Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries

Drug Discovery Today

Volumn 17, Issue 15-16, 2012, Pages 861-868

  Arachchige Don, Aruni S ^a   Tsang, Chi Kwan ^a   Kazdoba, Tatiana M ^b   D'Arcangelo, Gabriella ^b   Young, Wise ^c   Steven Zheng, X F ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; ERYTHROPOIETIN; MAMMALIAN TARGET OF RAPAMYCIN; METHYLPREDNISOLONE SODIUM SUCCINATE; NERVE GROWTH FACTOR; PROGESTERONE; RILUZOLE; TETRACYCLINE DERIVATIVE;

AGGRESSION; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANXIETY; BIPOLAR DISORDER; BLEEDING; CELL GROWTH; CENTRAL NERVOUS SYSTEM; CLINICAL STUDY; COGNITION; CONCUSSION; CONTUSION; DEPRESSION; DIFFUSE AXONAL INJURY; EPILEPSY; HUMAN; IRRITABILITY; METABOLISM; NEOPLASM; NEUROGENIC BOWEL; NEUROPATHIC PAIN; PARALYSIS; REVIEW; SLEEP DISORDER; SPINAL CORD INJURY; TRAUMATIC BRAIN INJURY; WHIPLASH INJURY;

ANIMALS; BRAIN INJURIES; CENTRAL NERVOUS SYSTEM; HUMANS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84864630240     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.04.010     Document Type: Review

References (71)

1. D.J. Thurman Traumatic brain injury in the United States: a public health perspective J. Head Trauma Rehabil. 14 1999 602 615 (Pubitemid 30027268)
2. J. Bruns Jr., and W.A. Hauser The epidemiology of traumatic brain injury: a review Epilepsia 44 Suppl. 10 2003 2 10 (Pubitemid 37280386)
3. S. Okie Traumatic brain injury in the war zone N. Engl. J. Med. 352 2005 2043 2047 (Pubitemid 40664304)
4. S. Thuret Therapeutic interventions after spinal cord injury Nat. Rev. Neurosci. 7 2006 628 643 (Pubitemid 44106745)
5. J.M. Provenzale Imaging of traumatic brain injury: a review of the recent medical literature AJR Am. J. Roentgenol. 194 2010 16 19
6. J. Fandino-Rivera Traumatic brain injury and ischemic stroke: a delayed sequela? Rev. Neurol. 38 2004 912 915 (Pubitemid 38923948)
7. J.R. Simpson Mild traumatic brain injury and postconcussion syndrome: the new evidence base for diagnosis and treatment J. Am. Acad. Psychiatry Law 39 2011 133 134
8. J.E. Risdall, and D.K. Menon Traumatic brain injury Philos. Trans. R. Soc. B 366 2011 241 250
9. J.W. McDonald, and C. Sadowsky Spinal-cord injury Lancet 359 2002 417 425 (Pubitemid 34158956)
10. K.S. Chua A brief review of traumatic brain injury rehabilitation Ann. Acad. Med. Singapore 36 2007 31 42 (Pubitemid 46512456)
11. G. Mandolesi Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity FASEB J. 18 2004 1934 1936 (Pubitemid 39602289)
12. T.A. Ferguson Armed response: how dying cells influence T-cell functions Immunol. Rev. 241 2011 77 88
13. D.C. Lie Neurogenesis in the adult brain: new strategies for central nervous system diseases Annu. Rev. Pharmacol. Toxicol. 44 2004 399 421 (Pubitemid 38263847)
14. R.K. Narayan Clinical trials in head injury J. Neurotrauma 19 2002 503 557 (Pubitemid 34587299)
15. J.W. Schouten Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature Curr. Opin. Crit. Care 13 2007 134 142 (Pubitemid 46328326)
16. A.I. Maas Clinical trials in traumatic brain injury: past experience and current developments Neurotherapeutics 7 2010 115 126
17. N.C. Royo Pharmacology of traumatic brain injury Curr. Opin. Pharmacol. 3 2003 27 32 (Pubitemid 36131323)
18. E. Park Traumatic brain injury: can the consequences be stopped? Can. Med. Assoc. J. 178 2008 1163 1170 (Pubitemid 351596226)
19. D.G. Stein, and D.W. Wright Progesterone in the clinical treatment of acute traumatic brain injury Expert Opin. Invest. Drugs 19 2010 847 857
20. S. Rossignol Spinal cord injury: time to move? J. Neurosci. 27 2007 11782 11792 (Pubitemid 350072087)
21. D.C. Baptiste, and M.G. Fehlings Emerging drugs for spinal cord injury Expert Opin. Emerg. Drugs 13 2008 63 80 (Pubitemid 351448703)
22. A.G. Rabchevsky, and P.H. Kitzman Latest approaches for the treatment of spasticity and autonomic dysreflexia in chronic spinal cord injury Neurotherapeutics 8 2011 274 282
23. M.B. Bracken A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study N. Engl. J. Med. 322 1990 1405 1411 (Pubitemid 20152525)
24. M.B. Bracken Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study JAMA 277 1997 1597 1604 (Pubitemid 27231191)
25. A.G. Rabchevsky Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward? Pharmacol. Ther. 132 2011 15 29
26. M.L. Wagner, and B.E. Landis Riluzole: a new agent for amyotrophic lateral sclerosis Ann. Pharmacother. 31 1997 738 744 (Pubitemid 27242384)
27. X. Mu Riluzole and methylprednisolone combined treatment improves functional recovery in traumatic spinal cord injury J. Neurotrauma 17 2000 773 780
28. W. Young Review of lithium effects on brain and blood Cell Transplant. 18 2009 951 975
29. S. David, and A.J. Aguayo Axonal elongation into peripheral nervous system 'bridges' after central nervous system injury in adult rats Science 214 1981 931 933 (Pubitemid 12220099)
30. G. Yiu, and Z. He Glial inhibition of CNS axon regeneration Nat. Rev. Neurosci. 7 2006 617 627 (Pubitemid 44106744)
31. L. McKerracher, and M.J. Winton Nogo on the go Neuron 36 2002 345 348 (Pubitemid 35284724)
32. K. Liu Neuronal intrinsic mechanisms of axon regeneration Annu. Rev. Neurosci. 34 2011 131 152
33. C. Tsang Targeting mammalian target of rapamycin (mTOR) for health and diseases Drug Discov. Today 12 2007 112 124 (Pubitemid 46176669)
34. A.S. Don, and X.F. Zheng Recent clinical trials of mTOR-targeted cancer therapies Rev. Recent Clin. Trials 6 2011 24 35
35. K.K. Park Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway Science 322 2008 963 966
36. J. Jaworski, and M. Sheng The growing role of mTOR in neuronal development and plasticity Mol. Neurobiol. 34 2006 205 219
37. L. Swiech Role of mTOR in physiology and pathology of the nervous system Biochim. Biophys. Acta 1784 2008 116 132
38. L. Swiech CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology J. Neurosci. 31 2011 4555 4568
39. J. Jaworski Control of dendritic arborization by the phosphoinositide- 3′-kinase-Akt-mammalian target of rapamycin pathway J. Neurosci. 25 2005 11300 11312 (Pubitemid 43083704)
40. V. Kumar Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways J. Neurosci. 25 2005 11288 11299 (Pubitemid 43083703)
41. Y. Jossin Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons J. Neurosci. 27 2007 4243 4252 (Pubitemid 46640708)
42. A. Ventruti Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain Neuroscience 189 2011 32 42
43. S. Chen Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury J. Cereb. Blood Flow Metab. 27 2007 939 949 (Pubitemid 46659022)
44. K. Liu PTEN deletion enhances the regenerative ability of adult corticospinal neurons Nat. Neurosci. 13 2010 1075 1081
45. L.Y. Hu ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats Neuroscience 169 2010 1046 1062
46. K. Ning PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons Hum. Mol. Genet. 19 2010 3159 3168
47. X. Wu PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes Biochem. Biophys. Res. Commun. 393 2010 514 518
48. J. Han Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin Mol. Cell. Neurosci. 39 2008 118 124
49. G. Pignataro Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options Curr. Opin. Pharmacol. 11 2011 378 394
50. S. Erlich Rapamycin is a neuroprotective treatment for traumatic brain injury Neurobiol. Dis. 26 2007 86 93 (Pubitemid 46436489)
51. R.R. Martel Inhibition of the immune response by rapamycin, a new antifungal antibiotic Can. J. Physiol. Pharmacol. 55 1977 48 51 (Pubitemid 8061941)
52. C.N. Sunnen Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice Epilepsia 52 2011 2065 2075
53. M. Wong Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies Epilepsia 51 2010 27 36
54. S.P. Sparagana Tuberous sclerosis complex: from basic science to clinical phenotypes: International Review of Child Neurology Series Neurology 67 2006 546
55. G. D'Arcangelo Rapamycin treatment suppresses epileptogenic activity in conditional Pten knockout mice Cell Cycle 9 2010 2487 2488
56. M.C. Ljungberg Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia Dis. Model. Mech. 2 2009 389 398
57. E. Shohami Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant J. Neuroimmunol. 72 1997 169 177 (Pubitemid 27062773)
58. M.H. DeLegge, and A. Smoke Neurodegeneration and Inflammation Nutr. Clin. Pract. 23 2008 35 41 (Pubitemid 351438966)
59. K.K. Park PTEN/mTOR and axon regeneration Exp. Neurol. 223 2010 45 50
60. P.D. Smith SOCS3 deletion promotes optic nerve regeneration in vivo Neuron 64 2009 617 623
61. E. Cattaneo Signalling through the JAK-STAT pathway in the developing brain Trends Neurosci. 22 1999 365 369 (Pubitemid 29339250)
62. R.E. Zigmond Changes in neuropeptide phenotype after axotomy of adult peripheral neurons and the role of leukemia inhibitory factor Perspect. Dev. Neurobiol. 4 1996 75 90 (Pubitemid 28144347)
63. V.B. Matthews, and M.A. Febbraio CNTF: a target therapeutic for obesity-related metabolic disease? J. Mol. Med. 86 2008 353 361
64. F. Hellal Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury Science 331 2011 928 931
65. V. Sengottuvel, and D. Fischer Facilitating axon regeneration in the injured CNS by microtubules stabilization Commun. Integr. Biol. 4 2011 391 393
66. V. Sengottuvel Taxol facilitates axon regeneration in the mature CNS J. Neurosci. 31 2011 2688 2699
67. S.H. Qi Neuroprotection of paclitaxel against cerebral ischemia/reperfusion-induced brain injury through JNK3 signaling pathway J. Recept. Signal Transduct. Res. 31 2011 402 407
68. L. Juillerat-Jeanneret The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles? Drug Discov. Today 13 2008 1099 1106
69. E. Rosivatz A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN) ACS Chem. Biol. 1 2006 780 790
70. F. Sun Sustained axon regeneration induced by co-deletion of PTEN and SOCS3 Nature 480 2011 372 375
71. X. Bo Gene therapy approaches for neuroprotection and axonal regeneration after spinal cord and spinal root injury Curr. Gene Ther. 11 2011 101 115