메뉴 건너뛰기




Volumn 150, Issue 12, 2009, Pages 5218-5229

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

EID: 71949118923     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0543     Document Type: Article
Times cited : (294)

References (65)
  • 1
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • Wellen KE, Hotamisligil GS 2005 Inflammation, stress, and diabetes. J Clin Invest 115:1111-1119
    • (2005) J Clin Invest , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 2
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM 1993 Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259:87-91
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 5
    • 53749100698 scopus 로고    scopus 로고
    • Increased interleukin (IL)-1β messenger ribonucleic acid expression in β-cells of individuals with type 2 diabetes and regulation of IL-1β in human islets by glucose and autostimulation
    • Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY 2008 Increased interleukin (IL)-1β messenger ribonucleic acid expression in β-cells of individuals with type 2 diabetes and regulation of IL-1β in human islets by glucose and autostimulation. J Clin Endocrinol Metab 93:4065-4074
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4065-4074
    • Böni-Schnetzler, M.1    Thorne, J.2    Parnaud, G.3    Marselli, L.4    Ehses, J.A.5    Kerr-Conte, J.6    Pattou, F.7    Halban, P.A.8    Weir, G.C.9    Donath, M.Y.10
  • 9
    • 0028303844 scopus 로고
    • Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
    • DOI 10.1038/368756a0
    • Lorenzo A, Razzaboni B, Weir GC, Yankner BA 1994 Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368:756-760 (Pubitemid 24153418)
    • (1994) Nature , vol.368 , Issue.6473 , pp. 756-760
    • Lorenzo, A.1    Razzaboni, B.2    Weir, G.C.3    Yankner, B.A.4
  • 11
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello CA 2009 Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27:519-550
    • (2009) Annu Rev Immunol , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 12
    • 0022445268 scopus 로고
    • Cytotoxicity of human pI 7 Interleukin-1 for pancreatic islets of Langerhans
    • Bendtzen K, Mandrup-Poulsen T, Nerup J, Nielsen JH, Dinarello CA, Svenson M 1986 Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science 232:1545-1547 (Pubitemid 16061563)
    • (1986) Science , vol.232 , Issue.4757 , pp. 1545-1547
    • Bendtzen, K.1    Mandrup-Poulsen, T.2    Nerup, J.3
  • 13
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • Mandrup-Poulsen T 1996 The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39:1005-1029
    • (1996) Diabetologia , vol.39 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 16
    • 62649128371 scopus 로고    scopus 로고
    • XOMA 052, an anti-IL-1β antibody, in a double-blind, placebo-controlled, dose escalation study of the safety and pharmacokinetics in patients with type 2 diabetes mellitus: A new approach to therapy
    • Donath MY, Weder C, Whitmore J, Bauer RJ, Der K, Scannon PJ, Dinarello CA, Solinger AM 2008 XOMA 052, an anti-IL-1β antibody, in a double-blind, placebo-controlled, dose escalation study of the safety and pharmacokinetics in patients with type 2 diabetes mellitus: a new approach to therapy. Diabetologia 51(Suppl 1):S7
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1
    • Donath, M.Y.1    Weder, C.2    Whitmore, J.3    Bauer, R.J.4    Der, K.5    Scannon, P.J.6    Dinarello, C.A.7    Solinger, A.M.8
  • 17
    • 42449091550 scopus 로고    scopus 로고
    • The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia
    • DOI 10.1210/en.2007-1059
    • Sauter NS, Schulthess FT, Galasso R, Castellani LW, Maedler K 2008 The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology 149:2208-2218 (Pubitemid 351574505)
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2208-2218
    • Sauter, N.S.1    Schulthess, F.T.2    Galasso, R.3    Castellani, L.W.4    Maedler, K.5
  • 18
    • 52949129811 scopus 로고    scopus 로고
    • Treatment with an interleukin 1β antibody improves glycemic control in diet-induced obesity
    • Osborn O, Brownell SE, Sanchez-Alavez M, Salomon D, Gram H, Bartfai T 2008 Treatment with an interleukin 1β antibody improves glycemic control in diet-induced obesity. Cytokine 44:141-148
    • (2008) Cytokine , vol.44 , pp. 141-148
    • Osborn, O.1    Brownell, S.E.2    Sanchez-Alavez, M.3    Salomon, D.4    Gram, H.5    Bartfai, T.6
  • 21
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH 1995 Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44:863-870
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 22
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G 1997 Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes [Erratum (1997) 46:536] 46:3-10 (Pubitemid 27009941)
    • (1997) Diabetes , vol.46 , Issue.1 , pp. 3-10
    • Boden, G.1
  • 23
    • 0022458220 scopus 로고
    • Experimental reduction of B-cell mass: Implications for the pathogenesis of diabetes
    • Weir GC, Leahy JL, Bonner-Weir S 1986 Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes. Diabetes Metab Rev 2:125-161 (Pubitemid 16079237)
    • (1986) Diabetes/Metabolism Reviews , vol.2 , Issue.1-2 , pp. 125-161
    • Weir, G.C.1    Leahy, J.L.2    Bonner-Weir, S.3
  • 24
    • 46749142851 scopus 로고    scopus 로고
    • Requirements of calcium fluxes and ERK kinase activation for glucose- And interleukin-1β-induced β-cell apoptosis
    • Fei H, Zhao B, Zhao S, Wang Q 2008 Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1β-induced β-cell apoptosis. Mol Cell Biochem 315:75-84
    • (2008) Mol Cell Biochem , vol.315 , pp. 75-84
    • Fei, H.1    Zhao, B.2    Zhao, S.3    Wang, Q.4
  • 25
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    • Senn JJ 2006 Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J Biol Chem 281:26865-26875
    • (2006) J Biol Chem , vol.281 , pp. 26865-26875
    • Senn, J.J.1
  • 28
    • 33745187112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
    • Song MJ, Kim KH, Yoon JM, Kim JB 2006 Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 346:739-745
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 739-745
    • Song, M.J.1    Kim, K.H.2    Yoon, J.M.3    Kim, J.B.4
  • 29
    • 9444249274 scopus 로고    scopus 로고
    • Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells
    • DOI 10.2337/diabetes.53.12.3209
    • Staiger H, Staiger K, Stefan N, Wahl HG, Machicao F, Kellerer M, Häring HU 2004 Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes 53:3209-3216 (Pubitemid 39564497)
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3209-3216
    • Staiger, H.1    Staiger, K.2    Stefan, N.3    Wahl, H.G.4    Machicao, F.5    Kellerer, M.6    Haring, H.-U.7
  • 30
    • 43149084152 scopus 로고    scopus 로고
    • Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic β-cells
    • Koshkin V, Dai FF, Robson-Doucette CA, Chan CB, Wheeler MB 2008 Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic β-cells. J Biol Chem 283:7936-7948
    • (2008) J Biol Chem , vol.283 , pp. 7936-7948
    • Koshkin, V.1    Dai, F.F.2    Robson-Doucette, C.A.3    Chan, C.B.4    Wheeler, M.B.5
  • 31
    • 9244231766 scopus 로고    scopus 로고
    • Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: Role of nuclear factor-κB and endoplasmic reticulum stress
    • DOI 10.1210/en.2004-0478
    • Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL 2004 Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: role of nuclear factor-κB and endoplasmic reticulum stress. Endocrinology 145:5087-5096 (Pubitemid 39551129)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 5087-5096
    • Kharroubi, I.1    Ladriere, L.2    Cardozo, A.K.3    Dogusan, Z.4    Cnop, M.5    Eizirik, D.L.6
  • 32
    • 0345354674 scopus 로고    scopus 로고
    • Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
    • DOI 10.2337/diabetes.52.3.726
    • Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY 2003 Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function. Diabetes 52:726-733 (Pubitemid 36323580)
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 726-733
    • Maedler, K.1    Oberholzer, J.2    Bucher, P.3    Spinas, G.A.4    Donath, M.Y.5
  • 34
    • 0036230225 scopus 로고    scopus 로고
    • Expression profiling of palmitate- And oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic β-cell function
    • Busch AK, Cordery D, Denyer GS, Biden TJ 2002 Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic β-cell function. Diabetes 51:977-987 (Pubitemid 34438339)
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 977-987
    • Busch, A.K.1    Cordery, D.2    Denyer, G.S.3    Biden, T.J.4
  • 36
    • 55149105005 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress
    • O'Neill LA 2008 The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol Rev 226:10-18
    • (2008) Immunol Rev , vol.226 , pp. 10-18
    • O'Neill, L.A.1
  • 37
    • 0035907302 scopus 로고    scopus 로고
    • Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4
    • DOI 10.1074/jbc.M011695200
    • Lee JY, Sohn KH, Rhee SH, Hwang D 2001 Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 276:16683-16689 (Pubitemid 37411459)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.20 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 39
    • 33947727646 scopus 로고    scopus 로고
    • The interleukin-1 receptor family
    • Boraschi D, Tagliabue A 2006 The interleukin-1 receptor family. Vitam Horm 74:229-254
    • (2006) Vitam Horm , vol.74 , pp. 229-254
    • Boraschi, D.1    Tagliabue, A.2
  • 44
    • 0025281303 scopus 로고
    • Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
    • Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K 1990 Establishment of a pancreatic β-cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127:126-132 (Pubitemid 20228111)
    • (1990) Endocrinology , vol.127 , Issue.1 , pp. 126-132
    • Miyazaki, J.-I.1    Araki, K.2    Yamato, E.3    Ikegami, H.4    Asano, T.5    Shibasaki, Y.6    Oka, Y.7    Yamamura, K.-I.8
  • 46
    • 21344456969 scopus 로고    scopus 로고
    • Redox control of exocytosis: Regulatory role of NADPH, thioredoxin, and glutaredoxin
    • DOI 10.2337/diabetes.54.7.2132
    • Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, In't Veld P, Renström E, Schuit FC 2005 Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin. Diabetes 54:2132-2142 (Pubitemid 40911277)
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 2132-2142
    • Ivarsson, R.1    Quintens, R.2    Dejonghe, S.3    Tsukamoto, K.4    In'T Veld, P.5    Renstrom, E.6    Schuit, F.C.7
  • 50
    • 0015394538 scopus 로고
    • Uptake of individual free fatty acids by skeletal muscle and liver in man
    • Hagenfeldt L, Wahren J, Pernow B, Räf L 1972 Uptake of individual free fatty acids by skeletal muscle and liver in man. J Clin Invest 51:2324-2330
    • (1972) J Clin Invest , vol.51 , pp. 2324-2330
    • Hagenfeldt, L.1    Wahren, J.2    Pernow, B.3    Räf, L.4
  • 53
    • 0019538149 scopus 로고
    • Molecular aspects of ligand binding to serum albumin
    • Kragh-Hansen U 1981 Molecular aspects of ligand binding to serum albumin. Pharmacol Rev 33:17-53
    • (1981) Pharmacol Rev , vol.33 , pp. 17-53
    • Kragh-Hansen, U.1
  • 54
    • 34848844641 scopus 로고    scopus 로고
    • Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components
    • Brikos C, Wait R, Begum S, O'Neill LA, Saklatvala J 2007 Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. Mol Cell Proteomics 6:1551-1559
    • (2007) Mol Cell Proteomics , vol.6 , pp. 1551-1559
    • Brikos, C.1    Wait, R.2    Begum, S.3    O'Neill, L.A.4    Saklatvala, J.5
  • 55
    • 0043168062 scopus 로고    scopus 로고
    • Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells
    • DOI 10.1046/j.1365-2249.2003.02211.x
    • Vives-Pi M, Somoza N, Fernández-Alvarez J, Vargas F, Caro P, Alba A, Gomis R, Labeta MO, Pujol-Borrell R 2003 Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet β-cells. Clin Exp Immunol 133:208-218 (Pubitemid 36918595)
    • (2003) Clinical and Experimental Immunology , vol.133 , Issue.2 , pp. 208-218
    • Vives-Pi, M.1    Somoza, N.2    Fernandez-Alvarez, J.3    Vargas, F.4    Caro, P.5    Alba, A.6    Gomis, R.7    Labeta, M.O.8    Pujol-Borrell, R.9
  • 56
    • 40149091387 scopus 로고    scopus 로고
    • Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition
    • DOI 10.1038/oby.2007.110, PII OBY2007110
    • Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA 2008 Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity (Silver Spring) 16:522-530 (Pubitemid 351328001)
    • (2008) Obesity , vol.16 , Issue.3 , pp. 522-530
    • Pinnick, K.E.1    Collins, S.C.2    Londos, C.3    Gauguier, D.4    Clark, A.5    Fielding, B.A.6
  • 58
    • 0035156817 scopus 로고    scopus 로고
    • Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function
    • Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY 2001 Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function. Diabetes 50:69-76 (Pubitemid 32047983)
    • (2001) Diabetes , vol.50 , Issue.1 , pp. 69-76
    • Maedler, K.1    Spinas, G.A.2    Dyntar, D.3    Moritz, W.4    Kaiser, N.5    Donath, M.Y.6
  • 60
    • 0026707739 scopus 로고
    • Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes
    • Deyerle KL, Sims JE, Dower SK, Bothwell MA 1992 Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes. J Immunol 149:1657-1665
    • (1992) J Immunol , vol.149 , pp. 1657-1665
    • Deyerle, K.L.1    Sims, J.E.2    Dower, S.K.3    Bothwell, M.A.4
  • 62
    • 51649111509 scopus 로고    scopus 로고
    • Ethanol mimics ligand-mediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells
    • Blanco AM, Perez-Arago A, Fernandez-Lizarbe S, Guerri C 2008 Ethanol mimics ligand-mediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells. J Neurochem 106:625-639
    • (2008) J Neurochem , vol.106 , pp. 625-639
    • Blanco, A.M.1    Perez-Arago, A.2    Fernandez-Lizarbe, S.3    Guerri, C.4
  • 63
    • 58549105701 scopus 로고    scopus 로고
    • Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages
    • Håversen L, Danielsson KN, Fogelstrand L, Wiklund O 2009 Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis 202:382-393
    • (2009) Atherosclerosis , vol.202 , pp. 382-393
    • Håversen, L.1    Danielsson, K.N.2    Fogelstrand, L.3    Wiklund, O.4
  • 65
    • 47949085624 scopus 로고    scopus 로고
    • Cutting edge: TLR2 is a functional receptor for acute-phase serum amyloid A
    • Cheng N, He R, Tian J, Ye PP, Ye RD 2008 Cutting edge: TLR2 is a functional receptor for acute-phase serum amyloid A. J Immunol 181:22-26
    • (2008) J Immunol , vol.181 , pp. 22-26
    • Cheng, N.1    He, R.2    Tian, J.3    Ye, P.P.4    Ye, R.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.