Tumor necrosis factor-α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: Nuclear factor-κB activation by TNF-α is obligatory

Diabetes

Volumn 51, Issue 5, 2002, Pages 1319-1336

  Ruan, Hong ^a   Hacohen, Nir ^a   Golub, Todd R ^a,b   Van Parijs, Luk ^c   Lodish, Harvey F ^a,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; DNA BINDING PROTEIN; FATTY ACID SYNTHASE; GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LIPOPROTEIN LIPASE; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; RETINOID X RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DEATH; CELL STRAIN 3T3; CONTROLLED STUDY; DNA MICROARRAY; ELECTROPHORETIC MOBILITY; EXPRESSED SEQUENCE TAG; GENE INDUCTION; GENE REPRESSION; INSULIN RESISTANCE; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE; WESTERN BLOTTING;

EID: 0036313033     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.5.1319     Document Type: Article

References (53)

1. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
2. Physiological and metabolic consequences of obesity
3. Obesity, insulin resistance, and its link to non-insulin-dependent diabetes mellitus
4. Tumor necrosis factor alpha: A key component of the obesity-diabetes link
5. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes: Central role of tumor necrosis factor-alpha
6. TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone
7. TNF-alpha and insulin resistance: Summary and future prospects
8. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
9. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance
10. Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat
11. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
12. The expression of tumor necrosis factor in human adipose tissue: Regulation by obesity, weight loss, and relationship to lipoprotein lipase
13. Tumor necrosis factor alpha inhibits signaling from the insulin receptor
14. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output
15. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
16. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity
17. The insulin signaling system
18. Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: Implication of the p 80 tumor necrosis factor receptor
19. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates
20. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
21. Tumor necrosis factor promotes phosphorylation and binding of insulin receptor substrate 1 to phosphatidylinositol 3-kinase in 3T3-L1 adipocytes
22. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling
23. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
24. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p 55 TNF receptor and activation of sphingomyelinase
25. Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
26. NF-kappa B: Ten years after
27. Function and activation of NF-kappa B in the immune system
28. AP-1 function and regulation
29. Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family
30. The role of TNF alpha in adipocyte metabolism
31. The I kappa B kinase: A master regulator of NF-kappa B, innate immunity, and epidermal differentiation
32. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKbeta
33. Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades
34. The adipocyte-secreted protein Acrp 30 enhances hepatic insulin action
35. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
36. NF-kappa B activation by tumor necrosis factor and interleukin-1
37. Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
38. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli
39. N-and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity
40. Principles of CDK regulation
41. GATA-6 induces p21(Cip1) expression and G 1 cell cycle arrest
42. The human GATA-6 gene: Structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals
43. Altered immune function in a morbidly obese pediatric population
44. Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase
45. Effects of tumour necrosis factor alpha (TNF alpha) on glucose transport and lipid metabolism of newly differentiated human fat cells in cell culture
46. Mechanisms of fatty acid-induced inhibition of glucose uptake
47. Effect of interferon on glucose tolerance and insulin sensitivity
48. The metabolic effects of tumor necrosis factor and other cytokines
49. Endocrinologic and metabolic effects of interleukin-6 in humans
50. Endocrine and metabolic effects of interferon-alpha in humans
51. Elaboration of type-1 plasminogen activator inhibitor from adipocytes: A potential pathogenetic link between obesity and cardiovascular disease
52. Attenuated fibrinolysis and accelerated atherogenesis in type II diabetic patients
53. Adrenomedullin, a multifunctional regulatory peptide