메뉴 건너뛰기




Volumn 35, Issue 4, 2015, Pages 932-940

Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: Implications for apoptosis and inflammation

Author keywords

Adipocytes; Autophagy; Endoplasmic reticulum stress; Inflammation; Palmitate

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CHLOROQUINE; FAT DROPLET; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INTERLEUKIN 6; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; MONOCYTE CHEMOTACTIC PROTEIN 1; PALMITIC ACID; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; CYTOKINE; PALMITIC ACID DERIVATIVE;

EID: 84923668958     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2085     Document Type: Article
Times cited : (51)

References (33)
  • 1
    • 79960820132 scopus 로고    scopus 로고
    • The growing challenge of obesity and cancer: An inflammatory issue
    • Harvey AE, Lashinger LM and Hursting SD: The growing challenge of obesity and cancer: an inflammatory issue. Ann NY Acad Sci 1229: 45-52, 2011.
    • (2011) Ann NY Acad Sci , vol.1229 , pp. 45-52
    • Harvey, A.E.1    Lashinger, L.M.2    Hursting, S.D.3
  • 2
    • 79959332548 scopus 로고    scopus 로고
    • Pathophysiological implications between chronic inflammation and the development of diabetes and obesity
    • González-Chávez A, Elizondo-Argueta S, Gutiérrez-Reyes G and Leon-Pedroza JI: Pathophysiological implications between chronic inflammation and the development of diabetes and obesity. Cir Cir 79: 209-216, 2011.
    • (2011) Cir Cir , vol.79 , pp. 209-216
    • González-Chávez, A.1    Elizondo-Argueta, S.2    Gutiérrez-Reyes, G.3    Leon-Pedroza, J.I.4
  • 3
    • 77956869772 scopus 로고    scopus 로고
    • Inflammation, a link between obesity and cardiovascular disease
    • Wang Z and Nakayama T: Inflammation, a link between obesity and cardiovascular disease. Mediators Inflamm 2010: 535918, 2010.
    • (2010) Mediators Inflamm , vol.2010 , pp. 535918
    • Wang, Z.1    Nakayama, T.2
  • 4
    • 45549103859 scopus 로고    scopus 로고
    • JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro
    • Takahashi K, Yamaguchi S, Shimoyama T, et al: JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro. Am J Physiol Endocrinol Metab 294: E898-E909, 2008.
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. E898-E909
    • Takahashi, K.1    Yamaguchi, S.2    Shimoyama, T.3
  • 5
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science 290: 1717-1721, 2000.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 7
    • 84863181426 scopus 로고    scopus 로고
    • The role of autophagy in endoplasmic reticulum stress-induced pancreatic beta cell death
    • Yin JJ, Li YB, Wang Y, et al: The role of autophagy in endoplasmic reticulum stress-induced pancreatic beta cell death. Autophagy 8: 158-164, 2012.
    • (2012) Autophagy , vol.8 , pp. 158-164
    • Yin, J.J.1    Li, Y.B.2    Wang, Y.3
  • 8
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang L, Li P, Fu S, Calay ES and Hotamisligil GS: Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 11: 467-478, 2010.
    • (2010) Cell Metab , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 9
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    • Saitoh T, Fujita N, Jang MH, et al: Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456: 264-268, 2008.
    • (2008) Nature , vol.456 , pp. 264-268
    • Saitoh, T.1    Fujita, N.2    Jang, M.H.3
  • 10
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS: Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900-917, 2010.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 11
    • 77954251401 scopus 로고    scopus 로고
    • Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes
    • Ost A, Svensson K, Ruishalme I, et al: Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med 16: 235-246, 2010.
    • (2010) Mol Med , vol.16 , pp. 235-246
    • Ost, A.1    Svensson, K.2    Ruishalme, I.3
  • 13
    • 77957078371 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and inflammation in obesity and diabetes
    • Hummasti S and Hotamisligil GS: Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res 107: 579-591, 2010.
    • (2010) Circ Res , vol.107 , pp. 579-591
    • Hummasti, S.1    Hotamisligil, G.S.2
  • 14
    • 0035805629 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    • Listenberger LL, Ory DS and Schaffer JE: Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 276: 14890-14895, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 14890-14895
    • Listenberger, L.L.1    Ory, D.S.2    Schaffer, J.E.3
  • 15
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T and Levine B: Methods in mammalian autophagy research. Cell 140: 313-26, 2010.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 17
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    • Ravikumar B, Vacher C, Berger Z, et al: Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 36: 585-595, 2004.
    • (2004) Nat Genet , vol.36 , pp. 585-595
    • Ravikumar, B.1    Vacher, C.2    Berger, Z.3
  • 18
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • Oyadomari S and Mori M: Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11: 381-389, 2004.
    • (2004) Cell Death Differ , vol.11 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 19
    • 84862295360 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy
    • Klionsky DJ, Abdalla FC, Abeliovich H, et al: Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544, 2012.
    • (2012) Autophagy , vol.8 , pp. 445-544
    • Klionsky, D.J.1    Abdalla, F.C.2    Abeliovich, H.3
  • 20
    • 33845459165 scopus 로고    scopus 로고
    • Autophagy is activated for cell survival after endoplasmic reticulum stress
    • Ogata M, Hino S, Saito A, et al: Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26: 9220-9231, 2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 9220-9231
    • Ogata, M.1    Hino, S.2    Saito, A.3
  • 21
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky JM and Glass CK: Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72: 219-246, 2010.
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 22
    • 84896879885 scopus 로고    scopus 로고
    • The reciprocal interaction between autophagic dysfunction and ER stress in adipose insulin resistance
    • Li H, Zhou B, Xu L, et al: The reciprocal interaction between autophagic dysfunction and ER stress in adipose insulin resistance. Cell Cycle 13: 565-579, 2014.
    • (2014) Cell Cycle , vol.13 , pp. 565-579
    • Li, H.1    Zhou, B.2    Xu, L.3
  • 23
    • 78649262849 scopus 로고    scopus 로고
    • Autophagy: Roles in obesity-induced ER stress and adiponectin downregulation in adipocytes
    • Zhou L and Liu F: Autophagy: roles in obesity-induced ER stress and adiponectin downregulation in adipocytes. Autophagy 6: 1196-1197, 2010.
    • (2010) Autophagy , vol.6 , pp. 1196-1197
    • Zhou, L.1    Liu, F.2
  • 24
    • 84878793136 scopus 로고    scopus 로고
    • The relationship between metabolism and the autophagy machinery during the innate immune response
    • Martinez J, Verbist K, Wang R and Green DR: The relationship between metabolism and the autophagy machinery during the innate immune response. Cell Metab 17: 895-900, 2013.
    • (2013) Cell Metab , vol.17 , pp. 895-900
    • Martinez, J.1    Verbist, K.2    Wang, R.3    Green, D.R.4
  • 25
    • 77953019823 scopus 로고    scopus 로고
    • Innate immunity and adipose tissue biology
    • Schäffler A and Schölmerich J: Innate immunity and adipose tissue biology. Trends Immunol 31: 228-235, 2010.
    • (2010) Trends Immunol , vol.31 , pp. 228-235
    • Schäffler, A.1    Schölmerich, J.2
  • 26
    • 84897018309 scopus 로고    scopus 로고
    • Toll-like receptor 2/4 links to free fatty acid-induced inflammation and β-cell dysfunction
    • Yin J, Peng Y, Wu J, Wang Y and Yao L: Toll-like receptor 2/4 links to free fatty acid-induced inflammation and β-cell dysfunction. J Leukoc Biol 95: 47-52, 2014.
    • (2014) J Leukoc Biol , vol.95 , pp. 47-52
    • Yin, J.1    Peng, Y.2    Wu, J.3    Wang, Y.4    Yao, L.5
  • 27
    • 84901062946 scopus 로고    scopus 로고
    • Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
    • González-Rodríguez A, Mayoral R, Agra N, et al: Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis 5: e1179, 2014.
    • (2014) Cell Death Dis , vol.5 , pp. e1179
    • González-Rodríguez, A.1    Mayoral, R.2    Agra, N.3
  • 28
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine B and Klionsky DJ: Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477, 2004.
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 29
    • 73449083755 scopus 로고    scopus 로고
    • Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress
    • Ishida Y and Nagata K: Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress. Autophagy 5: 1217-1219, 2009.
    • (2009) Autophagy , vol.5 , pp. 1217-1219
    • Ishida, Y.1    Nagata, K.2
  • 30
    • 77953506788 scopus 로고    scopus 로고
    • ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy
    • Qin L, Wang Z, Tao L and Wang Y: ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy 6: 239-247, 2010.
    • (2010) Autophagy , vol.6 , pp. 239-247
    • Qin, L.1    Wang, Z.2    Tao, L.3    Wang, Y.4
  • 31
    • 84870170324 scopus 로고    scopus 로고
    • Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression
    • Jansen HJ, van Essen P, Koenen T, et al: Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression. Endocrinology 153: 5866-5874, 2012.
    • (2012) Endocrinology , vol.153 , pp. 5866-5874
    • Jansen, H.J.1    Van Essen, P.2    Koenen, T.3
  • 32
    • 84890848068 scopus 로고    scopus 로고
    • Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway
    • Chen ML, Yi L, Jin X, et al: Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Autophagy 9: 2033-2045, 2013.
    • (2013) Autophagy , vol.9 , pp. 2033-2045
    • Chen, M.L.1    Yi, L.2    Jin, X.3
  • 33
    • 79953176280 scopus 로고    scopus 로고
    • Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation
    • Harris J, Hartman M, Roche C, et al: Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 286: 9587-9597, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 9587-9597
    • Harris, J.1    Hartman, M.2    Roche, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.