The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

Bratislava Medical Journal

Volumn 116, Issue 4, 2015, Pages 252-258

  Altinoz, E ^a   Turkoz, Y ^b   Vardi, N ^b  

^a KARABUK UNIVERSITY   (Turkey)

^b INONU UNIVERSITY   (Turkey)

Author keywords

Acrylamide; Liver; N acetylcysteine; Oxidative stress; Small and large intestine

Indexed keywords

ACETYLCYSTEINE; ACRYLAMIDE; ANTIOXIDANTS; FREE RADICAL SCAVENGERS;

ANIMALS; CHEMICALLY INDUCED; DISEASE MODELS, ANIMAL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; INTESTINAL DISEASES; INTESTINE, LARGE; LIVER; MALE; PATHOLOGY; RATS; RATS, WISTAR;

ACETYLCYSTEINE; ACRYLAMIDE; ANIMALS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; FREE RADICAL SCAVENGERS; INTESTINAL DISEASES; INTESTINE, LARGE; LIVER; MALE; RATS; RATS, WISTAR;

EID: 84928521784     PISSN: 00069248     EISSN: 13360345     Source Type: Journal    
DOI: 10.4149/BLL_2015_049     Document Type: Article

References (66)

1. Blasiak J, Gloc E, Wozniak K et al. Genetoxicity of acrylamide in human lymphocytes. Chemico-Biological Interac 2004; 149: 137-149.
2. LoPachin RM, Balaban CD, Ross JF. Acrylamide axonopathy revisited. Toxicol Appl Pharmacol 2003; 188: 135-153.
3. Tareke E, Rydberg P, Karlsson P et al. Acrylamide: a cooking carcinogen. Chemical Res Toxicol 2000; 13: 517-522.
4. Dearfield KL, Abernathy CO, Ottley MS et al. Acrylamide: its metabolism, developmental and reproductive effects, genotoxicity, and carcinogenicity. Mutat Res 1988; 195: 45-77.
5. Johnson KA, Gorzinski SJ, Bodner KM et al. Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol 1986; 85: 154-168.
6. Tareke E, Rydberg P, Karlsson P et al. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J Agri Food Chem 2002; 50: 4998-5006.
7. Stadler RH, Blank I, Varga N et al. Acrylamide from Maillard reaction products. Nature 2002; 419: 449-450.
8. Ikeda G, Miller E, Sapienza P et al. Comparative tissue distribution and excretion of (1-14C)acrylamide in beagle dogs and miniature pigs. Food Chem Toxicol 1987; 25 (11): 871-875.
9. Shipp A, Lawrence G, Gentry R et al. Acrylamide: Review of toxicity data and dose-response analyses for cancer and noncancer effects. Crit Rev Toxicol 2006; 36: 481-608.
10. Bast A, Haenen GRMM, Doelman CJA. Oxidants and antioxidants: State of the art. Am J Med 1991; 91: 302-313.
11. Akkus I. Serbest radikaller ve fizyolojik etkileri. Mimoza Basin Yayin dagitim Konya 1995: 32-42.
12. Shamberger RJ, Andreone TL, Willis CE. Antioxidants and cancer: IV. Initiating activity of malonaldehyde as a carcinogen. J Natl Cancer Inst 1974;5 3: 1771-1773.
13. Voitkun V, Zhitkovich A. Analysis of DNA-protein crosslinking activity of malondialdehyde in vitro. Mutat Res 1999; 424: 97-106.
14. Srivastava SP, Sabri MI, Agrawal AK et al. Effect of single and repeated doses of acrylamide and bis-acrylamide on glutathione-S-transferase and dopamine receptors in rat brain. Brain Res 1986; 371: 319-323.
15. Zhu YJ, Zeng T, Zhu YB et al. Effects of Acrylamide on the Nervous Tissue Antioxidant System and Sciatic Nerve Electrophysiology in the Rat. Neurochem Res 2008; 33: 2310-2317.
16. Church DF, Pryor WA. Free radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985; 64: 111-126.
17. Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. 2nd ed. Oxford: Clarendon Press 1989; 317-321.
18. Bridges AB, Scott NA, Parry GJ et al. Age, sex, cigarette smoking and indices of free radical activity in healthy humans. Eur J Med 1993; 2: 205-208.
19. Kalra J, Chaudhary AK, Prasad K. Increased production of oxygen free radicals in cigarette smokers. Int J Exp Pathol 1991; 72: 1-7.
20. Brown KM, Morrice PC, Duthie GG. Vitamin E suppresses indexes of lipid peroxidation and platelet count in blood of smokers and nonsmokers but plasma lipoprotein concentrations remain unchanged. Am J Clin Nutr 1994; 60: 383-387.
21. Gonenc A, Ozkan Y, Torun M et al. Plasma malondialdehyde (MDA) levels in breast and lung cancer patients. J Clin Pharm Ther 2001; 26: 141-144.
22. Scherer G, Engl J, Urban M et al. Relationship between machinederived smoke yields and biomarkers in cigarette smokers in Germany. Regul Toxicol Pharmacol 2007; 47: 171-183.
23. Huang CCJ, Li CM, Wu CF et al. Analysis of urinary N-acetyl-S-(propionamide)-cysteine as a biomarker for the assessment of acrylamide exposure in smokers. Environ Res 2007; 104: 346-351.
24. Meister A, Larsson A. Glutathione synthetase deficiency and other disorders of the g-glutamyl cycle. In: Scriver CR, Beaudet AL, Sly WS, Valle D (Eds). The metabolic basis of inherited disease. 6th ed. New York: McGraw-Hill 1989; 855-868.
25. Griffith OW, Meister A. Origin and turnover of mitochondrial glutathione. Proc Natl Acad Sci USA 1985; 82: 4668-72.
26. Chen Z, Lash LH. Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers. J Pharmacol Exp Ther 1998; 285: 608-618.
27. Reed DJ, Fariss MW. Glutathione depletion and susceptibility. Pharmacol Rev 1994; 36: 235-335.
28. Klatt P, Lamas S. Regulation of protein function by S-glutathionylation in response to oxidative and nitrosative stress. Eur J Biochem 2000; 267: 4928-4944.
29. Fratelli M, Demol H, Puype M et al. Identification by redox proteomics of glutathionylated proteins in oxidativelystressed human T lymphocytes. PNAS 2002; 99: 3505-3510.
30. Mannervik, B. Adv Enzymol 1985; 57: 357-417.
31. Cnubben NHP, Rietjens IMCM, Wortelboer H et al. The interplay of glutathione-related processes in antioxidant defense. Environ Toxicol Pharmacol 2001; 10; 141-152.
32. Srivastava SP, Das M, Mukhtar H et al. Effect of Acrylamide on Glutatione-S-Transferase Activity in Different Regions of Rat Brain. Bull. Environ. Contam. Toxicol 1984; 32: 166-170.
33. Fryer AA, Hume R, Strange RC. The development of glutathione S-transferase and glutathione peroxidase activities in human lung. Biochim Biophys Acta 1986; 883: 448-453.
34. Ishii T, Matsuse T, Igarashi H et al. Tobacco smoke reduces viability in human lung fibroblasts: Protective effect of glutathione S-transferase P1. Am J Physiol Lung Cell Mol Physiol 2001; 280: 1189-1195.
35. Aruoma OI, Halliwell B, Hoey BM et al. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989; 6: 593-597.
36. Sprong RC, Winkelhuyzen-Janssen AM, Aarsman CJ et al. Lowdose N-acetylcysteine protects rats against endotoxin-mediated oxidative stress, but high-dose increases mortality. Am J RespirCrit Care Med 1998; 157: 1283-1293.
37. Wang AL, Wang JP, Wang H et al. A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice. Hepatol Res 2006; 34(3): 199-206.
38. LoPachin RM, Lehning EJ. Acrylamide-induced distal axon degeneration: a proposed mechanism of action. NeuroToxicol 1994; 15: 247-260.
39. LoPachin RM, Lehning EJ, Opanashuk LA et al. Rate of neurotoxicant exposure determines morphologic manifestations of distal axonopathy. Toxicol Appl Pharmacol 2000; 167: 75-86.
40. LoPachin RM, Ross JF, Lehning EJ. Nerve terminals as the primary site of acrylamide action. NeuroToxicol 2002 a; 23: 43-59.
41. Elman GL. Tissue sulphydryl groups. Arch Biochem Biophys 1979; 95: 351-358.
42. Ohkawa H, Ohishi N, Yagi K. Assay of lipid peroksides in animal tissue by thiobarbutiric acid reaction. Anal Biochem 1979; 95: 351.
43. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-7139.
44. Dearfield, KL, Douglas GR, Ehling UH et al. Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk. Mutat Res 1995; 330: 71-99.
45. Biederman M, Grob K. Model studies on acrylamide formation in potato, wheat flour and corn starch: ways to reduce acrylamide contents in bakery ware. Mitteilungen fur Lebensmittel Hygiene 2003; 94: 406-422.
46. Lingnert H. Acrylamide in food-mechanisms of formation and influencing factors during heating of foods. The Swedish Institute For Food and Biotechnology Chairman of Expert Committee 2002.
47. Becalski A, Lau BP, Lewis D et al. Acrylamide in French fries: influence of free amino acids and sugars. J Agric Food Chem 2003; 51 (3): 802-808.
48. Halliwel B. Reactive oxygen species in living systems: source, biochemistry, and role in human. Am J Med 1991; 91: 314-322.
49. Cheeseman KH, Slater TF. An introduction to free radical biochemistry. Br Med Bull 1993; 49 (3): 479-480.
50. Puppel N, Tjaden Z, Fueller F et al. DNA strand breaking capacity of acrylamide and glycidamide in mammalian cells. Mutat Res 2005; 580: 71-80.
51. Park J, Kamendulis LM, Friedman MA et al. Acrylamide-induced Cellular Transformation. Toxicol Sci 2002; 65: 177-183.
52. Shukla PK, Khanna VK, Ali MM et al. Protective Effect of Acorus calamus Against Acrylamide Induced Neurotoxicity. Phytother Res 2002; 16: 256-260.
53. Srivastava SP, Das M, Seth PR. Enhancement of lipid peroxidation in rat liver on acute exposure to styrene and acrylamide. A consequence of glutathione depletion. Chemico-Biol Int 198; 45: 373-380.
54. Yousef MI, El-Demerdash FM. Acrylamide-induced oxidative stress and biochemical perturbations in rats. Toxicology 2006; 219: 133-141.
55. Odland L, Romert L, Clemedson C et al. Glutathione content, glutathione transferase activity and lipid peroxidation in acrylamide-treated neuroblastoma N1E 115 cells. Toxicol In Vitro 1994; 8: 263-267.
56. Bjorge C, Brunborg G, Wiger R et al. A comparative study of chemically induced DNA damage in isolated human and rat testicular cells. Reprod Toxicol 10; 509-519.
57. Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I., 2005. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activition and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity. Antioxid Redox Signal 1996; 7: 32-41.
58. Cao J, Liu Y, Jia L et al. Curcumin Attenuates Acrylamide-Induced Cytotoxicity and Genotoxicity in HepG2 Cells by ROS Scavenging. J Agric Food Chem 2008; 56: 12 059-12 063.
59. Cotgreave IA. N-Acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol 1997; 38: 205-227.
60. Zafarullah M, Li WQ, Sylvester J et al. Molecularmechanisms of N-acetylcysteine actions. Cell Mol Life Sci 2003; 60: 6-20.
61. Eskiocak S, Altaner S, Bayir S et al. The Effect of N-acetylcysteine on Brain Tissue of Rats Fed with High-Cholesterol Diet. Turk J Biochem 2008; 33: 58-63.
62. Rodríguez-Ramiro I, Ramos S, Bravo L et al. Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway. J Nutr Biochem 2011; 22: 1186-1194.
63. Alturfan AA, Tozan-Beceren A, Sehirli AO et al. Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats. Mol Biol Rep 2012; 39 (4): 4589-4596.
64. Lieshout EMMV, Bedaf MMG, Pieter M et al. Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels. Carcinogenesis 1998; 11 (4): 2055-2057.
65. Sumner SC, MacNeela JP, Fennell TR. Characterization and quantitation of urinary metabolites of (1,2,3-13C)-acrylamide in rats and mice using 13C nuclear magnetic resonance spectroscopy. Chem ResToxicol 1992; 5: 81-89.
66. Calleman CJ, Bergmark E, Costa LG. Acrylamide is metabolized to glycidamide in the rat: evidence from hemoglobin adduct formation. Chem Res Toxicol 1990; 3: 406-412.