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Volumn 16, Issue 1, 2015, Pages 85-95

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T reg cells and macrophages in adipose tissue

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E4BP4; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR PLZF; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; KRUPPEL LIKE FACTOR; NFIL3 PROTEIN, MOUSE; ZBTB16 PROTEIN, MOUSE;

EID: 84923384136     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3047     Document Type: Article
Times cited : (319)

References (52)
  • 1
    • 66149179356 scopus 로고    scopus 로고
    • Antigen presentation by CD1 lipids, T cells, and NKT cells in microbial immunity
    • Cohen, N.R., Garg, S., Brenner, M.B. Antigen presentation by CD1 lipids, T cells, and NKT cells in microbial immunity. Adv. Immunol. 102, 1-94 (2009).
    • (2009) Adv. Immunol. , vol.102 , pp. 1-94
    • Cohen, N.R.1    Garg, S.2    Brenner, M.B.3
  • 2
    • 51349121407 scopus 로고    scopus 로고
    • The transcription factor PLZF directs the effector program of the NKT cell lineage
    • Savage, A.K. et al. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29, 391-403 (2008).
    • (2008) Immunity , vol.29 , pp. 391-403
    • Savage, A.K.1
  • 3
    • 50049084627 scopus 로고    scopus 로고
    • The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions
    • Kovalovsky, D. et al. The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat. Immunol. 9, 1055-1064 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1055-1064
    • Kovalovsky, D.1
  • 4
    • 65949112929 scopus 로고    scopus 로고
    • Stepwise development of MAIT cells in mouse and human
    • Martin, E. et al. Stepwise development of MAIT cells in mouse and human. PLoS Biol. 7, e54 (2009).
    • (2009) PLoS Biol , vol.7 , pp. 54
    • Martin, E.1
  • 5
    • 68149108582 scopus 로고    scopus 로고
    • TCR-inducible PLZF transcription factor required for innate phenotype of a subset of T cells with restricted TCR diversity
    • Kreslavsky, T. et al. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of T cells with restricted TCR diversity. Proc. Natl. Acad. Sci. USA 106, 12453-12458 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 12453-12458
    • Kreslavsky, T.1
  • 6
    • 84857488339 scopus 로고    scopus 로고
    • Development and function of invariant natural killer T cells producing TH2-and TH17-cytokines
    • Watarai, H. et al. Development and function of invariant natural killer T cells producing TH2-and TH17-cytokines. PLoS Biol. 10, e1001255 (2012).
    • (2012) PLoS Biol. , vol.10 , pp. 1001255
    • Watarai, H.1
  • 7
    • 84872943896 scopus 로고    scopus 로고
    • Invariant natural killer T cells: An innate activation scheme linked to diverse effector functions
    • Brennan, P.J., Brigl, M., Brenner, M.B. Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat. Rev. Immunol. 13, 101-117 (2013).
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 101-117
    • Brennan, P.J.1    Brigl, M.2    Brenner, M.B.3
  • 8
    • 79251497664 scopus 로고    scopus 로고
    • Presumed guilty: Natural killer T cell defects and human disease
    • Berzins, S.P., Smyth, M.J., Baxter, A.G. Presumed guilty: natural killer T cell defects and human disease. Nat. Rev. Immunol. 11, 131-142 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 131-142
    • Berzins, S.P.1    Smyth, M.J.2    Baxter, A.G.3
  • 9
    • 10044286529 scopus 로고    scopus 로고
    • Going both ways: Immune regulation via CD1d-dependent NKT cells
    • Godfrey, D.I., Kronenberg, M. Going both ways: immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 114, 1379-1388 (2004).
    • (2004) J. Clin. Invest. , vol.114 , pp. 1379-1388
    • Godfrey, D.I.1    Kronenberg, M.2
  • 11
    • 0037328355 scopus 로고    scopus 로고
    • Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission
    • Araki, M. et al. Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission. Int. Immunol. 15, 279-288 (2003).
    • (2003) Int. Immunol. , vol.15 , pp. 279-288
    • Araki, M.1
  • 12
    • 0034742480 scopus 로고    scopus 로고
    • Circulating V(24+) V11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage
    • van der Vliet, H.J. et al. Circulating V(24+) V11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin. Immunol. 100, 144-148 (2001).
    • (2001) Clin. Immunol. , vol.100 , pp. 144-148
    • Van Der Vliet, H.J.1
  • 13
    • 84858800459 scopus 로고    scopus 로고
    • Lipid-antigen presentation by CD1d+ B cells is essential for the maintenance of invariant natural killer T cells
    • Bosma, A., Abdel-Gadir, A., Isenberg, D.A., Jury, E.C., Mauri, C. Lipid-antigen presentation by CD1d+ B cells is essential for the maintenance of invariant natural killer T cells. Immunity 36, 477-490 (2012).
    • (2012) Immunity , vol.36 , pp. 477-490
    • Bosma, A.1    Abdel-Gadir, A.2    Isenberg, D.A.3    Jury, E.C.4    Mauri, C.5
  • 14
    • 79251645844 scopus 로고    scopus 로고
    • Mechanism of regulation of autoimmunity by i NKT cells
    • Novak, J., Lehuen, A. Mechanism of regulation of autoimmunity by i NKT cells. Cytokine 53, 263-270 (2011).
    • (2011) Cytokine , vol.53 , pp. 263-270
    • Novak, J.1    Lehuen, A.2
  • 15
    • 69249155107 scopus 로고    scopus 로고
    • Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity
    • Lynch, L. et al. Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity. Eur. J. Immunol. 39, 1893-1901 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1893-1901
    • Lynch, L.1
  • 16
    • 84866520055 scopus 로고    scopus 로고
    • Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
    • Lynch, L. et al. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 37, 574-587 (2012).
    • (2012) Immunity , vol.37 , pp. 574-587
    • Lynch, L.1
  • 17
    • 58149347227 scopus 로고    scopus 로고
    • Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    • Lumeng, C.N., DelProposto, J.B., Westcott, D.J., Saltiel, A.R. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 57, 3239-3246 (2008).
    • (2008) Diabetes , vol.57 , pp. 3239-3246
    • Lumeng, C.N.1    Delproposto, J.B.2    Westcott, D.J.3    Saltiel, A.R.4
  • 18
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer, M. et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930-939 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 930-939
    • Feuerer, M.1
  • 19
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    • Cipolletta, D. et al. PPAR-is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486, 549-553 (2012).
    • (2012) Nature , vol.486 , pp. 549-553
    • Cipolletta, D.1
  • 20
    • 84859997837 scopus 로고    scopus 로고
    • Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity
    • Ji, Y. et al. Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J. Biol. Chem. 287, 13561-13571 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 13561-13571
    • Ji, Y.1
  • 21
    • 84865992180 scopus 로고    scopus 로고
    • Natural killer T cells in adipose tissue prevent insulin resistance
    • Schipper, H.S. et al. Natural killer T cells in adipose tissue prevent insulin resistance. J. Clin. Invest. 122, 3343-3354 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 3343-3354
    • Schipper, H.S.1
  • 22
    • 84871871453 scopus 로고    scopus 로고
    • A novel function of adipocytes in lipid antigen presentation to i NKT cells
    • Huh, J.Y. et al. A novel function of adipocytes in lipid antigen presentation to i NKT cells. Mol. Cell. Biol. 33, 328-339 (2013).
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 328-339
    • Huh, J.Y.1
  • 23
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg, S.P. et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112, 1796-1808 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1
  • 24
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng, C.N., Bodzin, J.L., Saltiel, A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175-184 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 25
    • 84865992180 scopus 로고    scopus 로고
    • Natural killer T cells in adipose tissue prevent insulin resistance
    • Schipper, H.S. et al. Natural killer T cells in adipose tissue prevent insulin resistance. J. Clin. Invest. 122, 3343-3354 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 3343-3354
    • Schipper, H.S.1
  • 26
    • 84863808516 scopus 로고    scopus 로고
    • Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4
    • Ji, Y. et al. Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4. J. Biol. Chem. 287, 24378-24386 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 24378-24386
    • Ji, Y.1
  • 27
    • 84888346690 scopus 로고    scopus 로고
    • Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in Mice
    • Hams, E., Locksley, R.M., McKenzie, A.N., Fallon, P.G. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in Mice. J. Immunol. 191, 5349-5353 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 5349-5353
    • Hams, E.1    Locksley, R.M.2    McKenzie, A.N.3    Fallon, P.G.4
  • 28
    • 0035976526 scopus 로고    scopus 로고
    • Physiological migration of hematopoietic stem and progenitor cells
    • Wright, D.E., Wagers, A.J., Gulati, A.P., Johnson, F.L., Weissman, I.L. Physiological migration of hematopoietic stem and progenitor cells. Science 294, 1933-1936 (2001).
    • (2001) Science , vol.294 , pp. 1933-1936
    • Wright, D.E.1    Wagers, A.J.2    Gulati, A.P.3    Johnson, F.L.4    Weissman, I.L.5
  • 29
    • 0033120557 scopus 로고    scopus 로고
    • Cutting edge: LFA-1 is required for liver NK1.1+TCR+ cell development: Evidence that liver NK1.1+TCR+ cells originate from multiple pathways
    • Ohteki, T., Maki, C., Koyasu, S., Mak, T.W., Ohashi, P.S. Cutting edge: LFA-1 is required for liver NK1.1+TCR+ cell development: evidence that liver NK1.1+TCR+ cells originate from multiple pathways. J. Immunol. 162, 3753-3756 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 3753-3756
    • Ohteki, T.1    Maki, C.2    Koyasu, S.3    Mak, T.W.4    Ohashi, P.S.5
  • 30
    • 19344371631 scopus 로고    scopus 로고
    • Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids
    • Geissmann, F. et al. Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol. 3, e113 (2005).
    • (2005) PLoS Biol , vol.3 , pp. 113
    • Geissmann, F.1
  • 31
    • 79958273555 scopus 로고    scopus 로고
    • PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions
    • Thomas, S.Y. et al. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J. Exp. Med. 208, 1179-1188 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1179-1188
    • Thomas, S.Y.1
  • 32
    • 84871181695 scopus 로고    scopus 로고
    • Shared and distinct transcriptional programs underlie the hybrid nature of i NKT cells
    • Cohen, N.R. et al. Shared and distinct transcriptional programs underlie the hybrid nature of i NKT cells. Nat. Immunol. 14, 90-99 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 90-99
    • Cohen, N.R.1
  • 33
    • 17144374753 scopus 로고    scopus 로고
    • Toward an understanding of NKT cell biology: Progress and paradoxes
    • Kronenberg, M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu. Rev. Immunol. 23, 877-900 (2005).
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 877-900
    • Kronenberg, M.1
  • 35
    • 84872943896 scopus 로고    scopus 로고
    • Invariant natural killer T cells: An innate activation scheme linked to diverse effector functions
    • Brennan, P.J., Brigl, M., Brenner, M.B. Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat. Rev. Immunol. 13, 101-117 (2013).
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 101-117
    • Brennan, P.J.1    Brigl, M.2    Brenner, M.B.3
  • 36
    • 84877018173 scopus 로고    scopus 로고
    • Transcriptional regulation of the NKT cell lineage
    • Constantinides, M.G., Bendelac, A. Transcriptional regulation of the NKT cell lineage. Curr. Opin. Immunol. 25, 161-167 (2013).
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 161-167
    • Constantinides, M.G.1    Bendelac, A.2
  • 37
    • 84886673181 scopus 로고    scopus 로고
    • Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells
    • Lee, Y.J., Holzapfel, K.L., Zhu, J., Jameson, S.C., Hogquist, K.A. Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nat. Immunol. 14, 1146-1154 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1146-1154
    • Lee, Y.J.1    Holzapfel, K.L.2    Zhu, J.3    Jameson, S.C.4    Hogquist, K.A.5
  • 38
    • 83755166410 scopus 로고    scopus 로고
    • Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses
    • Chang, P.P. et al. Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. Nat. Immunol. 13, 35-43 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 35-43
    • Chang, P.P.1
  • 39
    • 79954992071 scopus 로고    scopus 로고
    • The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
    • Motomura, Y. et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12, 450-459 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 450-459
    • Motomura, Y.1
  • 40
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi, S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531-562 (2004).
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 41
    • 84864820799 scopus 로고    scopus 로고
    • IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells
    • Cheng, G. et al. IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. J. Immunol. 189, 1780-1791 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 1780-1791
    • Cheng, G.1
  • 42
    • 77956943528 scopus 로고    scopus 로고
    • Identification of regulatory Foxp3+ invariant NKT cells induced by TGF
    • Monteiro, M. et al. Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-. J. Immunol. 185, 2157-2163 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 2157-2163
    • Monteiro, M.1
  • 43
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran, A.E. et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208, 1279-1289 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1
  • 44
    • 79960419019 scopus 로고    scopus 로고
    • A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger
    • Constantinides, M.G., Picard, D., Savage, A.K., Bendelac, A. A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger. J. Immunol. 187, 309-315 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 309-315
    • Constantinides, M.G.1    Picard, D.2    Savage, A.K.3    Bendelac, A.4
  • 45
    • 84907008497 scopus 로고    scopus 로고
    • IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset
    • Sag, D., Krause, P., Hedrick, C.C., Kronenberg, M., Wingender, G. IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset. J. Clin. Invest. 124, 3725-3740 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 3725-3740
    • Sag, D.1    Krause, P.2    Hedrick, C.C.3    Kronenberg, M.4    Wingender, G.5
  • 46
    • 84889663497 scopus 로고    scopus 로고
    • Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation
    • Xu, X. et al. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab. 18, 816-830 (2013).
    • (2013) Cell Metab , vol.18 , pp. 816-830
    • Xu, X.1
  • 47
    • 84873473809 scopus 로고    scopus 로고
    • Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance
    • Wu, L., Van Kaer, L. Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance. Adipocyte 2, 12-16 (2013).
    • (2013) Adipocyte , vol.2 , pp. 12-16
    • Wu, L.1    Van Kaer, L.2
  • 48
    • 84901992453 scopus 로고    scopus 로고
    • Adipose i NKT cells
    • Lynch, L. Adipose i NKT cells. Immunology 142, 337-346 (2014).
    • (2014) Immunology , vol.142 , pp. 337-346
    • Lynch, L.1
  • 50
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    • Fontenot, J.D. et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22, 329-341 (2005).
    • (2005) Immunity , vol.22 , pp. 329-341
    • Fontenot, J.D.1
  • 51
    • 78650937547 scopus 로고    scopus 로고
    • Paired analysis of TCR and TCR chains at the single-cell level in mice
    • Dash, P. et al. Paired analysis of TCR and TCR chains at the single-cell level in mice. J. Clin. Invest. 121, 288-295 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 288-295
    • Dash, P.1
  • 52
    • 84886726570 scopus 로고    scopus 로고
    • CD1d-lipid antigen recognition by the TCR
    • Uldrich, A.P. et al. CD1d-lipid antigen recognition by the TCR. Nat. Immunol. 14, 1137-1145 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1137-1145
    • Uldrich, A.P.1


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