Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo

Journal of Neurochemistry

Volumn 103, Issue 1, 2007, Pages 181-189

  Lingor, Paul ^a,b   Teusch, Nicole ^c   Schwarz, Katrin ^c   Mueller, Reinhold ^c   Mack, Helmut ^c   Bähr, Mathias ^a,b   Mueller, Bernhard K ^c  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b Deutsche Forschungsgemeinschaft   (Germany)

^c ABBOTT GMBH AND CO KG   (Germany)

Author keywords

Neurite outgrowth; Ntera 2; Optic nerve; Regeneration; Rho kinase inhibitors

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; DIMETHYLFASUDIL; FASUDIL; H 1152; PROTEOCHONDROITIN SULFATE; RHO KINASE; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NERVE CELL; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVE REGENERATION; OPTIC NERVE; PRIORITY JOURNAL; RETINA GANGLION CELL;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMIDES; ANIMALS; AXONS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NERVE CRUSH; NERVE REGENERATION; NEURITES; NEURONS; OPTIC NERVE; OPTIC NERVE INJURIES; PROTEIN-SERINE-THREONINE KINASES; PROTEOCHONDROITIN SULFATES; PYRIDINES; RATS; RATS, WISTAR;

MAMMALIA; RATTUS;

EID: 34548638861     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04756.x     Document Type: Article

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