메뉴 건너뛰기




Volumn 85, Issue , 2016, Pages 99-110

Prospects for mTOR-mediated functional repair after central nervous system trauma

Author keywords

Axogenesis; Axon regeneration; MTOR; Myelination; Spinal cord injury

Indexed keywords

APC PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; COFILIN; DDIT4; FIBROBLAST GROWTH FACTOR 2; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; OSTEOPONTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN NOGO; PROTEIN P75; RAPAMYCIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SEMAPHORIN 3A; SHORT HAIRPIN RNA; SIRTP801; UNCLASSIFIED DRUG; TARGET OF RAPAMYCIN KINASE;

EID: 84945936988     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.10.002     Document Type: Review
Times cited : (51)

References (197)
  • 1
    • 77956239734 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves
    • Abe N., Borson S.H., Gambello M.J., Wang F., Cavalli V. Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. J. Biol. Chem. 2010, 285:28034-28043.
    • (2010) J. Biol. Chem. , vol.285 , pp. 28034-28043
    • Abe, N.1    Borson, S.H.2    Gambello, M.J.3    Wang, F.4    Cavalli, V.5
  • 3
    • 14644437069 scopus 로고    scopus 로고
    • Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A
    • Ahmed Z., Dent R.G., Suggate E.L., Barrett L.B., Seabright R.J., Berry M., Logan A. Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A. Mol. Cell. Neurosci. 2005, 28:509-523.
    • (2005) Mol. Cell. Neurosci. , vol.28 , pp. 509-523
    • Ahmed, Z.1    Dent, R.G.2    Suggate, E.L.3    Barrett, L.B.4    Seabright, R.J.5    Berry, M.6    Logan, A.7
  • 4
    • 33745113228 scopus 로고    scopus 로고
    • Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro
    • Ahmed Z., Suggate E.L., Brown E.R., Dent R.G., Armstrong S.J., Barrett L.B., Berry M., Logan A. Schwann cell-derived factor-induced modulation of the NgR/p75NTR/EGFR axis disinhibits axon growth through CNS myelin in vivo and in vitro. Brain 2006, 129:1517-1533.
    • (2006) Brain , vol.129 , pp. 1517-1533
    • Ahmed, Z.1    Suggate, E.L.2    Brown, E.R.3    Dent, R.G.4    Armstrong, S.J.5    Barrett, L.B.6    Berry, M.7    Logan, A.8
  • 5
    • 68349104302 scopus 로고    scopus 로고
    • ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors
    • Ahmed Z., Berry M., Logan A. ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors. Mol. Cell. Neurosci. 2009, 42:128-133.
    • (2009) Mol. Cell. Neurosci. , vol.42 , pp. 128-133
    • Ahmed, Z.1    Berry, M.2    Logan, A.3
  • 7
    • 77951607959 scopus 로고    scopus 로고
    • GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4
    • Alabed Y.Z., Pool M., Ong Tone S., Sutherland C., Fournier A.E. GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4. J. Neurosci. 2010, 30:5635-5643.
    • (2010) J. Neurosci. , vol.30 , pp. 5635-5643
    • Alabed, Y.Z.1    Pool, M.2    Ong Tone, S.3    Sutherland, C.4    Fournier, A.E.5
  • 8
    • 84876734646 scopus 로고    scopus 로고
    • MTOR signalling for biological control and cancer
    • Alayev A., Holz M.K. mTOR signalling for biological control and cancer. J. Cell. Physiol. 2013, 228:1658-1664.
    • (2013) J. Cell. Physiol. , vol.228 , pp. 1658-1664
    • Alayev, A.1    Holz, M.K.2
  • 9
    • 0033579163 scopus 로고    scopus 로고
    • Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity
    • Ali I.U., Schrim L.M., Dean M. Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J. Natl. Cancer Inst. 1999, 91:1922-1932.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1922-1932
    • Ali, I.U.1    Schrim, L.M.2    Dean, M.3
  • 10
    • 33746581895 scopus 로고    scopus 로고
    • Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3 beta and stimulate axonal growth
    • Arevalo M.A., Rodriguez-Tébar A. Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3 beta and stimulate axonal growth. Mol. Biol. Cell 2006, 17:3369-3377.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 3369-3377
    • Arevalo, M.A.1    Rodriguez-Tébar, A.2
  • 11
    • 12344252023 scopus 로고    scopus 로고
    • Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo
    • Arlotta P., Molyneaux B.J., Chen J., Inoue J., Kominami R., Macklis J.D. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron 2005, 45:207-221.
    • (2005) Neuron , vol.45 , pp. 207-221
    • Arlotta, P.1    Molyneaux, B.J.2    Chen, J.3    Inoue, J.4    Kominami, R.5    Macklis, J.D.6
  • 13
    • 84884691211 scopus 로고    scopus 로고
    • Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain
    • Aschauer D.F., Kreuz S., Rumpel S. Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain. PLoS One 2013, 8. 10.1371/journal.pone.0076310.eCollection 2013.
    • (2013) PLoS One , vol.8
    • Aschauer, D.F.1    Kreuz, S.2    Rumpel, S.3
  • 14
    • 79851503308 scopus 로고    scopus 로고
    • GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo
    • Azim K., Butt A.M. GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo. Glia 2011, 59:540-553.
    • (2011) Glia , vol.59 , pp. 540-553
    • Azim, K.1    Butt, A.M.2
  • 15
    • 0034307763 scopus 로고    scopus 로고
    • Live or let die - retinal ganglion cell death and survival during development and in lesioned CNS
    • Bähr M. Live or let die - retinal ganglion cell death and survival during development and in lesioned CNS. Trends Neurosci. 2000, 23:483-490.
    • (2000) Trends Neurosci. , vol.23 , pp. 483-490
    • Bähr, M.1
  • 16
    • 69049118154 scopus 로고    scopus 로고
    • Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth
    • Barros C.S., Nguyen T., Spencer K.S., Nishiyama A., Colognato H., Müller U. Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth. Development 2009, 136:2717-2724.
    • (2009) Development , vol.136 , pp. 2717-2724
    • Barros, C.S.1    Nguyen, T.2    Spencer, K.S.3    Nishiyama, A.4    Colognato, H.5    Müller, U.6
  • 17
    • 84871908441 scopus 로고    scopus 로고
    • Neuroglial pharmacology: myelination as a shared mechanism of action of psychotropic treatments
    • Bartzokis G. Neuroglial pharmacology: myelination as a shared mechanism of action of psychotropic treatments. J. Neuropharmacol. 2012, 62:2137-2153.
    • (2012) J. Neuropharmacol. , vol.62 , pp. 2137-2153
    • Bartzokis, G.1
  • 18
    • 84897840044 scopus 로고    scopus 로고
    • Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination
    • Bercury K.K., Dai J., Sachs H.H., Ahrendsen J.T., Wood T.L., Macklin W.B. Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination. J. Neurosci. 2014, 34:4466-4480.
    • (2014) J. Neurosci. , vol.34 , pp. 4466-4480
    • Bercury, K.K.1    Dai, J.2    Sachs, H.H.3    Ahrendsen, J.T.4    Wood, T.L.5    Macklin, W.B.6
  • 19
    • 0028310855 scopus 로고
    • Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats
    • Berkelaar M., Clarke D.B., Wang Y.C., Bray G.M., Aguayo A.J. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J. Neurosci. 1994, 14:4368-4374.
    • (1994) J. Neurosci. , vol.14 , pp. 4368-4374
    • Berkelaar, M.1    Clarke, D.B.2    Wang, Y.C.3    Bray, G.M.4    Aguayo, A.J.5
  • 20
    • 0029986963 scopus 로고    scopus 로고
    • Peripheral nerve implants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve
    • Berry M., Carlisle J., Hunter A. Peripheral nerve implants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve. J. Neurocytol. 1996, 25:147-170.
    • (1996) J. Neurocytol. , vol.25 , pp. 147-170
    • Berry, M.1    Carlisle, J.2    Hunter, A.3
  • 21
    • 0033301201 scopus 로고    scopus 로고
    • Optic nerve regeneration after intravitreal peripheral nerve implants: trajectories of axons regrowing through the optic chiasm into the optic tracts
    • Berry M., Carlile J., Hunter A., Tsang W., Rosenstiel P., Sievers J. Optic nerve regeneration after intravitreal peripheral nerve implants: trajectories of axons regrowing through the optic chiasm into the optic tracts. J. Neurocytol. 1999, 28:721-741.
    • (1999) J. Neurocytol. , vol.28 , pp. 721-741
    • Berry, M.1    Carlile, J.2    Hunter, A.3    Tsang, W.4    Rosenstiel, P.5    Sievers, J.6
  • 24
    • 73049105525 scopus 로고    scopus 로고
    • Remyelination - an effective means of neuroprotection
    • Bruce C.C., Zhao C., Franklin R.J. Remyelination - an effective means of neuroprotection. Horm. Behav. 2010, 57:56-62.
    • (2010) Horm. Behav. , vol.57 , pp. 56-62
    • Bruce, C.C.1    Zhao, C.2    Franklin, R.J.3
  • 25
    • 0035399823 scopus 로고    scopus 로고
    • Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate
    • Cai D., Qiu J., Cao Z., McAtee M., Bregman B.S., Filbin M.T. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J. Neurosci. 2001, 21:4731-4739.
    • (2001) J. Neurosci. , vol.21 , pp. 4731-4739
    • Cai, D.1    Qiu, J.2    Cao, Z.3    McAtee, M.4    Bregman, B.S.5    Filbin, M.T.6
  • 26
    • 84935071817 scopus 로고    scopus 로고
    • The expanding role of mTOR in cancer cell growth and proliferation
    • Cargnello M., Tcherkezian J., Roux P.P. The expanding role of mTOR in cancer cell growth and proliferation. Mutagenesis 2015, 30:169-176.
    • (2015) Mutagenesis , vol.30 , pp. 169-176
    • Cargnello, M.1    Tcherkezian, J.2    Roux, P.P.3
  • 27
    • 0027269766 scopus 로고
    • Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice
    • Carson M.J., Behringer R.R., Brinster R.L., McMorris F.A. Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice. Neuron 1993, 10:729-740.
    • (1993) Neuron , vol.10 , pp. 729-740
    • Carson, M.J.1    Behringer, R.R.2    Brinster, R.L.3    McMorris, F.A.4
  • 29
    • 34248657276 scopus 로고    scopus 로고
    • Remyelination in multiple sclerosis
    • Chari D.M. Remyelination in multiple sclerosis. Int. Rev. Neurobiol. 2007, 79:589-620.
    • (2007) Int. Rev. Neurobiol. , vol.79 , pp. 589-620
    • Chari, D.M.1
  • 30
    • 84870676088 scopus 로고    scopus 로고
    • Multifaceted effects of rapamycin on functional recovery after spinal injury in rats through autophagy promotion, anti-inflammation, and neuroprotection
    • Chen H.-C., Fong T.-H., Hsu P.-W., Chiu W.-T.C. Multifaceted effects of rapamycin on functional recovery after spinal injury in rats through autophagy promotion, anti-inflammation, and neuroprotection. J. Surg. Res. 2013, 179:E203-E210.
    • (2013) J. Surg. Res. , vol.179 , pp. E203-E210
    • Chen, H.-C.1    Fong, T.-H.2    Hsu, P.-W.3    Chiu, W.-T.C.4
  • 32
    • 20444394386 scopus 로고    scopus 로고
    • Inhibition of GSK3beta is a common event in neuroprotection by different survival factors
    • Chin P.C., Majdzadeh N., D'Mello S.R. Inhibition of GSK3beta is a common event in neuroprotection by different survival factors. Brain Res. Mol. Brain Res. 2005, 137:193-201.
    • (2005) Brain Res. Mol. Brain Res. , vol.137 , pp. 193-201
    • Chin, P.C.1    Majdzadeh, N.2    D'Mello, S.R.3
  • 33
    • 33847797307 scopus 로고    scopus 로고
    • The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection
    • Chong Z.Z., Li F., Maiese K. The pro-survival pathways of mTOR and protein kinase B target glycogen synthase kinase-3beta and nuclear factor-kappaB to foster endogenous microglial cell protection. Int. J. Mol. Med. 2007, 19:263-272.
    • (2007) Int. J. Mol. Med. , vol.19 , pp. 263-272
    • Chong, Z.Z.1    Li, F.2    Maiese, K.3
  • 34
    • 77954480424 scopus 로고    scopus 로고
    • PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons
    • Christie K.J., Webber C.A., Martinez J.A., Singh B., Zochodne D.W. PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons. J. Neurosci. 2010, 30:9306-9315.
    • (2010) J. Neurosci. , vol.30 , pp. 9306-9315
    • Christie, K.J.1    Webber, C.A.2    Martinez, J.A.3    Singh, B.4    Zochodne, D.W.5
  • 39
    • 84911390047 scopus 로고    scopus 로고
    • The injury resistant ability of melanopsin-expressing intrinsically photosensitive retinal ganglion cells
    • Cui Q., Ren C., Sollars P.J., Pickard G.E., So K.-F. The injury resistant ability of melanopsin-expressing intrinsically photosensitive retinal ganglion cells. Neuroscience 2015, 285:845-853.
    • (2015) Neuroscience , vol.285 , pp. 845-853
    • Cui, Q.1    Ren, C.2    Sollars, P.J.3    Pickard, G.E.4    So, K.-F.5
  • 40
    • 84923003519 scopus 로고    scopus 로고
    • Interaction of mTOR and Erk1/2 signalling to regulate oligodendrocyte differentiation
    • Dai J., Bercury K.K., Macklin W.B. Interaction of mTOR and Erk1/2 signalling to regulate oligodendrocyte differentiation. Glia 2014, 62:2096-2109.
    • (2014) Glia , vol.62 , pp. 2096-2109
    • Dai, J.1    Bercury, K.K.2    Macklin, W.B.3
  • 42
    • 84870523217 scopus 로고    scopus 로고
    • Combinatorial therapy stimulates long-distance regeneration, target reinnervation, and partial recovery of vision after optic nerve injury in mice
    • De Lima S., Habboub G., Benowitz L.I. Combinatorial therapy stimulates long-distance regeneration, target reinnervation, and partial recovery of vision after optic nerve injury in mice. Int. Rev. Neurobiol. 2012, 106:153-172.
    • (2012) Int. Rev. Neurobiol. , vol.106 , pp. 153-172
    • De Lima, S.1    Habboub, G.2    Benowitz, L.I.3
  • 43
    • 84888132419 scopus 로고    scopus 로고
    • The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signalling in rat and human oligodendrocyte progenitors
    • De Paula M.L., Cui Q.L., Hossain S., Antel J., Almazan G. The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signalling in rat and human oligodendrocyte progenitors. Glia 2014, 62:64-67.
    • (2014) Glia , vol.62 , pp. 64-67
    • De Paula, M.L.1    Cui, Q.L.2    Hossain, S.3    Antel, J.4    Almazan, G.5
  • 44
  • 45
    • 0141953237 scopus 로고    scopus 로고
    • Cytoskeletal dynamics and transport in growth cone motility and axon guidance
    • Dent E.W., Gertler F.B. Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron 2003, 40:209-227.
    • (2003) Neuron , vol.40 , pp. 209-227
    • Dent, E.W.1    Gertler, F.B.2
  • 46
    • 84928799060 scopus 로고    scopus 로고
    • Dendritic pathology and neurodegeneration: focus on mTOR
    • Di Polo A. Dendritic pathology and neurodegeneration: focus on mTOR. Neural Regen. Res. 2015, 10:559-561.
    • (2015) Neural Regen. Res. , vol.10 , pp. 559-561
    • Di Polo, A.1
  • 47
    • 84940467267 scopus 로고    scopus 로고
    • Regulation of mTORC1 by PI3K signalling
    • Dibble C.C., Cantley L.C. Regulation of mTORC1 by PI3K signalling. Trends Cell Biol. 2015, 10.1016/j.tcb.2015.06.002.
    • (2015) Trends Cell Biol.
    • Dibble, C.C.1    Cantley, L.C.2
  • 48
    • 84880364582 scopus 로고    scopus 로고
    • Do growth-stimulated retinal ganglion cell axons find their central targets after optic nerve injury? New insights by three-dimensional imaging of the visual pathway
    • Diekmann H., Leibinger M., Fischer D. Do growth-stimulated retinal ganglion cell axons find their central targets after optic nerve injury? New insights by three-dimensional imaging of the visual pathway. Exp. Neurol. 2013, 248:254-257.
    • (2013) Exp. Neurol. , vol.248 , pp. 254-257
    • Diekmann, H.1    Leibinger, M.2    Fischer, D.3
  • 49
    • 54049149462 scopus 로고    scopus 로고
    • Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS
    • Dill J., Wang H., Zhou F., Li S. Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS. J. Neurosci. 2008, 26:8914-8928.
    • (2008) J. Neurosci. , vol.26 , pp. 8914-8928
    • Dill, J.1    Wang, H.2    Zhou, F.3    Li, S.4
  • 50
    • 78650929230 scopus 로고    scopus 로고
    • Recent clinical trials of mTOR-targeted cancer therapies
    • Don A.S., Zheng Z.F. Recent clinical trials of mTOR-targeted cancer therapies. Rev. Recent Clin. Trials 2011, 6:24-34.
    • (2011) Rev. Recent Clin. Trials , vol.6 , pp. 24-34
    • Don, A.S.1    Zheng, Z.F.2
  • 52
    • 80053116581 scopus 로고    scopus 로고
    • The good, the bad and the ugly. Macrophages/microglia with a focus on myelin repair
    • Doring A., Yong V.W. The good, the bad and the ugly. Macrophages/microglia with a focus on myelin repair. Front. Biosci. (Schol. Ed.) 2011, 3:846-856.
    • (2011) Front. Biosci. (Schol. Ed.) , vol.3 , pp. 846-856
    • Doring, A.1    Yong, V.W.2
  • 53
    • 70350673949 scopus 로고    scopus 로고
    • Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth
    • Douglas M.R., Morrison K.C., Jacques S.J., Leadbeater W.E., Gonzalez A.M., Berry M., Logan A., Ahmed Z. Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth. Brain 2009, 132:3102-3121.
    • (2009) Brain , vol.132 , pp. 3102-3121
    • Douglas, M.R.1    Morrison, K.C.2    Jacques, S.J.3    Leadbeater, W.E.4    Gonzalez, A.M.5    Berry, M.6    Logan, A.7    Ahmed, Z.8
  • 54
    • 84936103778 scopus 로고    scopus 로고
    • Pten deletion promotes regrowth of corticospinal tract axons 1year after spinal cord injury
    • Du K., Zheng S., Zhang Q., Li S., Gao X., Wang J., Jiang L., Liu K. Pten deletion promotes regrowth of corticospinal tract axons 1year after spinal cord injury. J. Neurosci. 2015, 35:9754-9763.
    • (2015) J. Neurosci. , vol.35 , pp. 9754-9763
    • Du, K.1    Zheng, S.2    Zhang, Q.3    Li, S.4    Gao, X.5    Wang, J.6    Jiang, L.7    Liu, K.8
  • 55
    • 84925296648 scopus 로고    scopus 로고
    • Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling
    • Duan X., Qiao M., Bei F., Kim I.J., He Z., Sanes J.R. Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron 2015, 10.1016/j.neuron.2015.02.017.
    • (2015) Neuron
    • Duan, X.1    Qiao, M.2    Bei, F.3    Kim, I.J.4    He, Z.5    Sanes, J.R.6
  • 56
    • 84912528393 scopus 로고    scopus 로고
    • MTOR and autophagy: a dynamic relationship governed by nutrients and energy
    • Dunlop E.A., Tee A.R. mTOR and autophagy: a dynamic relationship governed by nutrients and energy. Semin. Cell Dev. Biol. 2014, 36:121-129.
    • (2014) Semin. Cell Dev. Biol. , vol.36 , pp. 121-129
    • Dunlop, E.A.1    Tee, A.R.2
  • 57
    • 84947867105 scopus 로고    scopus 로고
    • Role mTOR in glioblastoma
    • 01058-6, (pii: S0378-1119)
    • Duzgun Z., Eroglu Z., Avci C.B. Role mTOR in glioblastoma. Gene 2015, (15):01058-6. (pii: S0378-1119). 10.1016/j.gene.2015.08.060.
    • (2015) Gene , Issue.15
    • Duzgun, Z.1    Eroglu, Z.2    Avci, C.B.3
  • 58
    • 84926336177 scopus 로고    scopus 로고
    • Autism and the synapse: emerging mechanisms and mechanism-based therapies
    • (PMID 25695134)
    • Ebrahimi-Fakhari D., Sahin M. Autism and the synapse: emerging mechanisms and mechanism-based therapies. Curr. Opin. Neurol. 2015, (PMID 25695134).
    • (2015) Curr. Opin. Neurol.
    • Ebrahimi-Fakhari, D.1    Sahin, M.2
  • 60
    • 0037092042 scopus 로고    scopus 로고
    • An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling
    • Eickholt B.J., Walsh F.S., Doherty P. An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. J. Cell Biol. 2002, 157:211-217.
    • (2002) J. Cell Biol. , vol.157 , pp. 211-217
    • Eickholt, B.J.1    Walsh, F.S.2    Doherty, P.3
  • 61
  • 62
    • 45849106487 scopus 로고    scopus 로고
    • White matter in learning, cognition and psychiatric disorders
    • Fields R.D. White matter in learning, cognition and psychiatric disorders. Trends Neurosci. 2008, 31:361-370.
    • (2008) Trends Neurosci. , vol.31 , pp. 361-370
    • Fields, R.D.1
  • 63
    • 75749083357 scopus 로고    scopus 로고
    • What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye?
    • Fischer D. What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye?. Proc. Natl. Acad. Sci. U. S. A. 2010, 107. 10.1073/pnas.0912942107.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107
    • Fischer, D.1
  • 68
  • 70
    • 40349089504 scopus 로고    scopus 로고
    • The biology of CNS remyelination: the key to therapeutic advances
    • Franklin R.J., Kotter M.R. The biology of CNS remyelination: the key to therapeutic advances. J. Neurol. 2008, 255(Suppl. 1):19-25.
    • (2008) J. Neurol. , vol.255 , pp. 19-25
    • Franklin, R.J.1    Kotter, M.R.2
  • 75
    • 84901359464 scopus 로고    scopus 로고
    • PTEN: a master regulator of neuronal structure, function, and plasticity
    • Garcia-Junco-Clemente P., Golshani P. PTEN: a master regulator of neuronal structure, function, and plasticity. Commun. Integr. Biol. 2014, 7. 10.4161/cib.28358.
    • (2014) Commun. Integr. Biol. , vol.7
    • Garcia-Junco-Clemente, P.1    Golshani, P.2
  • 76
    • 84895730111 scopus 로고    scopus 로고
    • Myelin-associated inhibitors in axonal growth after CNS injury
    • Geoffroy C.G., Zheng B. Myelin-associated inhibitors in axonal growth after CNS injury. Curr. Opin. Neurobiol. 2014, 27:31-38.
    • (2014) Curr. Opin. Neurobiol. , vol.27 , pp. 31-38
    • Geoffroy, C.G.1    Zheng, B.2
  • 78
    • 84883040773 scopus 로고    scopus 로고
    • Transduction of the central nervous system after intracerebroventricular injection of adeno-associated viral vectors in neonatal and juvenile mice
    • Gholizadeh S., Tharmalingam S., MacAldaz M.E., Hampson D.R. Transduction of the central nervous system after intracerebroventricular injection of adeno-associated viral vectors in neonatal and juvenile mice. Hum. Gene Ther. Methods 2013, 24:205-213.
    • (2013) Hum. Gene Ther. Methods , vol.24 , pp. 205-213
    • Gholizadeh, S.1    Tharmalingam, S.2    MacAldaz, M.E.3    Hampson, D.R.4
  • 79
    • 84905511058 scopus 로고    scopus 로고
    • Sustained GSK3 activity markedly facilitates nerve regeneration
    • Gobrecht P., Leibinger M., Andreadaki A., Fischer D. Sustained GSK3 activity markedly facilitates nerve regeneration. Nat. Commun. 2014, 5. 10.1038/ncomms5561190.
    • (2014) Nat. Commun. , vol.5
    • Gobrecht, P.1    Leibinger, M.2    Andreadaki, A.3    Fischer, D.4
  • 81
    • 8744251609 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3β and the regulation of axon growth
    • Goold R.G., Gordon-Weeks P.R. Glycogen synthase kinase 3β and the regulation of axon growth. Biochem. Soc. Trans. 2004, 32:809-811.
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 809-811
    • Goold, R.G.1    Gordon-Weeks, P.R.2
  • 82
    • 84885113592 scopus 로고    scopus 로고
    • Small interfering RNAs (siRNAs) as a promising tool for ocular therapy
    • Guzman-Aranguez A., Loma P., Pintor J. Small interfering RNAs (siRNAs) as a promising tool for ocular therapy. Br. J. Pharmacol. 2013, 170:730-747.
    • (2013) Br. J. Pharmacol. , vol.170 , pp. 730-747
    • Guzman-Aranguez, A.1    Loma, P.2    Pintor, J.3
  • 84
    • 0036395051 scopus 로고    scopus 로고
    • Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats: a comparison with lentiviral vectors
    • Harvey A.R., Kamphuis W., Eggers R., Symons N.A., Blits B., Niclou S., Boer G.J., Verhaagen J. Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats: a comparison with lentiviral vectors. Mol. Cell. Neurosci. 2002, 21:141-157.
    • (2002) Mol. Cell. Neurosci. , vol.21 , pp. 141-157
    • Harvey, A.R.1    Kamphuis, W.2    Eggers, R.3    Symons, N.A.4    Blits, B.5    Niclou, S.6    Boer, G.J.7    Verhaagen, J.8
  • 85
    • 84870512887 scopus 로고    scopus 로고
    • Neurotrophic factors and the regeneration of adult retinal ganglion cell axons
    • Harvey A.R., Ooi J.W.W., Rodger J. Neurotrophic factors and the regeneration of adult retinal ganglion cell axons. Int. Rev. Neurobiol. 2012, 106:1-33.
    • (2012) Int. Rev. Neurobiol. , vol.106 , pp. 1-33
    • Harvey, A.R.1    Ooi, J.W.W.2    Rodger, J.3
  • 86
  • 88
    • 24944480788 scopus 로고    scopus 로고
    • The Akt/mTOR tango and its relevance to cancer
    • Hay N. The Akt/mTOR tango and its relevance to cancer. Cancer Cell 2005, 8:179-183.
    • (2005) Cancer Cell , vol.8 , pp. 179-183
    • Hay, N.1
  • 89
    • 78449305614 scopus 로고    scopus 로고
    • Intrinsic control of axon growth
    • He Z. Intrinsic control of axon growth. J. Biomed. Res. 2010, 24:2-5.
    • (2010) J. Biomed. Res. , vol.24 , pp. 2-5
    • He, Z.1
  • 91
    • 84907626815 scopus 로고    scopus 로고
    • The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
    • Heras-Sandoval D., Pérez-Rojas J.M., Hernández-Damián J., Pedraza-Chaverri J. The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell. Signal. 2014, 26:2694-2701.
    • (2014) Cell. Signal. , vol.26 , pp. 2694-2701
    • Heras-Sandoval, D.1    Pérez-Rojas, J.M.2    Hernández-Damián, J.3    Pedraza-Chaverri, J.4
  • 92
    • 75749114797 scopus 로고    scopus 로고
    • MTOR signalling: at the crossroads of plasticity, memory and disease
    • Hoeffer C.A., Klann E. mTOR signalling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 2009, 10.1016/j.tins.2009.11.003.
    • (2009) Trends Neurosci.
    • Hoeffer, C.A.1    Klann, E.2
  • 93
    • 77954874401 scopus 로고    scopus 로고
    • GSK3 signalling in neural development
    • Hur E.M., Zhou F.Q. GSK3 signalling in neural development. Nat Rev Neurosci. 2010, 11:539-551.
    • (2010) Nat Rev Neurosci. , vol.11 , pp. 539-551
    • Hur, E.M.1    Zhou, F.Q.2
  • 94
    • 40849084993 scopus 로고    scopus 로고
    • Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats
    • Ichikawa M., Yoshida J., Saito K., Sagawa H., Tokita Y., Watanabe M. Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats. Brain Res. 2008, 1201:23-33.
    • (2008) Brain Res. , vol.1201 , pp. 23-33
    • Ichikawa, M.1    Yoshida, J.2    Saito, K.3    Sagawa, H.4    Tokita, Y.5    Watanabe, M.6
  • 95
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • Inoki K., Corradetti M.N., Guan K.L. Dysregulation of the TSC-mTOR pathway in human disease. Nat. Genet. 2005, 37:19-24.
    • (2005) Nat. Genet. , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 96
    • 33745603987 scopus 로고    scopus 로고
    • Seama4D/plexin-B1 activates GSK-3beta through R-Ras Gap activity, inducing growth cone collapse
    • Ito Y., Oinuma I., Katoh H., Kaibuchi K., Negishi M. Seama4D/plexin-B1 activates GSK-3beta through R-Ras Gap activity, inducing growth cone collapse. EMBO Rep. 2006, 7:704-709.
    • (2006) EMBO Rep. , vol.7 , pp. 704-709
    • Ito, Y.1    Oinuma, I.2    Katoh, H.3    Kaibuchi, K.4    Negishi, M.5
  • 97
    • 0036116879 scopus 로고    scopus 로고
    • Remyelination within the CNS: do Schwann cells pave the way for oligodendrocytes?
    • Jasmin L., Ohara P.T. Remyelination within the CNS: do Schwann cells pave the way for oligodendrocytes?. Neuroscientist 2002, 8:198-203.
    • (2002) Neuroscientist , vol.8 , pp. 198-203
    • Jasmin, L.1    Ohara, P.T.2
  • 99
    • 0342927484 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 protects axotomised rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 in vivo
    • Kermer P., Klöcker N., Labes M., Bähr M. Insulin-like growth factor-1 protects axotomised rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 in vivo. J. Neurosci. 2000, 20:722-728.
    • (2000) J. Neurosci. , vol.20 , pp. 722-728
    • Kermer, P.1    Klöcker, N.2    Labes, M.3    Bähr, M.4
  • 101
    • 1642416335 scopus 로고    scopus 로고
    • Growth cone guidance cues for regenerating axons: where have they gone?
    • Koeberle P.D., Bähr M. Growth cone guidance cues for regenerating axons: where have they gone?. J. Neurobiol. 2004, 59:162-180.
    • (2004) J. Neurobiol. , vol.59 , pp. 162-180
    • Koeberle, P.D.1    Bähr, M.2
  • 102
    • 84878119767 scopus 로고    scopus 로고
    • Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signalling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis
    • Kumar S., Patel R., Moore S., Crawford D.K., Suwanna N., Mangiardi M., Tiwari-Woodruff S.K. Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signalling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis. Neurobiol. Dis. 2013, 56:131-144.
    • (2013) Neurobiol. Dis. , vol.56 , pp. 131-144
    • Kumar, S.1    Patel, R.2    Moore, S.3    Crawford, D.K.4    Suwanna, N.5    Mangiardi, M.6    Tiwari-Woodruff, S.K.7
  • 103
    • 78449235139 scopus 로고    scopus 로고
    • Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion
    • Kurimoto T., Yin Y., Omura K., Gilbert H.Y., Kim D., Cen L.P., Moko L., Kügler S., Benowitz L.I. Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion. J. Neurosci. 2010, 30:15654-15663.
    • (2010) J. Neurosci. , vol.30 , pp. 15654-15663
    • Kurimoto, T.1    Yin, Y.2    Omura, K.3    Gilbert, H.Y.4    Kim, D.5    Cen, L.P.6    Moko, L.7    Kügler, S.8    Benowitz, L.I.9
  • 105
    • 70350418625 scopus 로고    scopus 로고
    • MTOR signalling at a glance
    • Laplante M., Sabatini D.M. mTOR signalling at a glance. J. Cell Sci. 2009, 122:3589-3594.
    • (2009) J. Cell Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 108
    • 84909951876 scopus 로고    scopus 로고
    • Mammalian target of Rapamycin's distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS
    • Lee D.-H., Luo X., Yungher B.J., Bray E., Lee J.K., Park K.K. Mammalian target of Rapamycin's distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS. J. Neurosci. 2014, 34:15347-15355.
    • (2014) J. Neurosci. , vol.34 , pp. 15347-15355
    • Lee, D.-H.1    Luo, X.2    Yungher, B.J.3    Bray, E.4    Lee, J.K.5    Park, K.K.6
  • 109
    • 70449640540 scopus 로고    scopus 로고
    • Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukaemia inhibitory factor
    • Leibinger M., Müller A., Andreadaki A., Hauk T.G., Kirsch M., Fischer D. Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukaemia inhibitory factor. J. Neurosci. 2009, 29:14334-14341.
    • (2009) J. Neurosci. , vol.29 , pp. 14334-14341
    • Leibinger, M.1    Müller, A.2    Andreadaki, A.3    Hauk, T.G.4    Kirsch, M.5    Fischer, D.6
  • 110
    • 84859494283 scopus 로고    scopus 로고
    • Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation
    • Leibinger M., Andreadaki A., Fischer D. Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation. Neurobiol. Dis. 2012, 46:314-324.
    • (2012) Neurobiol. Dis. , vol.46 , pp. 314-324
    • Leibinger, M.1    Andreadaki, A.2    Fischer, D.3
  • 111
    • 0034659957 scopus 로고    scopus 로고
    • Lens injury stimulates axon regeneration in the mature rat optic nerve
    • Leon S., Yin Y., Nguyen J., Irwin N., Benowitz L.I. Lens injury stimulates axon regeneration in the mature rat optic nerve. J. Neurosci. 2000, 20:4615-4626.
    • (2000) J. Neurosci. , vol.20 , pp. 4615-4626
    • Leon, S.1    Yin, Y.2    Nguyen, J.3    Irwin, N.4    Benowitz, L.I.5
  • 113
  • 115
    • 84926140580 scopus 로고    scopus 로고
    • Inhibition of mTOR pathway restrains astrocyte proliferation, migration and production of inflammatory mediators after oxygen-glucose deprivation and reoxygenation
    • Li C.Y., Li X., Liu S.F., Qu W.S., Wang W., Tian D.S. Inhibition of mTOR pathway restrains astrocyte proliferation, migration and production of inflammatory mediators after oxygen-glucose deprivation and reoxygenation. Neurochem. Int. 2015, 10.1016/j.neuint.2015.03.001.
    • (2015) Neurochem. Int.
    • Li, C.Y.1    Li, X.2    Liu, S.F.3    Qu, W.S.4    Wang, W.5    Tian, D.S.6
  • 116
    • 34548638861 scopus 로고    scopus 로고
    • Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo
    • Lingor P., Teusch N., Schwarz K., Mueller R., Mack H., Bähr M., Mueller B.K. Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo. J. Neurochem. 2007, 103:181-189.
    • (2007) J. Neurochem. , vol.103 , pp. 181-189
    • Lingor, P.1    Teusch, N.2    Schwarz, K.3    Mueller, R.4    Mack, H.5    Bähr, M.6    Mueller, B.K.7
  • 117
    • 37549015155 scopus 로고    scopus 로고
    • ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells
    • Lingor P., Tönges L., Pieper N., Bermel C., Barski E., Planchamp V., Bähr M. ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells. Brain 2008, 131:250-263.
    • (2008) Brain , vol.131 , pp. 250-263
    • Lingor, P.1    Tönges, L.2    Pieper, N.3    Bermel, C.4    Barski, E.5    Planchamp, V.6    Bähr, M.7
  • 118
    • 33746068303 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after injury
    • Liu B., Chen H., Johns T.G., Neufeld A.H. Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after injury. J. Neurosci. 2006, 26:7532-7540.
    • (2006) J. Neurosci. , vol.26 , pp. 7532-7540
    • Liu, B.1    Chen, H.2    Johns, T.G.3    Neufeld, A.H.4
  • 120
    • 79959897174 scopus 로고    scopus 로고
    • Neuronal intrinsic mechanisms of axon regeneration
    • Liu K., Tedeschi A., Park K.K., He Z. Neuronal intrinsic mechanisms of axon regeneration. Annu. Rev. Neurosci. 2011, 34:131-152.
    • (2011) Annu. Rev. Neurosci. , vol.34 , pp. 131-152
    • Liu, K.1    Tedeschi, A.2    Park, K.K.3    He, Z.4
  • 121
    • 84856767925 scopus 로고    scopus 로고
    • Coordinating gene expression and axon assembly to control growth: potential role of GSK3 signaling
    • Liu C.-M., Hur E.-M., Zhou F.-Q. Coordinating gene expression and axon assembly to control growth: potential role of GSK3 signaling. Front. Mol. Neurosci. 2012, 5:1-11.
    • (2012) Front. Mol. Neurosci. , vol.5 , pp. 1-11
    • Liu, C.-M.1    Hur, E.-M.2    Zhou, F.-Q.3
  • 122
    • 84879134946 scopus 로고    scopus 로고
    • Inhibiting PTEN protects hippocampal neurons against stretch injury by decreasing membrane translocation of AMPA receptor GluR subunit
    • Liu Y., Wang L., Long Z., Wu Y., Wan Q., Jiang J., Wang Z. Inhibiting PTEN protects hippocampal neurons against stretch injury by decreasing membrane translocation of AMPA receptor GluR subunit. PLoS One 2013, 8.
    • (2013) PLoS One , vol.8
    • Liu, Y.1    Wang, L.2    Long, Z.3    Wu, Y.4    Wan, Q.5    Jiang, J.6    Wang, Z.7
  • 125
    • 84897948734 scopus 로고    scopus 로고
    • Signalling regulations of neuronal regenerative ability
    • Lu Y., Belin S., He Z. Signalling regulations of neuronal regenerative ability. Curr. Opin. Neurobiol. 2014, 27:135-142.
    • (2014) Curr. Opin. Neurobiol. , vol.27 , pp. 135-142
    • Lu, Y.1    Belin, S.2    He, Z.3
  • 127
    • 84881372849 scopus 로고    scopus 로고
    • Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury
    • Luo X., Salgueiro Y., Beckerman S.R., Lemmon V.P., Tsoulfas P., Park K.K. Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury. Exp. Neurol. 2013, 247:653-662.
    • (2013) Exp. Neurol. , vol.247 , pp. 653-662
    • Luo, X.1    Salgueiro, Y.2    Beckerman, S.R.3    Lemmon, V.P.4    Tsoulfas, P.5    Park, K.K.6
  • 129
    • 84907145182 scopus 로고    scopus 로고
    • Driving neural regeneration through the mammalian target of rapamycin
    • Maiese K. Driving neural regeneration through the mammalian target of rapamycin. Neural Regen. Res. 2014, 9:1413-1417.
    • (2014) Neural Regen. Res. , vol.9 , pp. 1413-1417
    • Maiese, K.1
  • 130
    • 84871721552 scopus 로고    scopus 로고
    • MTOR: on target for novel therapeutic strategies in the nervous system
    • Maiese K., Chong Z.Z., Shang Y.C., Wang S. mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol. Med. 2013, 19:51-60.
    • (2013) Trends Mol. Med. , vol.19 , pp. 51-60
    • Maiese, K.1    Chong, Z.Z.2    Shang, Y.C.3    Wang, S.4
  • 131
    • 84925115538 scopus 로고    scopus 로고
    • Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms
    • Marcos S., Nieto-Lopez F., Sandonìs A., Cardozo M.J., Di Marco F., Esteve P., Bovolenta P. Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms. J. Neurosci. 2015, 35:4729-4740.
    • (2015) J. Neurosci. , vol.35 , pp. 4729-4740
    • Marcos, S.1    Nieto-Lopez, F.2    Sandonìs, A.3    Cardozo, M.J.4    Di Marco, F.5    Esteve, P.6    Bovolenta, P.7
  • 132
    • 84907727475 scopus 로고    scopus 로고
    • Paracrine-mediated neuroprotection and neuritogenesis of axotomised retinal ganglion cells by human dental pulp stem cells: comparison with human bone marrow and adipose-derived mesenchymal stem cells
    • Mead B., Logan A., Berry M., Leadbeater W., Scheven B.A. Paracrine-mediated neuroprotection and neuritogenesis of axotomised retinal ganglion cells by human dental pulp stem cells: comparison with human bone marrow and adipose-derived mesenchymal stem cells. PLoS One 2014, 9. 10.1371/journal.pone.0109305.
    • (2014) PLoS One , vol.9
    • Mead, B.1    Logan, A.2    Berry, M.3    Leadbeater, W.4    Scheven, B.A.5
  • 133
    • 4344619713 scopus 로고    scopus 로고
    • Pharmacological inhibitors of glycogen synthase kinase 3
    • Meijer L., Flajolet M., Greengard P. Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol. Sci. 2004, 25:471-480.
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 471-480
    • Meijer, L.1    Flajolet, M.2    Greengard, P.3
  • 138
    • 22144482065 scopus 로고    scopus 로고
    • Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system
    • Morimoto T., Miyoshi T., Matsuda S., Tano Y., Fujikado T., Fukuda Y. Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system. Invest. Ophthalmol. Vis. Sci. 2005, 46:2147-2155.
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 2147-2155
    • Morimoto, T.1    Miyoshi, T.2    Matsuda, S.3    Tano, Y.4    Fujikado, T.5    Fukuda, Y.6
  • 140
    • 36749004288 scopus 로고    scopus 로고
    • Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation
    • Müller A., Hauk T.G., Fischer D. Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation. Brain 2007, 130:3308-3320.
    • (2007) Brain , vol.130 , pp. 3308-3320
    • Müller, A.1    Hauk, T.G.2    Fischer, D.3
  • 141
    • 67349139928 scopus 로고    scopus 로고
    • Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF
    • Müller A., Hauk T.G., Leibinger M., Marienfeld R., Fischer D. Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF. Mol. Cell. Neurosci. 2009, 41:233-246.
    • (2009) Mol. Cell. Neurosci. , vol.41 , pp. 233-246
    • Müller, A.1    Hauk, T.G.2    Leibinger, M.3    Marienfeld, R.4    Fischer, D.5
  • 142
    • 0034462121 scopus 로고    scopus 로고
    • Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
    • Nakamura N., Ramaswamy S., Vazquez F., Signoretti S., Loda M., Sellers W. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol. Cell. Biol. 2000, 20:8969-8982.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8969-8982
    • Nakamura, N.1    Ramaswamy, S.2    Vazquez, F.3    Signoretti, S.4    Loda, M.5    Sellers, W.6
  • 143
    • 84937019661 scopus 로고    scopus 로고
    • Regulation of mTOR signalling by semaphorin 3F-Neuropilin 2 interactions in vitro and in vivo
    • Nakayama H., Bruneau S., Kochupurakkal N., Coma S., Briscoe D.M., Klagsbrun M. Regulation of mTOR signalling by semaphorin 3F-Neuropilin 2 interactions in vitro and in vivo. Sci. Rep. 2015, 5:11789. 10.1038/srep11789.
    • (2015) Sci. Rep. , vol.5 , pp. 11789
    • Nakayama, H.1    Bruneau, S.2    Kochupurakkal, N.3    Coma, S.4    Briscoe, D.M.5    Klagsbrun, M.6
  • 144
    • 66149190566 scopus 로고    scopus 로고
    • Akt signals through the mammalian target of rapamycin, mTOR, pathway to regulate central nervous system myelination
    • Narayanan S.P., Flores A.I., Wang F., Macklin W.B. Akt signals through the mammalian target of rapamycin, mTOR, pathway to regulate central nervous system myelination. J. Neurosci. 2009, 29:6860-6870.
    • (2009) J. Neurosci. , vol.29 , pp. 6860-6870
    • Narayanan, S.P.1    Flores, A.I.2    Wang, F.3    Macklin, W.B.4
  • 147
    • 84880542981 scopus 로고    scopus 로고
    • Akt/mTOR signalling in myelination
    • Normén C., Suter U. Akt/mTOR signalling in myelination. Biochem. Soc. Trans. 2013, 41:944-950.
    • (2013) Biochem. Soc. Trans. , vol.41 , pp. 944-950
    • Normén, C.1    Suter, U.2
  • 148
    • 84879026548 scopus 로고    scopus 로고
    • PI3-kinase/Akt/mTOR signalling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease
    • O'Neil C. PI3-kinase/Akt/mTOR signalling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease. Exp. Gerontol. 2013, 48:647-653.
    • (2013) Exp. Gerontol. , vol.48 , pp. 647-653
    • O'Neil, C.1
  • 149
    • 10044292873 scopus 로고    scopus 로고
    • Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells
    • Park K., Luo J.M., Hisheh S., Harvey A.R., Cui Q. Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J. Neurosci. 2004, 24:1086-10815.
    • (2004) J. Neurosci. , vol.24 , pp. 1086-10815
    • Park, K.1    Luo, J.M.2    Hisheh, S.3    Harvey, A.R.4    Cui, Q.5
  • 152
    • 81755179427 scopus 로고    scopus 로고
    • Mediators of oligodendrocyte differentiation during remyelination
    • Patel J.R., Klein R.S. Mediators of oligodendrocyte differentiation during remyelination. FEBS Lett. 2011, 585:3730-3737.
    • (2011) FEBS Lett. , vol.585 , pp. 3730-3737
    • Patel, J.R.1    Klein, R.S.2
  • 153
    • 79951772197 scopus 로고    scopus 로고
    • New perspectives in cyclic AMP-mediated axon growth and guidance: the emerging epoch of Epac
    • Peace A.G., Shewan D.A. New perspectives in cyclic AMP-mediated axon growth and guidance: the emerging epoch of Epac. Brain Res. Bull. 2011, 84:280-288.
    • (2011) Brain Res. Bull. , vol.84 , pp. 280-288
    • Peace, A.G.1    Shewan, D.A.2
  • 154
    • 78650905544 scopus 로고    scopus 로고
    • A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons
    • Perdigolo A.L., Chaudhry N., Barnes G.N., Filbin M.T., Carter B.D. A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Mol. Cell. Neurosci. 2011, 46:235-244.
    • (2011) Mol. Cell. Neurosci. , vol.46 , pp. 235-244
    • Perdigolo, A.L.1    Chaudhry, N.2    Barnes, G.N.3    Filbin, M.T.4    Carter, B.D.5
  • 155
    • 84903549488 scopus 로고    scopus 로고
    • Lost in the jungle: new hurdles for optic nerve axon regeneration
    • Pernet V., Schwab M.E. Lost in the jungle: new hurdles for optic nerve axon regeneration. Trends Neurosci. 2014, 37:381-387.
    • (2014) Trends Neurosci. , vol.37 , pp. 381-387
    • Pernet, V.1    Schwab, M.E.2
  • 157
    • 84872820097 scopus 로고    scopus 로고
    • Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve
    • Pernet V., Joly S., Dalkara D., Jordi N., Schwarz O., Christ F., Schaffer D.V., Flannery J.G., Schwab M.E. Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve. Neurobiol. Dis. 2013, 51:202-213.
    • (2013) Neurobiol. Dis. , vol.51 , pp. 202-213
    • Pernet, V.1    Joly, S.2    Dalkara, D.3    Jordi, N.4    Schwarz, O.5    Christ, F.6    Schaffer, D.V.7    Flannery, J.G.8    Schwab, M.E.9
  • 158
  • 159
    • 0035949704 scopus 로고    scopus 로고
    • Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo
    • Pfeifer A., Brandon E.P., Kootstra N., Gage F.H., Verma I.M. Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:11450-11455.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 11450-11455
    • Pfeifer, A.1    Brandon, E.P.2    Kootstra, N.3    Gage, F.H.4    Verma, I.M.5
  • 162
    • 84892437005 scopus 로고    scopus 로고
    • PI3K-GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1
    • Saijilafu H.E.M., Liu C.M., Jiao Z., Xu W.L., Zhou F.Q. PI3K-GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1. Nat. Commun. 2013, 4:2690. 10.1038/ncomms3690.
    • (2013) Nat. Commun. , vol.4 , pp. 2690
    • Saijilafu, H.E.M.1    Liu, C.M.2    Jiao, Z.3    Xu, W.L.4    Zhou, F.Q.5
  • 163
    • 2442693021 scopus 로고    scopus 로고
    • Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration
    • Sandvig A., Berry M., Barrett L.B., Butt A., Logan A. Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration. Glia 2004, 46:225-251.
    • (2004) Glia , vol.46 , pp. 225-251
    • Sandvig, A.1    Berry, M.2    Barrett, L.B.3    Butt, A.4    Logan, A.5
  • 165
    • 80755181329 scopus 로고    scopus 로고
    • Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function
    • Schmidt T.M., Do M.T., Dacey D., Lucas R., Hattar S., Matynia A. Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function. J. Neurosci. 2011, 31:16094-16101.
    • (2011) J. Neurosci. , vol.31 , pp. 16094-16101
    • Schmidt, T.M.1    Do, M.T.2    Dacey, D.3    Lucas, R.4    Hattar, S.5    Matynia, A.6
  • 166
    • 84901050603 scopus 로고    scopus 로고
    • A role for melanopsin in alpha retinal ganglion cells and contrast detection
    • Schmidt T.M., Alam N.M., Chen K.P., Li W., Prusky G.T., Hattar S. A role for melanopsin in alpha retinal ganglion cells and contrast detection. Neuron 2014, 10.1016/j.neuron.2014.03.022.
    • (2014) Neuron
    • Schmidt, T.M.1    Alam, N.M.2    Chen, K.P.3    Li, W.4    Prusky, G.T.5    Hattar, S.6
  • 167
    • 81055157540 scopus 로고    scopus 로고
    • GSK-3β activation mediates Nogo-66-induced inhibition of neurite outgrowth in N2a cells
    • Shen J.W., Yi X.X., Xiong N.X., Wang H.J., Duan X.V.V., Zhao H.Y. GSK-3β activation mediates Nogo-66-induced inhibition of neurite outgrowth in N2a cells. Neurosci. Lett. 2011, 505:165-170.
    • (2011) Neurosci. Lett. , vol.505 , pp. 165-170
    • Shen, J.W.1    Yi, X.X.2    Xiong, N.X.3    Wang, H.J.4    Duan, X.V.V.5    Zhao, H.Y.6
  • 168
    • 0036785879 scopus 로고    scopus 로고
    • Age-related changes under-lie switch in netrin-1 responsiveness as growth cones advance along visual pathway
    • Shewan D., Dwivedy A., Anderson R., Holt C.E. Age-related changes under-lie switch in netrin-1 responsiveness as growth cones advance along visual pathway. Nat. Neurosci. 2002, 5:955-962.
    • (2002) Nat. Neurosci. , vol.5 , pp. 955-962
    • Shewan, D.1    Dwivedy, A.2    Anderson, R.3    Holt, C.E.4
  • 169
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glia scar
    • Silver J., Miller J.H. Regeneration beyond the glia scar. Nat. Rev. Neurosci. 2004, 5:146-156.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 170
    • 70449678738 scopus 로고    scopus 로고
    • Molecular dissection of reactive astrogliosis and glial scar formation
    • Sofroniew M.V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009, 32:638-647.
    • (2009) Trends Neurosci. , vol.32 , pp. 638-647
    • Sofroniew, M.V.1
  • 173
    • 0141615075 scopus 로고    scopus 로고
    • Targeting conditional gene modification into the serotonin neurons of the dorsal raphe nucleus by viral delivery of the Cre recombinase
    • Thévenot E., Côté F., Colin P., He Y., Leblois H., Perricaudet M., Mallet J., Vodjdani G. Targeting conditional gene modification into the serotonin neurons of the dorsal raphe nucleus by viral delivery of the Cre recombinase. Mol. Cell. Neurosci. 2003, 24:139-147.
    • (2003) Mol. Cell. Neurosci. , vol.24 , pp. 139-147
    • Thévenot, E.1    Côté, F.2    Colin, P.3    He, Y.4    Leblois, H.5    Perricaudet, M.6    Mallet, J.7    Vodjdani, G.8
  • 174
    • 0036829006 scopus 로고    scopus 로고
    • Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches
    • Thoenen H., Sendtner M. Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches. Nat. Neurosci. 2002, 5:1046-1050. (Suppl).
    • (2002) Nat. Neurosci. , vol.5 , pp. 1046-1050
    • Thoenen, H.1    Sendtner, M.2
  • 175
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of Rapamycin (mTOR) for health and diseases
    • Tsang C.K., Qi H., Liu L.F., Sheng X.F.S. Targeting mammalian target of Rapamycin (mTOR) for health and diseases. Drug Discov. Today 2007, 12:113-124.
    • (2007) Drug Discov. Today , vol.12 , pp. 113-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Sheng, X.F.S.4
  • 176
    • 66049119030 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation
    • Tyler W.A., Gangoli N., Gokina P., Kim H.A., Covey M., Levison S.W., Wood T.L. Activation of mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J. Neurosci. 2009, 29:6367-6378.
    • (2009) J. Neurosci. , vol.29 , pp. 6367-6378
    • Tyler, W.A.1    Gangoli, N.2    Gokina, P.3    Kim, H.A.4    Covey, M.5    Levison, S.W.6    Wood, T.L.7
  • 177
  • 179
    • 84901452070 scopus 로고    scopus 로고
    • Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling
    • Vigneswara V., Akpan N., Berry M., Logan A., Troy C.M., Ahmed Z. Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling. Brain 2014, 137:1656-1675.
    • (2014) Brain , vol.137 , pp. 1656-1675
    • Vigneswara, V.1    Akpan, N.2    Berry, M.3    Logan, A.4    Troy, C.M.5    Ahmed, Z.6
  • 180
    • 84897826499 scopus 로고    scopus 로고
    • Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of myelination
    • Wahl S.E., McLane L.E., Bercury K.K., Macklin W.B., Wood T.L. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of myelination. J. Neurosci. 2014, 34:4453-4465.
    • (2014) J. Neurosci. , vol.34 , pp. 4453-4465
    • Wahl, S.E.1    McLane, L.E.2    Bercury, K.K.3    Macklin, W.B.4    Wood, T.L.5
  • 181
    • 0035853114 scopus 로고    scopus 로고
    • Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury
    • Weidner N., Ner A., Salimi N., Tuszynski M.H. Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:3513-3518.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 3513-3518
    • Weidner, N.1    Ner, A.2    Salimi, N.3    Tuszynski, M.H.4
  • 182
    • 84921522339 scopus 로고    scopus 로고
    • Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive
    • Williams M.R., DeSpenza T., Li M., Gulledge A.T., Luikart B.W. Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive. J. Neurosci. 2015, 35:943-959.
    • (2015) J. Neurosci. , vol.35 , pp. 943-959
    • Williams, M.R.1    DeSpenza, T.2    Li, M.3    Gulledge, A.T.4    Luikart, B.W.5
  • 184
    • 84876783653 scopus 로고    scopus 로고
    • MTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development
    • Wood T.L., Bercury K.K., Cifelli S.E., Mursch L.E., Min J., Dai J., Macklin W.B. mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development. ASN Neuro 2013, 10.1042/AN20120092.
    • (2013) ASN Neuro
    • Wood, T.L.1    Bercury, K.K.2    Cifelli, S.E.3    Mursch, L.E.4    Min, J.5    Dai, J.6    Macklin, W.B.7
  • 185
    • 84938767959 scopus 로고    scopus 로고
    • Expressing constitutively active Rheb in adult neurons after a complete spinal cord injury enhances axonal regeneration beyond a chondroitinase-treated glial scar
    • Wu D., Klaw M.C., Connors T., Kholodilov N., Burke R.E., Tom V.J. Expressing constitutively active Rheb in adult neurons after a complete spinal cord injury enhances axonal regeneration beyond a chondroitinase-treated glial scar. J. Neurosci. 2015, 35:11068-11080. 10.1523/JNEUROSCI.0719-15.2015.
    • (2015) J. Neurosci. , vol.35 , pp. 11068-11080
    • Wu, D.1    Klaw, M.C.2    Connors, T.3    Kholodilov, N.4    Burke, R.E.5    Tom, V.J.6
  • 186
    • 32044465506 scopus 로고    scopus 로고
    • TOR signalling in growth and metabolism
    • Wullschleger S., Loewith R., Hall M.N. TOR signalling in growth and metabolism. Cell 2006, 124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 187
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signalling
    • Yang Q., Guan K.-L. Expanding mTOR signalling. Cell Res. 2007, 17:666-681.
    • (2007) Cell Res. , vol.17 , pp. 666-681
    • Yang, Q.1    Guan, K.-L.2
  • 188
    • 84945941485 scopus 로고    scopus 로고
    • Sensorimotor cortex injection of adeno-associated viral vector mediates knockout of PTEN in neurons of the brain and spinal cord of mice
    • Yang P., Qin Y., Zhang W., Bian Z., Wang R. Sensorimotor cortex injection of adeno-associated viral vector mediates knockout of PTEN in neurons of the brain and spinal cord of mice. J. Mol. Neurosci. 2015, 10.1007/s1203.015-0610-x.
    • (2015) J. Mol. Neurosci.
    • Yang, P.1    Qin, Y.2    Zhang, W.3    Bian, Z.4    Wang, R.5
  • 190
    • 84943457295 scopus 로고    scopus 로고
    • Viral vector based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target
    • Yungher B.J., Luo X., Salgueiro Y., Blackmore M.G., Park K.K. Viral vector based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target. Gene Ther. 2015, 10.1038/gt.2015.51.
    • (2015) Gene Ther.
    • Yungher, B.J.1    Luo, X.2    Salgueiro, Y.3    Blackmore, M.G.4    Park, K.K.5
  • 192
    • 17644415297 scopus 로고    scopus 로고
    • GSK-3β and microtubular assembly in axons
    • Zhou F.-Q., Snider W.D. GSK-3β and microtubular assembly in axons. Science 2005, 308:211-214.
    • (2005) Science , vol.308 , pp. 211-214
    • Zhou, F.-Q.1    Snider, W.D.2
  • 193
    • 2942735115 scopus 로고    scopus 로고
    • NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC
    • Zhou F.Q., Zhou J., Dedhar S., Wu Y.H., Snider W.D. NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron 2004, 42:897-912.
    • (2004) Neuron , vol.42 , pp. 897-912
    • Zhou, F.Q.1    Zhou, J.2    Dedhar, S.3    Wu, Y.H.4    Snider, W.D.5
  • 195
    • 84937683329 scopus 로고    scopus 로고
    • Gene silencing screen for mammalian axon regeneration identifies Inpp5f (Sac2) as an endogenous suppressor of repair after spinal cord injury
    • Zou Y., Stagi M., Wang X., Yigitkanli K., Siegel C.S., Nakatsu F., Cafferty W.B., Stritttmatter S. Gene silencing screen for mammalian axon regeneration identifies Inpp5f (Sac2) as an endogenous suppressor of repair after spinal cord injury. J. Neurosci. 2015, 35:10429-10439.
    • (2015) J. Neurosci. , vol.35 , pp. 10429-10439
    • Zou, Y.1    Stagi, M.2    Wang, X.3    Yigitkanli, K.4    Siegel, C.S.5    Nakatsu, F.6    Cafferty, W.B.7    Stritttmatter, S.8
  • 196
    • 84884545941 scopus 로고    scopus 로고
    • Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury
    • Zukor K., Belin S., Wang C., Keelan N., Wang X., He Z. Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. J. Neurosci. 2013, 33:15350-153651.
    • (2013) J. Neurosci. , vol.33 , pp. 15350-153651
    • Zukor, K.1    Belin, S.2    Wang, C.3    Keelan, N.4    Wang, X.5    He, Z.6
  • 197
    • 0035176077 scopus 로고    scopus 로고
    • Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation
    • Zumbrunn J., Kinoshita K., Hyman A.A., Näthke I.S. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr. Biol. 2001, 11:44-49.
    • (2001) Curr. Biol. , vol.11 , pp. 44-49
    • Zumbrunn, J.1    Kinoshita, K.2    Hyman, A.A.3    Näthke, I.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.