-
1
-
-
1942518840
-
PPARs and the complex journey to obesity
-
Evans, R.M., Barish, G.D. & Wang, Y.X. PPARs and the complex journey to obesity. Nat. Med. 10, 355-361 (2004).
-
(2004)
Nat. Med
, vol.10
, pp. 355-361
-
-
Evans, R.M.1
Barish, G.D.2
Wang, Y.X.3
-
2
-
-
33644645013
-
PPARδ: A dagger in the heart of the metabolic syndrome
-
Barish, G.D., Narkar, V.A. & Evans, R.M. PPARδ: A dagger in the heart of the metabolic syndrome. J. Clin. Invest. 116, 590-597 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 590-597
-
-
Barish, G.D.1
Narkar, V.A.2
Evans, R.M.3
-
3
-
-
84863111550
-
PPARs: Fatty acid sensors controlling metabolism. Semin
-
Poulsen, L., Siersbaek, M. & Mandrup, S. PPARs: Fatty acid sensors controlling metabolism. Semin. Cell Dev. Biol. 23, 631-639 (2012).
-
(2012)
Cell Dev. Biol
, vol.23
, pp. 631-639
-
-
Poulsen, L.1
Siersbaek, M.2
Mandrup, S.3
-
4
-
-
0028972025
-
15-Deoxy-δ 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
-
Forman, B.M. et al. 15-Deoxy-δ 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812 (1995).
-
(1995)
Cell
, vol.83
, pp. 803-812
-
-
Forman, B.M.1
-
5
-
-
0030952937
-
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
-
Forman, B.M., Chen, J. & Evans, R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Prooc. Natl. Acad. Sci. USA 94, 4312-4317 (1997).
-
(1997)
Prooc. Natl. Acad. Sci. USA
, vol.94
, pp. 4312-4317
-
-
Forman, B.M.1
Chen, J.2
Evans, R.M.3
-
6
-
-
0030462770
-
The peroxisome proliferator-activated receptors: Ligands and activators
-
Forman, B.M., Chen, J. & Evans, R.M. The peroxisome proliferator-activated receptors: Ligands and activators. Ann. NY Acad. Sci. 804, 266-275 (1996).
-
(1996)
Ann. NY Acad. Sci
, vol.804
, pp. 266-275
-
-
Forman, B.M.1
Chen, J.2
Evans, R.M.3
-
7
-
-
50649097541
-
Fat and beyond: The diverse biology of PPARγ
-
Tontonoz, P. & Spiegelman, B.M. Fat and beyond: The diverse biology of PPARγ. Annu. Rev. Biochem. 77, 289-312 (2008).
-
(2008)
Annu. Rev. Biochem
, vol.77
, pp. 289-312
-
-
Tontonoz, P.1
Spiegelman, B.M.2
-
8
-
-
34247636362
-
PPARγ2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
-
Medina-Gomez, G. et al. PPARγ2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet. 3, e64 (2007).
-
(2007)
Plos Genet
, vol.3
-
-
Medina-Gomez, G.1
-
9
-
-
84855447818
-
Role of PPARγ2 transcription factor in thiazolidinedione-induced insulin sensitization
-
Saraf, N., Sharma, P.K., Mondal, S.C., Garg, V.K. & Singh, A.K. Role of PPARγ2 transcription factor in thiazolidinedione-induced insulin sensitization. J. Pharm. Pharmacol. 64, 161-171 (2012).
-
(2012)
J. Pharm. Pharmacol
, vol.64
, pp. 161-171
-
-
Saraf, N.1
Sharma, P.K.2
Mondal, S.C.3
Garg, V.K.4
Singh, A.K.5
-
10
-
-
79961239382
-
Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. Wiley Interdiscip
-
Vacca, M., Degirolamo, C., Mariani-Costantini, R., Palasciano, G. & Moschetta, A. Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. Wiley Interdiscip. Rev. Syst. Biol. Med. 3, 562-587 (2011).
-
(2011)
Rev. Syst. Biol. Med
, vol.3
, pp. 562-587
-
-
Vacca, M.1
Degirolamo, C.2
Mariani-Costantini, R.3
Palasciano, G.4
Moschetta, A.5
-
12
-
-
34250212715
-
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
-
Nissen, S.E. & Wolski, K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. 356, 2457-2471 (2007).
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 2457-2471
-
-
Nissen, S.E.1
Wolski, K.2
-
13
-
-
77954988618
-
Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone
-
Graham, D.J. et al. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone. J. Am. Med. Assoc. 304, 411-418 (2010).
-
(2010)
J. Am. Med. Assoc
, vol.304
, pp. 411-418
-
-
Graham, D.J.1
-
15
-
-
40849134281
-
Effects of pioglitazone on major adverse cardiovascular events in high-risk patients with type 2 diabetes: Results from PROspective pioglitAzone Clinical Trial In macro Vascular Events (PROactive 10)
-
Wilcox, R., Kupfer, S. & Erdmann, E. Effects of pioglitazone on major adverse cardiovascular events in high-risk patients with type 2 diabetes: Results from PROspective pioglitAzone Clinical Trial In macro Vascular Events (PROactive 10). Am. Heart J. 155, 712-717 (2008).
-
(2008)
Am. Heart J
, vol.155
, pp. 712-717
-
-
Wilcox, R.1
Kupfer, S.2
Erdmann, E.3
-
16
-
-
34548590934
-
Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials
-
Lincoff, A.M., Wolski, K., Nicholls, S.J. & Nissen, S.E. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials. J. Am. Med. Assoc. 298, 1180-1188 (2007).
-
(2007)
J. Am. Med. Assoc
, vol.298
, pp. 1180-1188
-
-
Lincoff, A.M.1
Wolski, K.2
Nicholls, S.J.3
Nissen, S.E.4
-
17
-
-
84862684037
-
The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: Nested case-control study
-
Azoulay, L. et al. The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: Nested case-control study. Br. Med. J. 344, e3645 (2012).
-
(2012)
Br. Med. J
, vol.344
-
-
Azoulay, L.1
-
18
-
-
84866358522
-
Pioglitazone and risk of bladder cancer among diabetic patients in France: A population-based cohort study
-
Neumann, A. et al. Pioglitazone and risk of bladder cancer among diabetic patients in France: A population-based cohort study. Diabetologia 55, 1953-1962 (2012).
-
(2012)
Diabetologia
, vol.55
, pp. 1953-1962
-
-
Neumann, A.1
-
19
-
-
80053131732
-
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
-
Choi, J.H. et al. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature 477, 477-481 (2011).
-
(2011)
Nature
, vol.477
, pp. 477-481
-
-
Choi, J.H.1
-
20
-
-
79955692835
-
A role for central nervous system PPAR-γ in the regulation of energy balance
-
Ryan, K.K. et al. A role for central nervous system PPAR-γ in the regulation of energy balance. Nat. Med. 17, 623-626 (2011).
-
(2011)
Nat. Med
, vol.17
, pp. 623-626
-
-
Ryan, K.K.1
-
21
-
-
79955694276
-
Brain PPAR-γ promotes obesity and is required for the insulinsensitizing effect of thiazolidinediones
-
Lu, M. et al. Brain PPAR-γ promotes obesity and is required for the insulinsensitizing effect of thiazolidinediones. Nat. Med. 17, 618-622 (2011).
-
(2011)
Nat. Med
, vol.17
, pp. 618-622
-
-
Lu, M.1
-
22
-
-
84861047531
-
A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
-
Jonker, J.W. et al. A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485, 391-394 (2012).
-
(2012)
Nature
, vol.485
, pp. 391-394
-
-
Jonker, J.W.1
-
23
-
-
84863012459
-
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
-
Dutchak, P.A. et al. Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell 148, 556-567 (2012).
-
(2012)
Cell
, vol.148
, pp. 556-567
-
-
Dutchak, P.A.1
-
24
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
-
Tontonoz, P., Hu, E. & Spiegelman, B.M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147-1156 (1994).
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
25
-
-
0029981772
-
Differential activation of adipogenesis by multiple PPAR isoforms
-
Brun, R.P. et al. Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 10, 974-984 (1996).
-
(1996)
Genes Dev
, vol.10
, pp. 974-984
-
-
Brun, R.P.1
-
26
-
-
0033213637
-
PPARγ is required for placental, cardiac, and adipose tissue development
-
Barak, Y. et al. PPARγ is required for placental, cardiac, and adipose tissue development. Mol. Cell 4, 585-595 (1999).
-
(1999)
Mol. Cell
, vol.4
, pp. 585-595
-
-
Barak, Y.1
-
27
-
-
53549130485
-
White fat progenitor cells reside in the adipose vasculature
-
Tang, W. et al. White fat progenitor cells reside in the adipose vasculature. Science 322, 583-586 (2008).
-
(2008)
Science
, vol.322
, pp. 583-586
-
-
Tang, W.1
-
28
-
-
79960003581
-
Thiazolidinediones regulate adipose lineage dynamics
-
Tang, W., Zeve, D., Seo, J., Jo, A.Y. & Graff, J.M. Thiazolidinediones regulate adipose lineage dynamics. Cell Metab. 14, 116-122 (2011).
-
(2011)
Cell Metab
, vol.14
, pp. 116-122
-
-
Tang, W.1
Zeve, D.2
Seo, J.3
Jo, A.Y.4
Graff, J.M.5
-
29
-
-
12144291563
-
Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse
-
Imai, T. et al. Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse. Proc. Natl. Acad. Sci. USA 101, 4543-4547 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4543-4547
-
-
Imai, T.1
-
30
-
-
9144229185
-
Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
-
He, W. et al. Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc. Natl. Acad. Sci. USA 100, 15712-15717 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 15712-15717
-
-
He, W.1
-
31
-
-
0031051523
-
Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter
-
Hollenberg, A.N. et al. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter. J. Biol. Chem. 272, 5283-5290 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 5283-5290
-
-
Hollenberg, A.N.1
-
32
-
-
0037677767
-
Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors
-
Iwaki, M. et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52, 1655-1663 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 1655-1663
-
-
Iwaki, M.1
-
33
-
-
0027972524
-
Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance
-
Hofmann, C. et al. Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 134, 264-270 (1994).
-
(1994)
Endocrinology
, vol.134
, pp. 264-270
-
-
Hofmann, C.1
-
34
-
-
65249089760
-
Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding proteins
-
Tomaru, T., Steger, D.J., Lefterova, M.I., Schupp, M. & Lazar, M.A. Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding proteins. J. Biol. Chem. 284, 6116-6125 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 6116-6125
-
-
Tomaru, T.1
Steger, D.J.2
Lefterova, M.I.3
Schupp, M.4
Lazar, M.A.5
-
35
-
-
0036146384
-
Novel heterozygous mutation in peroxisome proliferator-activated receptor-γ gene in a patient with familial partial lipodystrophy
-
Agarwal, A.K. & Garg, A. A novel heterozygous mutation in peroxisome proliferator-activated receptor-γ gene in a patient with familial partial lipodystrophy. J. Clin. Endocrinol. Metab. 87, 408-411 (2002).
-
(2002)
J. Clin. Endocrinol. Metab
, vol.87
, pp. 408-411
-
-
Agarwal, A.K.1
Garg, A.A.2
-
36
-
-
0036894397
-
PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
-
Hegele, R.A., Cao, H., Frankowski, C., Mathews, S.T. & Leff, T. PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy. Diabetes 51, 3586-3590 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 3586-3590
-
-
Hegele, R.A.1
Cao, H.2
Frankowski, C.3
Mathews, S.T.4
Leff, T.5
-
37
-
-
0344375097
-
Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ
-
Savage, D.B. et al. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ. Diabetes 52, 910-917 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 910-917
-
-
Savage, D.B.1
-
38
-
-
0029016829
-
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
-
Lehmann, J.M. et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956 (1995).
-
(1995)
J. Biol. Chem
, vol.270
, pp. 12953-12956
-
-
Lehmann, J.M.1
-
39
-
-
84867062444
-
The PPARγ-FGF1 axis: An unexpected mediator of adipose tissue homeostasis
-
Sun, K. & Scherer, P.E. The PPARγ-FGF1 axis: An unexpected mediator of adipose tissue homeostasis. Cell Res. 22, 1416-1418 (2012).
-
(2012)
Cell Res
, vol.22
, pp. 1416-1418
-
-
Sun, K.1
Scherer, P.E.2
-
40
-
-
74049108945
-
Fibroblast growth factor 21: From pharmacology to physiology
-
Kliewer, S.A. & Mangelsdorf, D.J. Fibroblast growth factor 21: From pharmacology to physiology. Am. J. Clin. Nutr. 91, 254S-257S (2010).
-
(2010)
Am. J. Clin. Nutr
, vol.91
, pp. 254S-257S
-
-
Kliewer, S.A.1
Mangelsdorf, D.J.2
-
41
-
-
0033995557
-
Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice
-
Miller, D.L., Ortega, S., Bashayan, O., Basch, R. & Basilico, C. Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice. Mol. Cell Biol. 20, 2260-2268 (2000).
-
(2000)
Mol. Cell Biol
, vol.20
, pp. 2260-2268
-
-
Miller, D.L.1
Ortega, S.2
Bashayan, O.3
Basch, R.4
Basilico, C.5
-
42
-
-
84863116228
-
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
-
Wei, W. et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc. Natl. Acad. Sci. USA 109, 3143-3148 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 3143-3148
-
-
Wei, W.1
-
43
-
-
0035091701
-
Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
-
Way, J.M. et al. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor γ activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology 142, 1269-1277 (2001).
-
(2001)
Endocrinology
, vol.142
, pp. 1269-1277
-
-
Way, J.M.1
-
44
-
-
72049114437
-
The skinny on fat: Lipolysis and fatty acid utilization in adipocytes
-
Ahmadian, M., Duncan, R.E. & Sul, H.S. The skinny on fat: Lipolysis and fatty acid utilization in adipocytes. Trends Endocrinol. Metab. 20, 424-428 (2009).
-
(2009)
Trends Endocrinol. Metab
, vol.20
, pp. 424-428
-
-
Ahmadian, M.1
Duncan, R.E.2
Sul, H.S.3
-
45
-
-
76049086229
-
PPARγ activation in adipocytes is sufficient for systemic insulin sensitization
-
Sugii, S. et al. PPARγ activation in adipocytes is sufficient for systemic insulin sensitization. Proc. Natl. Acad. Sci. USA 106, 22504-22509 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 22504-22509
-
-
Sugii, S.1
-
46
-
-
0031441286
-
Troglitazone action is independent of adipose tissue
-
Burant, C.F. et al. Troglitazone action is independent of adipose tissue. J. Clin. Invest. 100, 2900-2908 (1997).
-
(1997)
J. Clin. Invest
, vol.100
, pp. 2900-2908
-
-
Burant, C.F.1
-
47
-
-
0038549106
-
Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice
-
Kim, J.K. et al. Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice. Diabetes 52, 1311-1318 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 1311-1318
-
-
Kim, J.K.1
-
48
-
-
0346027235
-
Muscle-specific Pparg deletion causes insulin resistance
-
Hevener, A.L. et al. Muscle-specific Pparg deletion causes insulin resistance. Nat. Med. 9, 1491-1497 (2003).
-
(2003)
Nat. Med
, vol.9
, pp. 1491-1497
-
-
Hevener, A.L.1
-
49
-
-
85047693638
-
Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
-
Norris, A.W. et al. Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J. Clin. Invest. 112, 608-618 (2003).
-
(2003)
J. Clin. Invest
, vol.112
, pp. 608-618
-
-
Norris, A.W.1
-
50
-
-
61649105063
-
Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice. Scand
-
Nan, Y.M. et al. Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice. Scand. J. Gastroenterol. 44, 358-365 (2009).
-
(2009)
J. Gastroenterol
, vol.44
, pp. 358-365
-
-
Nan, Y.M.1
-
51
-
-
0036310037
-
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
-
Mayerson, A.B. et al. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 51, 797-802 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 797-802
-
-
Mayerson, A.B.1
-
52
-
-
84862517200
-
Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of randomised trials
-
Musso, G., Cassader, M., Rosina, F. & Gambino, R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of randomised trials. Diabetologia 55, 885-904 (2012).
-
(2012)
Diabetologia
, vol.55
, pp. 885-904
-
-
Musso, G.1
Cassader, M.2
Rosina, F.3
Gambino, R.4
-
53
-
-
39849099238
-
Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease
-
Kallwitz, E.R., McLachlan, A. & Cotler, S.J. Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. World J. Gastroenterol. 14, 22-28 (2008).
-
(2008)
World J. Gastroenterol
, vol.14
, pp. 22-28
-
-
Kallwitz, E.R.1
McLachlan, A.2
Cotler, S.J.3
-
54
-
-
34548306770
-
The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis
-
Lutchman, G. et al. The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis. Hepatology 46, 424-429 (2007).
-
(2007)
Hepatology
, vol.46
, pp. 424-429
-
-
Lutchman, G.1
-
55
-
-
0141446024
-
Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
-
Gavrilova, O. et al. Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J. Biol. Chem. 278, 34268-34276 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 34268-34276
-
-
Gavrilova, O.1
-
56
-
-
0029911503
-
Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM
-
Berkowitz, K. et al. Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM. Diabetes 45, 1572-1579 (1996).
-
(1996)
Diabetes
, vol.45
, pp. 1572-1579
-
-
Berkowitz, K.1
-
57
-
-
0033613181
-
Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats
-
Higa, M. et al. Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. Proc. Natl. Acad. Sci. USA 96, 11513-11518 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11513-11518
-
-
Higa, M.1
-
58
-
-
0036310015
-
Peroxisomal proliferator-activated receptor-γ upregulates glucokinase gene expression in beta-cells
-
Kim, H.I. et al. Peroxisomal proliferator-activated receptor-γ upregulates glucokinase gene expression in beta-cells. Diabetes 51, 676-685 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 676-685
-
-
Kim, H.I.1
-
59
-
-
0033864402
-
Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter
-
Kim, H.I. et al. Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter. Diabetes 49, 1517-1524 (2000).
-
(2000)
Diabetes
, vol.49
, pp. 1517-1524
-
-
Kim, H.I.1
-
60
-
-
0141450254
-
Targeted elimination of peroxisome proliferator-activated receptor γ in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
-
Rosen, E.D. et al. Targeted elimination of peroxisome proliferator-activated receptor γ in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol. Cell Biol. 23, 7222-7229 (2003).
-
(2003)
Mol. Cell Biol
, vol.23
, pp. 7222-7229
-
-
Rosen, E.D.1
-
61
-
-
57749098781
-
In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor γ response element in the mouse pdx-1 promoter
-
Gupta, D. et al. In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor γ response element in the mouse pdx-1 promoter. J. Biol. Chem. 283, 32462-32470 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 32462-32470
-
-
Gupta, D.1
-
62
-
-
34447627877
-
PPARγ, a lipid-activated transcription factor as a regulator of dendritic cell function
-
Szatmari, I., Rajnavolgyi, E. & Nagy, L. PPARγ, a lipid-activated transcription factor as a regulator of dendritic cell function. Ann. NY Acad. Sci. 1088, 207-218 (2006).
-
(2006)
Ann. NY Acad. Sci
, vol.1088
, pp. 207-218
-
-
Szatmari, I.1
Rajnavolgyi, E.2
Nagy, L.3
-
63
-
-
34547627893
-
PPARγ in immunity and inflammation: Cell types and diseases
-
Széles, L., Torocsik, D. & Nagy, L. PPARγ in immunity and inflammation: Cell types and diseases. Biochim. Biophys. Acta 1771, 1014-1030 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 1014-1030
-
-
Széles, L.1
Torocsik, D.2
Nagy, L.3
-
64
-
-
78649388701
-
STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells
-
Szanto, A. et al. STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells. Immunity 33, 699-712 (2010).
-
(2010)
Immunity
, vol.33
, pp. 699-712
-
-
Szanto, A.1
-
65
-
-
0032540012
-
5PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
-
Tontonoz, P., Nagy, L., Alvarez, J.G., Thomazy, V.A. & Evans, R.M. 5PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93, 241-252 (1998).
-
(1998)
Cell
, vol.93
, pp. 241-252
-
-
Tontonoz, P.1
Nagy, L.2
Alvarez, J.G.3
Thomazy, V.A.4
Evans, R.M.5
-
66
-
-
84863104065
-
PPARs at the crossroads of lipid signaling and inflammation
-
Wahli, W. & Michalik, L. PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol. Metab. 23, 351-363 (2012).
-
(2012)
Trends Endocrinol. Metab
, vol.23
, pp. 351-363
-
-
Wahli, W.1
Michalik, L.2
-
67
-
-
0036781460
-
Peroxisome proliferator-activated receptor-γ in macrophage lipid homeostasis
-
Lee, C.H. & Evans, R.M. Peroxisome proliferator-activated receptor-γ in macrophage lipid homeostasis. Trends Endocrinol. Metab. 13, 331-335 (2002).
-
(2002)
Trends Endocrinol. Metab
, vol.13
, pp. 331-335
-
-
Lee, C.H.1
Evans, R.M.2
-
68
-
-
0032540325
-
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARy
-
Nagy, L., Tontonoz, P., Alvarez, J.G., Chen, H. & Evans, R.M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARy. Cell 93, 229-240 (1998).
-
(1998)
Cell
, vol.93
, pp. 229-240
-
-
Nagy, L.1
Tontonoz, P.2
Alvarez, J.G.3
Chen, H.4
Evans, R.M.5
-
69
-
-
0035132330
-
PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
-
Chawla, A. et al. PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med. 7, 48-52 (2001).
-
(2001)
Nat. Med
, vol.7
, pp. 48-52
-
-
Chawla, A.1
-
70
-
-
34249907880
-
Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
-
Hevener, A.L. et al. Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J. Clin. Invest. 117, 1658-1669 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 1658-1669
-
-
Hevener, A.L.1
-
71
-
-
34347354309
-
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
-
Odegaard, J.I. et al. Macrophage-specific PPARγ controls alternative activation and improves insulin resistance. Nature 447, 1116-1120 (2007).
-
(2007)
Nature
, vol.447
, pp. 1116-1120
-
-
Odegaard, J.I.1
-
72
-
-
79959824776
-
Epigenetic codes of PPARγ in metabolic disease
-
Sugii, S. & Evans, R.M. Epigenetic codes of PPARγ in metabolic disease. FEBS Lett. 585, 2121-2128 (2011).
-
(2011)
FEBS Lett
, vol.585
, pp. 2121-2128
-
-
Sugii, S.1
Evans, R.M.2
-
73
-
-
84862986986
-
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Tmg cells
-
Cipolletta, D. et al. PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Tmg cells. Nature 486, 549-543 (2012).
-
(2012)
Nature
, vol.486
, pp. 549
-
-
Cipolletta, D.1
-
74
-
-
84860375795
-
Thiazolidinediones and PPARγ agonists: Time for a reassessment
-
Cariou, B., Charbonnel, B. & Staels, B. Thiazolidinediones and PPARγ agonists: Time for a reassessment. Trends Endocrinol. Metab. 23, 205-215 (2012).
-
(2012)
Trends Endocrinol. Metab
, vol.23
, pp. 205-215
-
-
Cariou, B.1
Charbonnel, B.2
Staels, B.3
-
75
-
-
0041820128
-
Differential influences of peroxisome proliferator-activated receptors γ and -α on food intake and energy homeostasis
-
Larsen, P.J. et al. Differential influences of peroxisome proliferator-activated receptors γ and -α on food intake and energy homeostasis. Diabetes 52, 2249-2259 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 2249-2259
-
-
Larsen, P.J.1
-
76
-
-
33745214257
-
Energy balance and food intake: The role of PPARγ gene polymorphisms
-
Cecil, J.E., Watt, P., Palmer, C.N. & Hetherington, M. Energy balance and food intake: The role of PPARγ gene polymorphisms. Physiol. Behav. 88, 227-233 (2006).
-
(2006)
Physiol. Behav
, vol.88
, pp. 227-233
-
-
Cecil, J.E.1
Watt, P.2
Palmer, C.N.3
Hetherington, M.4
-
77
-
-
59649109871
-
Expression of peroxisome proliferator-activated receptor-γ in key neuronal subsets regulating glucose metabolism and energy homeostasis
-
Sarruf, D.A. et al. Expression of peroxisome proliferator-activated receptor-γ in key neuronal subsets regulating glucose metabolism and energy homeostasis. Endocrinology 150, 707-712 (2009).
-
(2009)
Endocrinology
, vol.150
, pp. 707-712
-
-
Sarruf, D.A.1
-
78
-
-
84868121739
-
Peroxisome proliferator-activated receptor γ (PPAR-γ) and neurodegenerative disorders
-
Chen, Y.C. et al. Peroxisome proliferator-activated receptor γ (PPAR-γ) and neurodegenerative disorders. Mol. Neurobiol. 46, 114-124 (2012).
-
(2012)
Mol. Neurobiol
, vol.46
, pp. 114-124
-
-
Chen, Y.C.1
-
79
-
-
82355191934
-
PPAR-γ agonism for cardiovascular and renal protection
-
Sarafidis, P.A., Georgianos, P.I. & Lasaridis, A.N. PPAR-γ agonism for cardiovascular and renal protection. Cardiovasc. Ther. 29, 377-384 (2011).
-
(2011)
Cardiovasc. Ther
, vol.29
, pp. 377-384
-
-
Sarafidis, P.A.1
Georgianos, P.I.2
Lasaridis, A.N.3
-
80
-
-
21544479710
-
Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention
-
Zhang, H. et al. Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention. Proc. Natl. Acad. Sci. USA 102, 9406-9411 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 9406-9411
-
-
Zhang, H.1
-
81
-
-
23844463115
-
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
-
Kuba, K. et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat. Med. 11, 875-879 (2005).
-
(2005)
Nat. Med
, vol.11
, pp. 875-879
-
-
Kuba, K.1
-
82
-
-
84857714626
-
Peroxisome proliferator-activated receptor-γ agonists repress epithelial sodium channel expression in the kidney
-
Borsting, E., Cheng, V.P., Glass, C.K., Vallon, V. & Cunard, R. Peroxisome proliferator-activated receptor-γ agonists repress epithelial sodium channel expression in the kidney. Am. J. Physiol. Renal Physiol. 302, F540-F551 (2012).
-
(2012)
Am. J. Physiol. Renal Physiol
, vol.302
, pp. F540-F551
-
-
Borsting, E.1
Cheng, V.P.2
Glass, C.K.3
Vallon, V.4
Cunard, R.5
-
83
-
-
23844472901
-
Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption
-
Guan, Y. et al. Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption. Nat. Med. 11, 861-866 (2005).
-
(2005)
Nat. Med
, vol.11
, pp. 861-866
-
-
Guan, Y.1
-
84
-
-
67649183494
-
Thiazolidinediones may contribute to the intramyocardial lipid accumulation in diabetic myocardium: Effects on cardiac function
-
Marfella, R. et al. Thiazolidinediones may contribute to the intramyocardial lipid accumulation in diabetic myocardium: Effects on cardiac function. Heart 95, 1020-1022 (2009).
-
(2009)
Heart
, vol.95
, pp. 1020-1022
-
-
Marfella, R.1
-
85
-
-
34948910262
-
Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice
-
Son, N.H. et al. Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice. J. Clin. Invest. 117, 2791-2801 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 2791-2801
-
-
Son, N.H.1
-
86
-
-
24044476859
-
Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-γ both induce cardiac hypertrophy in mice
-
Duan, S.Z., Ivashchenko, C.Y., Russell, M.W., Milstone, D.S. & Mortensen, R.M. Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-γ both induce cardiac hypertrophy in mice. Circ. Res. 97, 372-379 (2005).
-
(2005)
Circ. Res
, vol.97
, pp. 372-379
-
-
Duan, S.Z.1
Ivashchenko, C.Y.2
Russell, M.W.3
Milstone, D.S.4
Mortensen, R.M.5
-
87
-
-
84855289573
-
Thiazolidinediones on PPARγ: The roles in bone remodeling
-
Wei, W. & Wan, Y. Thiazolidinediones on PPARγ: The roles in bone remodeling. PPAR Res. 2011, 867180 (2011).
-
(2011)
PPAR Res
, vol.2011
, pp. 867180
-
-
Wei, W.1
Wan, Y.2
-
88
-
-
2142652189
-
PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
-
Akune, T. et al. PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J. Clin. Invest. 113, 846-855 (2004).
-
(2004)
J. Clin. Invest
, vol.113
, pp. 846-855
-
-
Akune, T.1
-
89
-
-
36849034568
-
PPAR-γ regulates osteoclastogenesis in mice
-
Wan, Y., Chong, L.W. & Evans, R.M. PPAR-γ regulates osteoclastogenesis in mice. Nat. Med. 13, 1496-1503 (2007).
-
(2007)
Nat. Med
, vol.13
, pp. 1496-1503
-
-
Wan, Y.1
Chong, L.W.2
Evans, R.M.3
-
90
-
-
84864615516
-
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ
-
Qiang, L. et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell 150, 620-632 (2012).
-
(2012)
Cell
, vol.150
, pp. 620-632
-
-
Qiang, L.1
-
91
-
-
58849102970
-
Posttranslational modifications of PPAR-γ: Fine-tuning the metabolic master regulator
-
van Beekum, O., Fleskens, V. & Kalkhoven, E. Posttranslational modifications of PPAR-γ: Fine-tuning the metabolic master regulator. Obesity (Silver Spring) 17, 213-219 (2009).
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 213-219
-
-
Van Beekum, O.1
Fleskens, V.2
Kalkhoven, E.3
-
92
-
-
0038776380
-
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ
-
Hu, E., Kim, J.B., Sarraf, P. & Spiegelman, B.M. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science 274, 2100-2103 (1996).
-
(1996)
Science
, vol.274
, pp. 2100-2103
-
-
Hu, E.1
Kim, J.B.2
Sarraf, P.3
Spiegelman, B.M.4
-
93
-
-
0030964085
-
Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase
-
Camp, H.S. & Tafuri, S.R. Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase. J. Biol. Chem. 272, 10811-10816 (1997).
-
(1997)
J. Biol. Chem
, vol.272
, pp. 10811-10816
-
-
Camp, H.S.1
Tafuri, S.R.2
-
94
-
-
0029775642
-
Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ
-
Zhang, B. et al. Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor γ. J. Biol. Chem. 271, 31771-31774 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 31771-31774
-
-
Zhang, B.1
-
95
-
-
33745670848
-
Peroxisome proliferator-activated receptor γ recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis
-
Iankova, I. et al. Peroxisome proliferator-activated receptor γ recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. Mol. Endocrinol. 20, 1494-1505 (2006).
-
(2006)
Mol. Endocrinol
, vol.20
, pp. 1494-1505
-
-
Iankova, I.1
-
96
-
-
21744438445
-
Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations
-
Compe, E. et al. Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations. Mol. Cell Biol. 25, 6065-6076 (2005).
-
(2005)
Mol. Cell Biol
, vol.25
, pp. 6065-6076
-
-
Compe, E.1
-
97
-
-
0032189782
-
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
-
Ristow, M., Muller-Wieland, D., Pfeiffer, A., Krone, W. & Kahn, C.R. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N. Engl. J. Med. 339, 953-959 (1998).
-
(1998)
N. Engl. J. Med
, vol.339
, pp. 953-959
-
-
Ristow, M.1
Muller-Wieland, D.2
Pfeiffer, A.3
Krone, W.4
Kahn, C.R.5
-
98
-
-
0141920726
-
Genetic modulation of PPARγ phosphorylation regulates insulin sensitivity
-
Rangwala, S.M. et al. Genetic modulation of PPARγ phosphorylation regulates insulin sensitivity. Dev. Cell 5, 657-663 (2003).
-
(2003)
Dev. Cell
, vol.5
, pp. 657-663
-
-
Rangwala, S.M.1
-
100
-
-
59049083003
-
Tumor necrosis factor-α regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35
-
Utreras, E. et al. Tumor necrosis factor-α regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. J. Biol. Chem. 284, 2275-2284 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 2275-2284
-
-
Utreras, E.1
-
101
-
-
77954941113
-
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARy by Cdk5
-
Choi, J.H. et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARy by Cdk5. Nature 466, 451-456 (2010).
-
(2010)
Nature
, vol.466
, pp. 451-456
-
-
Choi, J.H.1
-
102
-
-
77950226740
-
Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
-
Petrovic, N. et al. Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 285, 7153-7164 (2010).
-
(2010)
J. Biol. Chem
, vol.285
, pp. 7153-7164
-
-
Petrovic, N.1
-
103
-
-
0347989317
-
Brown adipose tissue: Function and physiological significance
-
Cannon, B. & Nedergaard, J. Brown adipose tissue: Function and physiological significance. Physiol. Rev. 84, 277-359 (2004).
-
(2004)
Physiol. Rev
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
104
-
-
77950237717
-
The changed metabolic world with human brown adipose tissue: Therapeutic visions
-
Nedergaard, J. & Cannon, B. The changed metabolic world with human brown adipose tissue: Therapeutic visions. Cell Metab. 11, 268-272 (2010).
-
(2010)
Cell Metab
, vol.11
, pp. 268-272
-
-
Nedergaard, J.1
Cannon, B.2
-
105
-
-
23044470775
-
PPARγ in the control of brown adipocyte differentiation
-
Nedergaard, J., Petrovic, N., Lindgren, E.M., Jacobsson, A. & Cannon, B. PPARγ in the control of brown adipocyte differentiation. Biochim. Biophys. Acta 1740, 293-304 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1740
, pp. 293-304
-
-
Nedergaard, J.1
Petrovic, N.2
Lindgren, E.M.3
Jacobsson, A.4
Cannon, B.5
-
106
-
-
84858039282
-
PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
-
Ohno, H., Shinoda, K., Spiegelman, B.M. & Kajimura, S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 15, 395-404 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 395-404
-
-
Ohno, H.1
Shinoda, K.2
Spiegelman, B.M.3
Kajimura, S.4
-
107
-
-
80054074025
-
PPARs and lipid ligands in inflammation and metabolism
-
Harmon, G.S., Lam, M.T. & Glass, C.K. PPARs and lipid ligands in inflammation and metabolism. Chem. Rev. 111, 6321-6340 (2011).
-
(2011)
Chem. Rev
, vol.111
, pp. 6321-6340
-
-
Harmon, G.S.1
Lam, M.T.2
Glass, C.K.3
-
108
-
-
33646229801
-
Aspects of the regulatory mechanisms of PPAR functions: Analysis of a bidirectional response element and regulation by sumoylation
-
Shimizu, M., Yamashita, D., Yamaguchi, T., Hirose, F. & Osumi, T. Aspects of the regulatory mechanisms of PPAR functions: Analysis of a bidirectional response element and regulation by sumoylation. Mol. Cell Biochem. 286, 33-42 (2006).
-
(2006)
Mol. Cell Biochem
, vol.286
, pp. 33-42
-
-
Shimizu, M.1
Yamashita, D.2
Yamaguchi, T.3
Hirose, F.4
Osumi, T.5
-
109
-
-
26444471700
-
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
-
Pascual, G. et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ. Nature 437, 759-763 (2005).
-
(2005)
Nature
, vol.437
, pp. 759-763
-
-
Pascual, G.1
-
110
-
-
0034674567
-
Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand-dependent activation
-
Hauser, S. et al. Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand-dependent activation. J. Biol. Chem. 275, 18527-18533 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 18527-18533
-
-
Hauser, S.1
-
111
-
-
0035831494
-
Interferon-γ-induced regulation of peroxisome proliferator-activated receptor γ and STATs in adipocytes
-
Waite, K.J., Floyd, Z.E., Arbour-Reily, P. & Stephens, J.M. Interferon-γ-induced regulation of peroxisome proliferator-activated receptor γ and STATs in adipocytes. J. Biol. Chem. 276, 7062-7068 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 7062-7068
-
-
Waite, K.J.1
Floyd, Z.E.2
Arbour-Reily, P.3
Stephens, J.M.4
-
112
-
-
27844511538
-
Selective estrogen receptor modulators (SERMs): Mechanisms of anticarcinogenesis and drug resistance
-
Lewis, J.S. & Jordan, V.C. Selective estrogen receptor modulators (SERMs): Mechanisms of anticarcinogenesis and drug resistance. Mutat. Res. 591, 247-263 (2005).
-
(2005)
Mutat. Res
, vol.591
, pp. 247-263
-
-
Lewis, J.S.1
Jordan, V.C.2
-
114
-
-
84855795379
-
Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism
-
Hughes, T.S. et al. Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism. Structure 20, 139-150 (2012).
-
(2012)
Structure
, vol.20
, pp. 139-150
-
-
Hughes, T.S.1
-
115
-
-
56749130032
-
Structure of the intact PPAR-γ-RXR-nuclear receptor complex on DNA
-
Chandra, V. et al. Structure of the intact PPAR-γ-RXR-nuclear receptor complex on DNA. Nature 456, 350-356 (2008).
-
(2008)
Nature
, vol.456
, pp. 350-356
-
-
Chandra, V.1
-
116
-
-
74049159051
-
Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation
-
Higgins, L.S. & Depaoli, A.M. Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation. Am. J. Clin. Nutr. 91, 267S-272S (2010).
-
(2010)
Am. J. Clin. Nutr
, vol.91
, pp. 267S-272S
-
-
Higgins, L.S.1
Depaoli, A.M.2
-
117
-
-
46149115894
-
Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist
-
Tavera-Mendoza, L.E. et al. Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc. Natl. Acad. Sci. USA 105, 8250-8255 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 8250-8255
-
-
Tavera-Mendoza, L.E.1
-
118
-
-
84870902173
-
Targeted estrogen delivery reverses the metabolic syndrome
-
Finan, B. et al. Targeted estrogen delivery reverses the metabolic syndrome. Nat. Med. 18, 1847-1856 (2012).
-
(2012)
Nat. Med
, vol.18
, pp. 1847-1856
-
-
Finan, B.1
-
119
-
-
34447643245
-
Differential effect of pioglitazone (PGZ) and rosiglitazone (RGZ) on postprandial glucose and lipid metabolism in patients with type 2 diabetes mellitus: A prospective, randomized crossover study
-
Chappuis, B. et al. Differential effect of pioglitazone (PGZ) and rosiglitazone (RGZ) on postprandial glucose and lipid metabolism in patients with type 2 diabetes mellitus: A prospective, randomized crossover study. Diabetes Metab. Res. Rev. 23, 392-399 (2007).
-
(2007)
Diabetes Metab. Res. Rev
, vol.23
, pp. 392-399
-
-
Chappuis, B.1
-
120
-
-
35148837113
-
Pioglitazone and rosiglitazone have different effects on serum lipoprotein particle concentrations and sizes in patients with type 2 diabetes and dyslipidemia
-
Deeg, M.A. et al. Pioglitazone and rosiglitazone have different effects on serum lipoprotein particle concentrations and sizes in patients with type 2 diabetes and dyslipidemia. Diabetes Care 30, 2458-2464 (2007).
-
(2007)
Diabetes Care
, vol.30
, pp. 2458-2464
-
-
Deeg, M.A.1
-
121
-
-
21544466158
-
A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia
-
Goldberg, R.B. et al. A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. Diabetes Care 28, 1547-1554 (2005).
-
(2005)
Diabetes Care
, vol.28
, pp. 1547-1554
-
-
Goldberg, R.B.1
-
122
-
-
0034735992
-
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone
-
Sakamoto, J. et al. Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem. Biophys. Res. Commun. 278, 704-711 (2000).
-
(2000)
Biochem. Biophys. Res. Commun
, vol.278
, pp. 704-711
-
-
Sakamoto, J.1
-
123
-
-
84868607245
-
Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects
-
Rosenson, R.S., Wright, R.S., Farkouh, M. & Plutzky, J. Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects. Am. Heart J. 164, 672-680 (2012).
-
(2012)
Am. Heart J
, vol.164
, pp. 672-680
-
-
Rosenson, R.S.1
Wright, R.S.2
Farkouh, M.3
Plutzky, J.4
-
124
-
-
77955042456
-
Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes
-
Rabøl, R. et al. Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes. Diabetes Obes. Metab. 12, 806-814 (2010).
-
(2010)
Diabetes Obes. Metab
, vol.12
, pp. 806-814
-
-
Rabøl, R.1
-
125
-
-
34548182594
-
PPAR dual agonists: Are they opening Pandora's Box?
-
Balakumar, P., Rose, M., Ganti, S.S., Krishan, P. & Singh, M. PPAR dual agonists: Are they opening Pandora's Box? Pharmacol. Res. 56, 91-98 (2007).
-
(2007)
Pharmacol. Res
, vol.56
, pp. 91-98
-
-
Balakumar, P.1
Rose, M.2
Ganti, S.S.3
Krishan, P.4
Singh, M.5
-
126
-
-
17444442152
-
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
-
Mukherjee, R. et al. Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 386, 407-410 (1997).
-
(1997)
Nature
, vol.386
, pp. 407-410
-
-
Mukherjee, R.1
-
127
-
-
0031789309
-
Characterization of mouse retinoid X receptor (RXR)-β gene promoter: Negative regulation by tumor necrosis factor (TNF)-α
-
Sugawara, A. et al. Characterization of mouse retinoid X receptor (RXR)-β gene promoter: Negative regulation by tumor necrosis factor (TNF)-α. Endocrinology 139, 3030-3033 (1998).
-
(1998)
Endocrinology
, vol.139
, pp. 3030-3033
-
-
Sugawara, A.1
-
128
-
-
84863393440
-
High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling
-
Singh, A.B., Guleria, R.S., Nizamutdinova, I.T., Baker, K.M. & Pan, J. High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling. J. Cell Physiol. 227, 2632-2644 (2012).
-
(2012)
J. Cell Physiol
, vol.227
, pp. 2632-2644
-
-
Singh, A.B.1
Guleria, R.S.2
Nizamutdinova, I.T.3
Baker, K.M.4
Pan, J.5
-
129
-
-
77951865861
-
Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans
-
Lefebvre, B. et al. Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans. J. Clin. Invest. 120, 1454-1468 (2010).
-
(2010)
J. Clin. Invest
, vol.120
, pp. 1454-1468
-
-
Lefebvre, B.1
-
130
-
-
79955631150
-
Autophagy in the cellular energetic balance
-
Singh, R. & Cuervo, A.M. Autophagy in the cellular energetic balance. Cell Metab. 13, 495-504 (2011).
-
(2011)
Cell Metab
, vol.13
, pp. 495-504
-
-
Singh, R.1
Cuervo, A.M.2
-
131
-
-
84858020291
-
FAT SIGNALS—lipases and lipolysis in lipid metabolism and signaling
-
Zechner, R. et al. FAT SIGNALS—lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 15, 279-291 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 279-291
-
-
Zechner, R.1
-
132
-
-
50049091255
-
AMPK: A key regulator of energy balance in the single cell and the whole organism
-
Hardie, D.G. AMPK: A key regulator of energy balance in the single cell and the whole organism. Int. J. Obes. (Lond.) 32 (suppl. 4), S7-S12 (2008).
-
(2008)
Int. J. Obes. (Lond.)
, vol.32
, pp. SS7-S12
-
-
Hardie, D.G.1
-
133
-
-
77956797254
-
PPAR-γ signaling crosstalk in mesenchymal stem cells
-
Takada, I., Kouzmenko, A.P. & Kato, S. PPAR-γ signaling crosstalk in mesenchymal stem cells. PPAR Res. 2010, 341671 (2010).
-
(2010)
PPAR Res
, vol.2010
, pp. 341671
-
-
Takada, I.1
Kouzmenko, A.P.2
Kato, S.3
-
134
-
-
0036789137
-
The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects
-
Yu, J.G. et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 51, 2968-2974 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 2968-2974
-
-
Yu, J.G.1
-
135
-
-
0032587268
-
Rosiglitazone (BRL49653), a PPARγ-selective agonist, causes peroxisome proliferator-like liver effects in obese mice
-
Edvardsson, U. et al. Rosiglitazone (BRL49653), a PPARγ-selective agonist, causes peroxisome proliferator-like liver effects in obese mice. J. Lipid Res. 40, 1177-1184 (1999).
-
(1999)
J. Lipid Res
, vol.40
, pp. 1177-1184
-
-
Edvardsson, U.1
-
136
-
-
0041358763
-
Effect of rosiglitazone on the differential expression of obesity and insulin resistance associated proteins in lep/lep mice
-
Sanchez, J.C. et al. Effect of rosiglitazone on the differential expression of obesity and insulin resistance associated proteins in lep/lep mice. Proteomics 3, 1500-1520 (2003).
-
(2003)
Proteomics
, vol.3
, pp. 1500-1520
-
-
Sanchez, J.C.1
-
137
-
-
77953808473
-
Next-generation genomics: An integrative approach
-
Hawkins, R.D., Hon, G.C. & Ren, B. Next-generation genomics: An integrative approach. Nat. Rev. Genet. 11, 476-486 (2010).
-
(2010)
Nat. Rev. Genet
, vol.11
, pp. 476-486
-
-
Hawkins, R.D.1
Hon, G.C.2
Ren, B.3
-
138
-
-
55749095056
-
PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale
-
Lefterova, M.I. et al. PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev. 22, 2941-2952 (2008).
-
(2008)
Genes Dev
, vol.22
, pp. 2941-2952
-
-
Lefterova, M.I.1
-
139
-
-
77950634721
-
Cell-specific determinants of peroxisome proliferator-activated receptor γ function in adipocytes and macrophages
-
Lefterova, M.I. et al. Cell-specific determinants of peroxisome proliferator-activated receptor γ function in adipocytes and macrophages. Mol. Cell Biol. 30, 2078-2089 (2010).
-
(2010)
Mol. Cell Biol
, vol.30
, pp. 2078-2089
-
-
Lefterova, M.I.1
-
140
-
-
79954992662
-
Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis
-
Siersbeek, R. et al. Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis. EMBO J. 30, 1459-1472 (2011).
-
(2011)
EMBO J
, vol.30
, pp. 1459-1472
-
-
Siersbeek, R.1
-
141
-
-
64249157370
-
De-novo identification of PPARγ/RXR binding sites and direct targets during adipogenesis
-
Hamza, M.S. et al. De-novo identification of PPARγ/RXR binding sites and direct targets during adipogenesis. PLoS ONE 4, e4907 (2009).
-
(2009)
Plos ONE
, vol.4
-
-
Hamza, M.S.1
-
142
-
-
79952700353
-
Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites
-
Schmidt, S.F. et al. Cross species comparison of C/EBPα and PPARγ profiles in mouse and human adipocytes reveals interdependent retention of binding sites. BMC Genomics 12, 152 (2011).
-
(2011)
BMC Genomics
, vol.12
, pp. 152
-
-
Schmidt, S.F.1
-
143
-
-
84856987201
-
Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes
-
Schmidt, S.F., Jorgensen, M., Sandelin, A. & Mandrup, S. Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes. Transcription 3, 19-24 (2012).
-
(2012)
Transcription
, vol.3
, pp. 19-24
-
-
Schmidt, S.F.1
Jorgensen, M.2
Sandelin, A.3
Mandrup, S.4
-
144
-
-
84866936331
-
Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers
-
Sérandour, A.A. et al. Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers. Nucleic Acids Res. 40, 8255-8265 (2012).
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 8255-8265
-
-
Sérandour, A.A.1
|