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Volumn 64, Issue 21, 2004, Pages 7773-7779

Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

EID: 7444264727     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2487     Document Type: Article
Times cited : (188)

References (53)
  • 1
    • 0033579163 scopus 로고    scopus 로고
    • Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity
    • Bethesda
    • Ali IU, Schriml LM, Dean M. Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst (Bethesda) 1999;91:1922-32.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1922-1932
    • Ali, I.U.1    Schriml, L.M.2    Dean, M.3
  • 2
    • 0042316755 scopus 로고    scopus 로고
    • PTEN: One gene, many syndromes
    • Eng C. PTEN: one gene, many syndromes. Hum Mutat 2003;22:183-98.
    • (2003) Hum Mutat , vol.22 , pp. 183-198
    • Eng, C.1
  • 3
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 4
    • 0142011466 scopus 로고    scopus 로고
    • PTEN: From pathology to biology
    • Sulis ML, Parsons R. PTEN: from pathology to biology. Trends Cell Biol 2003;13:478-83.
    • (2003) Trends Cell Biol , vol.13 , pp. 478-483
    • Sulis, M.L.1    Parsons, R.2
  • 5
    • 0041450058 scopus 로고    scopus 로고
    • PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
    • Freeman DJ, Li AG, Wei G, et al. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell 2003;3:117-30.
    • (2003) Cancer Cell , vol.3 , pp. 117-130
    • Freeman, D.J.1    Li, A.G.2    Wei, G.3
  • 6
    • 1242284600 scopus 로고    scopus 로고
    • Regulation of cell migration by the C2 domain of the tumor suppressor PTEN
    • Wash DC
    • Raftopoulou M, Etienne-Manneville S, Self A, Nicholls S, Hall A. Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science (Wash DC) 2004;303:1179-81.
    • (2004) Science , vol.303 , pp. 1179-1181
    • Raftopoulou, M.1    Etienne-Manneville, S.2    Self, A.3    Nicholls, S.4    Hall, A.5
  • 7
    • 13144249184 scopus 로고    scopus 로고
    • High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
    • Suzuki A, de la Pompa JL, Stambolic V, et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 1998;8:1169-78.
    • (1998) Curr Biol , vol.8 , pp. 1169-1178
    • Suzuki, A.1    De La Pompa, J.L.2    Stambolic, V.3
  • 8
    • 13044250465 scopus 로고    scopus 로고
    • Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
    • Podsypanina K, Ellenson LH, Nemes A, et al. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci USA 1999;96:1563-8.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1563-1568
    • Podsypanina, K.1    Ellenson, L.H.2    Nemes, A.3
  • 9
  • 10
    • 0035824396 scopus 로고    scopus 로고
    • Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
    • Wash DC
    • Groszer M, Erickson R, Scripture-Adams DD, et al. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science (Wash DC) 2001;294:2186-9.
    • (2001) Science , vol.294 , pp. 2186-2189
    • Groszer, M.1    Erickson, R.2    Scripture-Adams, D.D.3
  • 11
    • 0036637660 scopus 로고    scopus 로고
    • PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum
    • Camb
    • Marino S, Krimpenfort P, Leung C, et al. PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development (Camb) 2002;129:3513-22.
    • (2002) Development , vol.129 , pp. 3513-3522
    • Marino, S.1    Krimpenfort, P.2    Leung, C.3
  • 12
    • 0035733762 scopus 로고    scopus 로고
    • Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    • Backman SA, Stambolic V, Suzuki A, et al. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet 2001;29:396-403.
    • (2001) Nat Genet , vol.29 , pp. 396-403
    • Backman, S.A.1    Stambolic, V.2    Suzuki, A.3
  • 13
    • 0035734381 scopus 로고    scopus 로고
    • Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease
    • Kwon CH, Zhu X, Zhang J, et al. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet 2001;29:404-11.
    • (2001) Nat Genet , vol.29 , pp. 404-411
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3
  • 14
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie Y, Suzuki A, Kataoka E, et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Investig 2004;113:1774-83.
    • (2004) J Clin Investig , vol.113 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3
  • 15
    • 0038067837 scopus 로고    scopus 로고
    • Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
    • Camb
    • Kimura T, Suzuki A, Fujita Y, et al. Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development (Camb) 2003;130:1691-700.
    • (2003) Development , vol.130 , pp. 1691-1700
    • Kimura, T.1    Suzuki, A.2    Fujita, Y.3
  • 16
    • 0036714806 scopus 로고    scopus 로고
    • Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland
    • Camb
    • Li G, Robinson GW, Lesche R, et al. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development (Camb) 2002;129:4159-70.
    • (2002) Development , vol.129 , pp. 4159-4170
    • Li, G.1    Robinson, G.W.2    Lesche, R.3
  • 17
    • 0037309972 scopus 로고    scopus 로고
    • Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation
    • Suzuki A, Itami S, Ohishi M, et al. Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res 2003;63:674-81.
    • (2003) Cancer Res , vol.63 , pp. 674-681
    • Suzuki, A.1    Itami, S.2    Ohishi, M.3
  • 18
    • 4243110417 scopus 로고    scopus 로고
    • Pten dose dictates cancer progression in the prostate
    • Dec 1; Epub 2003 Oct 27
    • Trotman LC, Niki M, Dotan ZA, et al. Pten dose dictates cancer progression in the prostate. PLoS Biol 2003 Dec 1;3:E59. Epub 2003 Oct 27.
    • (2003) PLoS Biol , vol.3
    • Trotman, L.C.1    Niki, M.2    Dotan, Z.A.3
  • 19
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • Wang S, Gao J, Lei Q, et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 2003;4:209-21.
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1    Gao, J.2    Lei, Q.3
  • 20
    • 0037672568 scopus 로고    scopus 로고
    • Recent advances in the molecular genetics of primary gliomas
    • Kitange GJ, Templeton KL, Jenkins RB. Recent advances in the molecular genetics of primary gliomas. Curr Opin Oncol 2003;15:197-203.
    • (2003) Curr Opin Oncol , vol.15 , pp. 197-203
    • Kitange, G.J.1    Templeton, K.L.2    Jenkins, R.B.3
  • 21
    • 0036293742 scopus 로고    scopus 로고
    • Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation
    • Bajenaru ML, Zhu Y, Hedrick NM, et al. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol 2002;22:5100-13.
    • (2002) Mol Cell Biol , vol.22 , pp. 5100-5113
    • Bajenaru, M.L.1    Zhu, Y.2    Hedrick, N.M.3
  • 22
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999;21:70-1.
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 23
    • 0034995242 scopus 로고    scopus 로고
    • T cell-specific loss of pten leads to defects in central and peripheral tolerance
    • Suzuki A, Yamaguchi MT, Ohteki T, et al. T cell-specific loss of pten leads to defects in central and peripheral tolerance. Immunity 2001;14:523-34.
    • (2001) Immunity , vol.14 , pp. 523-534
    • Suzuki, A.1    Yamaguchi, M.T.2    Ohteki, T.3
  • 24
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    • Wechsler-Reya RJ, Scott MP. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 1999;22:103-14.
    • (1999) Neuron , vol.22 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 25
    • 0034488835 scopus 로고    scopus 로고
    • Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision
    • Novak A, Guo C, Yang W, Nagy A, Lobe CG. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 2000;28:147-55.
    • (2000) Genesis , vol.28 , pp. 147-155
    • Novak, A.1    Guo, C.2    Yang, W.3    Nagy, A.4    Lobe, C.G.5
  • 26
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glial scar
    • Silver J, Miller JH. Regeneration beyond the glial scar. Nat Rev Neurosci 2004;5:146-56.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 27
    • 0028807384 scopus 로고
    • Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury
    • Frisen J, Johansson CB, Torok C, Risling M, Lendahl U. Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury. J Cell Biol 1995;131:453-64.
    • (1995) J Cell Biol , vol.131 , pp. 453-464
    • Frisen, J.1    Johansson, C.B.2    Torok, C.3    Risling, M.4    Lendahl, U.5
  • 28
    • 1542268981 scopus 로고    scopus 로고
    • For the long run: Maintaining germinal niches in the adult brain
    • Alvarez-Buylla A, Lim DA. For the long run: maintaining germinal niches in the adult brain. Neuron 2004;41:683-6.
    • (2004) Neuron , vol.41 , pp. 683-686
    • Alvarez-Buylla, A.1    Lim, D.A.2
  • 29
    • 0037421992 scopus 로고    scopus 로고
    • Neuronal or glial progeny: Regional differences in radial glia fate
    • Malatesta P, Hack MA, Hartfuss E, et al. Neuronal or glial progeny: regional differences in radial glia fate. Neuron 2003;37:751-64.
    • (2003) Neuron , vol.37 , pp. 751-764
    • Malatesta, P.1    Hack, M.A.2    Hartfuss, E.3
  • 30
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medullo-blastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A. Induction of medullo-blastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 2000;14:994-1004.
    • (2000) Genes Dev , vol.14 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    Van Der Gulden, H.3    Jonkers, J.4    Berns, A.5
  • 31
    • 1842527386 scopus 로고    scopus 로고
    • Radial glia serve as neuronal progenitors in all regions of the central nervous system
    • Anthony TE, Klein C, Fishell G, Heintz N. Radial glia serve as neuronal progenitors in all regions of the central nervous system. Neuron 2004;41:881-90.
    • (2004) Neuron , vol.41 , pp. 881-890
    • Anthony, T.E.1    Klein, C.2    Fishell, G.3    Heintz, N.4
  • 32
    • 0034652102 scopus 로고    scopus 로고
    • A role for nuclear PTEN in neuronal differentiation
    • Lachyankar MB, Sultana N, Schonhoff CM, et al. A role for nuclear PTEN in neuronal differentiation. J Neurosci 2000;20:1404-13.
    • (2000) J Neurosci , vol.20 , pp. 1404-1413
    • Lachyankar, M.B.1    Sultana, N.2    Schonhoff, C.M.3
  • 33
    • 0036007421 scopus 로고    scopus 로고
    • Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
    • Kozma SC, Thomas G. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioessays 2002;24:65-71.
    • (2002) Bioessays , vol.24 , pp. 65-71
    • Kozma, S.C.1    Thomas, G.2
  • 34
    • 3943106696 scopus 로고    scopus 로고
    • Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation
    • Uhlmann EJ, Li W, Scheidenhelm DK, et al. Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia 2004;47:180-88.
    • (2004) Glia , vol.47 , pp. 180-188
    • Uhlmann, E.J.1    Li, W.2    Scheidenhelm, D.K.3
  • 35
    • 0036713644 scopus 로고    scopus 로고
    • Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures
    • Uhlmann EJ, Wong M, Baldwin RL, et al. Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann Neurol 2002;52:285-96.
    • (2002) Ann Neurol , vol.52 , pp. 285-296
    • Uhlmann, E.J.1    Wong, M.2    Baldwin, R.L.3
  • 36
    • 0141478669 scopus 로고    scopus 로고
    • Overgrowth syndromes: Is dysfunctional PI3-kinase signalling a unifying mechanism?
    • Barker KT, Houlston RS. Overgrowth syndromes: is dysfunctional PI3-kinase signalling a unifying mechanism? Eur J Hum Genet 2003;11:665-70.
    • (2003) Eur J Hum Genet , vol.11 , pp. 665-670
    • Barker, K.T.1    Houlston, R.S.2
  • 37
    • 0242268407 scopus 로고    scopus 로고
    • mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
    • Kwon CH, Zhu X, Zhang J, Baker SJ. mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci USA 2003;100:12923-8.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12923-12928
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3    Baker, S.J.4
  • 38
    • 17944368972 scopus 로고    scopus 로고
    • An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
    • Podsypanina K, Lee RT, Politis C, et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci USA 2001;98:10320-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10320-10325
    • Podsypanina, K.1    Lee, R.T.2    Politis, C.3
  • 39
    • 17944377486 scopus 로고    scopus 로고
    • Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
    • Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001;98:10314-9.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10314-10319
    • Neshat, M.S.1    Mellinghoff, I.K.2    Tran, C.3
  • 40
    • 0037108682 scopus 로고    scopus 로고
    • Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
    • Kenerson HL, Aicher LD, True LD, Yeung RS. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res 2002;62:5645-50.
    • (2002) Cancer Res , vol.62 , pp. 5645-5650
    • Kenerson, H.L.1    Aicher, L.D.2    True, L.D.3    Yeung, R.S.4
  • 41
  • 42
    • 0035856918 scopus 로고    scopus 로고
    • c-Myc regulates mammalian body size by controlling cell number but not cell size
    • Trumpp A, Refaeli Y, Oskarsson T, et al. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature (Lond) 2001;414:768-73.
    • (2001) Nature (Lond) , vol.414 , pp. 768-773
    • Trumpp, A.1    Refaeli, Y.2    Oskarsson, T.3
  • 43
    • 0033539555 scopus 로고    scopus 로고
    • c-Myc enhances protein synthesis and cell size during B lymphocyte development
    • Iritani BM, Eisenman RN. c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proc Natl Acad Sci USA 1999;96:13180-5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13180-13185
    • Iritani, B.M.1    Eisenman, R.N.2
  • 44
    • 0033523928 scopus 로고    scopus 로고
    • Control of cell growth by c-Myc in the absence of cell division
    • Schuhmacher M, Staege MS, Pajic A, et al. Control of cell growth by c-Myc in the absence of cell division. Curr Biol 1999;9:1255-8.
    • (1999) Curr Biol , vol.9 , pp. 1255-1258
    • Schuhmacher, M.1    Staege, M.S.2    Pajic, A.3
  • 45
    • 0035916325 scopus 로고    scopus 로고
    • PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)
    • Mamillapalli R, Gavrilova N, Mihaylova VT, et al. PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol 2001;11:263-7.
    • (2001) Curr Biol , vol.11 , pp. 263-267
    • Mamillapalli, R.1    Gavrilova, N.2    Mihaylova, V.T.3
  • 46
    • 0035361602 scopus 로고    scopus 로고
    • PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells
    • Zhu X, Kwon CH, Schlosshauer PW, Ellenson LH, Baker SJ. PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells. Cancer Res 2001;61:4569-75.
    • (2001) Cancer Res , vol.61 , pp. 4569-4575
    • Zhu, X.1    Kwon, C.H.2    Schlosshauer, P.W.3    Ellenson, L.H.4    Baker, S.J.5
  • 47
    • 0034462121 scopus 로고    scopus 로고
    • Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
    • Nakamura N, Ramaswamy S, Vazquez F, et al. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 2000;20:8969-82.
    • (2000) Mol Cell Biol , vol.20 , pp. 8969-8982
    • Nakamura, N.1    Ramaswamy, S.2    Vazquez, F.3
  • 48
    • 0037030466 scopus 로고    scopus 로고
    • Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kipl expression in TSC2+/- cells
    • Uhlmann EJ, Apicelli AJ, Baldwin RL, et al. Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kipl expression in TSC2+/- cells. Oncogene 2002;21:4050-9.
    • (2002) Oncogene , vol.21 , pp. 4050-4059
    • Uhlmann, E.J.1    Apicelli, A.J.2    Baldwin, R.L.3
  • 49
    • 0035833356 scopus 로고    scopus 로고
    • Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression
    • Soucek T, Rosner M, Miloloza A, et al. Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression. Oncogene 2001;20:4904-9.
    • (2001) Oncogene , vol.20 , pp. 4904-4909
    • Soucek, T.1    Rosner, M.2    Miloloza, A.3
  • 50
    • 15844384256 scopus 로고    scopus 로고
    • A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
    • Fero ML, Rivkin M, Tasch M, et al. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 1996;85:733-44.
    • (1996) Cell , vol.85 , pp. 733-744
    • Fero, M.L.1    Rivkin, M.2    Tasch, M.3
  • 51
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Nakayama K, Ishida N, Shirane M, et al. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996;85:707-20.
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1    Ishida, N.2    Shirane, M.3
  • 52
    • 0037302119 scopus 로고    scopus 로고
    • Signaling pathways regulating gliomagenesis
    • Konopka G, Bonni A. Signaling pathways regulating gliomagenesis. Curr Mol Med 2003;3:73-84.
    • (2003) Curr Mol Med , vol.3 , pp. 73-84
    • Konopka, G.1    Bonni, A.2
  • 53
    • 0036490954 scopus 로고    scopus 로고
    • Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
    • Xiao A, Wu H, Pandolfi PP, Louis DN, Van Dyke T. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 2002;1:157-68.
    • (2002) Cancer Cell , vol.1 , pp. 157-168
    • Xiao, A.1    Wu, H.2    Pandolfi, P.P.3    Louis, D.N.4    Van Dyke, T.5


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