메뉴 건너뛰기




Volumn 5, Issue , 2002, Pages 1046-1050

Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN;

EID: 0036829006     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn938     Document Type: Review
Times cited : (310)

References (55)
  • 1
    • 0013067786 scopus 로고
    • The nerve growth factor: Thirty-five years later
    • Levi-Montalcini, R. The nerve growth factor: Thirty-five years later. EMBO J. 6, 1145-1154 (1987).
    • (1987) EMBO J. , vol.6 , pp. 1145-1154
    • Levi-Montalcini, R.1
  • 2
    • 0025524602 scopus 로고
    • The nerve growth factor family
    • Barde, Y.-A. The nerve growth factor family. Prog. Growth Factor Res. 2, 237-348 (1990).
    • (1990) Prog. Growth Factor Res. , vol.2 , pp. 237-348
    • Barde, Y.-A.1
  • 3
    • 0033635904 scopus 로고    scopus 로고
    • Neurotrophins: Key regulators of cell fate and cell shape in the vertebrate nervous system
    • Bibel, M. & Barde, Y.-A. Neurotrophins: Key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14, 2919-2937 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2919-2937
    • Bibel, M.1    Barde, Y.-A.2
  • 4
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • Kaplan, D. R. & Miller, F. D. Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 10, 381-391 (2000).
    • (2000) Curr. Opin. Neurobiol. , vol.10 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 5
    • 0034941330 scopus 로고    scopus 로고
    • Nerve growth factor signaling, neuroprotection, and neural repair
    • Sofroniew, M. V., Howe, C. L. & Mobley, W. C. Nerve growth factor signaling, neuroprotection, and neural repair. Annu. Rev. Neurosci. 24, 1217-1281 (2001).
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 1217-1281
    • Sofroniew, M.V.1    Howe, C.L.2    Mobley, W.C.3
  • 6
    • 0036591405 scopus 로고    scopus 로고
    • The many faces of p75 (NTR)
    • Hempstead, B. L. The many faces of p75 (NTR). Curr. Opin. Neurobiol. 12, 260-267 (2002).
    • (2002) Curr. Opin. Neurobiol. , vol.12 , pp. 260-267
    • Hempstead, B.L.1
  • 7
    • 0033709426 scopus 로고    scopus 로고
    • Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization
    • Donovan, M. J. et al. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 127, 4531-4540 (2000).
    • (2000) Development , vol.127 , pp. 4531-4540
    • Donovan, M.J.1
  • 8
    • 84984756890 scopus 로고    scopus 로고
    • Neurotrophic cross-talk between the nervous and immune systems: Implications for inflammatory and degenerative neurological diseases
    • Kerschensteiner, M., Stadelmann, C., Dechant, G., Wekerle, H. & Hohlfeld, R. Neurotrophic cross-talk between the nervous and immune systems: Implications for inflammatory and degenerative neurological diseases. Ann. Neurol. (in press).
    • Ann. Neurol.
    • Kerschensteiner, M.1    Stadelmann, C.2    Dechant, G.3    Wekerle, H.4    Hohlfeld, R.5
  • 9
    • 0022549757 scopus 로고
    • Nerve growth factor and Alzheimer's disease
    • Hefti, F. & Weiner, W. J. Nerve growth factor and Alzheimer's disease. Ann. Neurol. 20, 275-281 (1986).
    • (1986) Ann. Neurol. , vol.20 , pp. 275-281
    • Hefti, F.1    Weiner, W.J.2
  • 10
    • 0023643241 scopus 로고
    • Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
    • Fisher, W. et al. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329, 65-68 (1987).
    • (1987) Nature , vol.329 , pp. 65-68
    • Fisher, W.1
  • 12
    • 0029794239 scopus 로고    scopus 로고
    • The response ofmotoneurons to neurotrophins
    • Sendtner, M., Holtmann, B. & Hughes, R. A. The response ofmotoneurons to neurotrophins. Neurochem. Res. 21, 831-841 (1996).
    • (1996) Neurochem. Res. , vol.21 , pp. 831-841
    • Sendtner, M.1    Holtmann, B.2    Hughes, R.A.3
  • 13
    • 0026749255 scopus 로고
    • Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy
    • Sendtner, M. et al. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358, 502-504 (1992).
    • (1992) Nature , vol.358 , pp. 502-504
    • Sendtner, M.1
  • 14
    • 0028027060 scopus 로고
    • Arrests of motor neuron disease in wobbler mice cotreated with CNTF and BDNF
    • Mitsumoto, H. et al. Arrests of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science 265, 1107-1110 (1994).
    • (1994) Science , vol.265 , pp. 1107-1110
    • Mitsumoto, H.1
  • 15
    • 0007101117 scopus 로고    scopus 로고
    • Pharmacokinetics of intrathecally apllied BDNF and effects on spinal motoneurons
    • Dittrich, F. et al. Pharmacokinetics of intrathecally apllied BDNF and effects on spinal motoneurons. Exp. Neurol. 141, 225-239 (1996).
    • (1996) Exp. Neurol. , vol.141 , pp. 225-239
    • Dittrich, F.1
  • 16
    • 0030889462 scopus 로고    scopus 로고
    • Ligand-induced down-regulation of trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons
    • Knusel, B. et al. Ligand-induced down-regulation of trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons. Neuroscience 78, 851-862 (1997).
    • (1997) Neuroscience , vol.78 , pp. 851-862
    • Knusel, B.1
  • 17
    • 0002605482 scopus 로고    scopus 로고
    • (eds. Ingoglia, N.A. & Murray, M.) Marcel Dekker, New York and Basel
    • Thoenen, H. in Axonal Regeneration in the Central Nervous System (eds. Ingoglia, N.A. & Murray, M.) 675-697 (Marcel Dekker, New York and Basel, 2000).
    • (2000) Axonal Regeneration in the Central Nervous System , pp. 675-697
    • Thoenen, H.1
  • 19
    • 0035511739 scopus 로고    scopus 로고
    • Electrical activity and development of neural circuits
    • Zhang, L. I. & Poo, M.-M. Electrical activity and development of neural circuits. Nat. Neurosci. 4 (Suppl), 1207-1214 (2001).
    • (2001) Nat. Neurosci. , vol.4 , pp. 1207-1214
    • Zhang, L.I.1    Poo, M.-M.2
  • 23
    • 1842329729 scopus 로고    scopus 로고
    • Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons
    • Gravel, C., Gotz, R., Lorrain, A. & Sendtner, M. Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons. Nat. Med. 3, 765-770 (1997).
    • (1997) Nat. Med. , vol.3 , pp. 765-770
    • Gravel, C.1    Gotz, R.2    Lorrain, A.3    Sendtner, M.4
  • 24
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower, J. H. et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290, 767-773 (2000).
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.H.1
  • 25
    • 0032192146 scopus 로고    scopus 로고
    • Recent advances in inducible gene expression systems
    • Rossi, F. M. V. & Blau, H. M. Recent advances in inducible gene expression systems. Curr. Opin. Biotechnol. 9, 451-456 (1998).
    • (1998) Curr. Opin. Biotechnol. , vol.9 , pp. 451-456
    • Rossi, F.M.V.1    Blau, H.M.2
  • 26
    • 0033740246 scopus 로고    scopus 로고
    • Tetracycline-regulated gene expression in the brain
    • Mansuy, I. M. & Bujard, H. Tetracycline-regulated gene expression in the brain. Curr. Opin. Neurobiol. 10, 593-596 (2000).
    • (2000) Curr. Opin. Neurobiol. , vol.10 , pp. 593-596
    • Mansuy, I.M.1    Bujard, H.2
  • 27
    • 0034721123 scopus 로고    scopus 로고
    • Stem cells - Hype and hope
    • McKay, R. Stem cells - Hype and hope. Nature 406, 361-364 (2000).
    • (2000) Nature , vol.406 , pp. 361-364
    • McKay, R.1
  • 28
    • 0033578688 scopus 로고    scopus 로고
    • BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
    • Huang, Z. J. et al. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell 98, 739-755 (1999).
    • (1999) Cell , vol.98 , pp. 739-755
    • Huang, Z.J.1
  • 29
    • 0036602967 scopus 로고    scopus 로고
    • Exercise: A behavioral intervention to enhance brain health and plasticity
    • Cotman, C. W. & Berchtold, N. C. Exercise: A behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 25, 295-301 (2002).
    • (2002) Trends Neurosci. , vol.25 , pp. 295-301
    • Cotman, C.W.1    Berchtold, N.C.2
  • 30
    • 18144446836 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor I mediates effects of exercise on the brain
    • Carro, E., Nuñez, A., Busiguina, S. & Torres-Aleman, I. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J. Neurosci. 20, 2926-2933 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 2926-2933
    • Carro, E.1    Nuñez, A.2    Busiguina, S.3    Torres-Aleman, I.4
  • 31
    • 0035426212 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy
    • Carro, E., Trejo, J. L., Busiguina, S. & Torres-Aleman, I. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J. Neurosci. 21, 5678-5684 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 5678-5684
    • Carro, E.1    Trejo, J.L.2    Busiguina, S.3    Torres-Aleman, I.4
  • 33
    • 0036193248 scopus 로고    scopus 로고
    • Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors
    • Vigna, E. et al. Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors. Mol. Therapy 5, 252-261 (2002).
    • (2002) Mol. Therapy , vol.5 , pp. 252-261
    • Vigna, E.1
  • 34
    • 0037095710 scopus 로고    scopus 로고
    • TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo
    • Cheng, L., Saphieha, P., Kittlerova, P., Hauswirth, W. W. & Di Polo, A. TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J. Neurosci. 22, 3977-3986 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 3977-3986
    • Cheng, L.1    Saphieha, P.2    Kittlerova, P.3    Hauswirth, W.W.4    Di Polo, A.5
  • 35
    • 0036006816 scopus 로고    scopus 로고
    • Distinctive features of Trk neurotrophins receptor transactivation by G protein-coupled receptors
    • Lee, F. S., Rajagopal, R. & Chao, M. V. Distinctive features of Trk neurotrophins receptor transactivation by G protein-coupled receptors. Cytokine Growth Factor Rev. 13, 11-17 (2002).
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 11-17
    • Lee, F.S.1    Rajagopal, R.2    Chao, M.V.3
  • 36
    • 0030928225 scopus 로고    scopus 로고
    • Pharmacology of neurotrophic factors
    • Hefti, F. Pharmacology of neurotrophic factors. Annu. Rev. Pharmacol. 37, 239-267 (1997).
    • (1997) Annu. Rev. Pharmacol. , vol.37 , pp. 239-267
    • Hefti, F.1
  • 38
    • 0034176591 scopus 로고    scopus 로고
    • A new concept in neurodegeneration: TNF-alpha is a silencer of survival signals
    • Venters, H. D., Dantzer, R. & Kelley, K. W. A new concept in neurodegeneration: TNF-alpha is a silencer of survival signals. Trends Neurosci. 23, 175-180 (2000).
    • (2000) Trends Neurosci. , vol.23 , pp. 175-180
    • Venters, H.D.1    Dantzer, R.2    Kelley, K.W.3
  • 39
    • 0028788303 scopus 로고
    • A phase I study of recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis
    • The ALS CNTF Treatment Study (ACTS) Phase I-II Study Group
    • The ALS CNTF Treatment Study (ACTS) Phase I-II Study Group. A phase I study of recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis. Clin. Neuropharmacol. 18, 515-532 (1995).
    • (1995) Clin. Neuropharmacol. , vol.18 , pp. 515-532
  • 40
    • 9044219848 scopus 로고    scopus 로고
    • A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis
    • rhCNTF ALS Study Group
    • Miller, R. G. et al. A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group. Ann. Neurol. 39, 256-260 (1996).
    • (1996) Ann. Neurol. , vol.39 , pp. 256-260
    • Miller, R.G.1
  • 41
    • 2442646665 scopus 로고    scopus 로고
    • A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis
    • ALS CNTF Treatment Study group (ACTS)
    • ALS CNTF Treatment Study group (ACTS). A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. Neurology 46, 1244-1249 (1996).
    • (1996) Neurology , vol.46 , pp. 1244-1249
  • 42
    • 15844381714 scopus 로고    scopus 로고
    • Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients
    • Aebischer, P. et al. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat. Med. 2, 696-699 (1996).
    • (1996) Nat. Med. , vol.2 , pp. 696-699
    • Aebischer, P.1
  • 43
    • 0031028248 scopus 로고    scopus 로고
    • Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase I trial)
    • Penn, R. D., Kroin, J. S., York, M. M. & Cedarbaum, J. M. Intrathecal ciliary neurotrophic factor delivery for treatment of amyotrophic lateral sclerosis (phase I trial). Neurosurgery 40, 94-99 (1997).
    • (1997) Neurosurgery , vol.40 , pp. 94-99
    • Penn, R.D.1    Kroin, J.S.2    York, M.M.3    Cedarbaum, J.M.4
  • 44
    • 0034632379 scopus 로고    scopus 로고
    • Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF
    • Bachoud-Levi, A. C. et al. Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Hum. Gene Ther. 11, 1723-1729 (2000).
    • (2000) Hum. Gene Ther. , vol.11 , pp. 1723-1729
    • Bachoud-Levi, A.C.1
  • 45
    • 0005868926 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease
    • Ericsdotter Jönhagen, M. et al. Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease. Dementia Geriatr. Cogn. Disord. 9, 246-257 (1998).
    • (1998) Dementia Geriatr. Cogn. Disord. , vol.9 , pp. 246-257
    • Ericsdotter Jönhagen, M.1
  • 46
    • 0031752714 scopus 로고    scopus 로고
    • Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy
    • NGF Study Group
    • Apfel, S. C. et al. Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group. Neurology 51, 695-702 (1998).
    • (1998) Neurology , vol.51 , pp. 695-702
    • Apfel, S.C.1
  • 47
    • 0034328085 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial
    • rhNGF Clinical Investigator Group
    • Apfel, S. C. et al. Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator Group. JAMA 284, 2215-2221 (2000).
    • (2000) JAMA , vol.284 , pp. 2215-2221
    • Apfel, S.C.1
  • 48
    • 0034646215 scopus 로고    scopus 로고
    • A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection
    • AIDS Clinical Trials Group Team 291
    • McArthur, J. C. et al. A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291. Neurology 54, 1080-1088 (2000).
    • (2000) Neurology , vol.54 , pp. 1080-1088
    • McArthur, J.C.1
  • 49
    • 0035833962 scopus 로고    scopus 로고
    • Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy
    • Schifitto, G. et al. Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy. Neurology 57, 1313-1316 (2001).
    • (2001) Neurology , vol.57 , pp. 1313-1316
    • Schifitto, G.1
  • 50
    • 0344076149 scopus 로고    scopus 로고
    • A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)
    • A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III). Neurology 52, 1427-1433 (1999).
    • (1999) Neurology , vol.52 , pp. 1427-1433
  • 51
    • 0034208461 scopus 로고    scopus 로고
    • A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis
    • Ochs, G. et al. A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 1, 201-206 (2000).
    • (2000) Amyotroph. Lateral Scler. Other Motor Neuron Disord. , vol.1 , pp. 201-206
    • Ochs, G.1
  • 52
    • 0035692887 scopus 로고    scopus 로고
    • A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy
    • Wellmer, A., Misra, V. P., Sharief, M. K., Kopelman, P. G. & Anand, P. A double-blind placebo-controlled clinical trial of recombinant human brain-derived neurotrophic factor (rhBDNF) in diabetic polyneuropathy. J. Peripher. Nerv. Syst. 6, 204-210 (2001).
    • (2001) J. Peripher. Nerv. Syst. , vol.6 , pp. 204-210
    • Wellmer, A.1    Misra, V.P.2    Sharief, M.K.3    Kopelman, P.G.4    Anand, P.5
  • 53
    • 0033984963 scopus 로고    scopus 로고
    • Tolerability of recombinant-methionyl human neurotrophin-3 (r-metHuNT3) in healthy subjects
    • Chaudhry, V. et al. Tolerability of recombinant-methionyl human neurotrophin-3 (r-metHuNT3) in healthy subjects. Muscle Nerve 23, 189-192 (2000).
    • (2000) Muscle Nerve , vol.23 , pp. 189-192
    • Chaudhry, V.1
  • 54
    • 6844266272 scopus 로고    scopus 로고
    • Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study
    • The North America ALS/IGF-I Study Group
    • Lai, E. C. et al. Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group. Neurology 49, 1621-1630 (1997).
    • (1997) Neurology , vol.49 , pp. 1621-1630
    • Lai, E.C.1
  • 55
    • 0031722582 scopus 로고    scopus 로고
    • A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group
    • Borasio, G. D. et al. A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group. Neurology 51, 583-586 (1998).
    • (1998) Neurology , vol.51 , pp. 583-586
    • Borasio, G.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.