Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination

Journal of Neuroscience

Volumn 34, Issue 25, 2014, Pages 8432-8448

  Lebrun Julien, Frédéric ^a   Bachmann, Lea ^a   Norrmén, Camilla ^a   Trötzmüller, Martin ^b,c   Köfeler, Harald ^b,c   Rüegg, Markus A ^d   Hall, Michael N ^d   Suter, Ueli ^a  

^a ETH ZURICH   (Switzerland)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c Omics Center Graz   (Austria)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

mTOR; Myelin; Oligodendrocytes; TSC1; TSC2; Tuberous sclerosis

Indexed keywords

KI 67 ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MESSENGER RNA; MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PROTEIN KINASE B; PROTEOLIPID PROTEIN; RAPAMYCIN; S6 KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TUBERIN;

ANIMAL TISSUE; ARTICLE; CELL MATURATION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DOWN REGULATION; ELECTRON MICROSCOPY; GENE CONTROL; GENE DELETION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOMYELINATION; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LIPID ANALYSIS; LIPID COMPOSITION; LIPOGENESIS; MASS SPECTROMETRY; MORPHOMETRICS; MOUSE; MUTANT; MYELINATION; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

MTOR; MYELIN; OLIGODENDROCYTES; TSC1; TSC2; TUBEROUS SCLEROSIS;

ANIMALS; CENTRAL NERVOUS SYSTEM; FEMALE; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MULTIPROTEIN COMPLEXES; NERVE FIBERS, MYELINATED; OLIGODENDROGLIA; SPINAL CORD; TOR SERINE-THREONINE KINASES;

EID: 84902455406     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1105-14.2014     Document Type: Article

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