Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 in vivo

Journal of Neuroscience

Volumn 20, Issue 2, 2000, Pages 722-728

  Kermer, Pawel ^a,b   Klöcker, Nikolaj ^a   Labes, Monika ^a   Bähr, Mathias ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Apoptosis; Caspase 3; Insulin like growth factor I; Neuroprotection; PI3 K; PKB Akt; Retinal ganglion cells

Indexed keywords

CASPASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C; WORTMANNIN; AKT1 PROTEIN, RAT; ANDROSTANE DERIVATIVE; CASP3 PROTEIN, RAT; CASPASE; ENZYME INHIBITOR; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; SOMATOMEDIN B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ENZYME INHIBITION; FEMALE; NERVE FIBER TRANSECTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RETINA GANGLION CELL; ANIMAL; CELL DEATH; CELL SURVIVAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; OPTIC NERVE; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; AXOTOMY; CASPASE 3; CASPASES; CELL DEATH; CELL SURVIVAL; ENZYME INHIBITORS; FEMALE; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; OPTIC NERVE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RETINAL GANGLION CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 0342927484     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-02-00722.2000     Document Type: Article

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