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Volumn 19, Issue 5, 2013, Pages 557-566

Pparγ signaling and metabolism: The good, the bad and the future

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; GLUCOSE TRANSPORTER 4; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; RESISTIN; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84877329207     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3159     Document Type: Article
Times cited : (1522)

References (144)
  • 1
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • Evans, R.M., Barish, G.D. & Wang, Y.X. PPARs and the complex journey to obesity. Nat. Med. 10, 355-361 (2004).
    • (2004) Nat. Med , vol.10 , pp. 355-361
    • Evans, R.M.1    Barish, G.D.2    Wang, Y.X.3
  • 2
    • 33644645013 scopus 로고    scopus 로고
    • PPARδ: A dagger in the heart of the metabolic syndrome
    • Barish, G.D., Narkar, V.A. & Evans, R.M. PPARδ: A dagger in the heart of the metabolic syndrome. J. Clin. Invest. 116, 590-597 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 3
    • 84863111550 scopus 로고    scopus 로고
    • PPARs: Fatty acid sensors controlling metabolism. Semin
    • Poulsen, L., Siersbaek, M. & Mandrup, S. PPARs: Fatty acid sensors controlling metabolism. Semin. Cell Dev. Biol. 23, 631-639 (2012).
    • (2012) Cell Dev. Biol , vol.23 , pp. 631-639
    • Poulsen, L.1    Siersbaek, M.2    Mandrup, S.3
  • 4
    • 0028972025 scopus 로고
    • 15-Deoxy-δ 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
    • Forman, B.M. et al. 15-Deoxy-δ 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812 (1995).
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1
  • 5
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
    • Forman, B.M., Chen, J. & Evans, R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Prooc. Natl. Acad. Sci. USA 94, 4312-4317 (1997).
    • (1997) Prooc. Natl. Acad. Sci. USA , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 6
    • 0030462770 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptors: Ligands and activators
    • Forman, B.M., Chen, J. & Evans, R.M. The peroxisome proliferator-activated receptors: Ligands and activators. Ann. NY Acad. Sci. 804, 266-275 (1996).
    • (1996) Ann. NY Acad. Sci , vol.804 , pp. 266-275
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 7
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PPARγ
    • Tontonoz, P. & Spiegelman, B.M. Fat and beyond: The diverse biology of PPARγ. Annu. Rev. Biochem. 77, 289-312 (2008).
    • (2008) Annu. Rev. Biochem , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 8
    • 34247636362 scopus 로고    scopus 로고
    • PPARγ2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
    • Medina-Gomez, G. et al. PPARγ2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet. 3, e64 (2007).
    • (2007) Plos Genet , vol.3
    • Medina-Gomez, G.1
  • 9
    • 84855447818 scopus 로고    scopus 로고
    • Role of PPARγ2 transcription factor in thiazolidinedione-induced insulin sensitization
    • Saraf, N., Sharma, P.K., Mondal, S.C., Garg, V.K. & Singh, A.K. Role of PPARγ2 transcription factor in thiazolidinedione-induced insulin sensitization. J. Pharm. Pharmacol. 64, 161-171 (2012).
    • (2012) J. Pharm. Pharmacol , vol.64 , pp. 161-171
    • Saraf, N.1    Sharma, P.K.2    Mondal, S.C.3    Garg, V.K.4    Singh, A.K.5
  • 10
    • 79961239382 scopus 로고    scopus 로고
    • Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. Wiley Interdiscip
    • Vacca, M., Degirolamo, C., Mariani-Costantini, R., Palasciano, G. & Moschetta, A. Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. Wiley Interdiscip. Rev. Syst. Biol. Med. 3, 562-587 (2011).
    • (2011) Rev. Syst. Biol. Med , vol.3 , pp. 562-587
    • Vacca, M.1    Degirolamo, C.2    Mariani-Costantini, R.3    Palasciano, G.4    Moschetta, A.5
  • 12
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen, S.E. & Wolski, K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. 356, 2457-2471 (2007).
    • (2007) N. Engl. J. Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 13
    • 77954988618 scopus 로고    scopus 로고
    • Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone
    • Graham, D.J. et al. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. J. Am. Med. Assoc. 304, 411-418 (2010).
    • (2010) J. Am. Med. Assoc , vol.304 , pp. 411-418
    • Graham, D.J.1
  • 15
    • 40849134281 scopus 로고    scopus 로고
    • Effects of pioglitazone on major adverse cardiovascular events in high-risk patients with type 2 diabetes: Results from PROspective pioglitAzone Clinical Trial In macro Vascular Events (PROactive 10)
    • Wilcox, R., Kupfer, S. & Erdmann, E. Effects of pioglitazone on major adverse cardiovascular events in high-risk patients with type 2 diabetes: Results from PROspective pioglitAzone Clinical Trial In macro Vascular Events (PROactive 10). Am. Heart J. 155, 712-717 (2008).
    • (2008) Am. Heart J , vol.155 , pp. 712-717
    • Wilcox, R.1    Kupfer, S.2    Erdmann, E.3
  • 16
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials
    • Lincoff, A.M., Wolski, K., Nicholls, S.J. & Nissen, S.E. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials. J. Am. Med. Assoc. 298, 1180-1188 (2007).
    • (2007) J. Am. Med. Assoc , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 17
    • 84862684037 scopus 로고    scopus 로고
    • The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: Nested case-control study
    • Azoulay, L. et al. The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: Nested case-control study. Br. Med. J. 344, e3645 (2012).
    • (2012) Br. Med. J , vol.344
    • Azoulay, L.1
  • 18
    • 84866358522 scopus 로고    scopus 로고
    • Pioglitazone and risk of bladder cancer among diabetic patients in France: A population-based cohort study
    • Neumann, A. et al. Pioglitazone and risk of bladder cancer among diabetic patients in France: A population-based cohort study. Diabetologia 55, 1953-1962 (2012).
    • (2012) Diabetologia , vol.55 , pp. 1953-1962
    • Neumann, A.1
  • 19
    • 80053131732 scopus 로고    scopus 로고
    • Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
    • Choi, J.H. et al. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature 477, 477-481 (2011).
    • (2011) Nature , vol.477 , pp. 477-481
    • Choi, J.H.1
  • 20
    • 79955692835 scopus 로고    scopus 로고
    • A role for central nervous system PPAR-γ in the regulation of energy balance
    • Ryan, K.K. et al. A role for central nervous system PPAR-γ in the regulation of energy balance. Nat. Med. 17, 623-626 (2011).
    • (2011) Nat. Med , vol.17 , pp. 623-626
    • Ryan, K.K.1
  • 21
    • 79955694276 scopus 로고    scopus 로고
    • Brain PPAR-γ promotes obesity and is required for the insulinsensitizing effect of thiazolidinediones
    • Lu, M. et al. Brain PPAR-γ promotes obesity and is required for the insulinsensitizing effect of thiazolidinediones. Nat. Med. 17, 618-622 (2011).
    • (2011) Nat. Med , vol.17 , pp. 618-622
    • Lu, M.1
  • 22
    • 84861047531 scopus 로고    scopus 로고
    • A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
    • Jonker, J.W. et al. A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485, 391-394 (2012).
    • (2012) Nature , vol.485 , pp. 391-394
    • Jonker, J.W.1
  • 23
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    • Dutchak, P.A. et al. Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell 148, 556-567 (2012).
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1
  • 24
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
    • Tontonoz, P., Hu, E. & Spiegelman, B.M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147-1156 (1994).
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 25
    • 0029981772 scopus 로고    scopus 로고
    • Differential activation of adipogenesis by multiple PPAR isoforms
    • Brun, R.P. et al. Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 10, 974-984 (1996).
    • (1996) Genes Dev , vol.10 , pp. 974-984
    • Brun, R.P.1
  • 26
    • 0033213637 scopus 로고    scopus 로고
    • PPARγ is required for placental, cardiac, and adipose tissue development
    • Barak, Y. et al. PPARγ is required for placental, cardiac, and adipose tissue development. Mol. Cell 4, 585-595 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 585-595
    • Barak, Y.1
  • 27
    • 53549130485 scopus 로고    scopus 로고
    • White fat progenitor cells reside in the adipose vasculature
    • Tang, W. et al. White fat progenitor cells reside in the adipose vasculature. Science 322, 583-586 (2008).
    • (2008) Science , vol.322 , pp. 583-586
    • Tang, W.1
  • 28
    • 79960003581 scopus 로고    scopus 로고
    • Thiazolidinediones regulate adipose lineage dynamics
    • Tang, W., Zeve, D., Seo, J., Jo, A.Y. & Graff, J.M. Thiazolidinediones regulate adipose lineage dynamics. Cell Metab. 14, 116-122 (2011).
    • (2011) Cell Metab , vol.14 , pp. 116-122
    • Tang, W.1    Zeve, D.2    Seo, J.3    Jo, A.Y.4    Graff, J.M.5
  • 29
    • 12144291563 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse
    • Imai, T. et al. Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse. Proc. Natl. Acad. Sci. USA 101, 4543-4547 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4543-4547
    • Imai, T.1
  • 30
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
    • He, W. et al. Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc. Natl. Acad. Sci. USA 100, 15712-15717 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15712-15717
    • He, W.1
  • 31
    • 0031051523 scopus 로고    scopus 로고
    • Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter
    • Hollenberg, A.N. et al. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter. J. Biol. Chem. 272, 5283-5290 (1997).
    • (1997) J. Biol. Chem , vol.272 , pp. 5283-5290
    • Hollenberg, A.N.1
  • 32
    • 0037677767 scopus 로고    scopus 로고
    • Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors
    • Iwaki, M. et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52, 1655-1663 (2003).
    • (2003) Diabetes , vol.52 , pp. 1655-1663
    • Iwaki, M.1
  • 33
    • 0027972524 scopus 로고
    • Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance
    • Hofmann, C. et al. Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 134, 264-270 (1994).
    • (1994) Endocrinology , vol.134 , pp. 264-270
    • Hofmann, C.1
  • 34
    • 65249089760 scopus 로고    scopus 로고
    • Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding proteins
    • Tomaru, T., Steger, D.J., Lefterova, M.I., Schupp, M. & Lazar, M.A. Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding proteins. J. Biol. Chem. 284, 6116-6125 (2009).
    • (2009) J. Biol. Chem , vol.284 , pp. 6116-6125
    • Tomaru, T.1    Steger, D.J.2    Lefterova, M.I.3    Schupp, M.4    Lazar, M.A.5
  • 35
    • 0036146384 scopus 로고    scopus 로고
    • Novel heterozygous mutation in peroxisome proliferator-activated receptor-γ gene in a patient with familial partial lipodystrophy
    • Agarwal, A.K. & Garg, A. A novel heterozygous mutation in peroxisome proliferator-activated receptor-γ gene in a patient with familial partial lipodystrophy. J. Clin. Endocrinol. Metab. 87, 408-411 (2002).
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , pp. 408-411
    • Agarwal, A.K.1    Garg, A.A.2
  • 36
    • 0036894397 scopus 로고    scopus 로고
    • PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
    • Hegele, R.A., Cao, H., Frankowski, C., Mathews, S.T. & Leff, T. PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy. Diabetes 51, 3586-3590 (2002).
    • (2002) Diabetes , vol.51 , pp. 3586-3590
    • Hegele, R.A.1    Cao, H.2    Frankowski, C.3    Mathews, S.T.4    Leff, T.5
  • 37
    • 0344375097 scopus 로고    scopus 로고
    • Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ
    • Savage, D.B. et al. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ. Diabetes 52, 910-917 (2003).
    • (2003) Diabetes , vol.52 , pp. 910-917
    • Savage, D.B.1
  • 38
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
    • Lehmann, J.M. et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956 (1995).
    • (1995) J. Biol. Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1
  • 39
    • 84867062444 scopus 로고    scopus 로고
    • The PPARγ-FGF1 axis: An unexpected mediator of adipose tissue homeostasis
    • Sun, K. & Scherer, P.E. The PPARγ-FGF1 axis: An unexpected mediator of adipose tissue homeostasis. Cell Res. 22, 1416-1418 (2012).
    • (2012) Cell Res , vol.22 , pp. 1416-1418
    • Sun, K.1    Scherer, P.E.2
  • 40
    • 74049108945 scopus 로고    scopus 로고
    • Fibroblast growth factor 21: From pharmacology to physiology
    • Kliewer, S.A. & Mangelsdorf, D.J. Fibroblast growth factor 21: From pharmacology to physiology. Am. J. Clin. Nutr. 91, 254S-257S (2010).
    • (2010) Am. J. Clin. Nutr , vol.91 , pp. 254S-257S
    • Kliewer, S.A.1    Mangelsdorf, D.J.2
  • 41
    • 0033995557 scopus 로고    scopus 로고
    • Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice
    • Miller, D.L., Ortega, S., Bashayan, O., Basch, R. & Basilico, C. Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice. Mol. Cell Biol. 20, 2260-2268 (2000).
    • (2000) Mol. Cell Biol , vol.20 , pp. 2260-2268
    • Miller, D.L.1    Ortega, S.2    Bashayan, O.3    Basch, R.4    Basilico, C.5
  • 42
    • 84863116228 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
    • Wei, W. et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc. Natl. Acad. Sci. USA 109, 3143-3148 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 3143-3148
    • Wei, W.1
  • 43
    • 0035091701 scopus 로고    scopus 로고
    • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
    • Way, J.M. et al. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology 142, 1269-1277 (2001).
    • (2001) Endocrinology , vol.142 , pp. 1269-1277
    • Way, J.M.1
  • 44
    • 72049114437 scopus 로고    scopus 로고
    • The skinny on fat: Lipolysis and fatty acid utilization in adipocytes
    • Ahmadian, M., Duncan, R.E. & Sul, H.S. The skinny on fat: Lipolysis and fatty acid utilization in adipocytes. Trends Endocrinol. Metab. 20, 424-428 (2009).
    • (2009) Trends Endocrinol. Metab , vol.20 , pp. 424-428
    • Ahmadian, M.1    Duncan, R.E.2    Sul, H.S.3
  • 45
    • 76049086229 scopus 로고    scopus 로고
    • PPARγ activation in adipocytes is sufficient for systemic insulin sensitization
    • Sugii, S. et al. PPARγ activation in adipocytes is sufficient for systemic insulin sensitization. Proc. Natl. Acad. Sci. USA 106, 22504-22509 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 22504-22509
    • Sugii, S.1
  • 46
    • 0031441286 scopus 로고    scopus 로고
    • Troglitazone action is independent of adipose tissue
    • Burant, C.F. et al. Troglitazone action is independent of adipose tissue. J. Clin. Invest. 100, 2900-2908 (1997).
    • (1997) J. Clin. Invest , vol.100 , pp. 2900-2908
    • Burant, C.F.1
  • 47
    • 0038549106 scopus 로고    scopus 로고
    • Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice
    • Kim, J.K. et al. Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice. Diabetes 52, 1311-1318 (2003).
    • (2003) Diabetes , vol.52 , pp. 1311-1318
    • Kim, J.K.1
  • 48
    • 0346027235 scopus 로고    scopus 로고
    • Muscle-specific Pparg deletion causes insulin resistance
    • Hevener, A.L. et al. Muscle-specific Pparg deletion causes insulin resistance. Nat. Med. 9, 1491-1497 (2003).
    • (2003) Nat. Med , vol.9 , pp. 1491-1497
    • Hevener, A.L.1
  • 49
    • 85047693638 scopus 로고    scopus 로고
    • Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    • Norris, A.W. et al. Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J. Clin. Invest. 112, 608-618 (2003).
    • (2003) J. Clin. Invest , vol.112 , pp. 608-618
    • Norris, A.W.1
  • 50
    • 61649105063 scopus 로고    scopus 로고
    • Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice. Scand
    • Nan, Y.M. et al. Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice. Scand. J. Gastroenterol. 44, 358-365 (2009).
    • (2009) J. Gastroenterol , vol.44 , pp. 358-365
    • Nan, Y.M.1
  • 51
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • Mayerson, A.B. et al. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 51, 797-802 (2002).
    • (2002) Diabetes , vol.51 , pp. 797-802
    • Mayerson, A.B.1
  • 52
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of randomised trials
    • Musso, G., Cassader, M., Rosina, F. & Gambino, R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of randomised trials. Diabetologia 55, 885-904 (2012).
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3    Gambino, R.4
  • 53
    • 39849099238 scopus 로고    scopus 로고
    • Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease
    • Kallwitz, E.R., McLachlan, A. & Cotler, S.J. Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. World J. Gastroenterol. 14, 22-28 (2008).
    • (2008) World J. Gastroenterol , vol.14 , pp. 22-28
    • Kallwitz, E.R.1    McLachlan, A.2    Cotler, S.J.3
  • 54
    • 34548306770 scopus 로고    scopus 로고
    • The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis
    • Lutchman, G. et al. The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis. Hepatology 46, 424-429 (2007).
    • (2007) Hepatology , vol.46 , pp. 424-429
    • Lutchman, G.1
  • 55
    • 0141446024 scopus 로고    scopus 로고
    • Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    • Gavrilova, O. et al. Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J. Biol. Chem. 278, 34268-34276 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 34268-34276
    • Gavrilova, O.1
  • 56
    • 0029911503 scopus 로고    scopus 로고
    • Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM
    • Berkowitz, K. et al. Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM. Diabetes 45, 1572-1579 (1996).
    • (1996) Diabetes , vol.45 , pp. 1572-1579
    • Berkowitz, K.1
  • 57
    • 0033613181 scopus 로고    scopus 로고
    • Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats
    • Higa, M. et al. Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. Proc. Natl. Acad. Sci. USA 96, 11513-11518 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11513-11518
    • Higa, M.1
  • 58
    • 0036310015 scopus 로고    scopus 로고
    • Peroxisomal proliferator-activated receptor-γ upregulates glucokinase gene expression in beta-cells
    • Kim, H.I. et al. Peroxisomal proliferator-activated receptor-γ upregulates glucokinase gene expression in beta-cells. Diabetes 51, 676-685 (2002).
    • (2002) Diabetes , vol.51 , pp. 676-685
    • Kim, H.I.1
  • 59
    • 0033864402 scopus 로고    scopus 로고
    • Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter
    • Kim, H.I. et al. Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter. Diabetes 49, 1517-1524 (2000).
    • (2000) Diabetes , vol.49 , pp. 1517-1524
    • Kim, H.I.1
  • 60
    • 0141450254 scopus 로고    scopus 로고
    • Targeted elimination of peroxisome proliferator-activated receptor γ in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
    • Rosen, E.D. et al. Targeted elimination of peroxisome proliferator-activated receptor γ in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol. Cell Biol. 23, 7222-7229 (2003).
    • (2003) Mol. Cell Biol , vol.23 , pp. 7222-7229
    • Rosen, E.D.1
  • 61
    • 57749098781 scopus 로고    scopus 로고
    • In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor γ response element in the mouse pdx-1 promoter
    • Gupta, D. et al. In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor γ response element in the mouse pdx-1 promoter. J. Biol. Chem. 283, 32462-32470 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 32462-32470
    • Gupta, D.1
  • 62
    • 34447627877 scopus 로고    scopus 로고
    • PPARγ, a lipid-activated transcription factor as a regulator of dendritic cell function
    • Szatmari, I., Rajnavolgyi, E. & Nagy, L. PPARγ, a lipid-activated transcription factor as a regulator of dendritic cell function. Ann. NY Acad. Sci. 1088, 207-218 (2006).
    • (2006) Ann. NY Acad. Sci , vol.1088 , pp. 207-218
    • Szatmari, I.1    Rajnavolgyi, E.2    Nagy, L.3
  • 63
    • 34547627893 scopus 로고    scopus 로고
    • PPARγ in immunity and inflammation: Cell types and diseases
    • Széles, L., Torocsik, D. & Nagy, L. PPARγ in immunity and inflammation: Cell types and diseases. Biochim. Biophys. Acta 1771, 1014-1030 (2007).
    • (2007) Biochim. Biophys. Acta , vol.1771 , pp. 1014-1030
    • Széles, L.1    Torocsik, D.2    Nagy, L.3
  • 64
    • 78649388701 scopus 로고    scopus 로고
    • STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells
    • Szanto, A. et al. STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells. Immunity 33, 699-712 (2010).
    • (2010) Immunity , vol.33 , pp. 699-712
    • Szanto, A.1
  • 65
    • 0032540012 scopus 로고    scopus 로고
    • 5PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz, P., Nagy, L., Alvarez, J.G., Thomazy, V.A. & Evans, R.M. 5PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93, 241-252 (1998).
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3    Thomazy, V.A.4    Evans, R.M.5
  • 66
    • 84863104065 scopus 로고    scopus 로고
    • PPARs at the crossroads of lipid signaling and inflammation
    • Wahli, W. & Michalik, L. PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol. Metab. 23, 351-363 (2012).
    • (2012) Trends Endocrinol. Metab , vol.23 , pp. 351-363
    • Wahli, W.1    Michalik, L.2
  • 67
    • 0036781460 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ in macrophage lipid homeostasis
    • Lee, C.H. & Evans, R.M. Peroxisome proliferator-activated receptor-γ in macrophage lipid homeostasis. Trends Endocrinol. Metab. 13, 331-335 (2002).
    • (2002) Trends Endocrinol. Metab , vol.13 , pp. 331-335
    • Lee, C.H.1    Evans, R.M.2
  • 68
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARy
    • Nagy, L., Tontonoz, P., Alvarez, J.G., Chen, H. & Evans, R.M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARy. Cell 93, 229-240 (1998).
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.3    Chen, H.4    Evans, R.M.5
  • 69
    • 0035132330 scopus 로고    scopus 로고
    • PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • Chawla, A. et al. PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med. 7, 48-52 (2001).
    • (2001) Nat. Med , vol.7 , pp. 48-52
    • Chawla, A.1
  • 70
    • 34249907880 scopus 로고    scopus 로고
    • Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
    • Hevener, A.L. et al. Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J. Clin. Invest. 117, 1658-1669 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 1658-1669
    • Hevener, A.L.1
  • 71
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
    • Odegaard, J.I. et al. Macrophage-specific PPARγ controls alternative activation and improves insulin resistance. Nature 447, 1116-1120 (2007).
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1
  • 72
    • 79959824776 scopus 로고    scopus 로고
    • Epigenetic codes of PPARγ in metabolic disease
    • Sugii, S. & Evans, R.M. Epigenetic codes of PPARγ in metabolic disease. FEBS Lett. 585, 2121-2128 (2011).
    • (2011) FEBS Lett , vol.585 , pp. 2121-2128
    • Sugii, S.1    Evans, R.M.2
  • 73
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Tmg cells
    • Cipolletta, D. et al. PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Tmg cells. Nature 486, 549-543 (2012).
    • (2012) Nature , vol.486 , pp. 549
    • Cipolletta, D.1
  • 74
    • 84860375795 scopus 로고    scopus 로고
    • Thiazolidinediones and PPARγ agonists: Time for a reassessment
    • Cariou, B., Charbonnel, B. & Staels, B. Thiazolidinediones and PPARγ agonists: Time for a reassessment. Trends Endocrinol. Metab. 23, 205-215 (2012).
    • (2012) Trends Endocrinol. Metab , vol.23 , pp. 205-215
    • Cariou, B.1    Charbonnel, B.2    Staels, B.3
  • 75
    • 0041820128 scopus 로고    scopus 로고
    • Differential influences of peroxisome proliferator-activated receptors γ and -α on food intake and energy homeostasis
    • Larsen, P.J. et al. Differential influences of peroxisome proliferator-activated receptors γ and -α on food intake and energy homeostasis. Diabetes 52, 2249-2259 (2003).
    • (2003) Diabetes , vol.52 , pp. 2249-2259
    • Larsen, P.J.1
  • 76
    • 33745214257 scopus 로고    scopus 로고
    • Energy balance and food intake: The role of PPARγ gene polymorphisms
    • Cecil, J.E., Watt, P., Palmer, C.N. & Hetherington, M. Energy balance and food intake: The role of PPARγ gene polymorphisms. Physiol. Behav. 88, 227-233 (2006).
    • (2006) Physiol. Behav , vol.88 , pp. 227-233
    • Cecil, J.E.1    Watt, P.2    Palmer, C.N.3    Hetherington, M.4
  • 77
    • 59649109871 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor-γ in key neuronal subsets regulating glucose metabolism and energy homeostasis
    • Sarruf, D.A. et al. Expression of peroxisome proliferator-activated receptor-γ in key neuronal subsets regulating glucose metabolism and energy homeostasis. Endocrinology 150, 707-712 (2009).
    • (2009) Endocrinology , vol.150 , pp. 707-712
    • Sarruf, D.A.1
  • 78
    • 84868121739 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ (PPAR-γ) and neurodegenerative disorders
    • Chen, Y.C. et al. Peroxisome proliferator-activated receptor γ (PPAR-γ) and neurodegenerative disorders. Mol. Neurobiol. 46, 114-124 (2012).
    • (2012) Mol. Neurobiol , vol.46 , pp. 114-124
    • Chen, Y.C.1
  • 80
    • 21544479710 scopus 로고    scopus 로고
    • Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention
    • Zhang, H. et al. Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention. Proc. Natl. Acad. Sci. USA 102, 9406-9411 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 9406-9411
    • Zhang, H.1
  • 81
    • 23844463115 scopus 로고    scopus 로고
    • A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
    • Kuba, K. et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat. Med. 11, 875-879 (2005).
    • (2005) Nat. Med , vol.11 , pp. 875-879
    • Kuba, K.1
  • 82
    • 84857714626 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ agonists repress epithelial sodium channel expression in the kidney
    • Borsting, E., Cheng, V.P., Glass, C.K., Vallon, V. & Cunard, R. Peroxisome proliferator-activated receptor-γ agonists repress epithelial sodium channel expression in the kidney. Am. J. Physiol. Renal Physiol. 302, F540-F551 (2012).
    • (2012) Am. J. Physiol. Renal Physiol , vol.302 , pp. F540-F551
    • Borsting, E.1    Cheng, V.P.2    Glass, C.K.3    Vallon, V.4    Cunard, R.5
  • 83
    • 23844472901 scopus 로고    scopus 로고
    • Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption
    • Guan, Y. et al. Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption. Nat. Med. 11, 861-866 (2005).
    • (2005) Nat. Med , vol.11 , pp. 861-866
    • Guan, Y.1
  • 84
    • 67649183494 scopus 로고    scopus 로고
    • Thiazolidinediones may contribute to the intramyocardial lipid accumulation in diabetic myocardium: Effects on cardiac function
    • Marfella, R. et al. Thiazolidinediones may contribute to the intramyocardial lipid accumulation in diabetic myocardium: Effects on cardiac function. Heart 95, 1020-1022 (2009).
    • (2009) Heart , vol.95 , pp. 1020-1022
    • Marfella, R.1
  • 85
    • 34948910262 scopus 로고    scopus 로고
    • Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice
    • Son, N.H. et al. Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice. J. Clin. Invest. 117, 2791-2801 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 2791-2801
    • Son, N.H.1
  • 86
    • 24044476859 scopus 로고    scopus 로고
    • Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-γ both induce cardiac hypertrophy in mice
    • Duan, S.Z., Ivashchenko, C.Y., Russell, M.W., Milstone, D.S. & Mortensen, R.M. Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-γ both induce cardiac hypertrophy in mice. Circ. Res. 97, 372-379 (2005).
    • (2005) Circ. Res , vol.97 , pp. 372-379
    • Duan, S.Z.1    Ivashchenko, C.Y.2    Russell, M.W.3    Milstone, D.S.4    Mortensen, R.M.5
  • 87
    • 84855289573 scopus 로고    scopus 로고
    • Thiazolidinediones on PPARγ: The roles in bone remodeling
    • Wei, W. & Wan, Y. Thiazolidinediones on PPARγ: The roles in bone remodeling. PPAR Res. 2011, 867180 (2011).
    • (2011) PPAR Res , vol.2011 , pp. 867180
    • Wei, W.1    Wan, Y.2
  • 88
    • 2142652189 scopus 로고    scopus 로고
    • PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    • Akune, T. et al. PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J. Clin. Invest. 113, 846-855 (2004).
    • (2004) J. Clin. Invest , vol.113 , pp. 846-855
    • Akune, T.1
  • 89
    • 36849034568 scopus 로고    scopus 로고
    • PPAR-γ regulates osteoclastogenesis in mice
    • Wan, Y., Chong, L.W. & Evans, R.M. PPAR-γ regulates osteoclastogenesis in mice. Nat. Med. 13, 1496-1503 (2007).
    • (2007) Nat. Med , vol.13 , pp. 1496-1503
    • Wan, Y.1    Chong, L.W.2    Evans, R.M.3
  • 90
    • 84864615516 scopus 로고    scopus 로고
    • Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ
    • Qiang, L. et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell 150, 620-632 (2012).
    • (2012) Cell , vol.150 , pp. 620-632
    • Qiang, L.1
  • 91
    • 58849102970 scopus 로고    scopus 로고
    • Posttranslational modifications of PPAR-γ: Fine-tuning the metabolic master regulator
    • van Beekum, O., Fleskens, V. & Kalkhoven, E. Posttranslational modifications of PPAR-γ: Fine-tuning the metabolic master regulator. Obesity (Silver Spring) 17, 213-219 (2009).
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 213-219
    • Van Beekum, O.1    Fleskens, V.2    Kalkhoven, E.3
  • 92
    • 0038776380 scopus 로고    scopus 로고
    • Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ
    • Hu, E., Kim, J.B., Sarraf, P. & Spiegelman, B.M. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science 274, 2100-2103 (1996).
    • (1996) Science , vol.274 , pp. 2100-2103
    • Hu, E.1    Kim, J.B.2    Sarraf, P.3    Spiegelman, B.M.4
  • 93
    • 0030964085 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase
    • Camp, H.S. & Tafuri, S.R. Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase. J. Biol. Chem. 272, 10811-10816 (1997).
    • (1997) J. Biol. Chem , vol.272 , pp. 10811-10816
    • Camp, H.S.1    Tafuri, S.R.2
  • 94
    • 0029775642 scopus 로고    scopus 로고
    • Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ
    • Zhang, B. et al. Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ. J. Biol. Chem. 271, 31771-31774 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 31771-31774
    • Zhang, B.1
  • 95
    • 33745670848 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis
    • Iankova, I. et al. Peroxisome proliferator-activated receptor γ recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. Mol. Endocrinol. 20, 1494-1505 (2006).
    • (2006) Mol. Endocrinol , vol.20 , pp. 1494-1505
    • Iankova, I.1
  • 96
    • 21744438445 scopus 로고    scopus 로고
    • Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations
    • Compe, E. et al. Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations. Mol. Cell Biol. 25, 6065-6076 (2005).
    • (2005) Mol. Cell Biol , vol.25 , pp. 6065-6076
    • Compe, E.1
  • 97
    • 0032189782 scopus 로고    scopus 로고
    • Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    • Ristow, M., Muller-Wieland, D., Pfeiffer, A., Krone, W. & Kahn, C.R. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N. Engl. J. Med. 339, 953-959 (1998).
    • (1998) N. Engl. J. Med , vol.339 , pp. 953-959
    • Ristow, M.1    Muller-Wieland, D.2    Pfeiffer, A.3    Krone, W.4    Kahn, C.R.5
  • 98
    • 0141920726 scopus 로고    scopus 로고
    • Genetic modulation of PPARγ phosphorylation regulates insulin sensitivity
    • Rangwala, S.M. et al. Genetic modulation of PPARγ phosphorylation regulates insulin sensitivity. Dev. Cell 5, 657-663 (2003).
    • (2003) Dev. Cell , vol.5 , pp. 657-663
    • Rangwala, S.M.1
  • 100
    • 59049083003 scopus 로고    scopus 로고
    • Tumor necrosis factor-α regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35
    • Utreras, E. et al. Tumor necrosis factor-α regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. J. Biol. Chem. 284, 2275-2284 (2009).
    • (2009) J. Biol. Chem , vol.284 , pp. 2275-2284
    • Utreras, E.1
  • 101
    • 77954941113 scopus 로고    scopus 로고
    • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARy by Cdk5
    • Choi, J.H. et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARy by Cdk5. Nature 466, 451-456 (2010).
    • (2010) Nature , vol.466 , pp. 451-456
    • Choi, J.H.1
  • 102
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic, N. et al. Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 285, 7153-7164 (2010).
    • (2010) J. Biol. Chem , vol.285 , pp. 7153-7164
    • Petrovic, N.1
  • 103
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon, B. & Nedergaard, J. Brown adipose tissue: Function and physiological significance. Physiol. Rev. 84, 277-359 (2004).
    • (2004) Physiol. Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 104
    • 77950237717 scopus 로고    scopus 로고
    • The changed metabolic world with human brown adipose tissue: Therapeutic visions
    • Nedergaard, J. & Cannon, B. The changed metabolic world with human brown adipose tissue: Therapeutic visions. Cell Metab. 11, 268-272 (2010).
    • (2010) Cell Metab , vol.11 , pp. 268-272
    • Nedergaard, J.1    Cannon, B.2
  • 106
    • 84858039282 scopus 로고    scopus 로고
    • PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
    • Ohno, H., Shinoda, K., Spiegelman, B.M. & Kajimura, S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 15, 395-404 (2012).
    • (2012) Cell Metab , vol.15 , pp. 395-404
    • Ohno, H.1    Shinoda, K.2    Spiegelman, B.M.3    Kajimura, S.4
  • 107
    • 80054074025 scopus 로고    scopus 로고
    • PPARs and lipid ligands in inflammation and metabolism
    • Harmon, G.S., Lam, M.T. & Glass, C.K. PPARs and lipid ligands in inflammation and metabolism. Chem. Rev. 111, 6321-6340 (2011).
    • (2011) Chem. Rev , vol.111 , pp. 6321-6340
    • Harmon, G.S.1    Lam, M.T.2    Glass, C.K.3
  • 108
    • 33646229801 scopus 로고    scopus 로고
    • Aspects of the regulatory mechanisms of PPAR functions: Analysis of a bidirectional response element and regulation by sumoylation
    • Shimizu, M., Yamashita, D., Yamaguchi, T., Hirose, F. & Osumi, T. Aspects of the regulatory mechanisms of PPAR functions: Analysis of a bidirectional response element and regulation by sumoylation. Mol. Cell Biochem. 286, 33-42 (2006).
    • (2006) Mol. Cell Biochem , vol.286 , pp. 33-42
    • Shimizu, M.1    Yamashita, D.2    Yamaguchi, T.3    Hirose, F.4    Osumi, T.5
  • 109
    • 26444471700 scopus 로고    scopus 로고
    • A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
    • Pascual, G. et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ. Nature 437, 759-763 (2005).
    • (2005) Nature , vol.437 , pp. 759-763
    • Pascual, G.1
  • 110
    • 0034674567 scopus 로고    scopus 로고
    • Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand-dependent activation
    • Hauser, S. et al. Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand-dependent activation. J. Biol. Chem. 275, 18527-18533 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 18527-18533
    • Hauser, S.1
  • 111
    • 0035831494 scopus 로고    scopus 로고
    • Interferon-γ-induced regulation of peroxisome proliferator-activated receptor γ and STATs in adipocytes
    • Waite, K.J., Floyd, Z.E., Arbour-Reily, P. & Stephens, J.M. Interferon-γ-induced regulation of peroxisome proliferator-activated receptor γ and STATs in adipocytes. J. Biol. Chem. 276, 7062-7068 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 7062-7068
    • Waite, K.J.1    Floyd, Z.E.2    Arbour-Reily, P.3    Stephens, J.M.4
  • 112
    • 27844511538 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators (SERMs): Mechanisms of anticarcinogenesis and drug resistance
    • Lewis, J.S. & Jordan, V.C. Selective estrogen receptor modulators (SERMs): Mechanisms of anticarcinogenesis and drug resistance. Mutat. Res. 591, 247-263 (2005).
    • (2005) Mutat. Res , vol.591 , pp. 247-263
    • Lewis, J.S.1    Jordan, V.C.2
  • 113
  • 114
    • 84855795379 scopus 로고    scopus 로고
    • Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism
    • Hughes, T.S. et al. Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism. Structure 20, 139-150 (2012).
    • (2012) Structure , vol.20 , pp. 139-150
    • Hughes, T.S.1
  • 115
    • 56749130032 scopus 로고    scopus 로고
    • Structure of the intact PPAR-γ-RXR-nuclear receptor complex on DNA
    • Chandra, V. et al. Structure of the intact PPAR-γ-RXR-nuclear receptor complex on DNA. Nature 456, 350-356 (2008).
    • (2008) Nature , vol.456 , pp. 350-356
    • Chandra, V.1
  • 116
    • 74049159051 scopus 로고    scopus 로고
    • Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation
    • Higgins, L.S. & Depaoli, A.M. Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation. Am. J. Clin. Nutr. 91, 267S-272S (2010).
    • (2010) Am. J. Clin. Nutr , vol.91 , pp. 267S-272S
    • Higgins, L.S.1    Depaoli, A.M.2
  • 117
    • 46149115894 scopus 로고    scopus 로고
    • Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist
    • Tavera-Mendoza, L.E. et al. Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc. Natl. Acad. Sci. USA 105, 8250-8255 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 8250-8255
    • Tavera-Mendoza, L.E.1
  • 118
    • 84870902173 scopus 로고    scopus 로고
    • Targeted estrogen delivery reverses the metabolic syndrome
    • Finan, B. et al. Targeted estrogen delivery reverses the metabolic syndrome. Nat. Med. 18, 1847-1856 (2012).
    • (2012) Nat. Med , vol.18 , pp. 1847-1856
    • Finan, B.1
  • 119
    • 34447643245 scopus 로고    scopus 로고
    • Differential effect of pioglitazone (PGZ) and rosiglitazone (RGZ) on postprandial glucose and lipid metabolism in patients with type 2 diabetes mellitus: A prospective, randomized crossover study
    • Chappuis, B. et al. Differential effect of pioglitazone (PGZ) and rosiglitazone (RGZ) on postprandial glucose and lipid metabolism in patients with type 2 diabetes mellitus: A prospective, randomized crossover study. Diabetes Metab. Res. Rev. 23, 392-399 (2007).
    • (2007) Diabetes Metab. Res. Rev , vol.23 , pp. 392-399
    • Chappuis, B.1
  • 120
    • 35148837113 scopus 로고    scopus 로고
    • Pioglitazone and rosiglitazone have different effects on serum lipoprotein particle concentrations and sizes in patients with type 2 diabetes and dyslipidemia
    • Deeg, M.A. et al. Pioglitazone and rosiglitazone have different effects on serum lipoprotein particle concentrations and sizes in patients with type 2 diabetes and dyslipidemia. Diabetes Care 30, 2458-2464 (2007).
    • (2007) Diabetes Care , vol.30 , pp. 2458-2464
    • Deeg, M.A.1
  • 121
    • 21544466158 scopus 로고    scopus 로고
    • A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia
    • Goldberg, R.B. et al. A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. Diabetes Care 28, 1547-1554 (2005).
    • (2005) Diabetes Care , vol.28 , pp. 1547-1554
    • Goldberg, R.B.1
  • 122
    • 0034735992 scopus 로고    scopus 로고
    • Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone
    • Sakamoto, J. et al. Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem. Biophys. Res. Commun. 278, 704-711 (2000).
    • (2000) Biochem. Biophys. Res. Commun , vol.278 , pp. 704-711
    • Sakamoto, J.1
  • 123
    • 84868607245 scopus 로고    scopus 로고
    • Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects
    • Rosenson, R.S., Wright, R.S., Farkouh, M. & Plutzky, J. Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects. Am. Heart J. 164, 672-680 (2012).
    • (2012) Am. Heart J , vol.164 , pp. 672-680
    • Rosenson, R.S.1    Wright, R.S.2    Farkouh, M.3    Plutzky, J.4
  • 124
    • 77955042456 scopus 로고    scopus 로고
    • Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes
    • Rabøl, R. et al. Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes. Diabetes Obes. Metab. 12, 806-814 (2010).
    • (2010) Diabetes Obes. Metab , vol.12 , pp. 806-814
    • Rabøl, R.1
  • 126
    • 17444442152 scopus 로고    scopus 로고
    • Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
    • Mukherjee, R. et al. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 386, 407-410 (1997).
    • (1997) Nature , vol.386 , pp. 407-410
    • Mukherjee, R.1
  • 127
    • 0031789309 scopus 로고    scopus 로고
    • Characterization of mouse retinoid X receptor (RXR)-β gene promoter: Negative regulation by tumor necrosis factor (TNF)-α
    • Sugawara, A. et al. Characterization of mouse retinoid X receptor (RXR)-β gene promoter: Negative regulation by tumor necrosis factor (TNF)-α. Endocrinology 139, 3030-3033 (1998).
    • (1998) Endocrinology , vol.139 , pp. 3030-3033
    • Sugawara, A.1
  • 128
    • 84863393440 scopus 로고    scopus 로고
    • High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling
    • Singh, A.B., Guleria, R.S., Nizamutdinova, I.T., Baker, K.M. & Pan, J. High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling. J. Cell Physiol. 227, 2632-2644 (2012).
    • (2012) J. Cell Physiol , vol.227 , pp. 2632-2644
    • Singh, A.B.1    Guleria, R.S.2    Nizamutdinova, I.T.3    Baker, K.M.4    Pan, J.5
  • 129
    • 77951865861 scopus 로고    scopus 로고
    • Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans
    • Lefebvre, B. et al. Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans. J. Clin. Invest. 120, 1454-1468 (2010).
    • (2010) J. Clin. Invest , vol.120 , pp. 1454-1468
    • Lefebvre, B.1
  • 130
    • 79955631150 scopus 로고    scopus 로고
    • Autophagy in the cellular energetic balance
    • Singh, R. & Cuervo, A.M. Autophagy in the cellular energetic balance. Cell Metab. 13, 495-504 (2011).
    • (2011) Cell Metab , vol.13 , pp. 495-504
    • Singh, R.1    Cuervo, A.M.2
  • 131
    • 84858020291 scopus 로고    scopus 로고
    • FAT SIGNALS—lipases and lipolysis in lipid metabolism and signaling
    • Zechner, R. et al. FAT SIGNALS—lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 15, 279-291 (2012).
    • (2012) Cell Metab , vol.15 , pp. 279-291
    • Zechner, R.1
  • 132
    • 50049091255 scopus 로고    scopus 로고
    • AMPK: A key regulator of energy balance in the single cell and the whole organism
    • Hardie, D.G. AMPK: A key regulator of energy balance in the single cell and the whole organism. Int. J. Obes. (Lond.) 32 (suppl. 4), S7-S12 (2008).
    • (2008) Int. J. Obes. (Lond.) , vol.32 , pp. SS7-S12
    • Hardie, D.G.1
  • 133
    • 77956797254 scopus 로고    scopus 로고
    • PPAR-γ signaling crosstalk in mesenchymal stem cells
    • Takada, I., Kouzmenko, A.P. & Kato, S. PPAR-γ signaling crosstalk in mesenchymal stem cells. PPAR Res. 2010, 341671 (2010).
    • (2010) PPAR Res , vol.2010 , pp. 341671
    • Takada, I.1    Kouzmenko, A.P.2    Kato, S.3
  • 134
    • 0036789137 scopus 로고    scopus 로고
    • The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects
    • Yu, J.G. et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 51, 2968-2974 (2002).
    • (2002) Diabetes , vol.51 , pp. 2968-2974
    • Yu, J.G.1
  • 135
    • 0032587268 scopus 로고    scopus 로고
    • Rosiglitazone (BRL49653), a PPARγ-selective agonist, causes peroxisome proliferator-like liver effects in obese mice
    • Edvardsson, U. et al. Rosiglitazone (BRL49653), a PPARγ-selective agonist, causes peroxisome proliferator-like liver effects in obese mice. J. Lipid Res. 40, 1177-1184 (1999).
    • (1999) J. Lipid Res , vol.40 , pp. 1177-1184
    • Edvardsson, U.1
  • 136
    • 0041358763 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the differential expression of obesity and insulin resistance associated proteins in lep/lep mice
    • Sanchez, J.C. et al. Effect of rosiglitazone on the differential expression of obesity and insulin resistance associated proteins in lep/lep mice. Proteomics 3, 1500-1520 (2003).
    • (2003) Proteomics , vol.3 , pp. 1500-1520
    • Sanchez, J.C.1
  • 137
    • 77953808473 scopus 로고    scopus 로고
    • Next-generation genomics: An integrative approach
    • Hawkins, R.D., Hon, G.C. & Ren, B. Next-generation genomics: An integrative approach. Nat. Rev. Genet. 11, 476-486 (2010).
    • (2010) Nat. Rev. Genet , vol.11 , pp. 476-486
    • Hawkins, R.D.1    Hon, G.C.2    Ren, B.3
  • 138
    • 55749095056 scopus 로고    scopus 로고
    • PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale
    • Lefterova, M.I. et al. PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev. 22, 2941-2952 (2008).
    • (2008) Genes Dev , vol.22 , pp. 2941-2952
    • Lefterova, M.I.1
  • 139
    • 77950634721 scopus 로고    scopus 로고
    • Cell-specific determinants of peroxisome proliferator-activated receptor γ function in adipocytes and macrophages
    • Lefterova, M.I. et al. Cell-specific determinants of peroxisome proliferator-activated receptor γ function in adipocytes and macrophages. Mol. Cell Biol. 30, 2078-2089 (2010).
    • (2010) Mol. Cell Biol , vol.30 , pp. 2078-2089
    • Lefterova, M.I.1
  • 140
    • 79954992662 scopus 로고    scopus 로고
    • Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis
    • Siersbeek, R. et al. Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis. EMBO J. 30, 1459-1472 (2011).
    • (2011) EMBO J , vol.30 , pp. 1459-1472
    • Siersbeek, R.1
  • 141
    • 64249157370 scopus 로고    scopus 로고
    • De-novo identification of PPARγ/RXR binding sites and direct targets during adipogenesis
    • Hamza, M.S. et al. De-novo identification of PPARγ/RXR binding sites and direct targets during adipogenesis. PLoS ONE 4, e4907 (2009).
    • (2009) Plos ONE , vol.4
    • Hamza, M.S.1
  • 142
    • 79952700353 scopus 로고    scopus 로고
    • Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites
    • Schmidt, S.F. et al. Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites. BMC Genomics 12, 152 (2011).
    • (2011) BMC Genomics , vol.12 , pp. 152
    • Schmidt, S.F.1
  • 143
    • 84856987201 scopus 로고    scopus 로고
    • Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes
    • Schmidt, S.F., Jorgensen, M., Sandelin, A. & Mandrup, S. Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes. Transcription 3, 19-24 (2012).
    • (2012) Transcription , vol.3 , pp. 19-24
    • Schmidt, S.F.1    Jorgensen, M.2    Sandelin, A.3    Mandrup, S.4
  • 144
    • 84866936331 scopus 로고    scopus 로고
    • Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers
    • Sérandour, A.A. et al. Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers. Nucleic Acids Res. 40, 8255-8265 (2012).
    • (2012) Nucleic Acids Res , vol.40 , pp. 8255-8265
    • Sérandour, A.A.1


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