Activated Kupffer cells inhibit insulin sensitivity in obese mice

FASEB Journal

Volumn 29, Issue 7, 2015, Pages 2959-2969

  Tencerova, Michaela ^a,b   Aouadi, Myriam ^a,c   Vangala, Pranitha ^a   Nicoloro, Sarah M ^a   Yawe, Joseph C ^a   Cohen, Jessica L ^a   Shen, Yuefei ^a   Garcia Menendez, Lorena ^a,d   Pedersen, David J ^a   Gallagher Dorval, Karen ^a   Perugini, Richard A ^a   Gupta, Olga T ^a,e   Czech, Michael P ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c KAROLINSKA INSTITUTE   (Sweden)

^d PFIZER INC   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Hepatic steatosis; Insulin resistance; Liver macrophages; Small interfering RNA

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; FATTY ACID; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; RELA PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FATTY LIVER; GLUCOSE TOLERANCE; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; KUPFFER CELL; LIPID LIVER LEVEL; LIPOGENESIS; LIVER CELL; MALE; MOUSE; NONHUMAN; OBESITY; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG DELIVERY SYSTEM; GENE SILENCING; GENETICS; GLUCOSE TOLERANCE TEST; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; LIPID METABOLISM; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

MUS;

ANIMALS; CYTOKINES; DRUG DELIVERY SYSTEMS; FATTY LIVER; GENE SILENCING; GLUCOSE TOLERANCE TEST; HUMANS; IN VITRO TECHNIQUES; INJECTIONS, INTRAVENOUS; INSULIN RESISTANCE; KUPFFER CELLS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR RELA;

EID: 84940417328     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-270496     Document Type: Article

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