Palmitate induces autophagy in pancreatic β-cells via endoplasmic reticulum stress and its downstream JNK pathway

International Journal of Molecular Medicine

Volumn 32, Issue 6, 2013, Pages 1401-1406

  Chen, Ying Ying ^a   Sun, Lian Qing ^b   Wang, Bao An ^a   Zou, Xiao Man ^a   Mu, Yi Ming ^a   Lu, Ju Ming ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

cells; Autophagy; Endoplasmic reticulum stress; Lipotoxicity; Palmitate

Indexed keywords

3 METHYLADENINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INSULIN BETA RECEPTOR; INSULIN RECEPTOR; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; PALMITIC ACID; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TAUROURSODEOXYCHOLIC ACID; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL DAMAGE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; INSULIN-SECRETING CELLS; MAP KINASE SIGNALING SYSTEM; MICE; MODELS, BIOLOGICAL; PALMITATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; UP-REGULATION;

EID: 84892152979     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1530     Document Type: Article

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