Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 19, 2012, Pages

  Wu, Lan ^a   Parekh, Vrajesh V ^a   Gabriel, Curtis L ^a   Bracy, Deanna P ^a   Marks Shulman, Pamela A ^a   Tamboli, Robyn A ^a   Kim, Sungjune ^a,c   Mendez Fernandez, Yanice V ^a   Besra, Gurdyal S ^b   Lomenick, Jefferson P ^a   Williams, Brandon ^a   Wasserman, David H ^a   Van Kaer, Luc ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Alpha galactosylceramide; Cluster of differentiation 1d; Glycolipid reactive T cells; Obesity induced inflammation

Indexed keywords

1 O (ALPHA GALACTOPYRANOSYL) 2 HEXACOSANOYLAMINO 1,3,4 OCTADECANETRIOL; GAMMA INTERFERON; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL STIMULATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FAT INTAKE; FATTY LIVER; INSULIN RESISTANCE; LEUKOCYTE; LIPID STORAGE; MALE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL;

ADIPOSE TISSUE, WHITE; ANIMALS; ANTIGENS, CD1D; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; DIETARY FATS; FATTY LIVER; FEMALE; FLOW CYTOMETRY; GALACTOSYLCERAMIDES; INFLAMMATION; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; LIPIDS; LYMPHOCYTE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NATURAL KILLER T-CELLS; OBESITY;

MUS;

EID: 84860794660     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1200498109     Document Type: Article

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