Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth

Brain

Volumn 132, Issue 11, 2009, Pages 3102-3121

  Douglas, Michael R ^a,b   Morrison, Kevin C ^a   Jacques, Steven J ^a   Leadbeater, Wendy E ^a   Gonzalez, Ana Maria ^a   Berry, Martin ^a   Logan, Ann ^a   Ahmed, Zubair ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b RUSSELLS HALL HOSPITAL   (United Kingdom)

Author keywords

AG1478; Axon regeneration; Disinhibition; EGFR; Glia; Neurite outgrowth; RGC; SiRNA

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP; EPIDERMAL GROWTH FACTOR RECEPTOR; HYBRID PROTEIN; K 252A; MYELIN; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL]ACRYLAMIDE; NERVE GROWTH FACTOR; NEUROTROPHIN 3; NEUROTROPHIN RECEPTOR P75; PROTEIN TYROSINE KINASE A; RHO FACTOR; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL INTERACTION; CELL STIMULATION; CONTROLLED STUDY; DISEASE MODEL; FEMALE; GLIA; GROWTH INHIBITION; GROWTH REGULATION; MOUSE; MUELLER CELL; NERVE CELL INHIBITION; NERVE FIBER; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; OPTIC NERVE; OPTIC NERVE INJURY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RECEPTOR BLOCKING; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; TISSUE CULTURE; TRANSCRIPTION REGULATION;

ADAM PROTEINS; ANIMALS; AXONS; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYCLIC AMP; FEMALE; HUMANS; MICE; NERVE GROWTH FACTORS; NERVE REGENERATION; NEUROGLIA; OPTIC NERVE; QUINAZOLINES; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, TRKA; RECEPTOR, TRKB; RECEPTOR, TRKC; RECOMBINANT FUSION PROTEINS; RETINAL GANGLION CELLS; RNA, SMALL INTERFERING; TYRPHOSTINS;

EID: 70350673949     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awp240     Document Type: Article

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