuera M Barto Z Cervinkov Physiol Res 2009 58 239 246 18380536
14. Repeated acetaminophen dosing in rats: adaptation of hepatic antioxidant system. PJ O'Brien MR Slaughter A Swain JM Birmingham RW Greenhill F Elcok PJ Bugelski, Hum Exp Toxicol 2000 19 277 283 10.1191/096032700678815918 10918522
15. Intracellular signaling mechanisms of acetaminophen-induced cell death. H Jaeschke ML Bajt, Toxicol Sci 2006 89 31 41 10.1093/toxsci/kfi336 16177235
16. Double-prodrugs of L-cysteine: differential protection against acetaminophen-induced hepatotoxicity in mice. DL Crankshaw LI Berkeley JF Cohen FN SHirota HT Nagasawa, J Biochem Mol Toxicol 2002 16 235 244 10.1002/jbt.10044 12439865
17. Mechanism of action of N-acetyl-L-cysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. BH Lauterberg GB Corcoran JR Mitchell, J Clin Invest 1983 71 980 991 10.1172/JCI110853 6833497
18. Mechanism of action of paracetamol protective agents in mice in vivo. JO Miners R Drew DJ Birkett, Biochem Pharmacol 1984 33 2995 3000 10.1016/0006-2952(84)90599-9 6487352
19. S-Adenosylmethionine (SAMe) attenuates acetaminophen hepatotoxicity in C57BL/6 mice. M Valentovic M Terneus RC Harmon AB Carpenter, Toxicol Lett 2004 154 165 174 10.1016/j.toxlet.2004.07.010 15501608
20. Studies on paracetamol-induced lipid peroxidation. S Fairhurst DJ Barber B Clark AA Horton, Toxicology 1982 23 249 59 10.1016/0300-483X(82)90102-0 7112597
21. Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice. TR Knight MW Fariss A Farhood H Jaeschke, Toxicol Sci 2003 76 229 236 10.1093/toxsci/kfg220 12944590
22. Studies on the effects of L-ascorbic acid on acetaminophen-induced hepatotoxicity: 1. Inhibition of the covalent binding of acetaminophen metabolites to hepatic microsomes in vitro. BG Lake RA Harris JC Phillips SD Gangolli, Toxicol Appl Pharmacol 1981 60 229 240 10.1016/0041-008X(91)90227-6 7281186
23. Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen. D Nakae Y Yamamoto T Yoshiji T Kinugasa H Maruyama JL Farber Y Konishi, Am J Pathol 1990 136 787 795 2158237
24. Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine. I Sakaida K Kayano S Wasaki A Nagatomi Y Matsumura K Okita, Scand J Gastroenterol 1995 30 61 67 10.3109/00365529509093237 7701253
25. Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice. GB Corcoran BK Wong, J Pharmacol Exp Ther 1986 238 54 61 3723405
26. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. OI Aruoma B Halliwell BM Hoey J Butler, Free Radic Biol Med 1989 6 593 597 10.1016/0891-5849(89)90066-X 2546864
27. The effects of N-acetylcysteine on antioxidant enzyme activities in experimental testicular torsion. A ay A Alver M Küçük O Isik M Selçuk Eminaaolu S Caner Karahan O Deer, J Surg Res 2006 131 199 203 10.1016/j.jss.2005.11.572 16412470
28. Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. PNR Dekhuijzen, Eur Respir J 2004 23 629 636 10.1183/09031936.04.00016804 15083766
29. Role of taurine in preventing acetaminophen-induced hepatic injury in the rat. E Waters JH Wang HP Redmond QD Wu E Kay D Bouchier-Hayes, Am J Physiol Gastrointest Liver Physiol 2001 280 1274 G1279 11352821
30. The effects of taurine, taurine homologs and hypotaurine on cell membrane and antioxidative system alterations caused by type 2 diabetes in rat erythrocytes. D Gossai C Lau-Cam, Adv Exp Med Biol 2009 643 85 93 full-text 19239139
31. In vitro and in vivo effects of taurine and structurally related sulfur-containing compounds against phenylhydrazine-induced oxidative damage to erythrocytes. PK Pokhrel CA Lau-Cam, Adv Exp Med Biol 2000 483 503 522 full-text 11787637
32. Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. TR Green JH Fellman AL Eicher KL Pratt, Biochim Biophys Acta 1991 1073 91 97 1846756
33. Microsomal lipid peroxidation. JA Bugue SD Aust, Methods Enzymol 1978 52 302 310 full-text 672633
34. A fluorometric method for determination of oxidized and reduced glutathione in tissues. JP Hissin R Hilf, Anal Biochem 1976 74 214 226 10.1016/0003-2697(76)90326-2 962076
35. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T -synuclein toxicity. W Zhou CR Freed, J Biol Chem 2005 280 43150 43158 10.1074/jbc.M507124200 16227205
36. Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. CR Wheeler JA Salzman NM Elsayed ST Omaye DW Korte Jr, Anal Biochem 1990 184 193 199 10.1016/0003-2697(90)90668- Y 2327564
37. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. WH Habig MJ Pabst WB Jakoby, J Biol Chem 1974 249 7130 7139 4436300
38. Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice. GB Corcoran EL Todd WJ Racz H Hughes CV Smith JR Mitchell, J Pharmacol Exp Ther 1985 232 864 872 3973835
39. The effects of buthionine sulphoximine (BSO) on glutathione depletion. R Drew JO Miners, Biochem Pharmacol 1984 33 2989 2994 10.1016/0006-2952(84)90598-7 6148944
40. Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. C Saito C Zwingmann H Jaeschke, Hepatology 2010 51 246 254 19821517
41. In vivo studies of cysteine metabolism. Use of D-cysteinesulfinate, a novel cysteinesulfinate decarboxylase inhibitor, to probe taurine and pyruvate synthesis. CL Weinstein RH Haschmeyer OW Griffith, J Biol Chem 1988 263 16568 16579 3182803
42. Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation. X Shi DC Flynn DW Porter SS Leonard V Vallyathan V Castranova, Ann Clin Lab Sci 1997 27 365 374 9303176
43. Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis. Q di Wu JH Wang F Fennessy HP Redmond D Boucher-Hayes, Am J Physiol Cell Physiol 1999 277 1229 C1238
44. Beneficial effects of taurine against doxorubicin-induced cardiotoxicity in mice. T Ito S Muraoka K Takahashi Y Fujio SW Schaffer J Azuma, Adv Exp Med Biol 2009 643 65 74 full-text 19239137
45. Melatonin is more effective than taurine and 5-hydroxytryptophan against hyperglycemia-induced kidney cortex tubules injury. RA Derlacz M Sliwinska A Piekutowska K Winiarska J Drozak J Bryla, J Pineal Res 2007 42 203 209 10.1111/j.1600-079X.2006.00405.x 17286753
46. Effect of taurine on antioxidant enzymes system in B16F10 melanoma cells. J Yu AK Kim, Adv Exp Med Biol 2009 643 491 499 full-text 19239181
47. Protective role of taurine against mercuric chloride intoxicated rats. SS Samipillai G Jagadeesan, Rec Res Sci Technol 2009 1 081 087
48. Protective effects of taurine on glutathione and glutathione-dependent enzymes in ethanol-fed rats. G Pushpakiran K Mahalakshmi CV Anurandha, Pharmazie 2004 59 869 872 15587589
49. Killing of Schistosoma mansoni sporocysts by hemocytes from resistant Biomphalaria glabrata: role of reactive oxygen species. UK Hahn RC Bender CJ Bayne, J Parasitol 2001 87 292 299 2001 11318558
50. The reactivity of hypotaurine and cysteine sulfinic acid with peroxynitrite. M Fontana S Duprè L Pecci, Adv Exp Med Biol 2006 583 15 24 full-text 17153585
51. Glutathione and hypotaurine in vitro: effects on human sperm motility, DNA integrity and production of reactive oxygen species. ET Donnelly N McClure SEM Lewis, Mutagenesis 2000 15 61 68 10.1093/mutage/15.1.61 10640532
52. Effects of an organic hydroperoxide on the activity of antioxidant enzymes in cultured mammalian cells. T Ochi, Toxicology 1990 61 229 239 10.1016/0300-483X(90)90173-E 2330596
53. Inactivation of enzymes of the glutathione antioxidant system by treatment of cultured human keratinocytes with peroxides. DA Vessey KH Lee, J Invest Dermatol 1993 100 829 833 10.1111/1523-1747.ep12476735 8496623
54. Oxidative stress by acute acetaminophen administration in mouse liver. SL Arnaiz S Llesuy JC Cutrin A Boveris, Free Radic Biol Med 1995 19 303 310 10.1016/0891-5849(95)00023-Q 7557544
55. Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetylcysteine. ML Bajt TR Knight JJ Lemasters H Jaeschke, Toxicol Sci 2004 80 343 349 10.1093/toxsci/kfh151 15115886
56. Knock down of -glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity. S Akai H Hosomi K Minami K Tsuneyama M Katoh M Nakajima T Yokoi, J Biol Chem 2007 282 23996 24003 10.1074/jbc. M702819200 17573345
57. Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice. D Botta S Shi CC White MJ Dabrowski CL Keener SL Srinouanprachanh FM Farin CB Ware WC Ladiges RH Pierce, et al. J Biol Chem 2006 281 28865 28875 10.1074/jbc.M605143200 16840778